Equivalence Of Kernel Machine Regression And Kernel Distance Covariance For Multidimensional Trait Association Studies, 2015 university of colorado denver
Equivalence Of Kernel Machine Regression And Kernel Distance Covariance For Multidimensional Trait Association Studies, Wen-Yu Hua, Debashis Ghosh
Debashis Ghosh
Associating genetic markers with a multidimensional phenotype is an important yet challenging problem. In this work, we establish the equivalence between two popular methods: kernel-machine regression (KMR), and kernel distance covariance (KDC). KMR is a semiparametric regression framework that models covariate effects parametrically and genetic markers non-parametrically, while KDC represents a class of methods that include distance covariance (DC) and Hilbert-Schmidt independence criterion (HSIC), which are nonparametric tests of independence. We show that the equivalence between the score test of KMR and the KDC statistic under certain conditions can lead to a novel generalization of the KDC test that incorporates …
Can We Learn Anything About Pleading Changes From Existing Data?, 2015 University of Pennsylvania Carey Law School
Can We Learn Anything About Pleading Changes From Existing Data?, Jonah B. Gelbach
All Faculty Scholarship
In light of the gateway role that the pleading standard can play in our civil litigation system, measuring the empirical effects of pleading policy changes embodied in the Supreme Court's controversial Twombly and Iqbal cases is important. In my earlier paper, Locking the Doors to Discovery, I argued that in doing so, special care is required in formulating the object of empirical study. Taking party behavior seriously, as Locking the Doors does, leads to empirical results suggesting that Twombly and Iqbal have had substantial effects among cases that face Rule 12(b)(6) motions post-Iqbal. This paper responds to …
Assessing The Social And Ecological Factors That Influence Childhood Overweight And Obesity, 2014 East Tennessee State University
Assessing The Social And Ecological Factors That Influence Childhood Overweight And Obesity, Katie Callahan
Electronic Theses and Dissertations
The prevalence of childhood overweight and obesity is increasing at an alarming rate in the United States. Currently more than 1 in 3 children aged 2-19 are overweight or obese. This is of major concern because childhood overweight and obesity leads to chronic conditions such as type II diabetes and tracks into adulthood, where more severe adverse health outcomes arise. In this study I used the premise of the social ecological model (SEM) to analyze the common levels that a child is exposed to daily; the intrapersonal level, the interpersonal level, the school level, and the community level to better …
Successful Mdr-Tb Treatment Regimens Including Amikacin Are Associated With High Rates Of Hearing Loss, 2014 University of Pennsylvania
Successful Mdr-Tb Treatment Regimens Including Amikacin Are Associated With High Rates Of Hearing Loss, Chawangwa Modongo, Rafal S. Sobota, Boikobo Kesenogile, Ronald Ncube
Dartmouth Scholarship
Aminoglycosides are a critical component of multidrug-resistant tuberculosis (MDR-TB) treatment but data on their efficacy and adverse effects in Botswana is scarce. We determined the effect of amikacin on treatment outcomes and development of hearing loss in MDR-TB patients. Patients started on MDR-TB treatment between 2006 and 2012 were included. Multivariate analysis was used to determine the effect of amikacin on treatment outcomes and development of hearing loss.
Depicting Estimates Using The Intercept In Meta-Regression Models: The Moving Constant Technique, 2014 University of Connecticut - Storrs
Depicting Estimates Using The Intercept In Meta-Regression Models: The Moving Constant Technique, Blair T. Johnson Dr., Tania B. Huedo-Medina Dr.
Blair T. Johnson
In any scientific discipline, the ability to portray research patterns graphically often aids greatly in interpreting a phenomenon. In part to depict phenomena, the statistics and capabilities of meta-analytic models have grown increasingly sophisticated. Accordingly, this article details how to move the constant in weighted meta-analysis regression models (viz. “meta-regression”) to illuminate the patterns in such models across a range of complexities. Although it is commonly ignored in practice, the constant (or intercept) in such models can be indispensible when it is not relegated to its usual static role. The moving constant technique makes possible estimates and confidence intervals at …
The Structure Of Child And Adolescent Aggression: Confirmatory Factor Analysis Of A Brief Peer Conflict Scale, 2014 University of New Orleans
The Structure Of Child And Adolescent Aggression: Confirmatory Factor Analysis Of A Brief Peer Conflict Scale, Justin Russell
University of New Orleans Theses and Dissertations
The importance of simultaneous consideration of forms and functions in youth measures of aggressive behavior is well established. Competing models have presented these highly interrelated constructs as either independent (e.g., reactive or overt) or paired factors (e.g., reactive and overt). The current study examines these models in the context of assessing the viability of a new self-report measure, the Peer Conflict Scale – 20 Item Version. Confirmatory factor analyses were conducted on PCS 20 responses from 1,048 school-age youth living in the Gulf Coast region. Both models significantly improved upon one or two-factor alternatives, and demonstrated partial invariance across gender …
Impacts Of Climate Change On The Evolution Of The Electrical Grid, 2014 University of Tennessee - Knoxville
Impacts Of Climate Change On The Evolution Of The Electrical Grid, Melissa Ree Allen
Doctoral Dissertations
Maintaining interdependent infrastructures exposed to a changing climate requires understanding 1) the local impact on power assets; 2) how the infrastructure will evolve as the demand for infrastructure changes location and volume and; 3) what vulnerabilities are introduced by these changing infrastructure topologies. This dissertation attempts to develop a methodology that will a) downscale the climate direct effect on the infrastructure; b) allow population to redistribute in response to increasing extreme events that will increase under climate impacts; and c) project new distributions of electricity demand in the mid-21st century.
