Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Gulf of Mexico (39)
- Remote sensing (34)
- Animals (32)
- Oil spill (24)
- Deepwater Horizon (23)
-
- Climate change (22)
- Humans (20)
- MODIS (19)
- Malaria (17)
- Ecology (16)
- Phytoplankton (16)
- Bacteria (14)
- Biodiversity (14)
- Conservation (14)
- Fish (14)
- GRACE (14)
- Foraminifera (13)
- Proteomics (13)
- Stable isotopes (13)
- Cave (12)
- Ecosystem (12)
- Epigenetics (12)
- Metabolism (12)
- Paleoceanography (12)
- Sea level (12)
- Zooplankton (12)
- Aging (11)
- Biomass (11)
- Cancer (11)
- Coral (11)
- Publication Year
- Publication
-
- USF Tampa Graduate Theses and Dissertations (860)
- Marine Science Faculty Publications (727)
- International Journal of Speleology (103)
- Integrative Biology Faculty and Staff Publications (88)
- C-IMAGE data (85)
-
- Molecular Biosciences Faculty Publications (77)
- C-IMAGE Publications (59)
- USF St. Petersburg campus Faculty Publications (12)
- Numeracy (10)
- Journal of Ecological Anthropology (6)
- School of Information Faculty Publications (6)
- University of South Florida (USF) M3 Publishing (6)
- Alambique. Revista académica de ciencia ficción y fantasía / Jornal acadêmico de ficção científica e fantasía (4)
- School of Geosciences Faculty and Staff Publications (4)
- Academic Services Faculty and Staff Publications (3)
- Claudia J. Dold (3)
- National Cave and Karst Management Symposium 2013 (3)
- Chemistry Faculty Publications (2)
- Genocide Studies and Prevention: An International Journal (2)
- Physical Education and Exercise Science Faculty Publications (2)
- Suburban Sustainability (2)
- Academic Resources Faculty and Staff Publications (1)
- Chemical, Biological and Materials Engineering Faculty Publications (1)
- Environmental Sustainability Books (1)
- Food and Gardening Working Group (1)
- Journal of Global Education and Research (1)
- Mathematics and Statistics Faculty Publications (1)
- Physics Faculty Publications (1)
- Psychology Faculty Publications (1)
- Service-Learning Syllabi (1)
- Publication Type
- File Type
Articles 1 - 30 of 2077
Full-Text Articles in Entire DC Network
Multivalency Of The Mdmx Acidic Domain Slims Use Different Binding Modes To Inhibit Mdmx And P53, Malissa Fenton
Multivalency Of The Mdmx Acidic Domain Slims Use Different Binding Modes To Inhibit Mdmx And P53, Malissa Fenton
USF Tampa Graduate Theses and Dissertations
Regulation of protein binding through autoinhibition commonly occurs via interactions involving intrinsically disordered regions (IDRs). These intramolecular interactions can directly or allosterically inhibit intermolecular protein or DNA binding, regulate enzymatic activity, and control the assembly of large macromolecular complexes. Autoinhibitory interactions mediated by protein disorder are inherently transient, making their identification and characterization challenging. In this work, we explore the structural and functional diversity of disorder-mediated autoinhibition for a variety of biological mechanisms, with a focus on the role of multivalency and effective concentration. We also discuss the evolution of disordered motifs that participate in autoinhibition using examples where sequence …
Thermal Ecology And Swimming Performance Of Native Tadpoles Dryophytes Femoralis In Central Florida, Jessalyn Aretz
Thermal Ecology And Swimming Performance Of Native Tadpoles Dryophytes Femoralis In Central Florida, Jessalyn Aretz
USF Tampa Graduate Theses and Dissertations
Urbanization and climate warming have contributed to global amphibian declines in recent decades. Amphibians are particularly vulnerable to climate and urban-induced warming because their physiological processes are dependent on temperature across all life stages, but few studies have been done on tadpole responses to warming in comparison to adult responses. The study objective was to determine how the thermal ecology and swimming performance of a native Florida tadpole varied with rearing temperature and urban level, and whether these traits are plastic or adaptive. We collected eggs from wild populations of pine woods treefrog (Dryophytes femoralis) tadpoles at an urban and …
Effects Of Diminazene Aceturate On Drosophila Melanogaster: A Lipidomic Analysis, Gabriela Suarez
Effects Of Diminazene Aceturate On Drosophila Melanogaster: A Lipidomic Analysis, Gabriela Suarez
USF Tampa Graduate Theses and Dissertations
