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Expression Of Fused In Sarcoma Mutations In Mice Recapitulates The Neuropathology Of Fus Proteinopathies And Provides Insight Into Disease Pathogenesis, Christophe Verbeeck, Mariely Dejesus-Hernandez, Carolina Ceballos-Diaz, Jannet Kocerha, Todd Golde, Pritam Das, Rosa Rademakers, Dennis W. Dickson, Thomas Kukar
Expression Of Fused In Sarcoma Mutations In Mice Recapitulates The Neuropathology Of Fus Proteinopathies And Provides Insight Into Disease Pathogenesis, Christophe Verbeeck, Mariely Dejesus-Hernandez, Carolina Ceballos-Diaz, Jannet Kocerha, Todd Golde, Pritam Das, Rosa Rademakers, Dennis W. Dickson, Thomas Kukar
Jannet Kocerha
Background: Mutations in the gene encoding the RNA-binding protein fused in sarcoma (FUS) can cause familial and sporadic amyotrophic lateral sclerosis (ALS) and rarely frontotemproal dementia (FTD). FUS accumulates in neuronal cytoplasmic inclusions (NCIs) in ALS patients with FUS mutations. FUS is also a major pathologic marker for a group of less common forms of frontotemporal lobar degeneration (FTLD), which includes atypical FTLD with ubiquitinated inclusions (aFTLD-U), neuronal intermediate filament inclusion disease (NIFID) and basophilic inclusion body disease (BIBD). These diseases are now called FUS proteinopathies, because they share this disease marker. It is unknown how FUS mutations cause disease …
Endurance Tests Are The Most Reliable Core Stability Related Measurements, Andy Waldhelm, Li Li
Endurance Tests Are The Most Reliable Core Stability Related Measurements, Andy Waldhelm, Li Li
Li Li
Purpose: To determine the intra-tester reliability of clinical measurements that assess five components related to core stability: strength, endurance, flexibility, motor control, and function.
Methods: Participants were 15 college-aged males who had not suffered any orthopedic injury in the past year. Core strength measurements included eight isometric tests and a sit-up test. The four core endurance tests were the trunk flexor test, trunk extensor test, and bilateral side bridge tests. Flexibility tests included the sit-and-reach test and active range of the trunk and hip joint motions. Proprioception via passive reposition tests of the hips and a single limb balance test …
The Path To Microrna Therapeutics In Psychiatric And Neurodegenerative Disorders, Anthony W. S. Chan, Jannet Kocerha
The Path To Microrna Therapeutics In Psychiatric And Neurodegenerative Disorders, Anthony W. S. Chan, Jannet Kocerha
Jannet Kocerha
The microRNA (miRNA) class of non-coding RNAs exhibit a diverse range of regulatory roles in neuronal functions that are conserved from lower vertebrates to primates. Disruption of miRNA expression has compellingly been linked to pathogenesis in neuropsychiatric and neurodegenerative disorders, such as schizophrenia, Alzheimer’s disease, and autism. The list of transcript targets governed by a single miRNA provide a molecular paradigm applicable for therapeutic intervention. Indeed, reports have shown that specific manipulation of a miRNA in cell or animal models can significantly alter phenotypes linked with neurological disease. Here, we review how a diverse range of biological systems, including Drosophila, …
Muscular Activity Characteristics Associated With Preparation For Gait Transition, Li Li, Lorna L. Ogden
Muscular Activity Characteristics Associated With Preparation For Gait Transition, Li Li, Lorna L. Ogden
Li Li
Purpose: The purpose of this study was to investigate lower extremity neuromuscular activity patterns during gait transitions with continuously changing locomotion speeds.
Methods: Muscular activities related to gait transitions (walk to run and run to walk) induced by changing treadmill speed were compared to muscular activities during walk and run at constant speeds. All transition and constant speed conditions were conducted in similar speed range. Surface electromyographic activities of gluteus maximus (GM), rectus femoris (RF), vastus lateralis (VL), biceps femoris long head (BFL), tibialis anterior (TA), gastrocnemius (GA), and soleus (SL) were collected and analyzed. The influences of speed and …
People Can Live Longer By Having More Physical Activity, Li Li
People Can Live Longer By Having More Physical Activity, Li Li
Li Li
We all know being physically active is good for you. But do we know how good? People can live up to 3 years longer, even with as little as 15 min of physical activity a day, according to last October's report by Wen and his colleagues1 at the China Medical University in Taiwan, China.
Many researchers in the field of sport and health sciences know being physically active can bring many benefits to one's life. But this message has sometimes been disseminated using a negative tone. So much so, Bortz2 of California, USA, has coined the word “inactivity” …