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Taxol-Stabilized Microtubules Can Position The Cytokinetic Furrow In Mammalian Cells, Katie Shannon, Julie C. Canman, C. Ben Moree, Jennifer S. Tirnauer, Edward D. Salmon
Taxol-Stabilized Microtubules Can Position The Cytokinetic Furrow In Mammalian Cells, Katie Shannon, Julie C. Canman, C. Ben Moree, Jennifer S. Tirnauer, Edward D. Salmon
Biological Sciences Faculty Research & Creative Works
How microtubules act to position the plane of cell division during cytokinesis is a topic of much debate. Recently, we showed that a subpopulation of stable microtubules extends past chromosomes and interacts with the cell cortex at the site of furrowing, suggesting that these stabilized microtubules may stimulate contractility. To test the hypothesis that stable microtubules can position furrows, we used taxol to rapidly suppress microtubule dynamics during various stages of mitosis in PtK1 cells. Cells with stabilized prometaphase or metaphase microtubule arrays were able to initiate furrowing when induced into anaphase by inhibition of the spindle checkpoint. In these …
Enhanced Fixation Reveals The Apical Cortical Fringe Of Actin Filaments As A Consistent Feature Of The Pollen Tube, A Lovy-Wheeler, Kl Wilsen, Ti Baskin, Pk Hepler
Enhanced Fixation Reveals The Apical Cortical Fringe Of Actin Filaments As A Consistent Feature Of The Pollen Tube, A Lovy-Wheeler, Kl Wilsen, Ti Baskin, Pk Hepler
Biology Department Faculty Publication Series
No abstract provided.