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Articles 1 - 27 of 27
Full-Text Articles in Entire DC Network
The Role Of Protein Kinase C Epsilon In Hydrogen Peroxide And Nitric Oxide Release During Oxidative Stress Caused By Extracorporeal Shockwave Lithotripsy, Edward S. Iames
The Role Of Protein Kinase C Epsilon In Hydrogen Peroxide And Nitric Oxide Release During Oxidative Stress Caused By Extracorporeal Shockwave Lithotripsy, Edward S. Iames
PCOM Biomedical Studies Student Scholarship
Clinical extracorporeal shock wave lithotripsy (ESWL) treatment to ablate kidney stones can cause acute damage to the renal microvasculature. Accumulation of continued treatment with shockwave therapy can lead to chronic damage to the kidney, and lead to clinical hypertension. Shockwaves have been shown to stimulate endothelial cells to release superoxide (SO), which is converted to hydrogen peroxide (H2O2), and reacts with nitric oxide (NO) to produce peroxynitrite anion (OONO-), creating a powerful oxidant that increases oxidative stress while simultaneously reducing NO bioavailability. Increased oxidative stress during events such as ESWL, also uncouples NO production …
Gestational Diabetes Clinic For Indigent Latinos, Sara Wilson Reece
Gestational Diabetes Clinic For Indigent Latinos, Sara Wilson Reece
Scholarly Posters
Gestational diabetes mellitus (GDM), “carbohydrate intolerance of variable severity with onset or fist recognition during pregnancy,” results from insulin resistance and relative insulin deficiency usually in second trimester.¹ • Gestational diabetes (GDM) impacts between 4% and 9% of all pregnancies. • Gestational diabetes (GDM) results in increased fetal complications of macrosomia, shoulder dystocia and neonatal hyperglycemia as well as maternal risks of preeclampsia and polyhydramnois. • Women who are Hispanic or Asian decent are at highest risk of developing GDM. • Diagnosis ² • Perform 75-gramoral glucose tolerance test (OGTT) at 24 – 28 weeks of gestation in women not …
Analysis Of Chlamydia Pneumoniae And Ad-Like Pathology In The Brains Of Balb/C Mice Following Direct Intra-Cranial Infection, Jessica Rachel Barton, Christine J. Hammond, Amy L. Brady, Denah M. Appelt, Brian J. Balin, Christopher Scott Little
Analysis Of Chlamydia Pneumoniae And Ad-Like Pathology In The Brains Of Balb/C Mice Following Direct Intra-Cranial Infection, Jessica Rachel Barton, Christine J. Hammond, Amy L. Brady, Denah M. Appelt, Brian J. Balin, Christopher Scott Little
Scholarly Posters
Alzheimer’s disease (AD) is an age-related progressive neurodegenerative disorder and the most common form of dementia. The pathology in the central nervous system (CNS) impairs memory and cognition, hindering the capabilities and the quality of life of the individual. This project continues studying the role of infection and Alzheimer’s disease, as previous studies in this laboratory have done, and contributes to the overall understanding of the possible causes of this disease. In this study, BALB/c mice were infected, via direct intracranial injection, with a respiratory isolate (AR-39) of Chlamydia pneumoniae. Their brains were analyzed at 7 and 14 days post-infection, …
Infection Of Neuronal Cells By Chlamydia Pneumoniae And Herpes Simplex Virus Type 1 Alters Expression Of Genes Associated With Alzheimer’S Disease, Morgan M. Devins, Fiora D. Zoga, Brian J. Balin, Denah M. Appelt, Susan T. Hingley
Infection Of Neuronal Cells By Chlamydia Pneumoniae And Herpes Simplex Virus Type 1 Alters Expression Of Genes Associated With Alzheimer’S Disease, Morgan M. Devins, Fiora D. Zoga, Brian J. Balin, Denah M. Appelt, Susan T. Hingley
Scholarly Posters
Several studies have suggested an infectious etiology for Alzheimer’s disease (AD). We have been investigating a potential role for both Chlamydia pneumoniae and Herpes simplex virus type 1 (HSV1) in the initiation of sporadic late-onset AD. Our current study focuses on investigation of gene expression using Alzheimer-specific Real-Time PCR microarrays on RNA derived from SKNMC human neuronal cells infected with C. pneumoniae and/or HSV1. There are distinct differences in the patterns of gene regulation by the two pathogens. For example, C. pneumoniae induces expression of genes involved in amyloid production and processing, such as β-amyloid precursor protein (APP), β-site APP-cleaving …
Analysis Of Chlamydia Pneumoniae-Infected Monocytes Following Incubation With A Novel Peptide, Acaly18, Implicates The Inflammasome In Clearance Of Infection, Brian J. Balin, James D. Thacker, Charles Lim, Corey M. Caruthers, Susan T. Hingley, Juliana Zoga, Denah M. Appelt
Analysis Of Chlamydia Pneumoniae-Infected Monocytes Following Incubation With A Novel Peptide, Acaly18, Implicates The Inflammasome In Clearance Of Infection, Brian J. Balin, James D. Thacker, Charles Lim, Corey M. Caruthers, Susan T. Hingley, Juliana Zoga, Denah M. Appelt
Scholarly Posters
