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Comparison Of Nanodosimetric Parameters Of Track Structure Calculated By The Monte Carlo Codes Geant4-Dna And Ptra, P Lazarakis, M U. Bug, E Gargioni, S Guatelli, H Rabus, Anatoly B. Rosenfeld
Comparison Of Nanodosimetric Parameters Of Track Structure Calculated By The Monte Carlo Codes Geant4-Dna And Ptra, P Lazarakis, M U. Bug, E Gargioni, S Guatelli, H Rabus, Anatoly B. Rosenfeld
Anatoly Rozenfeld
The concept of nanodosimetry is based on the assumption that initial damage to cells is related to the number of ionizations (the ionization cluster size) directly produced by single particles within, or in the close vicinity of, short segments of DNA. The ionization cluster-size distribution and other nanodosimetric quantities, however, are not directly measurable in biological targets and our current knowledge is mostly based on numerical simulations of particle tracks in water, calculating track structure parameters for nanometric target volumes. The assessment of nanodosimetric quantities derived from particle-track calculations using different Monte Carlo codes plays, therefore, an important role for …
Monte Carlo Study Of The Potential Reduction In Out-Of-Field Dose Using A Patient-Specific Aperture In Pencil Beam Scanning Proton Therapy, Stephen J. Dowdell, Benjamin Clasie, Nicolas Depauw, Peter E. Metcalfe, Anatoly B. Rosenfeld, Hanne M. Kooy, Jacob B. Flanz, Harald Paganetti
Monte Carlo Study Of The Potential Reduction In Out-Of-Field Dose Using A Patient-Specific Aperture In Pencil Beam Scanning Proton Therapy, Stephen J. Dowdell, Benjamin Clasie, Nicolas Depauw, Peter E. Metcalfe, Anatoly B. Rosenfeld, Hanne M. Kooy, Jacob B. Flanz, Harald Paganetti
Anatoly Rozenfeld
This study is aimed at identifying the potential benefits of using a patientspecific aperture in proton beam scanning. For this purpose, an accurate Monte Carlo model of the pencil beam scanning (PBS) proton therapy (PT) treatment head at Massachusetts General Hospital (MGH) was developed based on an existing model of the passive double-scattering (DS) system. The Monte Carlo code specifies the treatment head at MGH with sub-millimeter accuracy. The code was configured based on the results of experimental measurements performed at MGH. This model was then used to compare out-of-field doses in simulated DS treatments and PBS treatments. For the …