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Amp Kinase-Mediated Activation Of The Bh3-Only Protein Bim Couples Energy Depletion To Stress-Induced Apoptosis., Caoimhín G. Concannon, Liam P. Tuffy, Petronela Weisová, Helena P. Bonner, David Dávila, Caroline Bonner, Marc C. Devocelle, Andreas Strasser, Manus W. Ward, Jochen HM Prehn 2010 Royal College of Surgeons in Ireland

Amp Kinase-Mediated Activation Of The Bh3-Only Protein Bim Couples Energy Depletion To Stress-Induced Apoptosis., Caoimhín G. Concannon, Liam P. Tuffy, Petronela Weisová, Helena P. Bonner, David Dávila, Caroline Bonner, Marc C. Devocelle, Andreas Strasser, Manus W. Ward, Jochen Hm Prehn

Physiology and Medical Physics Articles

Excitotoxicity after glutamate receptor overactivation induces disturbances in cellular ion gradients, resulting in necrosis or apoptosis. Excitotoxic necrosis is triggered by rapid, irreversible ATP depletion, whereas the ability to recover cellular bioenergetics is suggested to be necessary for the activation of excitotoxic apoptosis. In this study, we demonstrate that even a transient decrease in cellular bioenergetics and an associated activation of adenosine monophosphate-activated protein kinase (AMPK) is necessary for the activation of excitotoxic apoptosis. We show that the Bcl-2 homology domain 3 (BH3)-only protein Bim, a proapoptotic Bcl-2 family member, is activated in multiple excitotoxicity paradigms, mediates excitotoxic apoptosis ...


Solution Of A Nonlinear System For Uncertainty Quantification In Inverse Problems, Jodi Mead 2010 Boise State University

Solution Of A Nonlinear System For Uncertainty Quantification In Inverse Problems, Jodi Mead

Jodi Mead

No abstract provided.


Growth Of Metamorphic Ingap For Wide-Bandgap Photovoltaic Junction By Mbe, John Simon, Stephanie Tomasulo, Paul J. Simmonds, Manuel J. Romero, Minjoo Larry Lee 2010 Yale University

Growth Of Metamorphic Ingap For Wide-Bandgap Photovoltaic Junction By Mbe, John Simon, Stephanie Tomasulo, Paul J. Simmonds, Manuel J. Romero, Minjoo Larry Lee

Paul J. Simmonds

Metamorphic triple-junction solar cells can currently attain efficiencies as high as 41.1%. Using additional junctions could lead to efficiencies above 50%, but require the development of a wide bandgap (2.0-2.2eV) material to act as the top layer. In this work we demonstrate wide bandgap InyGa1-yP grown on GaAsxP1-x via solid source molecular beam epitaxy. Unoptimized tensile GaAsxP1-x buffers grown on GaAs exhibit asymmetric strain relaxation, along with formation of faceted trenches 100-300 nm deep in the [01-1] direction. Smaller grading step size and higher substrate temperatures minimizes ...


How And Why To Avoid Soil Compaction, Mahdi Al-Kaisi 2010 Iowa State University

How And Why To Avoid Soil Compaction, Mahdi Al-Kaisi

Integrated Crop Management News

This spring most Iowa soils have plenty of moisture in the profile and in some areas may exceed field capacity, causing many producers to enter fields at less-than-ideal soil conditions. High soil moisture increases soil compaction caused by field traffic and machinery. Over the past decade the size of Iowa farms has increased, leading to larger and heavier equipment. However, equipment size is only one factor among many causes of the soil compaction problem.


Monitor Soil Moisture This Spring, Mahdi Al-Kaisi 2010 Iowa State University

Monitor Soil Moisture This Spring, Mahdi Al-Kaisi

Integrated Crop Management News

Current wet soil conditions present challenges to early season fieldwork. Whether it is planting beans or corn, cultivating or rotary hoeing – there is high potential to cause significant soil structure damage. Make a risk assessment before rushing out to the field on the first few days of dry weather to work the ground. When soil moisture is at or exceeds field capacity, there is an increased potential for soil compaction, particularly at topsoil depths.


Take Pride In America In Southern Nevada: Quarterly Progress Report, Period Covering January 5, 2010 - April 4, 2010, Margaret N. Rees 2010 University of Nevada, Las Vegas

Take Pride In America In Southern Nevada: Quarterly Progress Report, Period Covering January 5, 2010 - April 4, 2010, Margaret N. Rees

Anti-littering Programs

  • The team presented the strategic plan to the Board for review and feedback.
  • The team presented their revised Charter to the Board and received approval.
  • the team met with AAEQ Manufacturing, a company interested in assisting with recycling and messaging efforts.
  • The team began planning a unified recycling messaging for SNAP.
  • The team met with the marketing firm B&P and discussed ideas for the messaging campaign.
  • The team began collaborating with the Clark County School District on a "Hector's Helpers" program using Youth Initiative funding the BLM received.
  • The team assisted the City of Las Vegas Keep America ...