Chlamydia pneumoniae infection may be a trigger for the pathology observed in sporadic lateonset Alzheimer’s disease as a function of initiating neuroinflammation following entry of the organism into the brain. We have hypothesized that one entry mechanism may be by bloodborne infected monocytes trafficking the infection into the brain. This study focuses on infection of monocytes in vitro followed by analysis using immunofluorescence labeling and RT-PCR-microarray techniques. The microarrays utilized consisted of an Alzheimer’s disease pathway array and an innate and adaptive immunity array from SAbiosciences. Analysis by real time PCR for both gene arrays was performed on uninfected and …
Alzheimer's Disease Association With Chlamydia Pneumoniae, Andrew Short
Alzheimer's Disease Association With Chlamydia Pneumoniae, Andrew Short
PCOM Biomedical Studies Student Scholarship
Exogenous bacteria, such as Chlamydia pneumoniae, may be a cause of inflammation that contributes to the progression of Alzheimer's disease (AD). Inflammation has been previously established as a contributor to AD progression. Balin et al. first reported C. pneumoniae in the brains of post-mortem late onset AD patients. PCR analysis showed that 17/19 AD patients were positive for the organism in areas of the brain with typical AD-related neuropathology while 18/19 control patients were PCR-negative. Gerard et al. determined, using real-time PCR, that C. pneumoniae-infected cells colocalize with both neuritic senile plaques and neurofibrillary tangles, the defining pathologies of AD. …
Does Cardiac Resynchronization Therapy And Aerobic Exercise Improve Exercise Tolerance / Ability In Heart Failure Patiens Better Then Either Intervention Alone Or No Intervention At All?, Douglas Ader
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this systematic review is to determine whether or not cardiac resynchronization therapy with aerobic exercise improves exercise tolerance / ability better then either treatment alone or no intervention at all.
Is Monotherapy Treatment Of Etanercept Effective Against Plaque Psoriasis?, Joseph Devito
Is Monotherapy Treatment Of Etanercept Effective Against Plaque Psoriasis?, Joseph Devito
PCOM Physician Assistant Studies Student Scholarship
Objective: The objective of this systematic review is to determine whether or not monotherapy treatment of etanercept is effective against plaque psoriasis.
Is Acupuncture An Effective Adjunctive Treatment For Chronic Asthma In Adults?, Armand Delrosario
Is Acupuncture An Effective Adjunctive Treatment For Chronic Asthma In Adults?, Armand Delrosario
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this systematic review is to determine whether acupuncture is an effective adjunctive treatment for chronic asthma in adults.
Does Tranexamic Acid Effectively And Safely Reduce Menstrual Blood Loss (Mbl) In Women With Menorrhagia Or Iud Induced Mbl?, Veronica W. Chang
Does Tranexamic Acid Effectively And Safely Reduce Menstrual Blood Loss (Mbl) In Women With Menorrhagia Or Iud Induced Mbl?, Veronica W. Chang
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: To determine if Tranexamic Acid effectively and safely reduce menstrual blood loss (MBL) in women with Menorrhagia or IUD induced MBL?
Is Besifloxacin Ophthalmic Suspension 0.6% Safe And Effective For The Treatment Of Bacterial Conjunctivitis?, Hetal R. Desai
Is Besifloxacin Ophthalmic Suspension 0.6% Safe And Effective For The Treatment Of Bacterial Conjunctivitis?, Hetal R. Desai
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this systematic review is to determine whether or not besifloxacin ophthalmic suspension 0.6% is safe and effective for the treatment of bacterial conjunctivitis.
Is The Use Of Narrowband Ultraviolet B (Nb-Uvb) Phototherapy Effective Monotherapy In The Treatment Of Adults With Plaque Psoriasis?, Andrea M. Cardine
Is The Use Of Narrowband Ultraviolet B (Nb-Uvb) Phototherapy Effective Monotherapy In The Treatment Of Adults With Plaque Psoriasis?, Andrea M. Cardine
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this systematic review is to determine whether or not narrowband ultraviolet B (NB-UVB) phototherapy is effective monotherapy in the treatment of adults with plaque psoriasis.
Is Vitamin E Supplementation Effective In Reducing Mortality Related To Cardiovascular Events In People With Type 2 Diabetes Mellitus?, Payal Amin
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this systematic review is to determine whether or not Vitamin E is effective in reducing the mortality related to cardiovascular event in patients with Type 2 Diabetes mellitus.
Does A Diet That Consists Of High Fiber Prevent The Recurrence Of Colorectal Adenomas In Patients Who Have Previously Had At Least One Adenoma Detected Via Colonoscopy?, Conor Luskin
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: To determine whether ingesting a diet high in fiber will decrease the incidence of colorectal adenoma recurrence in a person who has previously had colorectal adenomas.
Is Acupuncture An Effective Treatment For Patients With Irritable Bowel Syndrome?, Amy Leber
Is Acupuncture An Effective Treatment For Patients With Irritable Bowel Syndrome?, Amy Leber
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this systematic review is to determine whether or not acupuncture is an effective treatment for patients with Irritable Bowel Syndrome.
