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Inhibition Studies Of Serine Hydrolases By Cyclic Phosphates And Phosphonates, Supratik Dutta 2010 University of Missouri-St. Louis

Inhibition Studies Of Serine Hydrolases By Cyclic Phosphates And Phosphonates, Supratik Dutta

Dissertations

The serine hydrolase superfamily is one of the largest known enzyme families comprising approximately 1% of the predicted protein product in human genome. This family of enzymes contains a catalytic triad that is mainly consists of serine, aspartic acid/glutamic acid and histidine residues in their active sites. It has been proposed that the potential drug targets for Alzheimer’s disease and diabetes type 2 are enzymes that belong to this enzyme family. Acetylcholinesterase is an enzyme that catalyses the breakdown of acetylcholine, a neurotransmitter that helps transport information from one nerve cell to another. Breakdown of acetylcholine in Alzheimer ...


First-Principles Study Of The Variation Of Electron Transport In A Single Molecular Junction With The Length Of The Molecular Wire, Partha Pratim, Ranjit Pati 2010 Michigan Technological University

First-Principles Study Of The Variation Of Electron Transport In A Single Molecular Junction With The Length Of The Molecular Wire, Partha Pratim, Ranjit Pati

Department of Physics Publications

We report a first-principles study of quantum transport in a prototype two-terminal device consisting of a molecular nanowire acting as an inter-connect between two gold electrodes. The wire is composed of a series of bicyclo[1.1.1]pentane (BCP) cage-units. The length of the wire (L) is increased by sequentially increasing the number of BCP cage units in the wire from 1 to 3. A two terminal model device is made out of each of the three wires. A parameter free, nonequilibrium Green’s function approach, in which the bias effect is explicitly included within a many body framework ...


Prism: The Development Of An Online Repository For Information Security Education Resources, Vincent Garramone 2010 Regis University

Prism: The Development Of An Online Repository For Information Security Education Resources, Vincent Garramone

All Regis University Theses

The goal of this study was to develop, implement and evaluate an online system that would allow intuitive sharing and retrieval of information security (IS) education materials, and a corresponding taxonomic system relevant to common contexts in which IS concepts are taught. After determining initial requirements, popular open-source content management systems were evaluated. The most suitable solution was customized, and implemented as the Public Repository for Information Security Material (PRISM) website. An initial organizational taxonomy was developed, and the repository was populated with resources from several sources. Evaluations of PRISM suggest that core functionalities have been suitably designed and implemented ...


The First Vlbi Image Of The Young, Oxygen-Rich Supernova Remnant In Ngc 4449, M. F. Bietenholz, N. Bartel, D. Milisavljevic, R. A. Fesen 2010 York

The First Vlbi Image Of The Young, Oxygen-Rich Supernova Remnant In Ngc 4449, M. F. Bietenholz, N. Bartel, D. Milisavljevic, R. A. Fesen

Open Dartmouth: Faculty Open Access Articles

We report on sensitive 1.4-GHz VLBI radio observations of the unusually luminous supernova remnant SNR 4449-1 in the galaxy NGC 4449, which gave us the first well-resolved image of this object. The remnant's radio morphology consists of two approximately parallel bright ridges, suggesting similarities to the barrel shape seen for many older Galactic supernova remnants or possibly to SN 1987A. The angular extent of the remnant is 65 × 40 mas, corresponding to (3.7 × 2.3) × 1018 (D/3.8 Mpc) cm. We also present a new, high signal-to-noise ratio optical spectrum. By comparing the remnant's ...


Occupier Perceptions Of Green Workplace Environment: The Australian Experience, Hikari Kato, Linda Too, Ann Rask 2010 Bond University

Occupier Perceptions Of Green Workplace Environment: The Australian Experience, Hikari Kato, Linda Too, Ann Rask

Linda Too

Purpose – The purpose of this paper is to shed light on the perceptions by occupiers of green workplace environments. It examines how occupiers (both management and employees) perceive and evaluate the role of green workplace environments, and subsequently assesses the effectiveness of a green workplace environment. Design/methodology/approach – The paper relies on a data set derived from a survey of 128 respondents who have occupied Green Building Council Australia's Green Star-rated offices and buildings for more than 12 months. Findings – The findings suggest that green workplace offers greater psychological benefits (taking pride of the workplace environment) to occupiers ...


Elements Of Study On Dynamic Materials, Marine Rousseau, Gerard A. Maugin, Mihhail Berezovski 2010 Universite Pierre et Marie Curie

Elements Of Study On Dynamic Materials, Marine Rousseau, Gerard A. Maugin, Mihhail Berezovski

Publications

As a preliminary study to more complex situations of interest in small-scale technology, this paper envisages the elementary propagation properties of elastic waves in one-spatial dimension when some of the properties (mass density, elasticity) may vary suddenly in space or in time, the second case being of course more original. Combination of the two may be of even greater interest. Toward this goal, a critical examination of what happens to solutions at the crossing of pure space-like and time-like material discontinuities is given together with simple solutions for smooth transitions and numerical simulations in the discontinuous case. The effects on ...


