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Assessing The Accuracy Of Approximate Treatments Of Ion Hydration Based On Primitive Quasichemical Theory, Benoit Roux, Haibo Yu 2010 University of Chicago

Assessing The Accuracy Of Approximate Treatments Of Ion Hydration Based On Primitive Quasichemical Theory, Benoit Roux, Haibo Yu

Faculty of Science - Papers (Archive)

Quasichemical theory (QCT) provides a framework that can be used to partition the influence of the solvent surrounding an ion into near and distant contributions. Within QCT, the solvation properties of the ion are expressed as a sum of configurational integrals comprising only the ion and a small number of solvent molecules. QCT adopts a particularly simple form if it is assumed that the clusters undergo only small thermal fluctuations around a well-defined energy minimum and are affected exclusively in a mean-field sense by the surrounding bulk solvent. The fluctuations can then be integrated out via a simple vibrational analysis ...


A Combined Experimental And Theoretical Study Of Ion Solvation In Liquid N-Methylacetamide, Haibo Yu, Christopher L. Mazzanti, Troy W. Whitfield, Roger E. Koeppe II, Olaf S. Andersen, Benoit Roux 2010 University of Wollongong

A Combined Experimental And Theoretical Study Of Ion Solvation In Liquid N-Methylacetamide, Haibo Yu, Christopher L. Mazzanti, Troy W. Whitfield, Roger E. Koeppe Ii, Olaf S. Andersen, Benoit Roux

Faculty of Science - Papers (Archive)

Most current biomolecular simulations are based on potential energy functions that treat the electrostatic energy as a sum of pairwise Coulombic interactions between effective fixed atomic charges. This approximation, in which many-body induced polarization effects are included in an average way, is expected to be satisfactory for a wide range of systems, but less accurate for processes involving the transfer and partition of ions among heterogeneous environments. The limitations of these potential energy functions are perhaps most obvious in studies of ion permeation through membrane channels. In many cases, the pore is so narrow that the permeating ion must shed ...


Restored Nature, Familiar Culture: Contesting Visions For Preferred Environments In Australian Cities, D. Trigger, Lesley M. Head 2010 University of Wollongong

Restored Nature, Familiar Culture: Contesting Visions For Preferred Environments In Australian Cities, D. Trigger, Lesley M. Head

Faculty of Science - Papers (Archive)

How are preferences for “native” and “introduced” species of plants and animals given expression in Australian cities? Given the nation's predominantly European cultural heritage, how do urban Australians articulate multiple desires for living environments encountered in everyday life? In examining the cases of inner city parks, backyards, and more general views about flora and fauna appropriate for the city, the paper considers a range of deeply enculturated attachments to familiar landscapes. While residents have considerable interest in the possibilities of urban ecological restoration, our interviews, ethnographic observation, and textual analysis also reveal cultural preferences for introduced species and emplaced ...


Localization Of Low Molecular Weight Crystallin Peptides In The Aging Human Lens Using A Maldi Mass Spectrometry Imaging Approach, S. P. Su, Jason D. McArthur, J. A. Aquilina 2010 University of Wollongong

Localization Of Low Molecular Weight Crystallin Peptides In The Aging Human Lens Using A Maldi Mass Spectrometry Imaging Approach, S. P. Su, Jason D. Mcarthur, J. A. Aquilina

Faculty of Science - Papers (Archive)

Low molecular weight (LMW) peptides, derived from the breakdown of the major eye lens proteins, the crystallins, accumulate in the human lens with age. These LMW peptides are associated with age-related lens opacity and cataract, with some shown to inhibit the chaperone activity of α-crystallin. However, the mechanism(s) giving rise to the production of these peptides, as well as their distribution within the lens, are not well understood. In this study, we have mapped the distribution of these crystallin-derived peptides present in human lenses of different ages using matrix-assisted laser desorption/ionization-imaging mass spectrometry (MALDI-IMS). Our data showed that ...