Is Esomeprazole (Nexium) More Effective Than Omeprazole (Prilosec) In Reducing Heartburn And In Increasing The Rate Of Esophageal Healing In Adults With Endoscopically Diagnosed Erosive Esophagitis (Ee)?, Shawn P. Mahoney
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this systematic review is to determine whether Esomeprazole (Nexium) is more safe and effective than Omeprazole (Prilosec) in reducing Heartburn and in increasing the rate of esophageal healing in adults with endoscopically diagnosed Erosive Esophagitis (EE)
How Safe And Effective Is Infliximab In The Treatment Of Children With Moderate To Severe Crohn’S Disease?, Jackie Linh
How Safe And Effective Is Infliximab In The Treatment Of Children With Moderate To Severe Crohn’S Disease?, Jackie Linh
PCOM Physician Assistant Studies Student Scholarship
Objective: The objective of this systematic review is to determine whether or not “how safe and effective is infliximab in treatment of children with moderate to severe Crohn’s disease?”
Is L-Carnitine An Effective Treatment To Improve The Quality Of Life For Patients With Rett Syndrome?, Bernadette Mason
Is L-Carnitine An Effective Treatment To Improve The Quality Of Life For Patients With Rett Syndrome?, Bernadette Mason
PCOM Physician Assistant Studies Student Scholarship
Objective: To determine “Is L-carnitine an effective treatment to improve the quality of life for patients with Rett Syndrome?”
The Effectiveness And Safety Of Antibiotic Treatment In Healing Tympanic Membrane Perforation In Aboriginal Children, Shannon M. Rice
The Effectiveness And Safety Of Antibiotic Treatment In Healing Tympanic Membrane Perforation In Aboriginal Children, Shannon M. Rice
PCOM Physician Assistant Studies Student Scholarship
The objective of this systematic review is to determine whether or not antibiotic treatment is safe and effective in healing tympanic membrane (TM) perforation in Aboriginal children diagnosed with chronic suppurative otitis media and otitis media with effusion less than 16 years of age.
Is Alitretinoin (9-Cis-Retinoic Acid) Safe And Effective For Use In Hand Eczema?, Jeanne K. Seeberger
Is Alitretinoin (9-Cis-Retinoic Acid) Safe And Effective For Use In Hand Eczema?, Jeanne K. Seeberger
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: To determine if Alitretinoin is a safe and effective alternative to current treatments in reducing the symptoms of Hand Eczema (HE)
Is Topical 1% Pimecrolimus Cream An Effective Treatment For Rosacea?, Lauren Sloan
Is Topical 1% Pimecrolimus Cream An Effective Treatment For Rosacea?, Lauren Sloan
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this systematic review is to determine whether or not topical 1% pimecrolimus cream is an effective treatment for rosacea.
Is Liraglutide Safe And Effective As A Monotherapy For The Treatment Of Obesity In Type 2 Diabetics And Healthy Individuals?, Erica Sheeran
Is Liraglutide Safe And Effective As A Monotherapy For The Treatment Of Obesity In Type 2 Diabetics And Healthy Individuals?, Erica Sheeran
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this systematic review is to determine whether or not liraglutide is safe and effective as a monotherapy for the treatment of obesity in type 2 diabetics and healthy individuals.
Is Opt-80 A Safe And Effective Treatment For Patients With C.Difficile Infection?, Heather A. Shupp
Is Opt-80 A Safe And Effective Treatment For Patients With C.Difficile Infection?, Heather A. Shupp
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: Objective of this systematic review is to determine whether or not OPT-80 is a safe and effective treatment for patients with C.difficile infection.
Is 5% Imiquimod Cream More Efficacious At Sustained Clearance Of Genital Warts At 3 Months Compared To 1% Imiquimod, Ablation Therapy, And A Placebo Vehicle Cream?, David A. Smith
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this systematic review is to determine whether or not 5% Imiquimod is more efficacious at sustained treatment of genital warts at 3 months compared to 1% Imiquimod, ablation, and a placebo vehicle cream.
Is Sildenafil Citrate A Safe And Effective Treatment For Pulmonary Hypertension In Adults?, Atekelt Tadese
Is Sildenafil Citrate A Safe And Effective Treatment For Pulmonary Hypertension In Adults?, Atekelt Tadese
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: To determine whether or not the Phosphodiesterase inhibitors drug Sildenafil Citrate is safe and effective treatment for Pulmonary Hypertension in adults
Can Ultrafiltration Be Used As Primary Treatment Of Congestive Heart Failure?, Jennifer Tallis
Can Ultrafiltration Be Used As Primary Treatment Of Congestive Heart Failure?, Jennifer Tallis
PCOM Physician Assistant Studies Student Scholarship
Objective: To determine whether ultrafiltration can be used as primary treatment of Congestive Heart Failure.
Are Proton Pump Inhibitors A Safe And Effective Treatment For Gastroesophageal Reflux Disease In Infants Less Than Twelve Months Old?, Mariah Smith
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this systematic review is to determine whether or not proton pump inhibitors are a safe and effective treatment for gastroesophageal reflux disease in infants less than twelve months old.