Pesticides are agents designed to eradicate living organisms to preserve agricultural needs.1 Today the most commonly used pesticides are termed “modern pesticides”, they are characterized by lower lipophilicity and limited stability, making them less time persistent in the environment. Among these modern pesticides are organophosphorus, urea, phenoxy alkanoic, triazine, chloroacetanilide, and glyphosate-based pesticides.2 The issue faced with most of these pesticides is that they affect more than just the targeted pest and pose a danger to not only humans, but also entire ecosystems.1,3,4 While there are many different types of pesticides, insecticides show the most variance and …
Linking Shared Decision Making To Outcomes In Simulated Prenatal Genetic Counseling Sessions, Raquel C. Chavarria
Linking Shared Decision Making To Outcomes In Simulated Prenatal Genetic Counseling Sessions, Raquel C. Chavarria
USF Tampa Graduate Theses and Dissertations
Shared decision-making (SDM), defined as the collaborative process between patient and healthcare provider to arrive at a values-based clinical decision, may be valuable in genetic counseling (GC) given that patients are often faced with various options. Four published studies have measured or made conclusions about the use of SDM skills in GC settings, but only one study evaluated relationships between third-party observations of SDM in recorded GC sessions and patient-reported outcomes (i.e., anxiety and decisional conflict) and found no correlations between these measures. The purpose of this study was to evaluate relationships between SDM and measures of patient-reported experience (i.e., …
Evaluation Of Pediatric Genetics Clinics’ Workflows, Efficiencies, & Genetic Counselor Job Satisfaction, Ashlyn M. Keziah
Evaluation Of Pediatric Genetics Clinics’ Workflows, Efficiencies, & Genetic Counselor Job Satisfaction, Ashlyn M. Keziah
USF Tampa Graduate Theses and Dissertations
The organizational structures and workflows of pediatric/general genetics clinics exhibit significant variability across institutions. However, there is a notable lack of studies exploring which structural components within pediatric clinics contribute to increased patient volumes, while concurrently upholding genetic counselor work satisfaction and mitigating burnout risks. To address this gap, this multiple case study delves into the operational dynamics of several pediatric genetics clinics located throughout the state of Florida. We employed surveys and interviews to identify shared patterns and distinctions in clinic workflows and structures, subsequently evaluating efficiency and genetic counselor job satisfaction/burnout at each site. This study includes survey …
Under Pressure: The Soft Robotic Clap-And-Fling Of Cuvierina Atlantica, Daniel Mead
Under Pressure: The Soft Robotic Clap-And-Fling Of Cuvierina Atlantica, Daniel Mead
USF Tampa Graduate Theses and Dissertations
Evolution over billions of years has led to unique animals of all types. The tiny sea butterfly is one that remains mostly anonymous because of its size and low place on the food chain, but it is a swimming creature that when examined closely reveals a surprise. Shockingly, it has a swimming motion nearly identical to small insects flying at intermediate Reynolds numbers, referred to as the clap-and-fling. The centimeter long pteropod flapping briskly at 5Hz escapes attention with its size and speed. Modeling the clap-and-fling motion of the sea butterfly at a larger scale allows the benefits and uniqueness …
Analyzing The Relationship Between Preeclamptic Severity And Placental Methylation, Mackenzie C. Maggio
Analyzing The Relationship Between Preeclamptic Severity And Placental Methylation, Mackenzie C. Maggio
USF Tampa Graduate Theses and Dissertations
Preeclampsia (PE) is a life-threatening hypertensive disorder in pregnancy (HDP) characterized by high blood pressure and proteinuria after 20 weeks of gestation. PE poses significant risks to both maternal and child health. An incomplete etiopathogenesis, diverse disease heterogeneity, and limited intervention and detection strategies further exacerbate and perpetuate PE as a major public health concern. By assessing symptom severity of placental tissues from PE pregnancies and analyzing the DNA methylation differences, this thesis aimed to identify epigenetic variations contributing to disease heterogeneity. Using the publicly available dataset GSE 98224, differentially methylated region (DMR) analysis on placental samples (n=48) revealed increasing …
