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Kinetics Of Uv254 Inactivation Of Selected Viral Pathogens In A Static System, T. Cutler, C. Wang, Q. Qin, F. Zhou, K. Warren, K.-J. Yoon, S. J. Hoff, J. Ridpath, J. Zimmerman 2011 Iowa State University

Kinetics Of Uv254 Inactivation Of Selected Viral Pathogens In A Static System, T. Cutler, C. Wang, Q. Qin, F. Zhou, K. Warren, K.-J. Yoon, S. J. Hoff, J. Ridpath, J. Zimmerman

Veterinary Diagnostic and Production Animal Medicine Publications

Aims:  The objective of this study was to estimate UV254 inactivation constants for four viral pathogens: influenza virus type A, porcine respiratory and reproductive syndrome virus (PRRSV), bovine viral diarrhoea virus (BVDV) and reovirus.

Methods and Results:  Viruses in culture medium were exposed to one of nine doses of UV254 and then titrated for infectious virus. Analysis showed that viral inactivation by UV254 was more accurately described by a two-stage inactivation model vs a standard one-stage inactivation model.

Conclusions:  The results provided evidence for the existence of two heterogeneous viral subpopulations among the viruses tested, one highly ...


Statistical Analysis In Empirical Bayes And In Causal Inference, Hui Nie 2011 University of Pennsylvania

Statistical Analysis In Empirical Bayes And In Causal Inference, Hui Nie

Publicly Accessible Penn Dissertations

In Part I titled Empirical Bayes Estimation, we discuss the estimation of a heteroscedastic multivariate normal mean in terms of the ensemble risk. We first derive the ensemble minimax properties of various estimators that shrink towards zero through the empirical Bayes method. We then generalize our results to the case where the variances are given as a common unknown but estimable chi-squared random variable scaled by different known factors. We further provide a class of ensemble minimax estimators that shrink towards the common mean. We also make comparison and show differences between results from the heteroscedastic case and those from ...


Approximating Confidence Intervals About Discrete Time Survival/Cumulative Incidence Estimates Using The Delta Method, Alexis Dinno, Jong-Sung Kim 2011 Portland State University

Approximating Confidence Intervals About Discrete Time Survival/Cumulative Incidence Estimates Using The Delta Method, Alexis Dinno, Jong-Sung Kim

Community Health Faculty Publications and Presentations

Poster focuses on answering the questions whether and when and event will happen in a population at risk.


A Bayesian Approach To Dose-Response Assessment And Drug-Drug Interaction Analysis: Application To In Vitro Studies, Violeta G. Hennessey 2010 University of Texas Graduate School of Biomedical Sciences at Houston

A Bayesian Approach To Dose-Response Assessment And Drug-Drug Interaction Analysis: Application To In Vitro Studies, Violeta G. Hennessey

UT GSBS Dissertations and Theses (Open Access)

The considerable search for synergistic agents in cancer research is motivated by the therapeutic benefits achieved by combining anti-cancer agents. Synergistic agents make it possible to reduce dosage while maintaining or enhancing a desired effect. Other favorable outcomes of synergistic agents include reduction in toxicity and minimizing or delaying drug resistance. Dose-response assessment and drug-drug interaction analysis play an important part in the drug discovery process, however analysis are often poorly done. This dissertation is an effort to notably improve dose-response assessment and drug-drug interaction analysis.

The most commonly used method in published analysis is the Median-Effect Principle/Combination Index ...


Gene Expression In Hypothalamus, Liver, And Adipose Tissues And Food Intake Response To Melanocortin-4 Receptor Agonist In Pigs Expressing Melanocortin-4 Receptor Mutations, C. Richard Barb, Gary J. Hausman, Romdhane Rekaya, Clay A. Lents, Sender Lkhagvadorj, Long Qu, Weiguo Cai, Oliver P. Couture, Lloyd L. Anderson, Jack C. M. Dekkers, Christopher K. Tuggle 2010 United States Department of Agriculture