The research was structured in three parts. The first …
A Comparative Analysis Of Decision Trees Vis-À-Vis Other Computational Data Mining Techniques In Automotive Insurance Fraud Detection, 2014 Bond University
A Comparative Analysis Of Decision Trees Vis-À-Vis Other Computational Data Mining Techniques In Automotive Insurance Fraud Detection, Adrian Gepp, Kuldeep Kumar, J Holton Wilson, Sukanto Bhattacharya
Kuldeep Kumar
No abstract provided.
Normal Mixture And Contaminated Model With Nuisance Parameter And Applications, 2014 University of Kentucky
Normal Mixture And Contaminated Model With Nuisance Parameter And Applications, Qian Fan
Theses and Dissertations--Statistics
This paper intend to find the proper hypothesis and test statistic for testing existence of bilaterally contamination when there exists nuisance parameter. The test statistic is based on method of moments estimators. Union-Intersection test is used for testing if the distribution of population can be implemented by a bilaterally contaminated normal model with unknown variance. This paper also developed a hierarchical normal mixture model (HNM) and applied it to birth weight data. EM algorithm is employed for parameter estimation and a singular Bayesian information criterion (sBIC) is applied to choose the number components. We also proposed a singular flexible information …
Linking Instrumental Neutron Activation Analysis (Inaa) With Geology In The Ancestral Caddo Region, 2014 Heritage Research Center, Stephen F. Austin State University
Linking Instrumental Neutron Activation Analysis (Inaa) With Geology In The Ancestral Caddo Region, Robert Z. Selden Jr.
CRHR: Archaeology
This poster illustrates the success of a novel method of INAA that was employed to reveal geochemical signatures in Caddo ceramic vessel sherds that correlate with local surficial geology. The geochemical data from the sherd assemblage were used within an exploration of potential ceramic provenance, which was successful at demarcating sherds from ceramic vessels made from clays in either the Claiborne or Wilcox Groups. Further geochemical segregation was also apparent between the Recklaw Formation in the Claiborne Group, and the Weches Formation in the Wilcox Group. These results point to a high degree of geochemical variability within the East Texas …
Instrumental Neutron Activation Analysis (Inaa) Of Shell-Tempered Ceramics In The Ancestral Caddo Region: Rethinking Methods, 2014 Archeological & Environmental Consultants, LLC
Instrumental Neutron Activation Analysis (Inaa) Of Shell-Tempered Ceramics In The Ancestral Caddo Region: Rethinking Methods, Robert Z. Selden Jr., Timothy K. Perttula
CRHR: Archaeology
The geochemical analysis of shell-tempered ceramics in the ancestral Caddo region has been a matter of confusion since the mid-1990s. While Caddo archaeologists have long perceived most or all of the shell-tempered ceramics in East Texas to have originated from two different areas within the Red River basin, the geochemical data and interpretations remain inconsistent with that idea. This poster takes another look at this dataset, and considers an approach that was initially put forth by MURR, and then seemingly abandoned. Using only the geochemical data from shell-tempered sherds, we take a closer look at the contributions of calcium (Ca), …
Advances In Documentation, Digital Curation, Virtual Exhibition, And A Test Of 3d Geometric Morhpometrics: A Case Study Of The Vanderpool Vessels From The Ancestral Caddo Territory, 2014 Center for Regional Heritage Research, Stephen F. Austin State University
Advances In Documentation, Digital Curation, Virtual Exhibition, And A Test Of 3d Geometric Morhpometrics: A Case Study Of The Vanderpool Vessels From The Ancestral Caddo Territory, Robert Z. Selden Jr., Timothy K. Perttula, Michael J. O'Brien
CRHR: Archaeology
Three-dimensional (3D) digital scanning of archaeological materials is typically used as a tool for artifact documentation. With the permission of the Caddo Nation of Oklahoma, 3D documentation of Caddo funerary vessels from the Vanderpool site (41SM77) was conducted with the initial goal of ensuring that these data would be publicly available for future research long after the vessels were repatriated. A digital infrastructure was created to archive and disseminate the resultant 3D datasets, ensuring that they would be accessible by both researchers and the general public (CRHR 2014a). However, 3D imagery can be used for much more than documentation. To …
Multiple Comparison Procedures For Neuroimaging Genomewide Association Studies, 2014 University of Warwick
Multiple Comparison Procedures For Neuroimaging Genomewide Association Studies, Wen-Yu Hua, Thomas E. Nichols, Debashis Ghosh
Debashis Ghosh
