Digital Commons Network^™

Virtual Natural Lighting Solutions (Vnls) Inside Hospitals And Its Psychological Impact, Asmaa Alaa Hasanein Hasanein, Alaa Shams Al-Din Al-Aishi, Marwa Atef Abd Elhady

Mansoura Engineering Journal

This study examines the correlation between daylighting environments in hospitals, users evaluations, and ways of bringing virtual natural light into inner spaces, highlighting the importance of good daylighting design for physical and psychological well-being. Virtual Natural Lighting Solutions (VNLS) mimic the balanced spectrum of natural light, bridging the gap between natural and artificial light, and are crucial for tasks, circadian rhythm, and mood in healthcare settings. The research addresses the variability and limitations of natural light, proposing VNLS for healthcare lighting design, especially in hospitals lacking daylight. The study aims to develop a methodology for using VNLS in healthcare environments …

Compact 1 Ghz Electron Paramagnetic Resonance Spectrometers For Preclinical Imaging Studies, Tanden A. Hovey

Electronic Theses and Dissertations

Magnetic resonance is one of the most generally useful scientific techniques. New horizons of understanding are revealed as technological advances make possible explorations of nuclear spins and electron spins at higher and lower magnetic fields and electromagnetic frequencies. While the greatest current effort is on ever higher magnetic fields and microwave frequencies, both in nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR), the Eaton lab focusses on developing high signal-to-noise performance EPR at low microwave frequencies. EPR provides information about O2, pH, viscosity, glutathione concentrations, and reactive oxygen species in living organisms that MRI cannot. To yield clinically or …

Comparative Analysis Of Artificial Intelligence (Ai) Implications For Active Learning And Assessment At Various Curricular Levels Of Stem And Health Sciences In Developed Versus Underprivileged Countries, Vinay Munlapudi, Santanu De

FDLA Journal

Today’s all-pervasive emergence of artificial intelligence (AI) necessitates a comprehensive evaluation of its role in education, especially for occupational disciplines in health sciences and STEM. AI has reshaped student learning and instructors’ navigation of the evolving, post coronavirus infectious disease (COVID-19) global academic landscape. This study aimed at encapsulating evidence-based AI implications for student-centered, active learning and assessment at various curricular levels of science, technology, engineering, mathematics (STEM) and health sciences education in developed versus underprivileged or less developed countries. An extensive, scoping review of 65 recent, scholarly publications was conducted over six months through diverse search engines (PubMed, Google …

Chitosan Hydrogel For Removing Of Heavy Metal Ions From Water: A Review, Maysaa Ali, Shemaa Soud, Anaheed Hameed

Engineering and Technology Journal

Industrial and agricultural discharges have been shown as important sources for a wide range of contaminants like heavy metals. This study focused on the assessment of the toxic effect of heavy metals and illustrates some methods of eliminating or avoiding these contaminants. In certain methods, heavy metals (Cu, Zn, Cr, Ni, Pb, Hg, and Cd) are recovered, and range of absorbents are tested. A number of studies have reported the complex interaction of polymers with metal ions with the polymers for eliminating heavy metals (e.g. cellulose, chitosan, and chitin. Metal ions are absorbed by these polymers by the amine and …

Keynote Address And Meeting Program, Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.

A Computational Micropatterning Approach To Study Caveolae And Protein Localization In Vascular Biology, Andrew B. Grespin

Electronic Theses and Dissertations

Caveolae are specialized, flask-shaped membrane invaginations highly expressed in endothelium and dysregulated in atherosclerosis. Caveolae play a central role in buffering membrane tension, yet the principles governing their spatial organization remain elusive. Thus, we sought to generate the most comprehensive and systematic analysis of blood vessel caveolar spatial organization. However, cell culturing, the backbone of human-focused biological research, does not standardly do well to model physiologically relevant cell behaviors such as migration or polarity-based tissue formation, particularly for punctate proteins and structures like caveolae. Micropatterns are cell-adhesive shapes that biophysically confine cell(s) to a user defined geometry which stereotype organelle …

An Integrated Sensor-Fusion Framework For Performance-Based Compensation In Construction, Aly Ayman El-Ashry

Theses and Dissertations

Construction productivity has historically stagnated due to a reliance on subjective labor monitoring and “lagging” performance indicators. This research proposes a novel compensation model with the use of Total Energy Management System (TEMS) to translate labor effort and efficiency into payment incentives with the integration of Internet of Things (IoT) wearables and Statistical Process Control (SPC) charts.