A Differentially Methylated Region Analysis Between Three Disease States Of Major Depressive Disorder In Primarily African-American Cohorts, Lanie Katelynn Mullins
A Differentially Methylated Region Analysis Between Three Disease States Of Major Depressive Disorder In Primarily African-American Cohorts, Lanie Katelynn Mullins
USF Tampa Graduate Theses and Dissertations
Major depressive disorder (MDD) is a common and debilitating disorder that affects millions of people worldwide. MDD is a multifactorial disease with no established mechanism currently able to explain all facets of the disease or its etiology. Feedback loop mechanisms have been posited to explain the interactions of psychological and physical components of the disease etiology. Epigenetics, specifically DNA-methylation analyses, can shed light on the interaction between the within-person environment resulting from MDD symptomology, the persistence of the disease, and factors influencing remission. Here, a differentially methylated region analysis was conducted using samples derived from whole blood to interrogate the …
Preliminary Investigation Of Differences In Host Mitochondria Membrane Potential During Toxoplasma Gondii Infection, Bryan L. Ortega
Preliminary Investigation Of Differences In Host Mitochondria Membrane Potential During Toxoplasma Gondii Infection, Bryan L. Ortega
USF Tampa Graduate Theses and Dissertations
Toxoplasma gondii is an obligate intracellular protozoan with a broad host range of hosts, including various warm-blooded mammals, including humans. While infections can often be asymptomatic in immunocompetent individuals, they can pose significant risks to those who are immunocompromised, as well as pregnant women. Toxoplasmosis represents a significant burden on public health in the United States, with over 800,000 annual infections reported, often leading to severe complications such as symptomatic eye disease and congenital infections. Recent attention has developed regarding its potential association with human neuropathies such as Alzheimer's disease, dementia, and mood disorders. This project investigated differences in host …
Metatranscriptomic Insights Into The Interaction Between Microcystis Blooms And Hydrogen Peroxide, Taylor L. Hancock
Metatranscriptomic Insights Into The Interaction Between Microcystis Blooms And Hydrogen Peroxide, Taylor L. Hancock
USF Tampa Graduate Theses and Dissertations
For this dissertation I studied the interactions of hydrogen peroxide and cyanobacterial harmful algal blooms (cHABs) dominated by Microcystis in the Caloosahatchee River, FL. Specifically, I examined how taxonomic and functional succession relates to both natural hydrogen peroxide dynamics and hydrogen peroxide added to the environment as a cHAB treatment. Chapter 2 investigated how taxonomic succession and gene expression patterns relate to blooms and associated elevated hydrogen peroxide concentrations. The results showed that gene expressions related to cyanobacterial growth were positively correlated with hydrogen peroxide. The genes identified included enzymes capable of hydrogen peroxide generation which were expressed by blooming …
Genetic Counseling Student Self-Efficacy, Exam Anxiety, And Opinions Related To Study Materials For The Genetic Counseling Board Certification Exam., Jessica F. Stanton
Genetic Counseling Student Self-Efficacy, Exam Anxiety, And Opinions Related To Study Materials For The Genetic Counseling Board Certification Exam., Jessica F. Stanton
USF Tampa Graduate Theses and Dissertations
The Genetic Counseling Board Examination is a critical assessment for clinical practice in the field. However, the relationship between students’ test-related anxiety, confidence in their ability to study (i.e., self-efficacy), and the use of gamification for board examination preparation remains unexplored. This study compared gamification and traditional quiz-style study methods using two randomized groups of students preparing for the Genetic Counseling Board Examination. The primary objectives were to assess for changes in exam-related anxiety and self-efficacy after completing the respective study materials and to evaluate the acceptability and completion rates of these materials. Ninety-eight genetic counseling students or recent graduates …
Androgen Drives Melanoma Invasiveness And Metastatic Spread By Inducing Tumorigenic Fucosylation, Qian Liu
Androgen Drives Melanoma Invasiveness And Metastatic Spread By Inducing Tumorigenic Fucosylation, Qian Liu
