Machine Learning Methods For Prediction Of Human Infectious Virus And Imputation Of Hla Alleles,
2023
Michigan Technological University
Machine Learning Methods For Prediction Of Human Infectious Virus And Imputation Of Hla Alleles, Xiaoqing Gao
Dissertations, Master's Theses and Master's Reports
This dissertation contains three Chapters. The following is a concise description of each Chapters.
In Chapter 1, we introduced the Random Forest, a machine learning method, to foresee whether a virus is capable of infecting humans. The Covid pandemic informs us the importance of predicting the ability of a zoonotic virus that can infect humans from its genomic sequence. We used the -mer with and as features of a virus to predict if it can affect humans. We further employed the Boruta algorithm to select the important features, then fed those important features into the Random Forest method to train …
Eeg-Based Spanish Language Proficiency Classification: An Eeg Power Spectrum And Cross-Spectrum Analysis,
2023
University of New Hampshire, Durham
Eeg-Based Spanish Language Proficiency Classification: An Eeg Power Spectrum And Cross-Spectrum Analysis, Blaise Xavier O'Mara, Skyler Baumer
Honors Theses and Capstones
Second language proficiency may be predicted with electrophysiological techniques. In a machine learning application, this electrophysiological data may be used for language instructors and language students to assess their language learning. This study identifies how electroencephalogram (EEG) power spectrum and cross spectrum data of the brain cortex relates to Spanish second language (L2) proficiency of 20 Spanish language students of varying proficiency levels at the University of New Hampshire. The two metrics for assessing cortical power and processing were event-related desynchronization (ERD)—a measure of relative change in power—of the alpha (8-12 Hz) brain frequency band, and alpha and beta (13-30Hz) …
Bayesian Adaptive Clinical Trial Design,
2022
The Texas Medical Center Library
Bayesian Adaptive Clinical Trial Design, Mengyi Lu
Dissertations & Theses (Open Access)
The landscape of drug development in oncology has changed from conventional chemotherapies to molecular targeted therapies and immunotherapies, which provide innovative therapeutic modalities for treating cancers. These novel therapeutic agents work through mechanisms that fundamentally differ from standard chemotherapeutic agents, making the conventional trial design paradigm inefficient and dysfunctional. Specifically, the focus of dose-finding trials has shifted from finding the maximum tolerated dose (MTD) to the optimal biological dose (OBD), defined as the dose that optimizes the risk–benefit tradeoff. How to accurately identify the OBD and its dosing schedule is of great importance to maximize efficacy and safety of targeted …
Cov-Inception: Covid-19 Detection Tool Using Chest X-Ray,
2022
Southern Methodist University
Cov-Inception: Covid-19 Detection Tool Using Chest X-Ray, Aswini Thota, Ololade Awodipe, Rashmi Patel
SMU Data Science Review
Since the pandemic started, researchers have been trying to find a way to detect COVID-19 which is a cost-effective, fast, and reliable way to keep the economy viable and running. This research details how chest X-ray radiography can be utilized to detect the infection. This can be for implementation in Airports, Schools, and places of business. Currently, Chest imaging is not a first-line test for COVID-19 due to low diagnostic accuracy and confounding with other viral pneumonia. Different pre-trained algorithms were fine-tuned and applied to the images to train the model and the best model obtained was fine-tuned InceptionV3 model …
Factors Affecting Time To Recovery: A Covid-19 Survival Analysis,
2022
Northern Illinois University
Factors Affecting Time To Recovery: A Covid-19 Survival Analysis, Fernanda Montoya
Honors Capstones
This project is focused on the recovery rates of patients diagnosed with COVID-19 after different clinical trial drug treatments. Data for the clinical trial studied was obtained from the National Institute of Allergy and Infectious Diseases for the primary purpose of a survival analysis on patient time to recovery under a placebo and therapeutic drug treatment. Specifically, patients in this clinical trial were randomly selected to receive remdesivir, an antiviral drug, in combination with a placebo or baricitinib, a janus kinase inhibitor drug. Cox PH models were used to identify how the different treatment drugs affect time to recovery and …
The Effects Of Metronomic And Maximum-Tolerated Dose Chemotherapy In Colorectal Cancer Angiogenesis: A Combined Approach Using Endoscopic Diffuse Reflectance Spectroscopy And Mrna Expression,
2022
University of Arkansas, Fayetteville
The Effects Of Metronomic And Maximum-Tolerated Dose Chemotherapy In Colorectal Cancer Angiogenesis: A Combined Approach Using Endoscopic Diffuse Reflectance Spectroscopy And Mrna Expression, Ariel Isaac Mundo Ortiz
Graduate Theses and Dissertations
Colorectal cancer (CRC) continues to be one of the most incident and deadliest types of cancer worldwide. Chemotherapy has proven effective to reduce tumor burden for CRC patients, but there are several disadvantages associated with the use of mainstay maximtolerated dose (MTD) chemotherapeutic strategies. Metronomic chemotherapy (MET) has been developed as an alternative that addresses the shortcomings of maximum-tolerated dose chemotherapy but so far its effectiveness as a neoadjuvant strategy for CRC has not been explored.
