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Rna Modification Landscape And Its Contribution To Egg Production, Ian Thomas Rapisarda
Rna Modification Landscape And Its Contribution To Egg Production, Ian Thomas Rapisarda
Legacy Theses & Dissertations (2009 - 2024)
Germline stem cells differentiate into mature egg or sperm cells that go through the process of fertilization which gives rise to all sexually reproducing organisms. During this process of differentiation, germ cells undergo a switch from mitosis to meiosis that allows for proper development and specification of the future gamete. The mechanisms that facilitate this shift from mitosis to meiosis, however, are not well understood. To gain insight into this process, we used Drosophila oogenesis as our model. To identify what RNA modifications are present during oogenesis we genetically enriched for each stage of development and performed mass spectrometry. We …