Controlling Balance Decline Across The Menopause Using A Balance-Strategy Training Program: A Randomized, Controlled Trial, S. Fu, Nancy Low Choy, Jennifer Nitz 2010 Bond University

Controlling Balance Decline Across The Menopause Using A Balance-Strategy Training Program: A Randomized, Controlled Trial, S. Fu, Nancy Low Choy, Jennifer Nitz

Nancy Low Choy

Objective: To evaluate effectiveness and long-term benefits of a specific balance-strategy training program in sedentary women aged 40-60 years and whether participation leads to adoption of a more active lifestyle. Method: Fifty healthy women were admitted to the randomized, controlled trial on the basis of their activity level. Subjects were randomly assigned to an intervention or control group, with the former attending twice-weekly for 12 weeks. Assessments made pre- and post-intervention and at 9 months follow-up included: personal demographics, hormone replacement therapy medication, activity level, balance measures, somatosensory function, ankle flexibility and leg muscle strength. Results: The intervention group showed ...


On The Thresholds In Linear And Nonlinear Boolean Equations, Yifan Sun Dr 2010 Renmin University of China

On The Thresholds In Linear And Nonlinear Boolean Equations, Yifan Sun Dr

Yifan Sun

No abstract provided.


Physical Properties Of The Us Itase Firn And Ice Cores From South Pole To Taylor Dome, Debra A. Meese, Ian Baker 2010 Principal Investigator; University of Maine, Orono

Physical Properties Of The Us Itase Firn And Ice Cores From South Pole To Taylor Dome, Debra A. Meese, Ian Baker

University of Maine Office of Research Administration: Grant Reports

This award supports a project for physical properties research on snow pits and firn/ice cores with specific objectives that include stratigraphic analysis including determination of accumulation rates, annual layers, depth hoar, ice and wind crusts and rates of grain growth with depth. Studies of firn densification rates and how these parameters relate to the meteorology and climatology over the last 200 years of snow accumulation in Antarctica will also be investigated. The project will also determine the seasonality of accumulation by co-registration of stratigraphy and chemistry and determination of chemical species at the grain boundaries, how these may change ...


A Flume Experiment On The Effect Of Constriction Shape On The Formation Of Forced Pools, Douglas M. Thompson, C. R. McCarrick 2010 Connecticut College

A Flume Experiment On The Effect Of Constriction Shape On The Formation Of Forced Pools, Douglas M. Thompson, C. R. Mccarrick

Physics, Astronomy and Geophysics Faculty Publications

A series of 18 flume runs were conducted in a 6-m long, 0.5-m wide recirculating flume with a bed gradient of 0.8% to determine the influence of obstruction shape on the formation and characteristics of forced pools. Six different-shaped obstructions were added to the flume with the maximum width of the obstruction held constant at 20 cm, which equaled a 40% constriction of flow. The obstruction shapes used included a square, a rectangle, a right triangle with the hypotenuse-facing upstream, a right triangle with the hypotenuse-facing downstream, a combination of a square and triangle with the hypotenuse-facing upstream ...


Social Networking Privacy: A Qualitative Study Of The Risks And Effects Of Sharing Data To A Global Environment Via Facebook, Bryan L. Mack 2010 Regis University

Social Networking Privacy: A Qualitative Study Of The Risks And Effects Of Sharing Data To A Global Environment Via Facebook, Bryan L. Mack

All Regis University Theses

Young women have placed themselves at risk by disclosing private and sensitive data on their Facebook accounts. Privacy settings which can help prevent unauthorized access of this data exist, but some women choose to ignore them. This study is an attempt to gain an understanding of this phenomenon and answer the question of why young women choose to share personal information. Qualitative interviews of college students were conducted and the results interpreted in this paper. The results of this interview are intended to supply research for future studies which aim to minimize problems caused to individuals who choose to share ...


Sn 2010u: A Luminous Nova In Ngc 4214, Roberta M. Humphreys, José L. Prieto, Philip Rosenfield, L. Andrew Helton, Christopher S. Kochanek, K. Z. Stanek, Rubab Khan, Dorota Szczygiel, Karen Mogren, Robert A. Fesen 2010 University of Minnesota

Sn 2010u: A Luminous Nova In Ngc 4214, Roberta M. Humphreys, José L. Prieto, Philip Rosenfield, L. Andrew Helton, Christopher S. Kochanek, K. Z. Stanek, Rubab Khan, Dorota Szczygiel, Karen Mogren, Robert A. Fesen

Open Dartmouth: Faculty Open Access Articles

The luminosity, light curve, post-maximum spectrum, and lack of a progenitor on deep pre-outburst images suggest that SN 2010U was a luminous, fast nova. Its outburst magnitude is consistent with that for a fast nova using the maximum magnitude-rate of decline relationship for classical novae.


