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Quantifying Shear Stresses In Tissue Engineered Aortic Heart Valves, Raj Nitin Dave
Quantifying Shear Stresses In Tissue Engineered Aortic Heart Valves, Raj Nitin Dave
All Theses
Present heart valve prosthesis have limitations such as capability to grow, repair and remodel post implantation. Tissue engineering offers to be a promising alternative to overcome these limitations. Maturation of seeded human cells on the valve subjected to favorable growth conditions in the bioreactor is critical to the success of tissue engineered heart valves. Mechanical stress and strain which results from the pressure and flow conditions in the bioreactor plays a critical role on the developing valve tissue and are currently unknown. The goal of this research is to relate the magnitude of wall shear stress (WSS) within the heart …
Neomycin-Enhanced Carbodiimide Cross-Linking For Glycosaminoglycan Stability In Bioprosthetic Heart Valves, Joshua Leong
Neomycin-Enhanced Carbodiimide Cross-Linking For Glycosaminoglycan Stability In Bioprosthetic Heart Valves, Joshua Leong
All Theses
Valvular heart diseases lead to over 290,000 heart valve replacements worldwide each year, and approximately half of these involve replacement with a bioprosthetic heart valve (BHV) [1]. BHVs exhibit excellent hemocompatibility, but suffer from inadequate long-term durability with most adult implanted valves failing within 12 to 15 years after implantation [2]. Although this may be adequate for some individuals, BHV implantation may be contraindicated in younger individuals to avoid reoperation. Even in elder recipients, valve dysfunction can still cause death or reoperation that could be avoided with increased BHV durability. Therefore, investigation into methods of increasing BHV durability can not …