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Articles 1 - 9 of 9
Full-Text Articles in Entire DC Network
Comparison Of Design Approaches For Low-Cost Sampling Mechanisms In Open-Source Chemical Instrumentation, Greggory Murray, Samuel Bednarski, Michael Hall, Samuel W. Foster, Sijun Jin, Joshua J. Davis, Wei Xue, Eric Constans, James P. Grinias
Comparison Of Design Approaches For Low-Cost Sampling Mechanisms In Open-Source Chemical Instrumentation, Greggory Murray, Samuel Bednarski, Michael Hall, Samuel W. Foster, Sijun Jin, Joshua J. Davis, Wei Xue, Eric Constans, James P. Grinias
Faculty Scholarship for the College of Science & Mathematics
Robotic positioning systems are used in a variety of chemical instruments, primarily for liquid handling purposes, such as autosamplers from vials or well plates. Here, two approaches to the design of open-source autosampler positioning systems for use with 96-well plates are described and compared. The first system, a 3-axis design similar to many low-cost 3D printers that are available on the market, is constructed using an aluminum frame and stepper motors. The other system relies upon a series of 3D printed parts to achieve movement with a series of linker arms based on Selective Compliance Assembly Robot Arm (SCARA) design …
Silk-Cellulose Acetate Biocomposite Materials Regenerated From Ionic Liquid, Ashley Rivera-Galetti, Chrtstopher R. Gough, Farhan Kaleem, Michael Burch, Chris Ratcliffe, Ping Lu, David Salas-De La Cruz, Xiao Hu
Silk-Cellulose Acetate Biocomposite Materials Regenerated From Ionic Liquid, Ashley Rivera-Galetti, Chrtstopher R. Gough, Farhan Kaleem, Michael Burch, Chris Ratcliffe, Ping Lu, David Salas-De La Cruz, Xiao Hu
Faculty Scholarship for the College of Science & Mathematics
The novel use of ionic liquid as a solvent for biodegradable and natural organic biomaterials has increasingly sparked interest in the biomedical field. As compared to more volatile traditional solvents that rapidly degrade the protein molecular weight, the capability of polysaccharides and proteins to dissolve seamlessly in ionic liquid and form fine and tunable biomaterials after regeneration is the key interest of this study. Here, a blended system consisting of Bombyx Mori silk fibroin protein and a cellulose derivative, cellulose acetate (CA), in the ionic liquid 1-ethyl-3-methylimidazolium acetate (EMIMAc) was regenerated and underwent characterization to understand the structure and physical …
Accessing Improbable Foldamer Shapes With Strained Macrocycles., Ko Urushibara, Yann Ferrand, Zhiwei Liu, Kosuke Katagiri, Masatoshi Kawahata, Estelle Morvan, Ryan D'Elia, Vojislava Pophristic, Aya Tanatani, Ivan Huc
Accessing Improbable Foldamer Shapes With Strained Macrocycles., Ko Urushibara, Yann Ferrand, Zhiwei Liu, Kosuke Katagiri, Masatoshi Kawahata, Estelle Morvan, Ryan D'Elia, Vojislava Pophristic, Aya Tanatani, Ivan Huc
Faculty Scholarship for the College of Science & Mathematics
The alkylation of some secondary amide functions with a dimethoxybenzyl (DMB) group in oligomers of 8-amino-2-quinolinecarboxylic acid destabilizes the otherwise favored helical conformations, and allows for cyclization to take place. A cyclic hexamer and a cyclic heptamer were produced in this manner. After DMB removal, X-ray crystallography and NMR show that the macrocycles adopt strained conformations that would be improbable in noncyclic species. The high helix folding propensity of the main chain is partly expressed in these conformations, but it remains frustrated by macrocyclization. Despite being homomeric, the macrocycles possess inequivalent monomer units. Experimental and computational studies highlight specific fluxional …
Bruton's Tyrosine Kinase Targeting In Multiple Myeloma., Max Von Suskil, Kazi Nasrin Sultana, Weam Othman Elbezanti, Omar S Al-Odat, Robert Chitren, Amit K Tiwari, Kishore B Challagundla, Sandeep Kumar Srivastava, Subash C. Jonnalagadda, Tulin Budak-Alpdogan, Manoj K Pandey
Bruton's Tyrosine Kinase Targeting In Multiple Myeloma., Max Von Suskil, Kazi Nasrin Sultana, Weam Othman Elbezanti, Omar S Al-Odat, Robert Chitren, Amit K Tiwari, Kishore B Challagundla, Sandeep Kumar Srivastava, Subash C. Jonnalagadda, Tulin Budak-Alpdogan, Manoj K Pandey
Faculty Scholarship for the College of Science & Mathematics
Multiple myeloma (MM), a clonal plasma cell disorder, disrupts the bones' hematopoiesis and microenvironment homeostasis and ability to mediate an immune response against malignant clones. Despite prominent survival improvement with newer treatment modalities since the 2000s, MM is still considered a non-curable disease. Patients experience disease recurrence episodes with clonal evolution, and with each relapse disease comes back with a more aggressive phenotype. Bruton's Tyrosine Kinase (BTK) has been a major target for B cell clonal disorders and its role in clonal plasma cell disorders is under active investigation. BTK is a cytosolic kinase which plays a major role in …
Advances In Ultra-High-Pressure And Multi-Dimensional Liquid Chromatography Instrumentation And Workflows, Jelle De Vos, Dwight Stoll, Stephan Buckenmaier, Sebastiaan Eeltink, James P. Grinias
Advances In Ultra-High-Pressure And Multi-Dimensional Liquid Chromatography Instrumentation And Workflows, Jelle De Vos, Dwight Stoll, Stephan Buckenmaier, Sebastiaan Eeltink, James P. Grinias
Faculty Scholarship for the College of Science & Mathematics
The present contribution discusses recent advances in ultra-high-pressure liquid chromatography (UHPLC) and multi-dimensional liquid chromatography (MDLC) technology. First, new developments in UHPLC column technology and system design are highlighted. The latter includes a description of a novel injector concept enabling method speed-up, emerging detectors, and instrument diagnostics approaches. Next, online MDLC workflows are reviewed and advances in modulation technology are highlighted. Finally, key applications published in 2020 are reviewed.