Elastic Scattering Studies Of Aligned Dmpc Multilayers On Different Hydrations, Marcus Trapp, Fanni Juranyi, Moeava Tehei, Lambert van Eijck, Bruno Demé, Thomas Gutberlet, Judith Peters 2010 Institut de Biologie Structurale, France

Elastic Scattering Studies Of Aligned Dmpc Multilayers On Different Hydrations, Marcus Trapp, Fanni Juranyi, Moeava Tehei, Lambert Van Eijck, Bruno Demé, Thomas Gutberlet, Judith Peters

Faculty of Science - Papers (Archive)

Biological membranes, consisting mainly of phospholipids and proteins, are organized in a bilayered structure which exhibits dynamical behaviour within time regimes ranging from 10-12 s with the motion of alkyl chain defects and 1 s corresponding to collective excitations of the bilayer [1]. With the prominent role hydration plays on the structural phase behaviour of phospholipids membranes, it is essential for a better description of membranes to understand also the influence of hydration on the dynamics of membrane systems. In the present study we have performed neutron scattering investigations on highly oriented DMPC-d54 multilayers at two different relative humidity (rh ...


Preclinical Evaluation Of Novel All-In-One Formulations Of 5-Fluorouracil And Folinic Acid With Reduced Toxicity Profiles - Supplementary Data, Tamantha K. Stutchbury, Kara L. Vine, Julie M. Locke, Jeremy S. Chrisp, J. B. Bremner, P Clingan, Marie Ranson 2010 University of Wollongong

Preclinical Evaluation Of Novel All-In-One Formulations Of 5-Fluorouracil And Folinic Acid With Reduced Toxicity Profiles - Supplementary Data, Tamantha K. Stutchbury, Kara L. Vine, Julie M. Locke, Jeremy S. Chrisp, J. B. Bremner, P Clingan, Marie Ranson

Faculty of Science - Papers (Archive)

Objectives: 5-Fluorouracil (5-FU) in combination with its synergistic biomodulator folinic acid maintains a pivotal position in cancer chemotherapy. However, clinical limitations persist with the administration of these drugs in combination including phlebitis and catheter blockages, which are associated with reduced efficacy and/or quality of life for patients. We have previously reported novel all-in-one, pH neutral, parenteral 5-FU and folinic acid formulations (termed Fluorodex) incorporating beta-cyclodextrins. Fluorodex maintains potency while overcoming the accepted incompatibility of 5-FU and folinic acid.
Methods: We performed toxicological, pharmacokinetic and biodistribution, and efficacy evaluations of Fluorodex compared to 5-FU:folinic acid using several administration routes ...


Evidence For Specific Subunit Distribution And Interactions In The Quaternary Structure Of Α-Crystallin, Amie M. Morris, J. Andrew Aquilina 2010 University of Wollongong

Evidence For Specific Subunit Distribution And Interactions In The Quaternary Structure Of Α-Crystallin, Amie M. Morris, J. Andrew Aquilina

Faculty of Science - Papers (Archive)

The quaternary structure of α-crystallin is dynamic, a property which has thwarted crystallographic efforts towards structural characterization. In this study, we have used collision-induced dissociation mass spectrometry to examine the architecture of the polydisperse assemblies of α-crystallin. For total α-crystallin isolated directly from fetal calf lens using size-based chromatography, the αB-crystallin subunit was found to be preferentially dissociated from the oligomers, despite being significantly less abundant overall than the αA-crystallin subunits. Furthermore, upon mixing molar equivalents of purified αA- and αB-crystallin, the levels of their dissociation were found to decrease and increase, respectively, with time. Interestingly though, dissociation of subunits ...


Synthesis Of Hyacinthacine B-3 And Purported Hyacinthacine B-7, Christopher W.G. Au, Robert J. Nash, Stephen G. Pyne 2010 University of Wollongong

Synthesis Of Hyacinthacine B-3 And Purported Hyacinthacine B-7, Christopher W.G. Au, Robert J. Nash, Stephen G. Pyne

Faculty of Science - Papers (Archive)

The synthesis of hyacinthacines B-3 and B-7 has confirmed the structure of the former alkaloid and shown that the structure of the latter is incorrect.


