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Hepatotoxic And Nephrotoxic Effects Of Chronic Exposure To Vernonia Cinerea Crude Extract On Wistar Rats, Thularath Toommakorn, Sajee Waramit, Patchara Danaisawadi, Kantimanee Pradermwong
Hepatotoxic And Nephrotoxic Effects Of Chronic Exposure To Vernonia Cinerea Crude Extract On Wistar Rats, Thularath Toommakorn, Sajee Waramit, Patchara Danaisawadi, Kantimanee Pradermwong
The Thai Journal of Pharmaceutical Sciences
Vernonia cinerea L. (VC) has been used for smoking cessation and decreased appetite in Thailand. However, the safety of this plant concerning long-term consumption has never been reported. A 6-month toxicity study of VC water crude extract (VCWE) was performed in both genders of Wistar rats at doses of 15, 150, and 1500 mg/kg body weight/day orally. Recovery group received 1500 mg/kg for 6 months and then extended for 14 days without the extract. It was found that the males could not tolerate the highest dose of VCWE. There was no effect on bodyweight, relative organ weight, nor hematological parameters …
Current Perspectives On The Therapeutic Potential Of Mitragyna Speciosa And Its Derivatives On Animal Model, Norsyifa Harun, Illa Syafiqah Johari, Rima Atria Japarin, Farah Wahida Suhaimi, Zurina Hassan, Mohammed Shoaib
Current Perspectives On The Therapeutic Potential Of Mitragyna Speciosa And Its Derivatives On Animal Model, Norsyifa Harun, Illa Syafiqah Johari, Rima Atria Japarin, Farah Wahida Suhaimi, Zurina Hassan, Mohammed Shoaib
The Thai Journal of Pharmaceutical Sciences
The plant Mitragyna speciosa Korth. is receiving increased attention as a therapeutic substitution for opioid use disorder (OUD). The active alkaloids constituents of the plant, particularly mitragynine and 7-hydroxymitragynine, have been shown to modulate opioid receptors, acting as agonists at mu-opioid receptors. Given this pharmacology, several studies have examined the abuse and dependence potential of M. speciosa and its alkaloids in various animal models of dependence. In addition to action on opioid receptors, the Mitragyna alkaloids also appear to exert diverse activities at other receptors in the central nervous system which may explain the complex pharmacological profile of these alkaloids. …
Evidence For Intravenous Self-Administration Of Mitragynine In Fentanyl-Dependent Rats, Norsyifa Harun, Zurina Hassan, Surash Ramanathan, Mohammed Shoaib
Evidence For Intravenous Self-Administration Of Mitragynine In Fentanyl-Dependent Rats, Norsyifa Harun, Zurina Hassan, Surash Ramanathan, Mohammed Shoaib
The Thai Journal of Pharmaceutical Sciences
Introduction: Kratom (Mitragyna speciosa Korth) is currently used as an alternative for the self-treatment of pain and management of opioid dependence and withdrawal. Due to the opioid-like effect of the plant’s active alkaloid, mitragynine (MG), the evaluation of its ability to maintain self-administration in animal models of opioid dependence appears to be great significance. Objectives: Here, the ability of MG to cross-substitute to the reinforcing effects of the synthetic narcotic fentanyl is investigated. Methods: Rats with implanted catheters were allowed to self-administer fentanyl (2.0 μg/kg/infusion) on a fixed-ratio 1 of schedule of reinforcement. Results: A significant increase in lever pressing …
Acute Oral Toxicity Test Of Quercusinfectoria G. Olivier Extract In Rats, Tuanta Sematong, Sirinan Thubthimthed, Sareeya Reungpathanapong, Sarunya Laovitthayanggoon, Chuleratana Banchonglikitkul
Acute Oral Toxicity Test Of Quercusinfectoria G. Olivier Extract In Rats, Tuanta Sematong, Sirinan Thubthimthed, Sareeya Reungpathanapong, Sarunya Laovitthayanggoon, Chuleratana Banchonglikitkul
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Acute Oral Toxicity Test Of Anaxagorea Luzonensis A. Grey And Ziziphus Attopensis Pierre Extract In Rats, Phanukit Kunhachan, Tuanta Sematong, Parkpoom Siriarchavatana, Chantara Poonsiri, Amonrat Khayungamnawee, Sarunya Laovitthayanggoon, Sareeya Reungpathanapong, Sawai Nakakaew, Vicheon Kaeynok, Chuleratana Banchonglikitkul
Acute Oral Toxicity Test Of Anaxagorea Luzonensis A. Grey And Ziziphus Attopensis Pierre Extract In Rats, Phanukit Kunhachan, Tuanta Sematong, Parkpoom Siriarchavatana, Chantara Poonsiri, Amonrat Khayungamnawee, Sarunya Laovitthayanggoon, Sareeya Reungpathanapong, Sawai Nakakaew, Vicheon Kaeynok, Chuleratana Banchonglikitkul
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Acute Oral Toxicity Test Of Muntingia Calabura L. Extract In Rats, Tuanta Sematong, Parkpoom Siriarchavatana, Chantara Poonsiri, Amonrat Khayungamnawee, Sarunya Laovitthayanggoon, Phanukit Kunhachan, Sareeya Reungpathanapong, Sawai Nakakaew, Vicheon Kaeynok, Chuleratana Banchonglikitkul
Acute Oral Toxicity Test Of Muntingia Calabura L. Extract In Rats, Tuanta Sematong, Parkpoom Siriarchavatana, Chantara Poonsiri, Amonrat Khayungamnawee, Sarunya Laovitthayanggoon, Phanukit Kunhachan, Sareeya Reungpathanapong, Sawai Nakakaew, Vicheon Kaeynok, Chuleratana Banchonglikitkul
The Thai Journal of Pharmaceutical Sciences
No abstract provided.