Gene Expression In Hypothalamus, Liver, And Adipose Tissues And Food Intake Response To Melanocortin-4 Receptor Agonist In Pigs Expressing Melanocortin-4 Receptor Mutations, C. Richard Barb, Gary J. Hausman, Romdhane Rekaya, Clay A. Lents, Sender Lkhagvadorj, Long Qu, Weiguo Cai, Oliver P. Couture, Lloyd L. Anderson, Jack C. M. Dekkers, Christopher K. Tuggle

Animal Science Publications

Transcriptional profiling was used to identify genes and pathways that responded to intracerebroventricular injection of melanocortin-4 receptor (MC4R) agonist [Nle4, D-Phe7]-α-melanocyte stimulating hormone (NDP-MSH) in pigs homozygous for the missense mutation in the MC4R, D298 allele (n = 12), N298 allele (n = 12), or heterozygous (n = 12). Food intake (FI) was measured at 12 and 24 h after treatment. All pigs were killed at 24 h after treatment, and hypothalamus, liver, and back-fat tissue was collected. NDP-MSH suppressed (P < 0.004) FI at 12 and 24 h in all animals after treatment. In response to NDP-MSH, 278 genes in hypothalamus (q ≤ 0.07, P ≤ 0.001), 249 genes in liver (q ≤ 0.07, P ≤ 0.001), and 5,066 genes in ...


Gene Expression Profiling Of The Short-Term Adaptive Response To Acute Caloric Restriction In Liver And Adipose Tissues Of Pigs Differing In Feed Efficiency, Sender Lkhagvadorj, Long Qu, Weiguo Cai, Oliver P. Couture, C. Richard Barb, Gary J. Hausman, Dan Nettleton, Lloyd L. Anderson, Jack C. M. Dekkers, Christopher K. Tuggle 2010 Iowa State University

Gene Expression Profiling Of The Short-Term Adaptive Response To Acute Caloric Restriction In Liver And Adipose Tissues Of Pigs Differing In Feed Efficiency, Sender Lkhagvadorj, Long Qu, Weiguo Cai, Oliver P. Couture, C. Richard Barb, Gary J. Hausman, Dan Nettleton, Lloyd L. Anderson, Jack C. M. Dekkers, Christopher K. Tuggle

Animal Science Publications

Residual feed intake (RFI) is a measure of feed efficiency, in which low RFI denotes improved feed efficiency. Caloric restriction (CR) is associated with feed efficiency in livestock species and to human health benefits, such as longevity and cancer prevention. We have developed pig lines that differ in RFI, and we are interested in identifying the genes and pathways that underlie feed efficiency. Prepubertal Yorkshire gilts with low RFI (n = 10) or high RFI (n = 10) were fed ad libitum or fed at restricted intake of 80% of maintenance energy requirements for 8 days. We measured serum metabolites and hormones ...


Wavelet-Based Functional Linear Mixed Models: An Application To Measurement Error–Corrected Distributed Lag Models, Elizabeth J. Malloy, Jeffrey S. Morris, Sara D. Adar, Helen Suh, Diane R. Gold, Brent A. Coull 2010 American University

Wavelet-Based Functional Linear Mixed Models: An Application To Measurement Error–Corrected Distributed Lag Models, Elizabeth J. Malloy, Jeffrey S. Morris, Sara D. Adar, Helen Suh, Diane R. Gold, Brent A. Coull

Jeffrey S. Morris

Frequently, exposure data are measured over time on a grid of discrete values that collectively define a functional observation. In many applications, researchers are interested in using these measurements as covariates to predict a scalar response in a regression setting, with interest focusing on the most biologically relevant time window of exposure. One example is in panel studies of the health effects of particulate matter (PM), where particle levels are measured over time. In such studies, there are many more values of the functional data than observations in the data set so that regularization of the corresponding functional regression coefficient ...


Members’ Discoveries: Fatal Flaws In Cancer Research, Jeffrey S. Morris 2010 The University of Texas M.D. Anderson Cancer Center

Members’ Discoveries: Fatal Flaws In Cancer Research, Jeffrey S. Morris

Jeffrey S. Morris

A recent article published in The Annals of Applied Statistics (AOAS) by two MD Anderson researchers—Keith Baggerly and Kevin Coombes—dissects results from a highly-influential series of medical papers involving genomics-driven personalized cancer therapy, and outlines a series of simple yet fatal flaws that raises serious questions about the veracity of the original results. Having immediate and strong impact, this paper, along with related work, is providing the impetus for new standards of reproducibility in scientific research.