Accuracy, Resolution And Stability Properties Of A Modified Chebyshev Method, Jodi Mead, Rosemary A. Renaut 2010 Boise State University

Accuracy, Resolution And Stability Properties Of A Modified Chebyshev Method, Jodi Mead, Rosemary A. Renaut

Jodi Mead

While the Chebyshev pseudospectral method provides a spectrally accurate method, integration of partial differential equations with spatial derivatives of order M requires time steps of approximately O(N−2M) for stable explicit solvers. Theoretically, time steps may be increased to O(N−M) with the use of a parameter, α-dependent mapped method introduced by Kosloff and Tal-Ezer [ J. Comput. Phys., 104 (1993), pp. 457–469]. Our analysis focuses on the utilization of this method for reasonable practical choices for N, namely N ≲ 30, as may be needed for two- or three dimensional modeling. Results presented confirm that spectral accuracy with ...


Body Mass Index, Treatment Practices, And Mortality In Patients With Acute Heart Failure, Timothy Fitzgibbons, Olga Hardy, Darleen Lessard, Joel Gore, Jorge Yarzebski, Robert Goldberg 2010 University of Massachusetts Medical School

Body Mass Index, Treatment Practices, And Mortality In Patients With Acute Heart Failure, Timothy Fitzgibbons, Olga Hardy, Darleen Lessard, Joel Gore, Jorge Yarzebski, Robert Goldberg

Jorge L. Yarzebski

OBJECTIVES: Obesity is associated with an increased risk of heart failure (HF). Among patients presenting with acute HF, however, differences in clinical characteristics, treatment regimens, and short-term prognosis of varying weights are largely unknown, particularly from a broader population-based perspective. METHODS: A total of 3722 patients admitted with acute HF to 11 greater Worcester (Massachusetts, USA) hospitals during 1995 and 2000 were categorized as being lean (n = 216), normal weight (n = 1465), overweight (n = 1007), or obese (n = 1034) at the time of hospitalization. RESULTS: Obese patients with decompensated HF were significantly younger (mean age = 71 years) compared with patients ...


Prognosis Of Acute Myocardial Infarction Complicated By Complete Heart Block (The Worcester Heart Attack Study), Robert Goldberg, Juan Zevallos, Jorge Yarzebski, Joseph Alpert, Joel Gore, Z. Chen, James Dalen 2010 University of Massachusetts Medical School

Prognosis Of Acute Myocardial Infarction Complicated By Complete Heart Block (The Worcester Heart Attack Study), Robert Goldberg, Juan Zevallos, Jorge Yarzebski, Joseph Alpert, Joel Gore, Z. Chen, James Dalen

Jorge L. Yarzebski

As part of a community-based study of patients hospitalized with acute myocardial infarction (AMI) in the Worcester, Massachusetts, metropolitan area, changes over time in the incidence rates of complete heart block (CHB) complicating AMI, and the prognostic impact of CHB on the in-hospital and long-term survival of these patients were examined. In all, 4,762 patients with validated AMI hospitalized at 16 hospitals in the Worcester metropolitan area during 1975, 1978, 1981, 1984, 1986 and 1988 constituted the study sample. The incidence rates of CHB complicating AMI remained relatively stable at 5.8% over the 13-year (1975 to 1988) period ...


Changes Over Time In The Use Of Aspirin In Patients Hospitalized With Acute Myocardial Infarction (1975 To 1997): A Population-Based Perspective, Elizabeth Jackson, Ramya Sivasubramian, Frederick Spencer, Jorge Yarzebski, Darleen Lessard, Joel Gore, Robert Goldberg 2010 University of Michigan

Changes Over Time In The Use Of Aspirin In Patients Hospitalized With Acute Myocardial Infarction (1975 To 1997): A Population-Based Perspective, Elizabeth Jackson, Ramya Sivasubramian, Frederick Spencer, Jorge Yarzebski, Darleen Lessard, Joel Gore, Robert Goldberg

Jorge L. Yarzebski

OBJECTIVE: The purpose of this study was to examine 2 decade-long trends in the use of aspirin and associated outcomes in patients hospitalized with acute myocardial infarction. BACKGROUND: Aspirin has been shown to be beneficial in the secondary prevention of AMI. However, little is known about changes over time in the use of aspirin in patients hospitalized with AMI and associated outcomes, particularly from a more generalizable population-based perspective. METHODS: We examined trends in aspirin use and hospital and long-term outcomes in 9336 metropolitan Worcester, Mass, residents hospitalized with validated AMI in all area hospitals between 1975 and 1997. RESULTS ...