This research addresses the systemic problem of declining construction productivity caused by industry’s inability to objectively quantify human effort. While traditional models rely on post-facto production tallies, a significant research gap exists in real-time physiological labor monitoring. To bridge this, the proposed TEMS …

Electrospun Nanofiber Scaffolds For In Vitro 3d Tissue Engineering, Victoria E. Santillan, Samerender Nagam Hanumantharao, Stephanie Bule, Ronish M. Shrestha, Carter Rodzik, Alan Mendoza Estrada, Stephen L. Farias, Marina Tanasova, Smitha Rao

Michigan Tech Publications

Tissue engineering is widely used in research for investigating cellular proliferation, behavior, and responses to various stimuli. However, the predictive value of preclinical studies using cell culture plates is limited by the inability to recapitulate the complexity of the physiological microenvironment. Synthetic three-dimensional (3D) scaffolds can be engineered to mimic the complex morphology of the extracellular matrix of native tissues and can serve as physiologically relevant platforms for preclinical studies. In this study, 3D electrospun scaffolds were characterized to aid in breast cancer research. Unlike previous studies that focused primarily on scaffold fabrication or cell viability, this work systematically evaluates …

2026 Workshop On Bridging The Gaps: Tackling Microplastics And Nanoplastics Challenges In Coastal Ecosystems, Shenghua Wu, Kaushik Venkiteshwaran, Melike Dizbay-Onat, Alexandra Stenson, Jinhui Wang, Tina Miller-Way, Ebenezer Nyadjro, Bhuvnesh Bharti, John Weinstein, Yi Bao, Shihui Shen, Valerie Longa, Shenghua Zha, John Cleary, Marty Lind

Workshops

This report presents the findings from the 2026 Workshop on Tackling Microplastics and Nanoplastics (MNPs) in Coastal Ecosystems, which took place in Mobile, Alabama. More than 140 experts from universities, government, industry, and community organizations gathered to address the increasing issue of MNPs in coastal regions.

Design And Development Of A Perfusable Hydrogel Platform With Bioprinted Human-Endothelialized Microvascular Channels, Calvin A. Chernyatinskiy

All Theses

We developed an integrated bioprinting and perfusion platform to generate vascularized hydrogel constructs that support perfusable microchannel networks. Multiple hydrogel formulations, sacrificial ink systems, device geometries, and perfusion conditions were systematically evaluated to optimize print fidelity, mechanical stability, and cellular compatibility. Internally gelling alginate–calcium carbonate hydrogels were identified as a robust matrix, providing tunable gelation kinetics and structural stability during embedded printing. In parallel, Pluronic F-127 fugitive ink enabled reliable fabrication of continuous hollow channels due to its shear-thinning behavior and efficient post-print removal.

The finalized platform integrates stereolithographically fabricated perfusion chambers with extrusion-based bioprinting to produce three-dimensional, perfusable vascular …

A Treatise On Tool Development: The Arthroscope’S Cultural, Technological, And Metascientific Translation, Montgomery F. Waterer

Honors Theses

The arthroscope was a revolutionary development in the fields of medicine, engineering, and ethics. There are many valuable lessons to be learned from the story of its development and translation that are relevant to the future of medicine and society. Beginning with a brief description of the tool’s design, this paper will examine a period within the history of the arthroscope. This window contains multiple innovators and ends with the life and work of Dr. Robert Jackson. In examining the relevant historical facts of its development, this paper will then briefly address the importance of sports medicine in the development …

