Synthesis And Characterization Of Organic-Inorganic Hybrid Materials For Thermoelectric Devices, 2016 Western Kentucky University
Synthesis And Characterization Of Organic-Inorganic Hybrid Materials For Thermoelectric Devices, Paige M. Huzyak
Masters Theses & Specialist Projects
The development of organic-inorganic hybrid materials is of great interest in thermoelectrics for its potential to combine the desirable characteristics of both classes of materials. Thermoelectric materials must combine low thermal conductivity with high electrical conductivity, but in most materials, thermal and electrical conductivity are closely related and positively correlated. By combining the low thermal conductivity, flexibility, facile processing, and low cost of organic components with the high electrical conductivity and stability of inorganic components, materials with beneficial thermoelectric properties may be realized.
Here, we describe the synthesis and characterization of anthracene-containing organic-inorganic hybrid materials for thermoelectric purposes. Specifically, POSS-ANT …
A Sodium Salt Of The Dimer Of Boronoterephthalic Acid Anhydride, 2016 University of Dayton
A Sodium Salt Of The Dimer Of Boronoterephthalic Acid Anhydride, Scott Simmons, Albert Fratini, Vladimir Benin
Albert Fratini
The title compound, sodium bis(6-carboxy-1-hydroxy-3-oxo-1,3-dihydro-2,1-benzoxaborol-1-yl)oxidanium, Na+·C16H15B2O13-, was prepared in two steps from 2-bromo-p-xylene. Its crystal structure was determined at 140 K and has triclinic (P) symmetry. The compound presents a unique structural motif, including two units of the cyclic anhydride of boronoterephthalic acid, joined by a protonated, and thereby trivalent, oxonium center. Association in the crystal is realized by complementary hydrogen bonding of the carboxyl groups, as well as by coordination of the sodium cations to the oxygen centers on the five-membered rings.
Stimuli Responsive Polymer Self-Assembly And Disassembly, 2016 University of Massachusetts Amherst
Stimuli Responsive Polymer Self-Assembly And Disassembly, Jiaming Zhuang
Doctoral Dissertations
Stimuli responsive polymer assemblies have been long investigated for drug application due to their flexibility for surface functionalization to achieve desired interfacial property and capability of acting as a host for payloads encapsulation. These interfacial and host-guest properties are very critical and need to be customized really depending on nature of cargos and specific delivery application. More importantly, these properties are always desired to be adaptable in different environments. For instance, adjustable interfacial property can facilitate the carrier to overcome a variety of different barriers before it reach the target while changeable host-guest property allows to selectively releasing the payload …
Self-Assembly And Stimuli Responsive Disassembly Of Dendritic And Oligomeric Amphiphiles, 2016 University of Massachusetts Amherst
Self-Assembly And Stimuli Responsive Disassembly Of Dendritic And Oligomeric Amphiphiles, Krishna Reddy Raghupathi
Doctoral Dissertations
Stimuli response is a fundamental process prevalent in all living systems, where a specific function (response) is generated in the presence of a given environmental cue (stimulus). Engineering materials for this process is often accomplished through another basic process, “self-assembly”. By understanding the key aspects of these processes scientists have developed a broad range of materials for a wide array of applications. This dissertation will primarily focus on developing stimuli responsive nanocarriers based on supramolecular assemblies of amphiphilic dendrimers and oligomers for safe transport and selective release of molecular cargo. Our concurrent goal is to also investigate several parameters which …
Supramolecular Strategies For The Generation Of Nanoparticle Assemblies And Biomolecular Thin Films, 2016 University of Massachusetts Amherst
Supramolecular Strategies For The Generation Of Nanoparticle Assemblies And Biomolecular Thin Films, Bradley P. Duncan
Doctoral Dissertations
The conceptual framework of supramolecular chemistry elucidates a powerful set of strategies for chemists to generate functional nanomaterials based on intermolecular forces. My research focused on tuning the molecular interactions of nanoscale components to create larger structures with enhanced properties. In one approach, I developed and optimized an additive-free, nanoimprint lithography-based methodology to generate stable thin films from a variety of proteins. The generalized process retains intrinsic properties of the protein as demonstrated by selective cellular adhesion. The heat and pressure of the nanoimprinting process induces slight structural reorganization of the peptide side chains to yield highly stable films held …
Novel Biodegradable Protonic Ionic Liquid For The Fischer Indole Synthesis Reaction, 2016 Rowan University
Novel Biodegradable Protonic Ionic Liquid For The Fischer Indole Synthesis Reaction, William C. Neuhaus, Ian J. Bakanas, Joseph R. Lizza, Charles T. Boon Jr., Gustavo Moura-Letts
Faculty Scholarship for the College of Science & Mathematics
Novel eco-friendly tetramethylguanidinium propanesulfonic acid trifluoromethylacetate ([TMGHPS][TFA]) ionic liquid was developed as catalyst and medium for the Fischer indole synthesis of a wide variety of hydrazines and ketones. The indole products were isolated in high yields and with minimal amounts of organic solvent. This reaction showed that [TMGHPS][TFA] can be regenerated and reused with reproducible yields without eroding the integrity of the ionic liquid.
