Targeted Osmotic Lysis: A Novel Approach To Targeted Cancer Therapies, 2022 LSU Health Sciences Center - New Orleans
Targeted Osmotic Lysis: A Novel Approach To Targeted Cancer Therapies, Harry J. Gould, Dennis Paul
School of Medicine Faculty Publications
The conventional treatment of cancer has been based on the delivery of non-selective toxins and/or ionizing energy that affect both the cancer and normal tissues in the hope of destroying the offending disease before killing the patient. Unfortunately, resistance often develops to these treatments and patients experience severe, dose-limiting adverse effects that reduce treatment efficacy and compromise quality of life. Recent advances in our knowledge of the biology of tumor cells and their microenvironment, the recognition of surface proteins that are unique to specific cancers and essential to cell growth and survival and signaling pathways associate with invasion and metastasis …
Altop (Alternatives To Opiods) Newsletter, Spring 2022, 2022 Sacred Heart University
Altop (Alternatives To Opiods) Newsletter, Spring 2022, Dr. Susan L. Davis, Rn & Richard J. Henley College Of Nursing
News, Magazines and Reports
In this issue:
- Southwest Community Health Center Quality Improvement Staff (QIS)
- FNP-DNP Student's Quality Improvement Project
- Paul L. Jones Scholarship Recipients
- SHU Alumni Kimberly Testo's AANP National Year Award
- Preceptors' Workshop CEU Credits
Medical Norm Of Psychiatric Misdiagnoses In Rare Disease Patients, 2022 CUNY Hunter College
Medical Norm Of Psychiatric Misdiagnoses In Rare Disease Patients, Rachel Han
Publications and Research
Spring 2022 ENG 120 Student Final Research Paper on the medical norm of psychiatric misdiagnosis throughout the diagnostic journeys of rare disease patients. The idea of a norm was taken from Chimamanda Ngozi Adichie's Tedx Talk "The Danger of a Single Story". Paper discusses prevalence, harmful effects, and origin of this medical norm. Includes discussion of statistical data quoted relating to prevalence of rare diseases as well as anecdotal evidence of the severe ramifications of this norm. Discussion of how medically unexplained symptoms such as mysterious chronic pain often lead to the phenomenon of the psychogenic inference. Origins of this …
The Genetics Of Pain: An Exploration Of Gene-By-Environment Interactions And Their Effects On Pain, 2022 The University of Western Ontario
The Genetics Of Pain: An Exploration Of Gene-By-Environment Interactions And Their Effects On Pain, Mohamad F. Fakhereddin
Electronic Thesis and Dissertation Repository
The findings presented in this dissertation are part of the bigger SYMBIOME project which aims to use the biopsychosocial model of pain to develop a prognostic clinical phenotype for people that experience musculoskeletal (MSK) trauma. Chapter 2 presents an exploratory analysis to assess the relationships between genetic polymorphisms and pain severity and interference. Early childhood trauma was also explored as a moderator between genetic polymorphisms and pain outcomes. For pain severity, major allele carriers (A/A and G/A) of FKBP5 rs9394314 reported significantly higher scores than minor allele carriers (G/G). Further, major allele carriers who had at least one adverse childhood …
Analysis Of Zero Balancing Case Studies Through An Occupational Therapy Lens, 2022 Eastern Illinois University
Analysis Of Zero Balancing Case Studies Through An Occupational Therapy Lens, Deanna Waggy Otr, Msa, Czb, Csla
Journal of Transformative Touch
Does Zero Balancing positively impact occupational performance? This is a question many Occupational Therapists (OTs) ask when discerning if Zero Balancing (ZB) is an evidence-based treatment modality. Case studies from the book Experiencing the Power of Zero Balancing: Case Studies of Journeys to Health and Wholeness (Quarry & King, 2016) were reviewed and compared to the Occupational Therapy domain of practice to show clear evidence that each case study had a positive impact on occupational performance. A comparison chart shows a direct link between the occupational categories and documented evidence of improved occupational performance through practitioner observation and client feedback …
Pain Interference Across Chronic Pain Populations: Variability And Associated Psychosocial Processes, 2022 University of Kentucky
Pain Interference Across Chronic Pain Populations: Variability And Associated Psychosocial Processes, Stephanie Judge
Theses and Dissertations--Psychology
Chronic pain is one of the most common health complaints, yet the limited effectiveness of existing treatment options suggests that chronic pain is still not fully understood. The goals of this study are to identify and organize well-established and emerging psychosocial factors associated with pain interference, clarify the nature of between- and within-diagnostic group differences in psychosocial and demographic factors associated with pain interference, and identify interactions among diagnostic and psychosocial factors associated with pain interference.
