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Uptake And Metabolism Of 5’-Amp In The Erythrocyte Play Key Roles In The 5’-Amp Induced Model Of Deep Hypometabolism, Isadora Daniels
Uptake And Metabolism Of 5’-Amp In The Erythrocyte Play Key Roles In The 5’-Amp Induced Model Of Deep Hypometabolism, Isadora Daniels
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UPTAKE AND METABOLISM OF 5’-AMP IN THE ERYTHROCYTE PLAY KEY ROLES IN THE 5’-AMP INDUCED MODEL OF DEEP HYPOMETABOLISM
Publication No. ________
Isadora Susan Daniels, B.A.
Supervisory Professor: Cheng Chi Lee, Ph.D.
Mechanisms that initiate and control the natural hypometabolic states of mammals are poorly understood. The laboratory developed a model of deep hypometabolism (DH) initiated by uptake of 5’-adenosine monophosphate (5’-AMP) into erythrocytes. Mice enter DH when given a high dose of 5’-AMP and the body cools readily. Influx of 5’-AMP appears to inhibit thermoregulatory control. In a 15°C environment, mice injected with 5’-AMP (0.5 mg/gw) enter a Phase …