Misidentification Of Tansy, Tanacetum Macrophyllum, As Yarrow, Achillea Grandifolia: A Health Risk Or Benefit?, Niko Radulovic, Polina Blagojevic, Danielle Skropeta, Aleksandra Zarubica, Bojan Zlatkovic, Radosav Palic´ 2010 University of Wollongong

Misidentification Of Tansy, Tanacetum Macrophyllum, As Yarrow, Achillea Grandifolia: A Health Risk Or Benefit?, Niko Radulovic, Polina Blagojevic, Danielle Skropeta, Aleksandra Zarubica, Bojan Zlatkovic, Radosav Palic´

Faculty of Science - Papers (Archive)

Tansy, Tanacetum macrophyllum (Waldst. & Kit.) Sch. Bip., is often misidentified by herb collectors as yarrow, Achillea grand folia Friv. With the former, cases of poisoning induced by its ingestion are well documented, but the latter is widely used for ethnopharmacological purposes. The aim of this study was to estimate, based on the volatile metabolite profiles of the two species, the potential health risk connected with their misidentification. GC and GC-MS analysis of the essential oils hydrodistilled using a Clevenger-type apparatus from A. grandifolia, T macrophyllum, and two plant samples (reputedly of A. grandifolia, but in fact mixtures of A. grand ...


Late Pliocene Age Of Glacial Deposits At Heidemann Valley East Antarctica: Evidence For The Last Major Glaciation In The Vestfold Hills, Eric Colhoun, Kevin W. Kiernan, Anne McConnell, P G Quilty, David Fink, Colin V. Murray-Wallace, J M Whitehead 2010 University of Newcastle

Late Pliocene Age Of Glacial Deposits At Heidemann Valley East Antarctica: Evidence For The Last Major Glaciation In The Vestfold Hills, Eric Colhoun, Kevin W. Kiernan, Anne Mcconnell, P G Quilty, David Fink, Colin V. Murray-Wallace, J M Whitehead

Faculty of Science - Papers (Archive)

No abstract provided.


Esi-Ms And Thermal Melting Studies Of Nanoscale Platinum(Ii) Metallomacrocycles With Dna, Margaret M. Harding, Louis M. Rendina, David Schilter, Thitima Urathamakul, Jennifer L. Beck 2010 University of Sydney

Esi-Ms And Thermal Melting Studies Of Nanoscale Platinum(Ii) Metallomacrocycles With Dna, Margaret M. Harding, Louis M. Rendina, David Schilter, Thitima Urathamakul, Jennifer L. Beck

Faculty of Science - Papers (Archive)

The hydrophilic, long-chain diamine PEGda (O,O′-bis(2-aminoethyl)octadeca(ethylene glycol)), when complexed with cis-protected Pt(II) ions afforded water-soluble complexes of the type [Pt(N,N)(PEGda)](NO3)2 (N,N = N,N,N′,N′-tetramethyl-1,2-diaminoethane (tmeda), 1,2-diaminoethane (en), and 2,2′-bipyridine (2,2′-bipy)) featuring unusual 62-membered chelate rings. Equimolar mixtures containing either the 16-mer duplex DNA D2 or the single-stranded D2a and [Pt(N,N)(PEGda)]2+ were analyzed by negative-ion ESI-MS. Analysis of D2-Pt(II) mixtures showed the formation of 1:1 adducts of [Pt(en)(PEGda)]2+, [Pt(tmeda)(PEGda)]2 ...


Copper-Mediated Cyclization-Halogenation And Cyclization-Cyanation Reactions Of Β-Hydroxyalkynes And O-Alkynylphenols And Anilines, Nalivela K. Swamy, Arife Yazici, Stephen G. Pyne 2010 University of Wollongong

Copper-Mediated Cyclization-Halogenation And Cyclization-Cyanation Reactions Of Β-Hydroxyalkynes And O-Alkynylphenols And Anilines, Nalivela K. Swamy, Arife Yazici, Stephen G. Pyne

Faculty of Science - Papers (Archive)

The CuX (X = I, Br, Cl, CN)-mediated cyclization-halogenation and cyclization-cyanation reactions of β-hydroxyalkynes and o-alkynylphenol and -aniline derivatives give rise to 3-halo- and 3-cyanofuro[3,2-b]pyrroles, 3-iodo-, 3-bromo-, and 3-cyanobenzofurans, and 3-cyanoindoles, respectively. © 2010 American Chemical Society.