Comparative Evaluation Of Segmentation-Based And Pose-Assisted Head Temperature Estimation From Uas Thermal Imagery Under Controlled Conditions, Owais Ahmed, Justin A. Guye, Muhammad Hassan Tanveer, Adeel Khalid

Faculty Articles

This paper presents a vision-based framework for detecting humans and estimating head surface temperature from aerial thermal imagery acquired by Unmanned Aerial Systems (UAS). A comparative evaluation of recent object detection architectures was conducted to identify the most stable and reliable model for thermal human detection under varying flight altitudes. The selected framework integrates two head localization strategies, namely, segmentation-based mask slicing and pose-assisted keypoint localization, to extract head regions and compute per-pixel temperature values from radiometric metadata. The results show that cross-domain inference using pre-trained YOLOv11 models achieves reliable human detection across controlled outdoor environments. Between the two pipelines, …

Pid Control For Lower Limb Exoskeletons: A Framework Evaluation, Javlonbek Rakhmatillaev, Vytautas Bučinskas

Chemical Technology, Control and Management

This research provides a detailed guideline for implementing and evaluating Proportional Integral Derivative (PID) control frameworks in lower limb rehabilitation exoskeleton robotics. It examines the role of control systems within rehabilitation robotics, outlines the principles of PID control, describes exoskeleton architecture, explores applications of PID control, reviews optimization strategies, presents experimental validations, and considers future developments in the field. The proposed control framework incorporates aspects of mechanical design, actuator and sensor selection, and PID-based control algorithms, thereby promoting safe, accurate, and individualized rehabilitation support. Recommendations and effective guidance for future work are also presented.

Physiological And Neurological Impact Of Biophilic Design In Architectural Design Studios: A Case Study Of King Salman International University, Islam Ashraf Mohamed, Alaa El-Eishy, Marwa A. Soliman

Mansoura Engineering Journal

Biophilic design integrates nature into architecture to enrich sensory and cognitive experiences, enhance psychological well-being, and improve performance. This study explores its physiological and neural effects in design studios at King Salman International University through an experimental methodology combining theoretical review and lab-based investigation. Tools included electrocardiography (ECG) for heart rate variability (HRV), eye-tracking for visual attention, and the Self-Assessment Manikin (SAM) for emotional evaluation. Nine participants viewed five digital architectural scenes with varying biophilic integration. Direct nature connections elicited greater visual attention, pleasure, and perceived control, indicating higher engagement and relaxation.  A scene lacking biophilic elements led to reduced …

A Computational Approach To Graduated Centrifuge Profiles For Partial Gravity Planetary Environments, Cabell W. Jones

Mechanical & Aerospace Engineering Faculty Publications

Missions such as NASA’s Artemis and SpaceX’s Starship aspire towards creating permanent settlements beyond Earth. In order to achieve this goal, it must be considered that the gravity present on planetary surfaces such as the Moon (0.165 g) and Mars (0.378 g) may be insufficient to support human physiology for long term habitation. On near-Earth missions, issues such as muscular atrophy, neuro-ocular changes, cardiopulmonary variations, and bone mineral density loss have been observed proportional to the duration spent in microgravity. Further studies have suggested that the severity of these conditions scales linearly with decreasing gravity, meaning that astronaut health can …

A Review Of Bioactive Compounds Of Caesalpinia Sappan: Pre- And Post-Harvest Effect, Annisa Lugina Rachman, Santi Rosniawaty, Syariful Mubarok, Cucu Suherman, Yudithia Maxiselly