Conjugated Polymer-Based Biomaterials Through Controlled Self-Assembly, 2016 Florida International University
Conjugated Polymer-Based Biomaterials Through Controlled Self-Assembly, Megan Twomey
FIU Electronic Theses and Dissertations
Synthetic polymeric materials have gained significant use as biological materials (biomaterials) in biomedical and pharmaceutical applications. As a result, a demand for well-defined polymers with tunable properties has emerged. The synthetic versatility of polymeric biomaterials allows the opportunity to understand the structure-property relationship of materials and their cellular interactions. A novel class of polymeric biomaterials are conjugated polymers (CPs), which possess desirable physicochemical and excellent photophysical properties, including inherent fluorescence. The synthetic versatility of CPs allows easy modification of the conjugated backbone to tune emission and side chain structures to adjust biocompatibility through increased water solubility, controlled biodegradability, and incorporation …
Theoretical Investigation Of Interaction Between The Set Of Ligands And Α7 Nicotinic Acetylcholine Receptor, 2016 Saratov State University
Theoretical Investigation Of Interaction Between The Set Of Ligands And Α7 Nicotinic Acetylcholine Receptor, O. E. Glukhova, Tatiana Prytkova, D. S. Shmygin
Biology, Chemistry, and Environmental Sciences Faculty Articles and Research
Nicotinic acetylcholine receptors (nAChRs) are neuron receptor proteins that provide a transmission of nerve impulse through the synapses. They are composed of a pentametric assembly of five homologous subunits (5 α7 subunits for α7nAChR, for example), oriented around the central pore. These receptors might be found in the chemical synapses of central and peripheral nervous system, and also in the neuromuscular synapses. Transmembrane domain of the one of such receptors constitutes ion channel. The conductive properties of ion channel strongly depend on the receptor conformation changes in the response of binding with some molecule, f.e. acetylcholine. Investigation of interaction between …
Enhancement Of Supercapacitor Energy Storage By Leakage Reduction And Electrode Modification, 2016 University of South Florida
Enhancement Of Supercapacitor Energy Storage By Leakage Reduction And Electrode Modification, Tete Tevi
USF Tampa Graduate Theses and Dissertations
Supercapacitors have emerged in recent years as a promising energy storage technology. The main mechanism of energy storage is based on electrostatic separation of charges in a region at the electrode-electrolyte interface called double layer. Various electrode materials including carbon and conducting polymers have been used in supercapacitors. Also, supercapacitors offer high life cycle and high power density among electrochemical energy storage devices. Despite their interesting features, supercapacitors present some disadvantages that limit their competitivity with other storage devices in some applications. One of those drawbacks is high self-discharge or leakage. The leakage occurs when electrons cross the double layer …
Uplc–Qtof–Ms And Nmr Analyses Of Graviola (Annona Muricata) Leaves, 2016 Empresa Brasileira de Pesquisa Agropecuária
Uplc–Qtof–Ms And Nmr Analyses Of Graviola (Annona Muricata) Leaves, Ingrid De Moraes, Paulo Ribeiro, Flávio Schmidt, Kirley Canuto, Guilherme Zocolo, Edy De Brito, Rensheng Luo, Kristy Richards, Kevin Tran, Robert Smith
Chemistry & Biochemistry Faculty Works
No abstract provided.