USF Tampa Graduate Theses and Dissertations
Melanoma incidence and mortality rates are historically higher for men than women, with an estimated ~47% more new cases and twice the lethality in men in the US in 2023. Consistent with these discrepancies, emerging studies have highlighted the tumorigenic role of the male sex hormone androgen and its receptor (AR) in promoting melanoma aggressiveness. However, underlying cellular and molecular mechanisms and their precise pathological contributions are not well-defined. We recently discovered a sex-associated disparity in melanoma fucosylation, the post-translational modification of proteins with the dietary sugar L-fucose. Fucosylation, the conjugation of fucose moieties onto different glycan linkages on target …
Exploring The Swimming Behavior Of A Hydromechanical Copepod In The Context Of Positive Density Dependence, Eva J. Muir
Exploring The Swimming Behavior Of A Hydromechanical Copepod In The Context Of Positive Density Dependence, Eva J. Muir
USF Tampa Graduate Theses and Dissertations
This dissertation investigates the swimming behavior and population dynamics of the marine copepod, Acartia tonsa. This copepod is of interest as it utilizes hydromechanical signals within the environment to navigate its surroundings, resulting in a distinctive hop/sink swimming pattern. This adaptive trait serves several purposes including searching for mates, obtaining food, and detecting predators, however the evolution of this unique swimming style has not been explored. To address this knowledge gap, the first chapter of this dissertation explores the swimming characteristics and escape responses of captive-reared and wild-caught A. tonsa. When reared in aquaculture, A. tonsa populations experience higher populations …
Why Should Early-Career Scientists Publish In Society Journals, Stephen K. Dolan, Lori D. Banks, Wenqi Yu
Why Should Early-Career Scientists Publish In Society Journals, Stephen K. Dolan, Lori D. Banks, Wenqi Yu
Molecular Biosciences Faculty Publications
In this editorial, written by early-career scientists, we advocate for the invaluable role of society journals in our scientific community. By choosing to support these journals as authors, peer reviewers, and as editors, we can reinforce our academic growth and benefit from their re-investment back into the scientific ecosystem. Considering the numerous clear merits of this system for future generations of microbiologists and more broadly, society, we argue that early-career researchers should publish our high-quality research in society journals to shape the future of science and scientific publishing landscape.
The Inaugural Mbio Junior Editorial Board—Lessons Learned And The Path Forward Toward Improving The Peer Review Process, Cynthia Ayefoumi Adinortey, Stephen K. Dolan, Sarah Doore, Rebeccah Lijek, Diana Priscila Pires, Wenqi Yu, Elizabeth B. Draganova, Lennart Schada Von Borzyskowski
The Inaugural Mbio Junior Editorial Board—Lessons Learned And The Path Forward Toward Improving The Peer Review Process, Cynthia Ayefoumi Adinortey, Stephen K. Dolan, Sarah Doore, Rebeccah Lijek, Diana Priscila Pires, Wenqi Yu, Elizabeth B. Draganova, Lennart Schada Von Borzyskowski
Molecular Biosciences Faculty Publications
The inaugural Junior Editorial Board (JEB) of mBio consisted of 64 early-career researchers active from 2022 to 2023. The goal of the JEB was to train early-career researchers in the art of peer review under the guidance of experienced editors. JEB members gained hands-on experience in peer review by participating in modules detailing the publishing process through the lenses of the journal, editor, and reviewer. Ultimately, JEB members applied this new knowledge by reviewing mBio manuscripts. Here, we summarize the background, the mission, and the achievements of the first mBio JEB. We also include possible trajectories for the future editions …
Human Motion Detection Evaluated Through An Evoked Cortical Potential Frequency Spectrum, Howard E. Painter
Human Motion Detection Evaluated Through An Evoked Cortical Potential Frequency Spectrum, Howard E. Painter
USF Tampa Graduate Theses and Dissertations
