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Ultrasensitive Biosensing On The Zepto-Molar Level, Yongki Choi, Siu-Tung Yau
Ultrasensitive Biosensing On The Zepto-Molar Level, Yongki Choi, Siu-Tung Yau
Electrical and Computer Engineering Faculty Publications
Detection of analytes on the zepto-molar (10^-^2^1M) level has been achieved using a field-effect bio-detector. By applying a gating voltage to enzymes immobilized on the working electrode of the detector, amplification of the biocatalytic current was observed. The amplification is attributed to the modification of the tunnel barrier between the enzyme and the electrode by the gating voltage-induced electric field which exists at the solution-electrode interface. The detection was demonstrated with the glucose oxidase (GOx)-glucose and alcohol dehydrogenase (ADH)-ethanol biocatalytic systems. Glucose at zepto-molar level was detected with zepto-molar detection resolution. Equivalently, 30 glucose …