This dissertation uses a combined optics and molecular biology approach (using diffuse reflectance spectroscopy and mRNA expression) to study the changes in angiogenesis and …
Prognostic And Predictive Value Of Β-Blockers In The Eortc 1325/Keynote-054 Phase Iii Trial Of Pembrolizumab Versus Placebo In Resected High-Risk Stage Iii Melanoma,
2022
Edith Cowan University
Prognostic And Predictive Value Of Β-Blockers In The Eortc 1325/Keynote-054 Phase Iii Trial Of Pembrolizumab Versus Placebo In Resected High-Risk Stage Iii Melanoma, Oliver J. Kennedy, Michal Kicinski, Sara Valpione, Sara Gandini, Stefan Suciu, Christian U. Blank, Georgina V. Long, Victoria G. Atkinson, Stéphane Dalle, Andrew M. Haydon, Andrey Meshcheryakov, Adnan Khattak, Matteo S. Carlino, Shahneen Sandhu, James Larkin, Susana Puig, Paolo A. Ascierto, Piotr Rutkowski, Dirk Schadendorf, Rutger Koornstra, Leonel Hernandez-Aya, Anna M. Di Giacomo, Alfonsus J.M. Van Den Eertwegh, Jean Jacques Grob, Ralf Gutzmer, Rahima Jamal, Alexander C.J. Van Akkooi, Caroline Robert, Alexander M. M. Eggermont, Paul Lorigan, Mario Mandala
Research outputs 2022 to 2026
Background:
β-adrenergic receptors are upregulated in melanoma cells and contribute to an immunosuppressive, pro-tumorigenic microenvironment. This study investigated the prognostic and predictive value of β-adrenoreceptor blockade by β-blockers in the EORTC1325/KEYNOTE-054 randomised controlled trial.
Methods:
Patients with resected stage IIIA, IIIB or IIIC melanoma and regional lymphadenectomy received 200 mg of adjuvant pembrolizumab (n = 514) or placebo (n = 505) every three weeks for one year or until recurrence or unacceptable toxicity. At a median follow-up of 3 years, pembrolizumab prolonged recurrence-free survival (RFS) compared to placebo (hazard ratio (HR) 0.56, 95% confidence interval (CI) 0.47–0.68). β-blocker use was …
Reliever-Triggered Inhaled Glucocorticoid In Black And Latinx Adults With Asthma,
2022
Roseman University of Health Sciences
Reliever-Triggered Inhaled Glucocorticoid In Black And Latinx Adults With Asthma, Alex Colon
Annual Research Symposium
No abstract provided.
Oral, Cardiovascular And Respiratory Effects Of E-Cigarettes: Synthesis Of Literature,
2022
Roseman University of Health Sciences
Oral, Cardiovascular And Respiratory Effects Of E-Cigarettes: Synthesis Of Literature, Nareh Eshgian
Annual Research Symposium
No abstract provided.
Application And Efficacy Of Color-Coded Learning Models,
2022
Roseman University of Health Sciences
Application And Efficacy Of Color-Coded Learning Models, Parker Grossman
Annual Research Symposium
No abstract provided.