Electrical potentials were recorded from scalp of normal male subjects while they were viewing continuously moving sinusoidal gratings. Responses from the occipital cortex were amplified, digitized, stored and then transformed from the time domain to the frequency domain using a microcomputer based Fast Fourier Transform algorithm. High frequency components (Beta Activity) of the resulting power spectrum were analyzed for evidence on neural generators (electrical sources) in the striate cortex driven presumably by transient-cells (Y-cells or Magnocellular) responding to the continuously moving grating. Several stimulus parameters were examined: angular velocity, spatial frequency, direction (orientation), color, and intensity. A16 Hz component of …
Integration Of Algae And Biomass Processes To Synthesize Renewable Bioproducts For The Circular Economy, Jessica Martin
Integration Of Algae And Biomass Processes To Synthesize Renewable Bioproducts For The Circular Economy, Jessica Martin
USF Tampa Graduate Theses and Dissertations
Rapid population growth and global industrialization have substantially heightened the demand for fossil-based fuels and products in various sectors of the global economy, including energy production, transportation fuels, and as raw materials for petrochemicals. The intense consumption of fossil fuels has caused immense environmental impacts, especially pertaining to carbon dioxide emissions. Shifting to renewable feedstocks (raw materials) is expected to reduce these emissions by lowering the carbon footprint of fuels and products compared to traditional fossil-derived alternatives. This transition aligns with the goal of creating a sustainable and circular economy, emphasizing efficient resource use, and reducing waste generation through recycling …
Book Review: Kings, Conquerors, Psychopaths: From Alexander To Hitler To The Corporation, Tim Bakken
Book Review: Kings, Conquerors, Psychopaths: From Alexander To Hitler To The Corporation, Tim Bakken
Genocide Studies and Prevention: An International Journal
The book Kings, Conquerors, Psychopaths is a survey of a vast amount of human wrongdoing. It lays bare the motivations of aggressors who wish to subjugate nations or groups of people and corporate executives and government bureaucrats who make discretionary decisions that harm people. Along with cataloging mass killings by despots and soldiers, the book includes stories about Ponzi-schemers and the deaths of automobile drivers and passengers who were killed by vehicle defects known to the manufacturer. The book posits that “[p]owerful, elite forces are trying to force us backward toward a non-democratic state, one where power, wealth, and prerogative …
Targeting Bet Proteins Downregulates Mir-33a To Promote Synergy With Pim Inhibitors In Cmml, Christopher T. Letson
Targeting Bet Proteins Downregulates Mir-33a To Promote Synergy With Pim Inhibitors In Cmml, Christopher T. Letson
USF Tampa Graduate Theses and Dissertations
Chronic Myelomonocytic Leukemia (CMML) is a rare myeloid malignancy with a dismal prognosis and no therapeutic options which are capable of altering the natural course of the disease. There remains a significant need for novel therapies that are able to meaningfully improve patient outcomes. In this study we explore the effectiveness of Bromodomain and Extra-Terminal domain protein inhibitor (BETi) combinations in CMML. Preclinical studies in myeloid neoplasms have demonstrated efficacy of BETi. However, BETi demonstrate poor single agent activity in clinical trials. Several studies suggest that combinations with other anti-cancer inhibitors may enhance the efficacy of BETi. To nominate BETi …
Coupling Chemical And Genomic Data Of Marine Sediment-Associated Bacteria For Metabolite Profiling, Stephanie P. Suarez
Coupling Chemical And Genomic Data Of Marine Sediment-Associated Bacteria For Metabolite Profiling, Stephanie P. Suarez
USF Tampa Graduate Theses and Dissertations
Marine sediment-associated bacteria house many new and exciting novel secondary metabolites. These metabolites can be tested for bioactivity against various types of cancer and fungal, bacterial, and viral infections. In this thesis, we investigated the combination of biosynthetic gene cluster information with mass spectra to perform a chemical profiling of sediment- associated bacteria. Furthermore, we utilized a scoring technique to provide an identification and confidence score to each annotated compound. The sediment was collected from east Arthur Harbor, Palmer Station, Antarctica, at depths of 20 ft and 60 ft. After plating on agar, 52 unique bacterial strains were isolated, with …
Book Review: Habitantes De La Obscuridad (Fauna Ibero-Balear De Las Cuevas) – Inhabitants Of The Darkness (Ibero-Baleric Fauna Of Caves), Oana Teodora Moldovan
