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Influence Of Oxygen Microenvironment On Microfluidic Glucose Sensor Performance, Chang-Soo Kim, Jongwon Park

Electrical and Computer Engineering Faculty Research & Creative Works

We propose a novel method to overcome significant problems of baseline drift and sensitivity degradation in amperometric biosensors based on oxidase enzyme reactions. A novel glucose microsensor with a built-in electrochemical oxygen manipulation microsystem is introduced to demonstrate three novel functionalities; one-point in situ self-calibration (zero-point), broadening of dynamic range and increase in sensitivity. The influence of electrochemically generated oxygen microenvironment on the sensor output within a fluidic structure is investigated.