Recent research in neuroimaging has been focusing on assessing associations between genetic variants measured on a genomewide scale and brain imaging phenotypes. Many publications in the area use massively univariate analyses on a genomewide basis for finding single nucleotide polymorphisms that influence brain structure. In this work, we propose using various dimensionalityreduction methods on both brain MRI scans and genomic data, motivated by the Alzheimer’s Disease Neuroimaging Initiative (ADNI) study. We also consider a new multiple testing adjustments inspired from the idea of local false discovery rate of Efron and others (2001). Our proposed procedure is able to find associations …
Garma Toolbox For Matlab, 2014 Cleveland State University
Methods For Integrative Analysis Of Genomic Data, 2014 Virginia Commonwealth University
Methods For Integrative Analysis Of Genomic Data, Paul Manser
Theses and Dissertations
In recent years, the development of new genomic technologies has allowed for the investigation of many regulatory epigenetic marks besides expression levels, on a genome-wide scale. As the price for these technologies continues to decrease, study sizes will not only increase, but several different assays are beginning to be used for the same samples. It is therefore desirable to develop statistical methods to integrate multiple data types that can handle the increased computational burden of incorporating large data sets. Furthermore, it is important to develop sound quality control and normalization methods as technical errors can compound when integrating multiple genomic …
Dynamic Bayesian Approaches To The Statistical Calibration Problem, 2014 Virginia Commonwealth University
Dynamic Bayesian Approaches To The Statistical Calibration Problem, Derick Lorenzo Rivers
Theses and Dissertations
The problem of statistical calibration of a measuring instrument can be framed both in a statistical context as well as in an engineering context. In the first, the problem is dealt with by distinguishing between the "classical" approach and the "inverse" regression approach. Both of these models are static models and are used to estimate "exact" measurements from measurements that are affected by error. In the engineering context, the variables of interest are considered to be taken at the time at which you observe the measurement. The Bayesian time series analysis method of Dynamic Linear Models (DLM) can be used …
From Amazon To Apple: Modeling Online Retail Sales, Purchase Incidence And Visit Behavior, 2013 Melbourne Business School
From Amazon To Apple: Modeling Online Retail Sales, Purchase Incidence And Visit Behavior, Anastasios Panagiotelis, Michael S. Smith, Peter Danaher
Michael Stanley Smith
In this study we propose a multivariate stochastic model for website visit duration, page views, purchase incidence and the sale amount for online retailers. The model is constructed by composition from carefully selected distributions, and involves copula components. It allows for the strong nonlinear relationships between the sales and visit variables to be explored in detail, and can be used to construct sales predictions. The model is readily estimated using maximum likelihood, making it an attractive choice in practice given the large sample sizes that are commonplace in online retail studies. We examine a number of top-ranked U.S. online retailers, …
Spectral Density Shrinkage For High-Dimensional Time Series, 2013 University of California - San Diego
Spectral Density Shrinkage For High-Dimensional Time Series, Mark Fiecas, Rainer Von Sachs
Mark Fiecas
Flexible Partially Linear Single Index Regression Models For Multivariate Survival Data, 2013 The University of Western Ontario
Flexible Partially Linear Single Index Regression Models For Multivariate Survival Data, Na Lei
Electronic Thesis and Dissertation Repository
Survival regression models usually assume that covariate effects have a linear form. In many circumstances, however, the assumption of linearity may be violated. The present work addresses this limitation by adding nonlinear covariate effects to survival models. Nonlinear covariates are handled using a single index structure, which allows high-dimensional nonlinear effects to be reduced to a scalar term. The nonlinear single index approach is applied to modeling of survival data with multivariate responses, in three popular models: the proportional hazards (PH) model, the proportional odds (PO) model, and the generalized transformation model. Another extension of the PH and PO model …
Reaching The Gold Standard: Assessing Driving Ability Among Student And Expert Drivers, 2013 California Polytechnic State University, San Luis Obispo
Reaching The Gold Standard: Assessing Driving Ability Among Student And Expert Drivers, Alyssa Davis
Statistics
No abstract provided.