Thirty-Year Trends (1975-2005) In The Magnitude, Patient Characteristics, And Hospital Outcomes Of Patients With Acute Myocardial Infarction Complicated By Ventricular Fibrillation, Robert Goldberg, Jorge Yarzebski, Frederick Spencer, Juan Zevallos, Darleen Lessard, Joel Gore 2010 University of Massachusetts Medical School

Thirty-Year Trends (1975-2005) In The Magnitude, Patient Characteristics, And Hospital Outcomes Of Patients With Acute Myocardial Infarction Complicated By Ventricular Fibrillation, Robert Goldberg, Jorge Yarzebski, Frederick Spencer, Juan Zevallos, Darleen Lessard, Joel Gore

Jorge L. Yarzebski

Limited contemporary data are available describing the incidence rates, hospital prognosis, and factors associated with the occurrence of ventricular fibrillation (VF) in patients hospitalized with acute myocardial infarction (AMI). The objectives of our study were to examine 3-decade-long trends (1975 to 2005) in the magnitude, predictors, and hospital case-fatality rates associated with VF in residents of a large New England metropolitan area hospitalized at all area medical centers with an uncomplicated AMI. The study population consisted of 7,472 residents of the Worcester (Massachusetts) metropolitan area hospitalized with an uncomplicated AMI in 15 annual periods from 1975 to 2005. The ...


Temporal Trends (1975 Through 1990) In The Incidence And Case-Fatality Rates Of Primary Ventricular Fibrillation Complicating Acute Myocardial Infarction. A Communitywide Perspective, David Chiriboga, Jorge Yarzebski, Robert Goldberg, Joel Gore, Joseph Alpert 2010 University of Massachusetts Medical School

Temporal Trends (1975 Through 1990) In The Incidence And Case-Fatality Rates Of Primary Ventricular Fibrillation Complicating Acute Myocardial Infarction. A Communitywide Perspective, David Chiriboga, Jorge Yarzebski, Robert Goldberg, Joel Gore, Joseph Alpert

Jorge L. Yarzebski

BACKGROUND: As part of a population-based study of acute myocardial infarction, we examined changes over time in the incidence and in-hospital case-fatality rates of primary ventricular fibrillation complicating acute myocardial infarction. METHODS AND RESULTS: Patients with validated acute myocardial infarction hospitalized at 16 hospitals in the Worcester, Mass, metropolitan area between 1975 and 1990 comprised the study sample. During the 15-year study period, 5.1% of patients developed primary ventricular fibrillation in the setting of uncomplicated acute myocardial infarction, with this rate remaining relatively constant over time. Both age- and multivariable-adjusted analyses showed no significant trend in the incidence rates ...


Coronary Heart Disease: Epidemiology, Risk Factors, And Temporal Trends, Robert Goldberg, Jorge Yarzebski 2010 University of Massachusetts Medical School

Coronary Heart Disease: Epidemiology, Risk Factors, And Temporal Trends, Robert Goldberg, Jorge Yarzebski

Jorge L. Yarzebski

Citation: Goldberg RJ, Yarzebski JL. Coronary Heart Disease: Epidemiology, Risk Factors, and Temporal Trends. Chapter 1, pp. 3 24. In Lifestyle Medicine. Rippe JM (Ed.). 1999. Blackwell Science Publishers.


Long-Term Trends (1986-2003) In The Use Of Coronary Reperfusion Strategies In Patients Hospitalized With Acute Myocardial Infarction In Central Massachusetts, Robert J. Goldberg, Frederick A. Spencer, Joseph Okolo, Darleen M. Lessard, Jorge L. Yarzebski, Joel M. Gore 2010 University of Massachusetts Medical School

Long-Term Trends (1986-2003) In The Use Of Coronary Reperfusion Strategies In Patients Hospitalized With Acute Myocardial Infarction In Central Massachusetts, Robert J. Goldberg, Frederick A. Spencer, Joseph Okolo, Darleen M. Lessard, Jorge L. Yarzebski, Joel M. Gore

Jorge L. Yarzebski

BACKGROUND: The objectives of our study were to examine long-term (1986-2003) trends in the use of percutaneous coronary interventions (PCI) and thrombolytic therapy in the management of patients hospitalized at all Central Massachusetts medical centers with acute myocardial infarction (AMI). Our secondary study goal was to examine factors associated with use of these coronary reperfusion strategies. Limited contemporary data are available about changing trends in the use of coronary reperfusion strategies, particularly from a population-based perspective. METHODS: The sample consisted of 9422 greater Worcester (MA) residents hospitalized with AMI at all metropolitan Worcester medical centers in 10 annual periods between ...


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