Chemical Investigation Of Antarctic Marine Organisms & Their Role In Modern Drug Discovery, 2016 University of South Florida
Chemical Investigation Of Antarctic Marine Organisms & Their Role In Modern Drug Discovery, Jacqueline Lee Fries
USF Tampa Graduate Theses and Dissertations
The chemicals produced by biological systems, whether proteins, peptides, or terpenes, will always provide an intriguing topic for researchers. Invisibly controlling every aspect of nature, these molecules are responsible for life, evolution, and death. Specifically, here is described the secondary metabolites produced by Antarctic marine organisms as well as others, and how they are used to defend or attract other animals while potentially providing health benefits to mankind. This is done through collection, extraction, and separation of individual specimens. The respective mixtures of compounds after isolation are then analyzed via spectroscopic methods such as nuclear magnetic resonance spectroscopy, mass spectrometry, …
Reducing Dynamic Disorder In Small-Molecule Organic Semiconductors By Suppressing Large-Amplitude Thermal Motions, 2016 University of Cambridge, UK
Reducing Dynamic Disorder In Small-Molecule Organic Semiconductors By Suppressing Large-Amplitude Thermal Motions, Steffen Illig, Alexander S. Eggeman, Alessandro Troisi, Lang Jiang, Chris Warwick, Mark Nikolka, Guillaume Schweicher, Stephen G. Yeates, Yves Henri Geerts, John E. Anthony, Henning Sirringhaus
Chemistry Faculty Publications
Thermal vibrations and the dynamic disorder they create can detrimentally affect the transport properties of van der Waals bonded molecular semiconductors. The low-energy nature of these vibrations makes it difficult to access them experimentally, which is why we still lack clear molecular design rules to control and reduce dynamic disorder. In this study we discuss the promising organic semiconductors rubrene, 2,7-dioctyl[1]benzothieno[3,2-b][1]benzothio-phene and 2,9-di-decyl-dinaphtho-[2,3-b:20,30-f]-thieno-[3,2-b]-thiophene in terms of an exceptionally low degree of dynamic disorder. In particular, we analyse diffuse scattering in transmission electron microscopy, to show that small molecules that have their side chains attached along the long axis of their …
Expression Of Acyl Carrier Proteins In Spinach, 2016 Butler University
Expression Of Acyl Carrier Proteins In Spinach, Katherine Schmid, J. Ohlrogge
Katherine Schmid
Dr. Schmid and Dr. Ohlrogge's contribution to the Proceedings of the 9th International Symposium on Plant Lipids; Wye, England; July 8-13, 1990.
Cyclopropane Fatty Acid Expression In Plants, 2016 Butler University
Cyclopropane Fatty Acid Expression In Plants, Katherine Schmid
Katherine Schmid
Pants [sic] are transformed with a bacterial cyclopropane fatty acid synthase gene to produce lipids containing cyclopropane fatty acids. Using this technology dihydrosterculate is produced in oilseed crops such as rape.
