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Splenic Stromal Niches Support Hematopoiesis Of Dendritic-Like Cells From Precursors In Bone Marrow And Spleen., Pravin Periasamy, Jonathan Tan, Kristin Griffiths, Helen O'Neill Sep 2015

Splenic Stromal Niches Support Hematopoiesis Of Dendritic-Like Cells From Precursors In Bone Marrow And Spleen., Pravin Periasamy, Jonathan Tan, Kristin Griffiths, Helen O'Neill

Jonathan Tan

Objective The aims of this study are to test the ability of stromal cells from murine spleen to support hematopoiesis, to define the tissue source of precursors that seed these hematopoietic niches, and to determine the type of cells produced. Materials and Methods Cloned isolates of murine spleen stroma have been developed that support hematopoiesis. Analysis has been investigated in terms of tissue source of progenitors. Type and number of cells produced were analyzed by flow cytometry. Results Hematopoietic precursors that seed cocultures exist in spleen and bone marrow (BM), but not thymus. Cell production is highest if overlay cells …


Effect Of Superconsciousness External Energy On Atomic, Crystalline And Powder Characteristics Of Carbon Allotrope Powders, Mahendra Kumar Trivedi, Rama Mohan Tallapragada Nov 2009

Effect Of Superconsciousness External Energy On Atomic, Crystalline And Powder Characteristics Of Carbon Allotrope Powders, Mahendra Kumar Trivedi, Rama Mohan Tallapragada

Mahendra Kumar Trivedi

Scientists are searching for eluding link between spirituality and science. Some believe fundamental essences of universe to be energy and information. As per current understanding, energy and matter always coexisted and is considered one and the same. Energy is considered as ‘matter in perpetual motion’ and matter as ‘stationary energy’. Interconversion between matter and energy has been defined by Einstein’s famous energy–mass equation (E=mc2) which has been proven by nuclear physicists using complex nuclear reactions involving high energy particles. However, many spiritual masters have claimed to realise this energy–matter interconversion using their spiritual powers/energy but scientifically unknown and unverified. It …


Monsters And The Moral Imagination, Stephen Asma Oct 2009

Monsters And The Moral Imagination, Stephen Asma

Stephen T Asma

The article discusses the cultural interest in monsters in the 21st century. The author speculates on the reasons for the interest, citing anxiety after the September 11, 2001 terrorist attacks, the war in Iraq, or the global financial crisis of 2008-2009. He notes a conference in September 2009 at the University of Oxford entitled "Monsters and the Monstrous." Cultural uses of monsters, he notes, include scolding ourselves for failure to be inclusive, the medievals' punishment for the sin of pride, or the ancient Greeks' warnings of impending calamity. He notes that monster stories can promote the individual's thought about what …


Mechanism Of Cadmium-Mediated Inhibition Of Msh2-Msh6 Function In Dna Mismatch Repair, Manju Hingorani Oct 2009

Mechanism Of Cadmium-Mediated Inhibition Of Msh2-Msh6 Function In Dna Mismatch Repair, Manju Hingorani

Manju Hingorani

The observation that Cadmium (Cd(2+)) inhibits Msh2-Msh6, which is responsible for identifying base pair mismatches and other discrepancies in DNA, has led to the proposal that selective targeting of this protein and consequent suppression of DNA repair or apoptosis promote the carcinogenic effects of the heavy metal toxin. It has been suggested that Cd(2+) binding to specific sites on Msh2-Msh6 blocks its DNA binding and ATPase activities. To investigate the mechanism of inhibition, we measured Cd(2+) binding to Msh2-Msh6, directly and by monitoring changes in protein structure and enzymatic activity. Global fitting of the data to a multiligand binding model …


Identification Of Cancer-Associated Gene Pathways From Analysis Of Expression Data, Shuangge Ma Aug 2009

Identification Of Cancer-Associated Gene Pathways From Analysis Of Expression Data, Shuangge Ma

Shuangge Ma

No abstract provided.


Identification Of Synechococcus Sp. Iu 625 Phycocyanin Gene And Bioinformatic Analyses Of Cyanobacterial Phycocyanin., Tin-Chun Chu, Aline Oliveira, Arti Rana, Lee Lee Jun 2009

Identification Of Synechococcus Sp. Iu 625 Phycocyanin Gene And Bioinformatic Analyses Of Cyanobacterial Phycocyanin., Tin-Chun Chu, Aline Oliveira, Arti Rana, Lee Lee

Tin-Chun Chu, Ph.D.

No abstract provided.


Lecture 5, Shuangge Ma Jun 2009

Lecture 5, Shuangge Ma

Shuangge Ma

No abstract provided.


Final Project, Shuangge Ma Jun 2009

Final Project, Shuangge Ma

Shuangge Ma

No abstract provided.


Lecture 4, Shuangge Ma Jun 2009

Lecture 4, Shuangge Ma

Shuangge Ma

No abstract provided.


Lecture 4, Shuangge Ma Jun 2009

Lecture 4, Shuangge Ma

Shuangge Ma

No abstract provided.