Covid-19 Ramifications And Effects,
2022
Roseman University of Health Sciences
Covid-19 Ramifications And Effects, Landon Ledingham
Annual Research Symposium
No abstract provided.
Evaluation On Appropriateness Of Fluoroquinolone Use In An Acute Care Hospital,
2022
Roseman University of Health Sciences
Evaluation On Appropriateness Of Fluoroquinolone Use In An Acute Care Hospital, Cynthia Huang
Annual Research Symposium
No abstract provided.
Covid-19 Variant, Vaccine And Booster,
2022
Roseman University of Health Sciences
Covid-19 Variant, Vaccine And Booster, Manas Mandal
Annual Research Symposium
No abstract provided.
Rna Sequencing Reveals That Cyp3a5 Sirna Treatment Induces Cell Cycle Blockade And Senescence In Mdapca2b Human Prostate Cancer Cells,
2022
Roseman University of Health Sciences
Rna Sequencing Reveals That Cyp3a5 Sirna Treatment Induces Cell Cycle Blockade And Senescence In Mdapca2b Human Prostate Cancer Cells, Jeetesh Sharma
Annual Research Symposium
No abstract provided.
Evaluation Of Appropriate Initiation And De-Escalation Of Piperacillin-Tazobactam In Hospitalized Patients At An Acute Care Hospital,
2022
Roseman University of Health Sciences
Evaluation Of Appropriate Initiation And De-Escalation Of Piperacillin-Tazobactam In Hospitalized Patients At An Acute Care Hospital, Ivy Yang
Annual Research Symposium
No abstract provided.
Student Perception On The Implementation Of An End-Of-The-Day Quiz And Its Impact On Student Learning And Class Attendance In A Three-Year Accelerated Doctorate Program Of Pharmacy.,
2022
Roseman University of Health Sciences
Student Perception On The Implementation Of An End-Of-The-Day Quiz And Its Impact On Student Learning And Class Attendance In A Three-Year Accelerated Doctorate Program Of Pharmacy., Desiree Chong, Jousef Alandy0dy, Arup Chakraborty
Annual Research Symposium
No abstract provided.
Participation In Curriculum And Cultural Ambassador Group To Enhance Student Belongingness,
2022
Roseman University of Health Sciences
Participation In Curriculum And Cultural Ambassador Group To Enhance Student Belongingness, Jake Tuft, Jacob Schvaneveldt
Annual Research Symposium
COVID-19 negatively impacted students' abilities to participate in live, in-person events; students were unable to interact with peers or build relationships critical to success and well-being. Quarantine, social distancing and video conferencing did not create this problem however, it simply amplified the fact that dental students seemingly lack camaraderie and a sense of belongingness. The Curriculum and Cultural Ambassador group was created to allow students to bond over shared goals in the hopes of improving their experiences within dental school. This group gives students the ability to “Be the Change” on campus and enact real-time change to foster a sense …
A Standardized Approach To Blood Pressure Training In First-Year Medical Students,
2022
Roseman University of Health Sciences
A Standardized Approach To Blood Pressure Training In First-Year Medical Students, Andrew Romney
Annual Research Symposium
No abstract provided.
Succinic Semialdehyde Dehydrogenase Deficiency (Ssadhd): Qualitative Needs Assessment For Patients With A Rare Neurological Disorder,
2022
Noorda College of Osteopathic Medicine
Succinic Semialdehyde Dehydrogenase Deficiency (Ssadhd): Qualitative Needs Assessment For Patients With A Rare Neurological Disorder, Cassandra Bovee, Kayla Woodring
Annual Research Symposium
No abstract provided.
Identifying Bias In Healthcare And Creating Intervention Strategies At Colleges Of Medicine And Other Healthcare Professions,
2022
Roseman University of Health Sciences
Identifying Bias In Healthcare And Creating Intervention Strategies At Colleges Of Medicine And Other Healthcare Professions, Cameron Chalmers, Emmanuel Oyalabu
Annual Research Symposium
No abstract provided.
