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Synthesis Of Trifluoromethyl-Imines By Solid Acid/Superacid Catalyzed Microwave-Assisted Approach, Abid Shaikh, Markku Savolainen, Shainaz M. Landge, Jinbo Hu, G. K. S. Prakash, George A. Olah, Béla Török

Abid Shaikh

Trifluoromethyl, Imine, Clay, Solid acids, Solid superacid, Catalysis, Microwave irradiation Abstract: A new solid acid/superacid catalyzed microwave assisted synthesis of trifluoromethyl-imines is described. Various α,α,α-trifluoromethylketones react readily with primary amines to produce the corresponding imines. Two different strategies have been employed; one is the application of microwave irradiation coupled with solvent-free solid acid catalysis. The other method, for highly deactivated substrates includes the use of a pressure vessel at 175 °C temperature, with solid superacid catalysis. Using the solid acid K-10 montmorillonite or the superacidic perfluorinated resinsulfonic acid Nafion-H, a wide variety of trifluoromethylated imines have been synthesized using the …