Small Heat-Shock Proteins Interact With A Flanking Domain To Suppress Polyglutamine Aggregation, Amy L. Roberston, Stephen J. Headey, Helen M. Saunders, Heath Ecroyd, Martin J. Scanlon, John A. Carver, Stephen P. Bottomley 2010 Monash University

Small Heat-Shock Proteins Interact With A Flanking Domain To Suppress Polyglutamine Aggregation, Amy L. Roberston, Stephen J. Headey, Helen M. Saunders, Heath Ecroyd, Martin J. Scanlon, John A. Carver, Stephen P. Bottomley

Faculty of Science - Papers (Archive)

Small heat-shock proteins (sHsps) are molecular chaperones that play an important protective role against cellular protein misfolding by interacting with partially unfolded proteins on their off-folding pathway, preventing their aggregation. Polyglutamine (polyQ) repeat expansion leads to the formation of fibrillar protein aggregates and neuronal cell death in nine diseases, including Huntington disease and the spinocerebellar ataxias (SCAs). There is evidence that sHsps have a role in suppression of polyQ-induced neurodegeneration; for example, the sHsp alphaB-crystallin (αB-c) has been identified as a suppressor of SCA3 toxicity in a Drosophila model. However, the molecular mechanism for this suppression is unknown. In this ...


Products Of The Benzene + O(3p) Reaction, Craig A. Taatjes, David L. Osborn, Talitha M. Selby, Giovanni Meloni, Adam J. Trevitt, Evgeny Epifanovsky, Anna I. Krylov, Baptiste Sirjean, Enoch Dames, Hai Wang 2010 University of Wollongong

Products Of The Benzene + O(3p) Reaction, Craig A. Taatjes, David L. Osborn, Talitha M. Selby, Giovanni Meloni, Adam J. Trevitt, Evgeny Epifanovsky, Anna I. Krylov, Baptiste Sirjean, Enoch Dames, Hai Wang

Faculty of Science - Papers (Archive)

No abstract provided.


Novel Technique Shows Different Hydrophobic Chemical Signatures Of Exotic And Indigenous Plant Soils With Similar Effects Of Extracts On Indigenous Species Seedling Growth, Emilie-Jane Ens, Kristine O. French, John B. Bremner, Jurgen Korth 2010 University of Wollongong

Novel Technique Shows Different Hydrophobic Chemical Signatures Of Exotic And Indigenous Plant Soils With Similar Effects Of Extracts On Indigenous Species Seedling Growth, Emilie-Jane Ens, Kristine O. French, John B. Bremner, Jurgen Korth

Faculty of Science - Papers (Archive)

Changes to ecosystem abiotic parameters are regarded as possible mechanisms facilitating plant invasion and community composition shifts. This study compared the hydrophobic chemical signatures of soil from exotic bitou bush (Chrysanthemoides monilifera spp. rotundata) invaded, indigenous acacia (Acacia longifolia var. sophorae) dominated and bare sand (unvegetated) habitats using a novel, rapid, capturing technique which utilised AmberliteA (R) XAD4 resin filled bags that were placed in situ. The hydrophobic chemical signature of the bitou bush soil extract was significantly different to the acacia soil and bare sand extracts. High concentrations of 18 sesquiterpenes dominated the hydrophobic signature of the bitou bush ...


Materialising Masculinity: Men And Interior Design, Andrew Gorman-Murray 2010 University of Wollongong

Materialising Masculinity: Men And Interior Design, Andrew Gorman-Murray

Faculty of Science - Papers (Archive)

No abstract provided.


Managing The Ground Parrot In Its Fiery Habitat In South-Eastern Australia, Jack Baker, Robert J. Whelan, Lyn Evans, Stephen Moore, Melinda Norton 2010 University of Wollongong

Managing The Ground Parrot In Its Fiery Habitat In South-Eastern Australia, Jack Baker, Robert J. Whelan, Lyn Evans, Stephen Moore, Melinda Norton

Faculty of Science - Papers (Archive)

The Ground Parrot (Pezoporus wallicus) is a rare and iconic endemic of heathlands in southern Australia. It is threatened by frequent and widespreadfire. The species has been an integral element in the development of our understanding of the impacts offire regimes in heathlands and is an integral part of conservation management of thesefire-prone ecosystems. This long-term study documents the densities of Ground Parrots in three areas of long-unburnt habitat in southernNewSouth Wales. Using area searches and aural surveys, we estimated densities of Ground Parrots at Barren Grounds Nature Reserve–Budderoo National Park (1983–2009), Beecroft Weapons Range (1997–2008) and ...