Beneficial Impacts Of Incorporating The Non-Natural Amino Acid Azulenyl-Alanine Into The Trp-Rich Antimicrobial Peptide Bucathl4b., Areetha R D'Souza, Matthew R Necelis, Alona Kulesha, Gregory A. Caputo, Olga V Makhlynets
Beneficial Impacts Of Incorporating The Non-Natural Amino Acid Azulenyl-Alanine Into The Trp-Rich Antimicrobial Peptide Bucathl4b., Areetha R D'Souza, Matthew R Necelis, Alona Kulesha, Gregory A. Caputo, Olga V Makhlynets
Faculty Scholarship for the College of Science & Mathematics
Antimicrobial peptides (AMPs) present a promising scaffold for the development of potent antimicrobial agents. Substitution of tryptophan by non-natural amino acid Azulenyl-Alanine (AzAla) would allow studying the mechanism of action of AMPs by using unique properties of this amino acid, such as ability to be excited separately from tryptophan in a multi-Trp AMPs and environmental insensitivity. In this work, we investigate the effect of Trp→AzAla substitution in antimicrobial peptide buCATHL4B (contains three Trp side chains). We found that antimicrobial and bactericidal activity of the original peptide was preserved, while cytocompatibility with human cells and proteolytic stability was improved. We envision …
Role Of Antizyme Inhibitor Proteins In Cancers And Beyond, Venella Tulluri, Venkatesh V. Nemmara
Role Of Antizyme Inhibitor Proteins In Cancers And Beyond, Venella Tulluri, Venkatesh V. Nemmara
Faculty Scholarship for the College of Science & Mathematics
Polyamines are multivalent organic cations essential for many cellular functions, including cell growth, differentiation, and proliferation. However, elevated polyamine levels are associated with a slew of pathological conditions, including multiple cancers. Intracellular polyamine levels are primarily controlled by the autoregulatory circuit comprising two different protein types, Antizymes (OAZ) and Antizyme Inhibitors (AZIN), which regulate the activity of the polyamine biosynthetic enzyme ornithine decarboxylase (ODC). While OAZ functions to decrease the intracellular polyamine levels by inhibiting ODC activity and exerting a negative control of polyamine uptake, AZIN operates to increase intracellular polyamine levels by binding and sequestering OAZ to relieve ODC …
Effects Of Ionic Liquids On Metalloproteins., Aashka Y Patel, Keertana S Jonnalagadda, Nicholas Paradis, Timothy Vaden, Chun Wu, Gregory A. Caputo
Effects Of Ionic Liquids On Metalloproteins., Aashka Y Patel, Keertana S Jonnalagadda, Nicholas Paradis, Timothy Vaden, Chun Wu, Gregory A. Caputo
Faculty Scholarship for the College of Science & Mathematics
In the past decade, innovative protein therapies and bio-similar industries have grown rapidly. Additionally, ionic liquids (ILs) have been an area of great interest and rapid development in industrial processes over a similar timeline. Therefore, there is a pressing need to understand the structure and function of proteins in novel environments with ILs. Understanding the short-term and long-term stability of protein molecules in IL formulations will be key to using ILs for protein technologies. Similarly, ILs have been investigated as part of therapeutic delivery systems and implicated in numerous studies in which ILs impact the activity and/or stability of protein …
Flexible Nanopaper Composed Of Wood-Derived Nanofibrillated Cellulose And Graphene Building Blocks, Qing Li, Ming Dai, Xueren Qian, Tian Liu, Zhenbo Liu, Yu Liu, Ming Chen, Wang He, Suqing Zeng, Yu Meng, Chenchen Dai, Jing Shen, Yingtao Liu, Wenshuai Chen, Wenbo Liu, Ping Lu
Flexible Nanopaper Composed Of Wood-Derived Nanofibrillated Cellulose And Graphene Building Blocks, Qing Li, Ming Dai, Xueren Qian, Tian Liu, Zhenbo Liu, Yu Liu, Ming Chen, Wang He, Suqing Zeng, Yu Meng, Chenchen Dai, Jing Shen, Yingtao Liu, Wenshuai Chen, Wenbo Liu, Ping Lu
Faculty Scholarship for the College of Science & Mathematics
Nanopaper has attracted considerable interest in the fields of films and paper research. However, the challenge of integrating the many advantages of nanopaper still remains. Herein, we developed a facile strategy to fabricate multifunctional nanocomposite paper (NGCP) composed of wood-derived nanofibrillated cellulose (NFC) and graphene as building blocks. NFC suspension was consisted of long and entangled NFCs (10–30 nm in width) and their aggregates. Before NGCP formation, NFC was chemically modified with a silane coupling agent to ensure that it could interact strongly with graphene in NGCP. The resulting NGCP samples were flexible and could be bent repeatedly without any …