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Molecular Architecture Of Cardiometabolic Responses To Regular Exercise, Jacob L. Barber

Theses and Dissertations

Background: To investigate the molecular mechanisms, determinants, and predictors of cardiometabolic responses to regular exercise, this dissertation had two primary aims: 1) Examine the molecular architecture of cardiometabolic responses to exercise training (unsupervised approach) and 2) Identify molecular signatures of responsiveness to regular exercise within clinically relevant lipoprotein traits (supervised approach).

Methodology: Multi-omics data (17,945 muscle transcripts, 4,979 proteins, 411 metabolites) from participants (n=647) who completed 20 weeks of endurance training as part of the HERITAGE Family Study was collected before and after training. We employed an unsupervised machine learning approach (Aim 1) to identify patterns of molecular responses to …

Self Reported Cardiovascular Health And Health Behaviors In Women Veterans, Seth Byland

Theses and Dissertations

Objective: The purpose of this study is to describe self-reported cardiovascular health (CVH) and health behaviors in women veterans (WV). A cardiovascular score will be adapted from the existing American Heart Association CVH score. This score will be used to describe CVH in WV.

Methods: Data was collected from WV using an anonymous online survey. This survey asked questions about CVH, CVH behavior, and military specific questions. CVH scoring was determined by asking 6 questions that scored individuals for a total score from 0 to 12, with 12 being most ideal for CVH health. Scores were tallied and mean scores …

Effect Of Trb3 On Skeletal Muscle Mass Regulation And Exercise-Induced Adaptation, Ran Hee Choi

Theses and Dissertations

Skeletal muscle, which composes over 40% of body mass, is responsible for daily locomotion and energy metabolism. It is a malleable tissue that can adapt its structure and function in response to internal and external environmental stimuli. Changing muscle mass and energy substrate utilization is a common skeletal muscle adaptation in response to various pathological conditions, including type 2 diabetes and obesity. Failure to maintain skeletal muscle mass and function has been correlated with increasing morbidity and mortality, as well as poor quality of life. Hence, maintenance of skeletal muscle integrity is a recommended strategy in achieving better quality of …

Religiosity And Physical Fitness: A Study Of Middle-Aged Mormon Men, Janette Olsen

Theses and Dissertations

Research has related both physical fitness and religiosity to health. This study combined these ideas and examined the relationship between religiosity and physical fitness among middle aged Mormon men (n=110). Mormons are an ideal population for study because of their strict health code. Fitness variables were grip strength, waist/hip ratio, body mass index (BMI) and estimated maximal oxygen uptake (VO2max). A questionnaire assessed level of religiosity and separated subjects into two groups: highly religious (n=35) and less religious (n=14). Moderately religious subjects (n=61) were omitted. A one way ANOVA (between-groups design) found no significant differences in fitness variables between groups. …