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New Computational Approaches For Multiple Rna Alignment And Rna Search, Daniel Deblasio
New Computational Approaches For Multiple Rna Alignment And Rna Search, Daniel Deblasio
Electronic Theses and Dissertations
In this thesis we explore the the theory and history behind RNA alignment. Normal sequence alignments as studied by computer scientists can be completed in O(n2) time in the naive case. The process involves taking two input sequences and finding the list of edits that can transform one sequence into the other. This process is applied to biology in many forms, such as the creation of multiple alignments and the search of genomic sequences. When you take into account the RNA sequence structure the problem becomes even harder. Multiple RNA structure alignment is particularly challenging because covarying mutations make sequence …