Community-dwelling participants (N = 284) completed a one-time survey which included demographic information, information about pain and diagnosis, and five existing measures that assess …
Wound-Dwelling: Empowerment Through Masochistic Experiences, 2022 Lesley University
Wound-Dwelling: Empowerment Through Masochistic Experiences, Nizlyn
MFA in Visual Arts Theses
The psychoanalytic concept of the Skin Ego Theory describes the skin as a passage for pain and pleasure to travel through. Remnants of external experiences as well as internal struggles affect the penetrable barrier of the somatic wrapping and leave inscriptions on the flesh. Through my work, I have been exploring the skin’s ability to protect, envelope, and inscribe meaning through my papercuts, oil paintings, and clay sculptures. I procure the marks on my body through kink and BDSM, which then influence the work. Though my bruises may fade with time, my skin becomes tougher. By recontextualizing Skin Ego Theory …
Mindfulness And Pain Regulation: The Role Of Acceptance And Commitment Therapy For Individuals With Chronic Pain, 2022 University of New Hampshire, Durham
Mindfulness And Pain Regulation: The Role Of Acceptance And Commitment Therapy For Individuals With Chronic Pain, Ariana C. White
Honors Theses and Capstones
Chronic pain is a significant and widely prevalent health condition which requires comprehensive care to address the many facets contributing to symptomatology. In 2016, 20% of American adults (about 50 million) reported experiencing chronic pain, of which 7.4% indicated that chronic pain frequently limited their life and participation in activities within the past 3 months (CDC, 2018). As a result, many individuals with chronic pain turn to opioid-based medication for pain relief, but long-term use of opioids actually increases pain sensation (Tobin, 2019). Moreover, opioid medication is unable to target underlying mental health components which emerge as part of chronic …
Perceived Instability, Pain, And Psychological Factors Predict Function And Disability In Individuals With Chronic Ankle Instability, 2022 Old Dominion University
Perceived Instability, Pain, And Psychological Factors Predict Function And Disability In Individuals With Chronic Ankle Instability, Ashley M.B. Suttmiller, Julie M. Cavallario, Shelby E. Baez, Jessica C. Martinez, Ryan S. Mccann
Rehabilitation Sciences Faculty Publications
Context:
Chronic ankle instability (CAI) is associated with residual instability, pain, decreased function, and increased disablement. Injury-related fear has been associated with CAI, although its relationship to other impairments is unclear. The Fear-Avoidance Model is a theoretical framework hypothesizing a relationship between injury-related fear, chronic pain, pain catastrophizing, and disability. It has been useful in understanding fear's influence in other musculoskeletal conditions but has yet to be studied in those with CAI.
Objective:
To explore relationships between instability, pain catastrophizing, injury-related fear, pain, ankle function, and global disability in individuals with CAI.
Design:
Cross-Sectional Study
Setting:
Anonymous online survey
Patients …
Eye Movement Desensitization And Reprocessing: Standard Versus Pain-Focused Treatment Protocols, 2022 Claremont Colleges
Eye Movement Desensitization And Reprocessing: Standard Versus Pain-Focused Treatment Protocols, Joni Walsh
Scripps Senior Theses
Typically used as a trauma therapy, Eye Movement Desensitization and Reprocessing (EMDR) may be a promising intervention for chronic pain, given the relationship (and rates of comorbidity) between chronic pain and post-traumatic stress (PTS). The purpose of the proposed study is to investigate how EMDR therapy might best be implemented as an integrated treatment for chronic pain among individuals with post-traumatic stress symptoms. This study will be the first of its kind to directly compare the standard trauma-focused (TF) EMDR treatment to a popular emerging pain-focused (PF) EMDR treatment modification (Grant, 2000). This study will utilize a matched-participants design and …
Mindfulness To Manage Moral Injury: Rationale And Development Of A Live Online 7-Week Group Intervention For Veterans With Moral Injury, 2022 Old Dominion University
Mindfulness To Manage Moral Injury: Rationale And Development Of A Live Online 7-Week Group Intervention For Veterans With Moral Injury, Michelle L. Kelley, Megan Strowger, Victoria O. Chentsova, Adrian J. Bravo, Susan A. Gaylord, Elizabeth E. Burgin, Christine Vinci, Kenneth L. Ayers, Erum Agha
Psychology Faculty Publications
BACKGROUND: Military service puts service members at risk for moral injury. Moral injury is an array of symptoms (e.g., guilt, shame, anger) that develop from events that violate or transgress one's moral code.