Genetic Tests Of The Isolation Of Rare Coastal Dwarf Populations Of Banksia Spinulosa, Eleanor K. O'Brien, Lucia A. Aguilar, David J. Ayre, Robert J. Whelan 2010 University of Wollongong

Genetic Tests Of The Isolation Of Rare Coastal Dwarf Populations Of Banksia Spinulosa, Eleanor K. O'Brien, Lucia A. Aguilar, David J. Ayre, Robert J. Whelan

Faculty of Science - Papers (Archive)

In southern New South Wales, a suite of widespread plant species exhibit short-statured 'dwarf' growth forms on coastal headlands. It is unclear whether such populations are genetically distinct or whether dwarfism is a plastic response to the environment. We used four microsatellite markers to assess genetic differentiation among populations from coastal and inland sites for Banksia spinulosa var. spinulosa. We sampled plants from six locations, including from three 'dwarf' and three 'normal' populations. Mean levels of genetic diversity were slightly higher in the forest (Na≤7. 07±0.25; He≤0.80±0.09) than on the coast (N a ...


Calibration Of The Total Carbon Column Observing Network Using Aircraft Profile Data, Debra Wunch, G C Toon, Paul O. Wennberg, Steven C. Wofsy, Robert S. Stephens, M K.R. Fischer, O Uchino, J Abshire, P Bernath, S C Biraud, J-F Blavier, C Boone, K P. Bowman, E V. Browell, T Campos, B Connor, Bruce C. Daube, Nicholas M. Deutscher, M Diao, J W. Elkins, Christoph Gerbig, E Gottlieb, David W. Griffith, D F. Hurst, Rodrigo Jimenez, Gretchen Keppel-Aleks, E A. Kort, Ronald Macatangay, T Machidda, H Matsueda, F Moore, I Morino, S Park, J Robinson, C M. Roehl, Y Sawa, V Sherlock, C Sweeney, T Tanaka, M A. Zondlo 2010 California Institute of Technology

Calibration Of The Total Carbon Column Observing Network Using Aircraft Profile Data, Debra Wunch, G C Toon, Paul O. Wennberg, Steven C. Wofsy, Robert S. Stephens, M K.R. Fischer, O Uchino, J Abshire, P Bernath, S C Biraud, J-F Blavier, C Boone, K P. Bowman, E V. Browell, T Campos, B Connor, Bruce C. Daube, Nicholas M. Deutscher, M Diao, J W. Elkins, Christoph Gerbig, E Gottlieb, David W. Griffith, D F. Hurst, Rodrigo Jimenez, Gretchen Keppel-Aleks, E A. Kort, Ronald Macatangay, T Machidda, H Matsueda, F Moore, I Morino, S Park, J Robinson, C M. Roehl, Y Sawa, V Sherlock, C Sweeney, T Tanaka, M A. Zondlo

Faculty of Science - Papers (Archive)

The Total Carbon Column Observing Network (TCCON) produces precise measurements of the column average dry-air mole fractions of CO2, CO, CH4, N2O and H2O at a variety of sites worldwide. These observations rely on spectroscopic parameters that are not known with sufficient accuracy to compute total columns that can be used in combination with in situ measurements. The TCCON must therefore be calibrated to World Meteorological Orga-nization (WMO) in situ trace gas measurement scales. We present a calibration of TCCON data using WMO-scale instrumentation aboard aircraft that measured profiles over four TCCON stations during 2008 and 2009. These calibrations are ...


Co-Located Column And In Situ Measurements Of Co2 In The Tropics Compared With Model Simulations, T Warneke, A K. Petersen, C Gerbig, A Jordan, C Rodenbeck, M Rothe, Ronald Macatangay, J Norholt, O Schrems 2010 University of Bremen

Co-Located Column And In Situ Measurements Of Co2 In The Tropics Compared With Model Simulations, T Warneke, A K. Petersen, C Gerbig, A Jordan, C Rodenbeck, M Rothe, Ronald Macatangay, J Norholt, O Schrems

Faculty of Science - Papers (Archive)

The first ground-based remote sensing measurements of the column averaged volume mixing ratio of CO2 (XCO2) in tropical South America have been obtained at Paramaribo, Suriname (5.8 N, 55.2 W). The remote sensing observations are complemented by surface air-samples collected at the site, analyzed for CO2 and 13CO2. The surface in-situ measurements are strongly influenced by local sources. From the isotopic composition of the air samples the local source component is suggested to be dominated by the terrestrial biosphere. Using 13C from the NOAA/ESRL stations Ascension Is. (ASC), 7.9 S, 14.4W, and Ragged Point (RPB ...


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