Jurnal Kultivasi

Sappanwood (Caesalpinia sappan L.) is a shrub or small tree that thrives in tropical regions and has been widely distributed across various areas. It has long been used as a natural dye in textiles, cosmetics, and herbal beverages due to its content of various bioactive compounds. This literature review discusses the secondary metabolites in sappanwood, their health benefits, and strategies to enhance product quality through pre-harvest and post-harvest treatments. This literature review was conducted by searching for relevant journals on Google Scholar using relevant keywords. Sappanwood contains diverse secondary metabolites, including flavonoids, phenolics, anthraquinones, triterpenoids, steroids, alkaloids, and tannins, with …

Detection Of Breath, Phonation And Cough Sounds Using Sound Feature Vectors And Artificial Neural Networks By Calculating Lung Forced Vital Capacity With Mobile Infrastructures, Edmond Hajrizi

International Journal of Business and Technology

Objective: In this study, it is aimed to calculate the tidal volume capacity with mobile infrastructures and to determine the O2 and CO2 values from breath, phonation and cough sounds with the help of artificial neural networks using voice feature vectors. In addition, it is aimed to develop a method that will enable computation of forced expiratory volume via mobile devices.

Materials and Methods: Since sound disease diagnosis is basically a classification problem, tidal volume classification is considered as a pattern recognition problem. Our automatic O2 and CO2 classification study as a pattern recognition function includes three subcomponents; Identifying and …

Foundations Of Artificial Intelligence In Healthcare Diagnostics: A Systematic Survey, Raghad Tariq Al-Hassani

Al-Esraa University College Journal for Engineering Sciences

Artificial Intelligence (AI) is becoming the cornerstone of the future of healthcare diagnostics, that has to ability to change the healthcare diagnostic landscape in terms of diagnostic accuracy, speed, and availability. This systematic review investigates the basic methods, tools, applications, and challenges involved in the integration of AI in diagnostic medicine. It emphasizes the using of machine learning models, deep learning networks (e.g., CNNs), NLP for clinical documentation, and smart computing infrastructures, such as edge device and IoMT. They are making possible real-time, data-driven decision making that is already at human-expert-level performance or, in some cases, even better (in the …

The Effect Of Fascicular Elastin On The Mechanical And Functional Properties Of Healthy, Damaged, And Healing Tendon, Shawn Pavey

McKelvey School of Engineering Graduate Student Theses & Dissertations

Mechanical properties of tendon are highly influenced by structural protein composition and microscopic sub-structures. Within the largest subunit of tendon, the fascicle, the role of the elastin protein remains understudied despite impressive extensibility and fatigue resistance of its resulting elastic fibers. While previous work catalogued contributions of fascicular elastin across tendon type and species, the anticipated effects of elastin in fatigue and healing have not yet been explored. While previous knockout mouse models showed that disruption of elastic fibers led to altered mechanical properties (e.g., increased linear modulus), these models depended on heterozygous elastin deficiency or indirect knockout of proteins …

Comprehensive Review Of In Vitro Approaches For Environmental Heavy Metal Exposure, Manas Warke, Madeline English, Camila Padilla, Lexie Gasco, Wendy Leisner, Rupali Datta, Smitha Rao

Michigan Tech Publications

Heavy metals are ubiquitous environmental pollutants, contaminating air, soil, and water via the erosion of natural deposits, as well as originating from anthropogenic sources, such as agriculture, industries, transportation, and landfills. The increasing utilization of heavy metals over the years, combined with the persistent nature of metals in the environment poses a direct threat to human and environment health. Although regulatory limits have been established for toxic metals, assessing the associated health risks using real-life exposure scenarios remains challenging. In this review, we summarize the development and use of in vitro models based two- and three-dimensional cell culture systems, focusing …

Improved Triboelectric Nanogenerator By As-Prepared Lithium Niobate For Energy Harvesting And Sensing Applications, Jahid Inam Chowdhury, Md. Wasikur Rahman, Md Arafat Hossain, Nicholas Dimakis, Mohammed Jasim Uddin

