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- Antibody binding (1)
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Articles 1 - 6 of 6
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Redox-Active Coordination Complexes For Small Molecule Activation With Environmental Applications, Hanalei Lewine
Redox-Active Coordination Complexes For Small Molecule Activation With Environmental Applications, Hanalei Lewine
WWU Honors College Senior Projects
Nitrate and nitrate are harmful pollutants resulting from the overuse of nitrogen fertilizers in agriculture. The pyridinediimine ligand scaffold with a hemilabile pendant phosphine shows reactivity towards these species to selectively reduce them to NO on a mononitrosyl iron complex (MNIC). Experimental work is supported by DFT broken symmetry calculations.
Insulin: Roles And Functions In Biochemistry And U.S. Healthcare, Mia Brinkley
Insulin: Roles And Functions In Biochemistry And U.S. Healthcare, Mia Brinkley
WWU Honors College Senior Projects
I will be researching insulin through a variety of academic perspectives, utilizing both my biochemistry major and history minor, as well as my passion for healthcare and goals for my future career in medicine. I will begin by researching the history of the discovery of the hormone and the start of its use as a drug for diabetes. I will go into the biochemistry of the insulin protein and its interaction with the insulin receptor protein. I will then go into the problems it poses for those receiving it, regarding cost and access to low-income populations in the US. I …
Structure Of Blood Coagulation Factor Viii In Complex With Anti-C2 Domain Inhibitory Antibody, Estelle K. Ronayne, Shaun C. Peters, Joseph Gish, Celena Wilson, H. Trent Spencer, Christopher B. Doering, Pete Lollar, P. Clint Spiegel Jr., Kenneth C. Childers
Structure Of Blood Coagulation Factor Viii In Complex With Anti-C2 Domain Inhibitory Antibody, Estelle K. Ronayne, Shaun C. Peters, Joseph Gish, Celena Wilson, H. Trent Spencer, Christopher B. Doering, Pete Lollar, P. Clint Spiegel Jr., Kenneth C. Childers
WWU Honors College Senior Projects
Factor VIII (fVIII) is a procoagulant protein that binds to activated factor IX (fIXa) on platelet surfaces to form the intrinsic tenase complex. Due to the high immunogenicity of fVIII, generation of antibody inhibitors is a common occurrence in patients during hemophilia A treatment and spontaneously occurs in acquired hemophilia A patients. Non-classical antibody inhibitors, which block fVIII activation by thrombin and formation of the tenase complex, are the most common anti-C2 domain pathogenic inhibitors in hemophilia A murine models and have been identified in patient plasmas. In this study, we report on the X-ray crystal structure of a B …
Spike Protein Antibody Interactions Elicited By The Sars-Cov-2 Vaccine, Meghan Quinlan
Spike Protein Antibody Interactions Elicited By The Sars-Cov-2 Vaccine, Meghan Quinlan
WWU Honors College Senior Projects
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) arose as a novel virus in Wuhan China in December 2019. Then, as it rapidly spread across the world, it was declared a global health emergency by the World Health Organization in March 2020. SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19), has dramatically disrupted both normal life and the economy. In the past year and a half, there have been over 175 million cases globally1 (as of June 15, 2021). High death rates, disruption to education, and widespread job loss has necessitated the desperate need for a vaccine against SARS-CoV-2. A …
Multifunctional Polymer-Nanoparticle Composites For Surface-Enhanced Raman Scattering Applications, Aliandra E. Pierce, Samantha A. Patrick, Steven R. Emory
Multifunctional Polymer-Nanoparticle Composites For Surface-Enhanced Raman Scattering Applications, Aliandra E. Pierce, Samantha A. Patrick, Steven R. Emory
WWU Honors College Senior Projects
To create a multifunctional nanoparticle-based optical sensor, a pH-responsive microgel consisting of 20% polystyrene (PS) and 80% poly(2-vinylpyridine) (P2VP) surface-coated with gold nanoparticle (NP) seeds was synthesized. The pH-responsive microgel serves as a size-tunable scaffold for the assembly of the surface-enhanced Raman scatter active (SERS-active) metal, gold. The random copolymer of PS and P2VP (PS20P2VP80) is sterically stabilized by poly(ethyleneglycol) methyl ether methacrylate (PEGMA) and lightly crosslinked with divinylbenzene (DVB) to allow for reversible pH-swelling over multiple cycles of acid-base titration. The ability to swell and de-swell in response to changes in pH allows for the tuning of gold NP …
Indium Oxide-Based Catalysts For Solar Fuel Generation, Ryan Hagmann
Indium Oxide-Based Catalysts For Solar Fuel Generation, Ryan Hagmann
WWU Honors College Senior Projects
The need to pursue renewable, carbon neutral forms of energy has led to a far reaching-research effort to generate and store solar energy. It has been shown that indium oxide-based catalysts have the potential to reduce carbon dioxide to carbon monoxide or even continue reduction to methanol. Recent advances and current challenges in further developing indium oxide catalysis as a means of producing a sustainable liquid fuel supply will be addressed. This project will give an overview of the research in indium oxide catalysts for solar fuels generation and the immediate relevance of recent work within the Bussell Research Group …