Statistical Contributions To Proteomic Research, Jeffrey S. Morris, Keith A. Baggerly, Howard B. Gutstein, Kevin R. Coombes 2010 The University of Texas M.D. Anderson Cancer Center

Statistical Contributions To Proteomic Research, Jeffrey S. Morris, Keith A. Baggerly, Howard B. Gutstein, Kevin R. Coombes

Jeffrey S. Morris

Proteomic profiling has the potential to impact the diagnosis, prognosis, and treatment of various diseases. A number of different proteomic technologies are available that allow us to look at many proteins at once, and all of them yield complex data that raise significant quantitative challenges. Inadequate attention to these quantitative issues can prevent these studies from achieving their desired goals, and can even lead to invalid results. In this chapter, we describe various ways the involvement of statisticians or other quantitative scientists in the study team can contribute to the success of proteomic research, and we outline some of the ...


Informatics And Statistics For Analyzing 2-D Gel Electrophoresis Images, Andrew W. Dowsey, Jeffrey S. Morris, Howard G. Gutstein, Guang Z. Yang 2010 Imperial College London

Informatics And Statistics For Analyzing 2-D Gel Electrophoresis Images, Andrew W. Dowsey, Jeffrey S. Morris, Howard G. Gutstein, Guang Z. Yang

Jeffrey S. Morris

Whilst recent progress in ‘shotgun’ peptide separation by integrated liquid chromatography and mass spectrometry (LC/MS) has enabled its use as a sensitive analytical technique, proteome coverage and reproducibility is still limited and obtaining enough replicate runs for biomarker discovery is a challenge. For these reasons, recent research demonstrates the continuing need for protein separation by two-dimensional gel electrophoresis (2-DE). However, with traditional 2-DE informatics, the digitized images are reduced to symbolic data though spot detection and quantification before proteins are compared for differential expression by spot matching. Recently, a more robust and automated paradigm has emerged where gels are ...


Bayesian Random Segmentationmodels To Identify Shared Copy Number Aberrations For Array Cgh Data, Veerabhadran Baladandayuthapani, Yuan Ji, Rajesh Talluri, Luis E. Nieto-Barajas, Jeffrey S. Morris 2010 Texas A&M University

Bayesian Random Segmentationmodels To Identify Shared Copy Number Aberrations For Array Cgh Data, Veerabhadran Baladandayuthapani, Yuan Ji, Rajesh Talluri, Luis E. Nieto-Barajas, Jeffrey S. Morris

Jeffrey S. Morris

Array-based comparative genomic hybridization (aCGH) is a high-resolution high-throughput technique for studying the genetic basis of cancer. The resulting data consists of log fluorescence ratios as a function of the genomic DNA location and provides a cytogenetic representation of the relative DNA copy number variation. Analysis of such data typically involves estimation of the underlying copy number state at each location and segmenting regions of DNA with similar copy number states. Most current methods proceed by modeling a single sample/array at a time, and thus fail to borrow strength across multiple samples to infer shared regions of copy number ...


Behavior And Habitat Use Of Roseate Terns (Sterna Dougallii) Before And After Construction Of An Erosion Control Revetment, Corey Grinnell 2010 University of Massachusetts Amherst

Behavior And Habitat Use Of Roseate Terns (Sterna Dougallii) Before And After Construction Of An Erosion Control Revetment, Corey Grinnell

Masters Theses 1911 - February 2014

An erosion control revetment was constructed at the Falkner Island Unit of the Stewart B. McKinney National Wildlife Refuge, Connecticut during the winter of 2000–2001. At the time, Falkner Island was the fifth largest breeding colony site for the federally endangered Roseate Tern. This study measures and describes some baseline information regarding Roseate Tern nesting, behavior, and habitat use at Falkner Island during the three breeding seasons prior to revetment construction (1998–2000). This baseline information is then compared to similar information from the first breeding season following revetment construction (2001).

For Roseate Tern adults, this study examined changes ...


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