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Relationship Among Neurogenic Orthostatic Hypotension, Cerebral Hemodynamics, And Cognitive Functioning, Lindsay Robinson
Relationship Among Neurogenic Orthostatic Hypotension, Cerebral Hemodynamics, And Cognitive Functioning, Lindsay Robinson
Electronic Thesis and Dissertation Repository
Neurogenic orthostatic hypotension (NOH) is characterized by a drop in systolic blood pressure ≥20mmHg or diastolic blood pressure ≥10mmHg within three minutes of upright posture. A large drop in blood pressure can trigger cerebral hypoperfusion, which has been linked to deficits in cognitive function. The current thesis aimed to measure cerebral hemodynamics and cognitive function in 20 NOH patients and 20 controls in the supine and head-up tilt (HUT) positions. Information processing speed (IPS) was assessed using the Symbol-Digit Modalities Test and attention was measured using the Stroop Test. NOH patients had significantly slower IPS in both the supine(p