Book Review: Habitantes De La Obscuridad (Fauna Ibero-Balear De Las Cuevas) – Inhabitants Of The Darkness (Ibero-Baleric Fauna Of Caves), Oana Teodora Moldovan
International Journal of Speleology
NA
Red Mangrove (Rhizophora Mangle) Recruitment And Retention Dynamics On Eastern Oyster (Crassostrea Virginica) Reefs In A Subtropical Estuary, Noreen Selma Mathews
Red Mangrove (Rhizophora Mangle) Recruitment And Retention Dynamics On Eastern Oyster (Crassostrea Virginica) Reefs In A Subtropical Estuary, Noreen Selma Mathews
USF Tampa Graduate Theses and Dissertations
Mangroves are invading oyster reefs in areas no longer impacted by winter freezes and completely transforming them into mangrove islands. The mechanisms influencing the transition between these two habitat states remain unclear. Here, I test experimentally whether oyster reef (Crassostrea virginica) structure directly facilitates red mangrove (Rhizophora mangle) propagule capture via differences in propagule retention and successful mangrove establishment. In addition to oyster reef structure, I compared physical reef features of size, elevation, and wind-wave exposure to uncover whether these traits influenced mangrove retention. Recently- abscised red mangrove propagules were inserted onto 21 oyster reefs across 5 sites in Tampa …
Patterns In Biodiversity And Community Assemblage In Macrofaunal Fouling Communities On Tampa Bay Floating Docks, Cassidy C. Bell
Patterns In Biodiversity And Community Assemblage In Macrofaunal Fouling Communities On Tampa Bay Floating Docks, Cassidy C. Bell
USF Tampa Graduate Theses and Dissertations
Understanding biodiversity trends of highly disturbed urban landscapes is essential as anthropogenic factors continue to drive global biodiversity loss. Within marine ecosystems, macrofaunal fouling communities, aggregations of epibenthic invertebrates that colonize human-made structures, represent an ecologically important subset of urban coastlines. Tampa Bay is a highly urbanized estuary in Florida, USA, and is home to the state’s largest port, Port Tampa Bay. This makes the bay a prime site for the introduction of new species, with many organisms either considered invasive or cryptogenic, their origins left unclear. Many factors may contribute to the communities that form on urban structures including …
Regulated Intramembrane Proteolysis By M82 Peptidases: The Role Of Prss In The Staphylococcus Aureus Stress Response, Baylie M. Schott
Regulated Intramembrane Proteolysis By M82 Peptidases: The Role Of Prss In The Staphylococcus Aureus Stress Response, Baylie M. Schott
USF Tampa Graduate Theses and Dissertations
Staphylococcus aureus is a major threat to human health, which is only exacerbated by its resistance to methicillin and other frontline antibiotics. Consequently, annual hospitalizations resulting from methicillin-resistant Staphylococcus aureus (MRSA) have been recorded in the hundreds of thousands for decades. However, the global impact of this opportunistic pathogen cannot solely be attributed to its antibiotic resistance, as S. aureus is also an expert at adapting to host conditions and responding to external stress. Here we attempt to gain a better understanding of a S. aureus factor that aids in circumventing such external insult - PrsS - a membrane protease …
Hurricanes And Tropical Storms’ Impact On Water Quality In Lake Okeechobee, Florida, Daniela Vasquez Diaz
Hurricanes And Tropical Storms’ Impact On Water Quality In Lake Okeechobee, Florida, Daniela Vasquez Diaz
USF Tampa Graduate Theses and Dissertations
Hurricanes are natural events with catastrophic outcomes, while climate change's effects on their intensity and frequency remain discussed. However, it is crucial to analyze these through models and statistics to understand their behavior and impact on the basins. Particularly in lakes on tropical coasts since disruptive events such as hurricanes tend to be highly affected. Lake Okeechobee is a unique lake located in Florida and one of the largest freshwater lakes. The lake and some of its significant stations are the locations chosen to perform the investigation. The main focus of the investigation is determining the effect that hurricanes have …
Book Review: Australian Caves And Karst Systems, John Webb, Susan White, Garry K. Smith, Jo De Waele
Book Review: Australian Caves And Karst Systems, John Webb, Susan White, Garry K. Smith, Jo De Waele
International Journal of Speleology
No abstract provided.