Strain Localization Along The Atlantis Bank Oceanic Detachment Fault System, Southwest Indian Ridge, E. A. Miranda, Barbara John 2010 University of Wyoming

Strain Localization Along The Atlantis Bank Oceanic Detachment Fault System, Southwest Indian Ridge, E. A. Miranda, Barbara John

Geology and Geophysics Faculty Publications

Microstructural observations and mineral thermometry from in situ samples collected from the Atlantis Bank oceanic core complex (SW Indian Ridge) indicate that detachment faulting was initiated under hypersolidus conditions in the ductile regime and continued through subgreenschist temperatures through the ductile, semibrittle, and brittle regimes as strain localized along the exposed, now subhorizontal fault surface. Ductile, semibrittle, and brittle fabrics are developed within dominantly gabbroic rocks. Footwall rocks exhibit crystal plastic fabrics distributed over a structural thickness up to 400 m below the denuded fault surface exposed at the seafloor, whereas semibrittle and brittle fabrics are concentrated in the 80 ...


Kaluza-Klein Theory With Torsion Confined To The Extra-Dimension, Karthik H. Shankar, Kameshwar C. Wali 2010 Syracuse University

Kaluza-Klein Theory With Torsion Confined To The Extra-Dimension, Karthik H. Shankar, Kameshwar C. Wali

Physics

Here we consider a variant of the 5 dimensional Kaluza-Klein theory within the framework of Einstein-Cartan formalism that includes torsion. By imposing a set of constraints on torsion and Ricci rotation coefficients, we show that the torsion components are completely expressed in terms of the metric. Moreover, the Ricci tensor in 5D corresponds exactly to what one would obtain from torsion-free general relativity on a 4D hypersurface. The contributions of the scalar and vector elds of the standard K-K theory to the Ricci tensor and the affine connections are completely nulli ed by the contributions from torsion. As a consequence ...


Unconventional Pairing In The Iron Arsenide Superconductors, Rafael M. Fernandes, Daniel K. Pratt, Wei Tian, Jerel L. Zarestky, Andreas Kreyssig, Shibabrata Nandi, Min Gyu Kim, Alexander N. Thaler, Ni Ni, Paul C. Canfield, Robert J. McQueeney, Jörg Schalian, Alan I. Goldman 2010 Iowa State University

Unconventional Pairing In The Iron Arsenide Superconductors, Rafael M. Fernandes, Daniel K. Pratt, Wei Tian, Jerel L. Zarestky, Andreas Kreyssig, Shibabrata Nandi, Min Gyu Kim, Alexander N. Thaler, Ni Ni, Paul C. Canfield, Robert J. Mcqueeney, Jörg Schalian, Alan I. Goldman

Ames Laboratory Publications

We use magnetic long-range order as a tool to probe the Cooper-pair wave function in the iron arsenide superconductors. We show theoretically that antiferromagnetism and superconductivity can coexist in these materials only if Cooper pairs form an unconventional, sign-changing state. The observation of coexistence in Ba(Fe1−xCox)2As2 then demonstrates unconventional pairing in this material. The detailed agreement between theory and neutron-diffraction experiments, in particular, for the unusual behavior of the magnetic order below Tc, demonstrates the robustness of our conclusions. Our findings strongly suggest that superconductivity is unconventional in all members of the iron arsenide family.


Assessment Of Environmental Services Of Crep Wetlands In Iowa And Themidwestern Corn Belt, David L. Otis, William G. Crumpton, David Green, Anna K. Loan-Wilsey, Robin L. McNeely, Kevin L. Kane, Rex Johnson, Tom Cooper, Mark Vandever 2010 United States Geological Survey

Assessment Of Environmental Services Of Crep Wetlands In Iowa And Themidwestern Corn Belt, David L. Otis, William G. Crumpton, David Green, Anna K. Loan-Wilsey, Robin L. Mcneely, Kevin L. Kane, Rex Johnson, Tom Cooper, Mark Vandever

Iowa Cooperative Fish and Wildlife Research Unit Reports

This final project report is a compendium of 3 previously submitted progress reports and a 4th report for work accomplished from August – December, 2009.


