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Phosphate Salts Facilitate The Electrospinning Of Hyaluronic Acid Fiber Mats, Eric K. Brenner, Jessica D. Schiffman, Laura J. Toth, Janah C. Szewczyk, Caroline L. Schauer
Phosphate Salts Facilitate The Electrospinning Of Hyaluronic Acid Fiber Mats, Eric K. Brenner, Jessica D. Schiffman, Laura J. Toth, Janah C. Szewczyk, Caroline L. Schauer
Jessica D. Schiffman
Electrospinning is a cost effective and facile method to manufacture fiber mats appropriate for biomedical applications. Due to its high molecular weight and charged backbone, hyaluronic acid (HA) fiber mats with consistent fiber morphology have been difficult to electrospin from neutral pH solutions. Here, we present that the electrospinning of HA fibers in aqueous dimethylformamide solutions is facilitated by the addition of three phosphate salts. The salts—glycerol phosphate (GP), sodium phosphate (SP), and tripolyphosphate (TPP)—facilitated electrospinning of the solutions as characterized by conductivity measurements and fiber morphology. From tensile experiments, HA mats electrospun with SP demonstrated improved Young’s modulus (12 …
Crosslinking Poly(Allylamine) Fibers Electrospun From Basic And Acidic Solutions, Jessica D. Schiffman, Marjorie A. Kiechel, Amalie E. Donius, Ulrike G. K. Wegst, Caroline L. Schauer
Crosslinking Poly(Allylamine) Fibers Electrospun From Basic And Acidic Solutions, Jessica D. Schiffman, Marjorie A. Kiechel, Amalie E. Donius, Ulrike G. K. Wegst, Caroline L. Schauer
Jessica D. Schiffman
Mechanically robust, non-toxic polymer fiber mats are promising materials for a range of biomedical applications; however, further research into enhancing polymer selection is needed. In this study, poly(allylamine) (PAH), an amine-containing polyelectrolyte, was successfully electrospun from aqueous solutions into continuous, cylindrical fibers with a mean diameter of 150 ± 41 nm. A one-step crosslinking method using glutaraldehyde provides insight into the chemical and morphological changes that result from altering the molar ratio of amine to aldehyde groups, whereas a two-step crosslinking method yielded chemically and mechanically robust mats. These results indicate PAH fibrous mats synthesized from aqueous solutions could potentially …
Designing Electrospun Nanofiber Mats To Promote Wound Healing – A Review, Katrina A. Rieger, Nathan P. Birch, Jessica D. Schiffman
Designing Electrospun Nanofiber Mats To Promote Wound Healing – A Review, Katrina A. Rieger, Nathan P. Birch, Jessica D. Schiffman
Jessica D. Schiffman
Current strategies to treat chronic wounds offer limited relief to the 7.75 million patients who suffer from burns or chronic skin ulcers. Thus, as long as chronic wounds remain a global healthcare problem, the development of alternate treatments remain desperately needed. This review explores the recent strategies employed to tailor electrospun nanofiber mats towards accelerating the wound healing process. Porous nanofiber mats readily produced by the electrospinning process offer a promising solution to the management of wounds. The matrix chemistry, surface functionality, and mat degradation rate all can be fine-tuned to govern the interactions that occur at the materials–biology interface. …
Nanomanufacturing Of Biomaterials, Yoni Engel, Jessica D. Schiffman, Julie M. Goddard, Vincent M. Rotello
Nanomanufacturing Of Biomaterials, Yoni Engel, Jessica D. Schiffman, Julie M. Goddard, Vincent M. Rotello
Jessica D. Schiffman
In this review, we present a few of the many important objectives in the area of biomedical engineering that could open new pathways for nextgeneration biomaterials. We also provide examples of how materials for these goals can be created in an economically viable means through recent advances in high throughput production. These strategies highlight the potential for nanomanufacturing in a variety of areas of importance for human health and safety.