The Design And Synthesis Of Ghrelin Analogues As Non‐Invasive Ghs‐R1a Imaging Probes, 2016 The University of Western Ontario
The Design And Synthesis Of Ghrelin Analogues As Non‐Invasive Ghs‐R1a Imaging Probes, Carlie L. Charlton
Electronic Thesis and Dissertation Repository
The field of molecular imaging is constantly growing and evolving in order to provide the best possible healthcare for patients in various stages of disease and therapy. Molecular imaging aims to locate specific markers of disease by selectively targeting the markers of interest with high selectivity and visualizing the accumulation using external detection. The growth hormone secretagogue receptor-1a (GHS-R1a) has been shown to be involved in various important biological functions such as energy homeostasis and cardiac contractility. GHS-R1a has shown involvement in proliferation, migration and cell invasion of specific cancer subtypes. Therefore, targeting GHS-R1a is an important marker of different …
Ultrafast Spectroscopy And Energy Transfer In An Organic/Inorganic Composite Of Zinc Oxide And Graphite Oxide, 2016 Graduate Center, City University of New York
Ultrafast Spectroscopy And Energy Transfer In An Organic/Inorganic Composite Of Zinc Oxide And Graphite Oxide, Jeff A. Secor
Dissertations, Theses, and Capstone Projects
The energy transfers and nature of defect levels of an organic/inorganic composite of Zinc Oxide and Graphite are studied with multidimensional spectroscopy. The edge and surface states of each composite are uncovered using excitation emission experiments showing which defect states are mediating the energy transfer from the metal oxide to the graphite oxide. Multidimensional time resolved spectroscopy further describes the effect of the carbon phase on the energy transfer pathways in the material.
Synthesis Of Novel Aporphine-Inspired Neuroreceptor Ligands, 2016 Graduate Center, City University of New York
Synthesis Of Novel Aporphine-Inspired Neuroreceptor Ligands, Nirav R. Kapadia
Dissertations, Theses, and Capstone Projects
Aporphines are a group of tetracyclic alkaloids that belong to the ubiquitous tetrahydroisoquinoline family. The aporphine template is known to be associated with a range of biological activities. Aporphines have been explored as antioxidants, anti-tuberculosis, antimicrobial and anticancer agents. Within the Central Nervous Systems (CNS), aporphine alkaloids are known to possess high affinity for several clinically valuable targets including dopamine receptors (predominantly D1 and D2), serotonin receptors (5-HT1A and 5-HT7) and α adrenergic receptors. Aporphines are also inhibitors of the acetylcholinesterase enzyme – a clinical target for the treatment of Alzheimer’s disease. Considering the …
Metabolic Disorders, Drug Development, Drug Design And Biomarkers, 2016 Missouri University of Science and Technology
Metabolic Disorders, Drug Development, Drug Design And Biomarkers, Gjumrakch Aliev, Ramon Cacabelos, V. Prakash Reddy
Chemistry Faculty Research & Creative Works
No abstract provided.
Rapid Access To Conformationally-Constrained Oxatricycles Via Ugi-Smiles Couplings, 2016 Southern Illinois University Edwardsville
Rapid Access To Conformationally-Constrained Oxatricycles Via Ugi-Smiles Couplings, Bree Richey, Katelynn M. Mason, Michael S. Meyers, Sarah Luesse
SIUE Faculty Research, Scholarship, and Creative Activity
Use of allylamine and substituted 2-furaldehydes as components in Ugi-Smiles couplings of 2-nitrophenol provide ready access to N-aryl epoxyisoindolines. These adducts form via a dual event involving the Ugi-Smiles multicomponent reaction and an intramolecular Diels-Alder cycloaddition with the furan ring.
Kdac8 With High Basal Velocity Is Not Activated By N-Acetylthioureas, 2016 Xavier University of Louisiana
Kdac8 With High Basal Velocity Is Not Activated By N-Acetylthioureas, Tasha B. Toro, Subramanya Pingali, Thao P. Nguyen, Destane S. Garrett, Kyra A. Dodson, Kyara A. Nichols, Rashad A. Haynes, Florastina Payton-Stewart, Terry J. Watt
Faculty and Staff Publications
Lysine deacetylases (KDACs) are enzymes that reverse the post-translational modification of lysine acetylation. Recently, a series of N-acetylthioureas were synthesized and reported to enhance the activity of KDAC8 with a fluorogenic substrate. To determine if the activation was general, we synthesized three of the most potent N-acetylthioureas and measured their effect with peptide substrates and the fluorogenic substrate under multiple reaction conditions and utilizing two enzyme purification approaches. No activation was observed for any of the three N-acetylthioureas under any assayed conditions. Further characteriza- tion of KDAC8 kinetics with the fluorogenic substrate yielded a k cat /K M of 164 …