Formation Of Optical Bullets In Laser-Driven Plasma Bubble Accelerators, Peng Dong, Steven A. Reed, Sunghwan A. Yi, Serguei Y. Kalmykov, Gennady Shvets, Michael C. Downer, Nicholas H. Matlis, Wim P. Leemans, Christopher McGuffey, Stepan S. Bulanov, Vladimir Chvykov, Galina Kalintchenko, Karl Krushelnick, Anatoly Maksimchuk, Takeshi Matsuoka, Alexander G. R. Thomas, Victor Yanovsky 2010 University of Nebraska-Lincoln

Formation Of Optical Bullets In Laser-Driven Plasma Bubble Accelerators, Peng Dong, Steven A. Reed, Sunghwan A. Yi, Serguei Y. Kalmykov, Gennady Shvets, Michael C. Downer, Nicholas H. Matlis, Wim P. Leemans, Christopher Mcguffey, Stepan S. Bulanov, Vladimir Chvykov, Galina Kalintchenko, Karl Krushelnick, Anatoly Maksimchuk, Takeshi Matsuoka, Alexander G. R. Thomas, Victor Yanovsky

Serge Youri Kalmykov

Electron density bubbles—wake structures generated in plasma of density n_{e} ~ 10^{19} cm^{-3} by the light pressure of intense ultrashort laser pulses—are shown to reshape weak copropagating probe pulses into optical ‘‘bullets.’’ The bullets are reconstructed using frequency-domain interferometric techniques in order to visualize bubble formation. Bullets are confined in three dimensions to plasma-wavelength size, and exhibit higher intensity, broader spectrum and flatter temporal phase than surrounding probe light, evidence of their compression by the bubble. Bullets observed at 0.8 < n_{e} < 1.2 x 10^{19} cm^{-3} provide the first observation of bubble formation below the electron capture threshold. At higher n_{e}, bullets appear with high shot-to-shot stability together with relativistic electrons that vary widely in spectrum, and help relate bubble formation to fast electron generation.


Traveling And Stationary Intrinsic Localized Modes And Their Spatial Control In Electrical Lattices, LQ English, F Palmero, AJ Sievers, PG Kevrekidis, DH Barnak 2010 University of Massachusetts - Amherst

Traveling And Stationary Intrinsic Localized Modes And Their Spatial Control In Electrical Lattices, Lq English, F Palmero, Aj Sievers, Pg Kevrekidis, Dh Barnak

Panos Kevrekidis

This work focuses on the production of both stationary and traveling intrinsic localized modes (ILMs), also known as discrete breathers, in two closely related electrical lattices; we demonstrate experimentally that the interplay between these two ILM types can be utilized for the purpose of spatial control. We describe a novel mechanism that is responsible for the motion of driven ILMs in this system, and quantify this effect by modeling in some detail the electrical components comprising the lattice.


Maximal Class Numbers Of Cm Number Fields, Ryan C. Daileda, Raju Krishnamoorthy, Anton Malyshev 2010 Trinity University

Maximal Class Numbers Of Cm Number Fields, Ryan C. Daileda, Raju Krishnamoorthy, Anton Malyshev

Mathematics Faculty Research

Fix a totally real number field F of degree at least 2. Under the assumptions of the generalized Riemann hypothesis and Artin's conjecture on the entirety of Artin L-functions, we derive an upper bound (in terms of the discriminant) on the class number of any CM number field with maximal real subfield F. This bound is a refinement of a bound established by Duke in 2001. Under the same hypotheses, we go on to prove that there exist infinitely many CM-extensions of F whose class numbers essentially meet this improved bound and whose Galois groups are as large as ...


2008 Lake Ontario Lakewide Fishery Assessment, Brian F. Lantry, Jana R. Lantry, Ted Schaner 2010 USGS Great Lakes Science Center,

2008 Lake Ontario Lakewide Fishery Assessment, Brian F. Lantry, Jana R. Lantry, Ted Schaner

Technical Reports

Lake trout abundance in Lake Ontario is now at a low level that has not been observed since modern restoration efforts began in the 1970s. However, the continued observations of small numbers of naturally spawned age-2 lake trout in assessment surveys and the appearance of mature lake trout of suspected natural origin, despite low abundance of the stocked population, is encouraging. Changes in stocking policy for Canadian waters in the early 1990s has produced a situation where lake trout along the north shore are concentrated in the west and east and suggests that the lakewide indicators of restoration progress used ...


Dla-Lbg Cross-Correlation And Basic Properties Of Infrared Galaxies In Cosmological Simulations, Tae Song Lee 2010 University of Nevada Las Vegas

Dla-Lbg Cross-Correlation And Basic Properties Of Infrared Galaxies In Cosmological Simulations, Tae Song Lee

UNLV Theses, Dissertations, Professional Papers, and Capstones

PART I

We calculate the cross-correlation function (CCF) between damped Ly-alpha systems (DLAs) and Lyman break galaxies (LBGs) using cosmological hydrodynamic simulations at z = 3. We compute the CCF with two different methods. First, we assume that there is one DLA in each dark matter halo if its DLA cross section is non-zero. In our second approach we weight the pair-count by the DLA cross section of each halo, yielding a cross-section-weighted CCF. We also compute the angular CCF for direct comparison with observations. Finally, we calculate the auto-correlation functions of LBGs and DLAs, and their bias against the dark ...