OBJECTIVE: We describe adaption of in-person mindfulness training program, Mindfulness to Manage Chronic Pain (MMCP), to address symptoms of moral injury to be delivered live via the web. We discuss how we will assess benchmarks (i.e., recruitment, credibility and acceptability, completion rates, and adherence) of the Mindfulness to Manage Moral Injury (MMMI) program.
METHODS: Aim 1: To develop and then adapt the MMCP program based on …
Effect Of Auricular Acupressure On Acute Pain In Nursing Home Residents With Mild Dementia: A Single-Blind, Randomized, Sham-Controlled Study, 2022 Edith Cowan University
Effect Of Auricular Acupressure On Acute Pain In Nursing Home Residents With Mild Dementia: A Single-Blind, Randomized, Sham-Controlled Study, Jun Jun Zhang, Li Yu, Jun Hui Mei, Hong Xin Wang, Hai Xiang Gao, Ju Fang Fu, Ye Cheng, Lu Lu Gao, Lei Bu, Jian Qiang Yu, Carol Chunfeng Wang, Yu Xiang Li
Research outputs 2022 to 2026
Introduction. Acute pain is a prevalent problem for dementia residents in nursing homes. A variety of intervention strategies have been applied to address this problem. However, there remains an issue of inadequate pain control. This study aims to explore the analgesic efficacy of auricular acupressure (AA) for dementia residents with acute pain in nursing homes. Methods. A multicenter, single-blind, randomized, and sham-controlled clinical trial was performed in three nursing homes in Yinchuan, China. All of the 206 eligible patients with acute pain were randomly divided into two groups for real AA therapy or sham AA (at sham point stimulation) therapy. …
Sleeping With The Enemy: Examining The Relationship Between Sleep And Pain In Post-9/11 Veterans, 2021 Old Dominion University
Sleeping With The Enemy: Examining The Relationship Between Sleep And Pain In Post-9/11 Veterans, John L. Schwartz Jr.
Psychology Theses & Dissertations
United States veterans are a diverse group of individuals, yet as a result of their service, they share a unique set of customs, traditions, and values. Post-9/11 veterans are more likely to experience elevated levels of pain and poor sleep quality compared to their civilian counterparts; however, little is known about how beliefs related to veterans’ pain impact their sleep and how levels of pain acceptance influence the sleep-pain association. This study examined relationships between sleep and pain in a sample of 102 post-9/11 veterans. Results support associations between pain and sleep identified in other populations. Positive correlations were found …
The Subcomponents Of Affect Scale (Sas): Validating A Widely Used Affect Scale, 2021 Chapman University
The Subcomponents Of Affect Scale (Sas): Validating A Widely Used Affect Scale, Brooke N. Jenkins, Marie P. Cross, Candice Donaldson, Sarah D. Pressman, Michelle A. Fortier, Zeev N. Kain, Sheldon Cohen, Logan T. Martin, George Farkas
Psychology Faculty Articles and Research
Objective
There is a need for a brief affect scale that also encompasses different components of affect relevant for researchers interested in physiological and health outcomes. The Subcomponents of Affect Scale (SAS) meets this need. This 18-item scale has nine positive and nine negative affect items encompassing six subscales (calm, well-being, vigour, depression, anxiety, anger). Previous research using the SAS has demonstrated its predictive validity, but no work has tested its subscale structure or longitudinal validity.
Design
Data from the Common Cold Project in which individuals (N = 610) completed the SAS over the course of seven days were used. …
Shu Altop News Issue #4, Fall, 2021 Sacred Heart University
Shu Altop News Issue #4, Fall, Dr. Susan L. Davis, Rn & Richard J. Henley College Of Nursing
News, Magazines and Reports
Updates from the Davis & Henley College of Nursing Sacred Heart University Alternatives to Opioids for Pain Grant.
Alternatives to Opioids for Pain (ALTOP) is a HRSA funded project to help combat the opioid epidemic in Connecticut.