Computer Intensive Methods Lecture 13, Shuangge Ma Jun 2009

Computer Intensive Methods Lecture 13, Shuangge Ma

Shuangge Ma

No abstract provided.


Final Project (Description), Shuangge Ma Jun 2009

Final Project (Description), Shuangge Ma

Shuangge Ma

No abstract provided.


Final Project (Data), Shuangge Ma Jun 2009

Final Project (Data), Shuangge Ma

Shuangge Ma

No abstract provided.


Lecture 3, Shuangge Ma Jun 2009

Lecture 3, Shuangge Ma

Shuangge Ma

No abstract provided.


Lecture 2, Shuangge Ma Jun 2009

Lecture 2, Shuangge Ma

Shuangge Ma

No abstract provided.


Reference: Multiple Imputation, Shuangge Ma Jun 2009

Reference: Multiple Imputation, Shuangge Ma

Shuangge Ma

No abstract provided.


Reference: Weighted Bootstrap, Shuangge Ma Jun 2009

Reference: Weighted Bootstrap, Shuangge Ma

Shuangge Ma

No abstract provided.


Computer Intensive Methods Lecture 9, Shuangge Ma Jun 2009

Computer Intensive Methods Lecture 9, Shuangge Ma

Shuangge Ma

No abstract provided.


Computer Intensive Methods Lecture 8, Shuangge Ma Jun 2009

Computer Intensive Methods Lecture 8, Shuangge Ma

Shuangge Ma

No abstract provided.


Reference: Counter Examples [Bootstrap], Shuangge Ma Jun 2009

Reference: Counter Examples [Bootstrap], Shuangge Ma

Shuangge Ma

No abstract provided.


Computer Intensive Methods Lecture 7 (Lab 2), Shuangge Ma Jun 2009

Computer Intensive Methods Lecture 7 (Lab 2), Shuangge Ma

Shuangge Ma

No abstract provided.


Computer Intensive Methods Lecture 6, Shuangge Ma Jun 2009

Computer Intensive Methods Lecture 6, Shuangge Ma

Shuangge Ma

No abstract provided.


Reference: Block Jackknife, Shuangge Ma Jun 2009

Reference: Block Jackknife, Shuangge Ma

Shuangge Ma

No abstract provided.


Computer Intensive Methods Lecture 5, Shuangge Ma Jun 2009

Computer Intensive Methods Lecture 5, Shuangge Ma

Shuangge Ma

No abstract provided.


Reading: Simulate Multivariate Distribution, Shuangge Ma Jun 2009

Reading: Simulate Multivariate Distribution, Shuangge Ma

Shuangge Ma

No abstract provided.


Computer Intensive Methods Lecture 4, Shuangge Ma Jun 2009

Computer Intensive Methods Lecture 4, Shuangge Ma

Shuangge Ma

No abstract provided.


Computer Intensive Methods Lecture 3 (Lab 1), Shuangge Ma Jun 2009

Computer Intensive Methods Lecture 3 (Lab 1), Shuangge Ma

Shuangge Ma

No abstract provided.


Computer Intensive Methods Lecture 2, Shuangge Ma Jun 2009

Computer Intensive Methods Lecture 2, Shuangge Ma

Shuangge Ma

No abstract provided.


‘You Can Fly!’: Reimagining Peter Pan And Snowboarding’S Olympic Neverland, M. Popovic, Don Morrow May 2009

‘You Can Fly!’: Reimagining Peter Pan And Snowboarding’S Olympic Neverland, M. Popovic, Don Morrow

Donald Morrow

No abstract provided.


Discovery Of Dual Function Acridones As A New Antimalarial Chemotype, Jane X. Kelly, Martin J. Smilkstein, Reto Brun, Sergio Wittlin, Roland A. Cooper, Kristin D. Lane, Aaron Janowsky, Robert A. Johnson, Rozalia A. Dodean, Rolf Winter, David J. Hinrichs, Michael K. Riscoe May 2009

Discovery Of Dual Function Acridones As A New Antimalarial Chemotype, Jane X. Kelly, Martin J. Smilkstein, Reto Brun, Sergio Wittlin, Roland A. Cooper, Kristin D. Lane, Aaron Janowsky, Robert A. Johnson, Rozalia A. Dodean, Rolf Winter, David J. Hinrichs, Michael K. Riscoe

Roland A. Cooper

Preventing and delaying the emergence of drug resistance is an essential goal of antimalarial drug development. Monotherapy and highly mutable drug targets have each facilitated resistance, and both are undesirable in effective long-term strategies against multi-drug-resistant malaria. Haem remains an immutable and vulnerable target, because it is not parasite-encoded and its detoxification during haemoglobin degradation, critical to parasite survival, can be subverted by drug-haem interaction as in the case of quinolines and many other drugs. Here we describe a new antimalarial chemotype that combines the haem-targeting character of acridones, together with a chemosensitizing component that counteracts resistance to quinoline antimalarial …