Finite Strain Studies Of Single Crystal Fe3p Under High Pressures, John William Howard 2010 University of Nevada Las Vegas

Finite Strain Studies Of Single Crystal Fe3p Under High Pressures, John William Howard

UNLV Theses, Dissertations, Professional Papers, and Capstones

Fe3P (synthetic schreibersite) is a phosphide occurring in iron alloys. Phosphorousis often considered an undesired impurity causing brittleness. Conversely, in some cases the addition of iron phosphides to certain materials is beneficial (e.g.properties of certain frictional materials are enhanced). In terrestrial rock, we do not find Fe3P, although (Fe;Ni)3P (natural schreibersite) is found in nearly all iron-containing meteorites. In this project, we examine the unit cell parameters of Fe3P as function of pressure and derive the respective axial and bulk compressibilities. Both Vinet and Birch-Murnaghan formulations were used to relate pressure and unit cell volume, and ...


Theoretical And Computational Study Of Time Dependent Scattering On A 2d Surface, Michael Sohn 2010 University of Nevada Las Vegas

Theoretical And Computational Study Of Time Dependent Scattering On A 2d Surface, Michael Sohn

UNLV Theses, Dissertations, Professional Papers, and Capstones

The quantum mechanical treatment of the elastic scattring of atoms from a crystal surface provides valuable information, such as surface properties and gas-surface interaction potentials. However, since it is based on the stationary state solution, it does not provide the details of the scattering process in the neighborhood of the surface, especially when atoms are physically adsorbed. In this thesis, the time evolution of the scattering process is treated in 2D with a model potential, V(x, z) = -|g|δ(z) + λδ(z)cos(2πx/a), using the Gaussian wave packet approach. The focus is on the case where the ...


Photon Density Of States Of 47-Iron And 161-Dysprosium In Dyfe3 By Nuclear Resonant Inelastic X-Ray Scattering Under High Pressure, Elizabeth Anne Tanis 2010 University of Nevada Las Vegas

Photon Density Of States Of 47-Iron And 161-Dysprosium In Dyfe3 By Nuclear Resonant Inelastic X-Ray Scattering Under High Pressure, Elizabeth Anne Tanis

UNLV Theses, Dissertations, Professional Papers, and Capstones

The dual partial phonon density of states (DOS) from two different Mossbauer isotopes (161Dy and 57Fe) in the same material (DyFe3) was successfully measured using the nuclear resonant inelastic x-ray scattering (NRIXS) technique at high pressure. Nuclear inelastic scattering measurements yield an in-depth understanding of the element-specific dynamic properties. The Debye temperatures, the Lamb-Mossbauer factor (fLM), and the vibrational contributions to the Helmholtz free energy (Fvib), specific heat (cV ), entropy (Svib) and internal energy (Uvib) are calculated directly from the phonon density of states.


Assessing The Effect Of Simulation Models On Systems Learning In An Introductory Environmental Science Course, Heather J. Skaza 2010 University of Nevada Las Vegas

Assessing The Effect Of Simulation Models On Systems Learning In An Introductory Environmental Science Course, Heather J. Skaza

UNLV Theses, Dissertations, Professional Papers, and Capstones

While there is plenty of anecdotal evidence within the systems dynamics community supporting the use of systems simulations in the classroom to improve student understanding, there is little published, controlled, experimental research. This paper describes the results of a paired experiment testing the effect of using system dynamics simulations to increase systems understanding in an introductory environmental science course. We believed that the students using the systems simulations would demonstrate a greater systemic understanding of environmental issues than those who did not.

We conducted an experiment during the fall semester of 2009, with 304 students enrolled in four sections of ...


The Impact Of Individual Decision Making On Campus Sustainability Initiatives, Aurali Ella Dade 2010 University of Nevada Las Vegas

The Impact Of Individual Decision Making On Campus Sustainability Initiatives, Aurali Ella Dade

UNLV Theses, Dissertations, Professional Papers, and Capstones

Institutions of Higher Education (IHEs) have increasingly committed to become more sustainable in recent years. Despite this commitment, academic publications in the sustainability field assert that progress has been slower at IHEs than expected and that most IHEs have found sustainability initiatives difficult to implement. Comprehensive sustainability initiatives require cooperation from a broad set of constituents with diverse and sometimes conflicting goals. Creating a sustainable IHE also requires changes in both physical infrastructure and individual behavior. Any number of institutional factors can advance or limit progress towards these objectives.

Previous investigations have assessed individual case studies, compared IHEs in a ...


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