In this issue: • New Roles in Our Team • ANEW HRSA 2021-2022 Awardees • Southwest Community Health Center Chiropractic Care Services • Student Quality Improvement Project • Sacred Heart University Alumni Working at New Solutions Pain Management Clinic.
Black And White Health Disparities: Racial Bias In American Healthcare, 2021 Wilfrid Laurier University
Black And White Health Disparities: Racial Bias In American Healthcare, Yasmeen Almomani
Bridges: An Undergraduate Journal of Contemporary Connections
This paper explores the historical implications of race in American society that have led to implicit racism in the healthcare system. Racial bias in healthcare against Black people is a factor in the health disparities between Black and white people in America, such as the gap in life expectancy, infant death, and maternal mortality. Black people are more likely to report racial discrimination from healthcare providers, which is a reason for the decreased quality of care received. The past justifications of slavery, the Tuskegee syphilis study, and the medical experimentations on Black women are horrifying but were considered acceptable in …
An Investigation Of Occupational Therapy Utilizing Sensory Modulation To Manage Co-Morbid Chronic Pain And Substance Use In Order To Promote Occupational Performance And Recovery, 2021 University of St. Augustine for Health Sciences
An Investigation Of Occupational Therapy Utilizing Sensory Modulation To Manage Co-Morbid Chronic Pain And Substance Use In Order To Promote Occupational Performance And Recovery, Claire Ruth
Student Capstone Papers
Background: Those with chronic pain have worse drug and alcohol treatment outcomes and higher rates of relapse compared to those without pain or with reduced pain (Ilgen et al., 2020).
Methods: A descriptive study was employed with the aim of determining what are the sensory processing pattens of those with co-morbid chronic pain and in recovery for substance use. All participants completed the Adolescent and Adult Sensory Profile, the Brief Pain Inventory, and the Personal Recovery Outcome Measure (PROM).
Results: From the preliminary findings, individuals with co-morbid chronic pain and substance use may have atypical sensory processing …
Attitudes Toward Mindfulness And Adherence In Chronic Pain Management, 2021 University of Washington Tacoma
Attitudes Toward Mindfulness And Adherence In Chronic Pain Management, Sarah Johnson
Global Honors Theses
Chronic pain is a global public health problem, affecting 10-25% of the population. Mindfulness is an effective treatment but requires consistency. Because of its benefit, it is important to examine obstacles to mindfulness practice. In order to determine if negative attitudes toward mindfulness are related to non-adherence, 748 adults with chronic pain were recruited to fill out a series of questionnaires assessing treatment adherence and attitudes toward mindfulness. We found that positive attitudes toward mindfulness predicted reduced adherence. However, those who had more positive feelings toward mindfulness made more attempts at the therapy. Upper and middle-class participants had more positive …
Shu Altop News Issue #3, Summer, 2021 Sacred Heart University
Shu Altop News Issue #3, Summer, Dr. Susan L. Davis, Rn & Richard J. Henley College Of Nursing
News, Magazines and Reports
Updates from the Davis & Henley College of Nursing Sacred Heart University Alternatives to Opioids for Pain Grant.
Alternatives to Opioids for Pain (ALTOP) is a HRSA funded project to help combat the opioid epidemic in Connecticut.
Post-Operative Pain Management Modalities Employed In Clinical Trials For Adult Patients In Lmic; A Systematic Review, 2021 Aga Khan University
Post-Operative Pain Management Modalities Employed In Clinical Trials For Adult Patients In Lmic; A Systematic Review, Gauhar Afshan, Robyna Irshad Khan, Aliya Ahmed, Ali Sarfraz Siddiqui, Azhar Rehman, Syed Amir Raza, Rozina Kerai, Khawaja Mustafa
Department of Anaesthesia
Background: Unrelieved postoperative pain afflicts millions each year in low and middle income countries (LMIC). Despite substantial advances in the study of pain, this area remains neglected. Current systematic review was designed to ascertain the types of clinical trials conducted in LMIC on postoperative pain management modalities over the last decade.
Methods: A comprehensive search was performed in June 2019 on PubMed, Cochrane Library, CINAHL Plus, and Web of Science databases to identify relevant trials on the management of postoperative pain in LMIC. Out of 1450 RCTs, 108 studies were reviewed for quality evidence using structured form of critical appraisal …