Developing A Point-Of-Care Detection Kit For Parkinson’S Disease Using Gold Nanoparticle-Based Lateral Flow Assay, Ali Aljassabi
Developing A Point-Of-Care Detection Kit For Parkinson’S Disease Using Gold Nanoparticle-Based Lateral Flow Assay, Ali Aljassabi
USF Tampa Graduate Theses and Dissertations
Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease and the fastest-growing neurodegenerative disorder in the world. The major issue with PD is that it takes several years of biological changes until the patient starts to experience physiological symptoms that could affect their daily lives. The major hallmark of PD is the appearance of Lewy body inclusions in the neuron’s cytoplasm, which is rich in a protein called α-Synuclein (α-Syn). Several studies have shown that the levels of α-Syn in blood increase because the excess α-Syn is released from neurons into the bloodstream through extracellular vesicles. …
Thermodynamic Frustration Of Tad2 And Prr Contribute To Autoinhibition Of P53, Emily Gregory
Thermodynamic Frustration Of Tad2 And Prr Contribute To Autoinhibition Of P53, Emily Gregory
USF Tampa Graduate Theses and Dissertations
The intrinsically disordered transcription factor and tumor suppressor p53 binds to promoter response element DNA upon cellular stress and activates genes associated with cell cycle arrest, senescence, and apoptosis. Disruption of sequence specific binding to target gene promoters is heavily implicated in human health, where a majority of cancers contain mutations localized to the DNA binding domain (DBD) of p53. p53 DNA binding is regulated by posttranslational modifications, associations with cellular factors, and by an autoinhibitory intramolecular interaction. The autoinhibitory intramolecular interaction occurs when the disordered N-terminal transactivation domain (TAD) interacts with the ordered DBD. Previous work in the Daughdrill …
Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation And Progression, Janine M. Deblasi
Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation And Progression, Janine M. Deblasi
USF Tampa Graduate Theses and Dissertations
NRF2 is a redox-responsive transcription factor the directs the antioxidant program and several critical metabolic processes. Mutations in NRF2 or its negative regulator KEAP1 occur in up to one third of non-small cell lung cancers (NSCLCs) and are often associated with resistance to therapy and poor outcomes. In the present studies, murine alleles of the Keap1 and Nrf2 mutations found in human NSCLC were developed and I comprehensively investigated their impact on tumor initiation and progression. I observed that chronic Nrf2 stabilization by Keap1 loss-of-function or Nrf2 activating mutation was not sufficient to cause lung tumor initiation, even when p53 …
Development Of Antiviral Peptidomimetics, Songyi Xue
Development Of Antiviral Peptidomimetics, Songyi Xue
USF Tampa Graduate Theses and Dissertations
Protein-protein interactions (PPIs) are essential for biological processes and are associated with a number of diseases, including cancer, infectious diseases, and neurodegenerative diseases. As a result, modulation of PPIs has been recognized as one of the most promising strategies to develop the novel drugs. Peptide modulators always exhibit higher specificity and affinities with targets than small compounds or monoclonal antibodies, but their broad medicinal effectiveness is constrained by their poor bioavailability and biostability. Peptidomimetics, which have been developed to mimic the structure as well as function of bioactive peptides and proteins, have shown excellent potential in protein surface mimicry and …