School of Integrative Biological & Chemical Sciences Faculty Publications

Triboelectric nanogenerators (TENGs) have garnered significant research interest due to their ability to harvest mechanical energy efficiently. In this study, we report a TENG composed of polydimethylsiloxane (PDMS) and polyvinyl alcohol (PVA) as triboelectric layers. To enhance charge generation in the PDMS composite polymer, we incorporated lithium niobate (LiNbO3) nanoparticles, leveraging their piezoelectric and ferroelectric properties. The LiNbO3 nanoparticles were synthesized using a solid-state reaction method, resulting in two distinct phases: triclinic LiNbO3 and monoclinic LiNb3O8. Various weight percentages of LiNbO3 and LiNb3O8 nanoparticles were added to the PDMS matrix to optimize power generation. The maximum open-circuit voltage (VOC) and …

Optimizing Hip And Knee Assistance For Walking And Sit-To-Stand Transitions: An Intrinsic Muscle Mechanics Based Predictive Approach, Neethan Ratnakumar

Dissertations

As the global population ages, the demand for wearable assistive technologies continues to rise, driven by their potential to enhance mobility and independence in older adults. Effectively designed controllers for lower-limb exoskeletons to assist sit-to-stand (STS) and walking are crucial for delivering efficient, safe, and comfortable assistance during daily activities. Traditionally, controller optimization involves biomechanical modeling and user-specific customization. Musculoskeletal simulations play a central role in this process by providing insights into human-exoskeleton interaction dynamics, thereby informing and refining control strategies.

This work presents a simulation-driven approach for developing exoskeleton controllers for walking and STS using two distinct methods: optimal …

Polyphenols For The Mitigation Of Vascular Calcification; In Vitro And In Vivo Studies, Abdullah Altuhami

All Theses

Globally, cardiovascular diseases, in most cases associated with calcification, are the main cause of death. However, currently, the only effective cure is to undergo surgery to augment or receive a healthy donor heart, which could be very difficult due to the long waiting list and the associated risks. The possibility of body rejection of the foreign organs is attributed to immunoreaction or the risk of infection, since the donor must be on immunosuppressant drugs that lower the body's immunity and facilitate the body's acceptance of the new organ as one of its own. Taking that into consideration, using tissue-engineered vascular …

Effects Of Environmental Stressors On Human Tissue-On-A-Chip Platforms, Andie Padilla

Open Access Theses & Dissertations

As space exploration begins to extend beyond low earth orbit, it has become increasingly critical to understand the interaction of the extreme environment of space flight with human systems. While it is known that space-travel induces a vast array of complications to cardiac, neural, musculoskeletal, and immune systems, the mechanisms by which these complications occur are poorly understood. Current research to study the effects of microgravity and radiation are limited to ground simulations, which rarely account for the multifactorial stressors experienced during spaceflight, or long duration studies aboard the International Space Station. Similarly, traditional two-dimensional (2D) models lack the ability …

Inter-Cellular Forces Modulate Cell-Ecm Traction Forces, Zaria Booth

Mechanical & Aerospace Engineering Theses & Dissertations

Epithelial cells are among the most abundant cell types in the human body, making up sheets of epithelial tissues that cover the linings of organs and body cavities. Cellular adhesion and force transmission across epithelial tissues are crucial in maintaining tissue integrity and ensuring proper tissue regeneration. Defects in cellular force transmission have been found in various diseases, including cancer. Force transmission at cell-cell and cell-ECM junctions drive cell survival and development. It has been previously shown that changes in cell-ECM traction directly modulates forces at cell-cell contacts. In this study, we aim to determine the effects of perturbations in …

Biocomputing Approach To Modeling And Modulating Calcium Signaling, Sehee Sun

School of Computing: Dissertations, Theses, and Student Research

Biocomputing is an emerging field that seeks to perform computational tasks using biological substrates and processes. Unlike conventional computing systems based on silicon hardware, biocomputing leverages the parallelism, energy efficiency, and complex dynamics of living systems. Among various cellular mechanisms, calcium (Ca2+) signaling stands out as a central regulator of diverse biological functions, offering a promising basis for programmable logic and control in living cells.

This thesis introduces a novel framework for modeling and modulating Ca2+ dynamics using biologically inspired Boolean logic circuits. Specifically, we propose the Ca2+ Boolean Logic (CaBL) model, in which Ca2+ fluxes and interactions are abstracted …

Preliminary Study: Minimizing The Gap Between Pre-And Post-Spaceflight, Caleb E. Scheideger, Louis A. Diberardino

Aurora

Long-duration space missions pose significant challenges to astronaut health, primarily due to the detrimental effects of microgravity on musculoskeletal and cardiovascular systems. This research proposal aims to address the critical gap between pre- and post-spaceflight physiological conditions, focusing on the marked decline in muscle mass, bone density, and cardiovascular function. Existing countermeasures, such as resistive exercise, are insufficient to prevent muscle atrophy and bone demineralization, highlighting the need for novel solutions. Neuromuscular Electrical Stimulation (NMES) emerges as a promising intervention, capable of eliciting muscle contractions to maintain function and mitigate atrophy. By integrating NMES into existing exercise regimens, we hypothesize …

Development Of Translational Microscale Systems To Interrogate How Biophysical And Biochemical Cues Alter The Phenotype Of Hormone Positive Breast Cancer, Braulio Ortega Quesada

All Dissertations

Cancer is a complicated disease and one in every three diagnoses are women with breast cancer. Recent research shows that the progression of cancer depends strongly on interactions with other non-cancerous cells and non-cellular components. Metastasis, the spread of cancer to other parts of the body, is a key step in cancer progression and makes treatment harder, leading to poor response to treatments culminating in death in ~90% of patients. This dissertation focused on creating a series of microdevices as novel pre-clinical models of breast cancer. Two different devices were fabricated to (1) study how exposing cancer cells to the …

Design And Characterization Of Lignin-Based, Thermoresponsive Soft Composites With Improved Mechanical And Transport Properties, Missoury D. Wolff

All Dissertations

In an attempt to reduce reliance on petroleum-based polymers, lignin – an abundant biopolymer – has gained popularity as a sustainable alternative. However, research on lignin-containing soft composites – i.e., hydrogel (bio)composites – has largely been heuristic, providing limited insight into the fundamental structure-processing-property relationships that govern performance improvements in this emerging class of ‘green’ soft composites. As such, this dissertation presents a systematic investigation of how lignin molecular weight (MW), composite composition, and the concentrations of crosslinker and accelerator impact the mechanical and transport characteristics of soft composites composed of lignin, poly(N-isopropylacrylamide) (PNIPAm), and poly(vinyl alcohol) (PVA).

In the …

Locked Dimerized Cxcl12 Exerts Radiosensitizing Effects In Head And Neck Cancer, Oscar Villarreal Espinosa, Musaddiq Awan, Abdullah A. Memon, Anne Frei, Jamie Foeckler, Rachel Kuehn, Jennifer Bruening, Becky Massey, Stuart J. Wong, Monica Shukla, Julia Kasprzak, Amit Joshi, Michael B. Dwinell, Heather A. Himburg, Joseph Zenga

Biomedical Engineering Faculty Research and Publications

Background

Head and neck squamous cell carcinoma (HNSCC) presents significant treatment challenges, particularly in cases unrelated to human papillomavirus (HPV). The chemokine receptor CXCR4, interacting with its ligand CXCL12, plays a crucial role in tumor proliferation, metastasis, and treatment resistance. This study explores the therapeutic potential of engineered monomeric and dimerized CXCL12 variants (CXCL121 and CXCL122, respectively) in HNSCC and evaluates potential additive effects when combined with radiation therapy.

Methods

Clinical HNSCC biopsies were evaluated for CXCR4 expression in both previously untreated and radiorecurrent disease. HNSCC cell lines were then treated with combinations of CXCL12 variants and radiotherapy and interrogated …