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Small or Companion Animal Medicine Commons

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1184 full-text articles. Page 1 of 17.

Survey Of Canine Monogenetic Diseases With Established Molecular Bases, Brent J. Pepin, Samantha J. Hau, Erin N. Bradley, Janessa R. Thompson, Timothy H. Helms, Amie M. Johnson, Marisa Rotolo, Miranda M. Uriell, Matthew T. Brewer, Steve A. Carlson 2017 Iowa State University

Survey Of Canine Monogenetic Diseases With Established Molecular Bases, Brent J. Pepin, Samantha J. Hau, Erin N. Bradley, Janessa R. Thompson, Timothy H. Helms, Amie M. Johnson, Marisa Rotolo, Miranda M. Uriell, Matthew T. Brewer, Steve A. Carlson

Matthew T. Brewer

The development of a dog breed often involves selection, which intentionally propagates valued genetic traits. Unfortunately, untoward traits can be collaterally propagated during this process. For the purpose of identifying trends in canine genetic diseases, we examined 36 randomly chosen canine pathologies involving single gene mutations. For each disease we provide a brief summary of breed predilection, clinical signs, the underlying genetic mutation, and the availability of a commercial diagnostic test. The following trends were noted in this non-exhaustive list of diseases. First, these genetic diseases primarily involve the ophthalmic (28%) and nervous systems (28%). Second, no single breed was ...


Endoscopic Assessment Of The Duodenum In Dogs With Inflammatory Bowel Disease, J. E. Slovak, Chong Wang, J. A. Morrison, K. L. Deitz, Dana N. Levine, C. Otoni, R. R. King, L. E. Gerber, K. R. Hanson, A. P. Lundberg, Albert E. Jergens 2016 Iowa State University

Endoscopic Assessment Of The Duodenum In Dogs With Inflammatory Bowel Disease, J. E. Slovak, Chong Wang, J. A. Morrison, K. L. Deitz, Dana N. Levine, C. Otoni, R. R. King, L. E. Gerber, K. R. Hanson, A. P. Lundberg, Albert E. Jergens

Chong Wang

Background: Endoscopy is performed for direct inspection of the mucosa and acquisition of biopsies in dogs with inflammatory bowel disease (IBD). Aim: To evaluate the interobserver agreement in the endoscopic assessment of duodenal mucosa in dogs with IBD. Methods: Thirty-five archived endoscopic images of grossly normal (n = 6) and inflamed (n = 29) duodenal mucosa were displayed to 3 expert and 5 trainee endoscopists. Each image was assessed independently by endoscopists for mucosal abnormalities using established indices (of hyperemia, granularity, friability, lymphatic dilatation, and erosions) or interpreted as normal mucosa (trial 1). A repeated trial (trial 2) was performed with the ...


Alterations Of The Ileal And Colonic Mucosal Microbiota In Canine Chronic Enteropathies, Eric Cassmann, Robin White, Todd Atherly, Chong Wang, Yaxuan Sun, Samir Khoda, Curtis L. Mosher, Mark R. Ackermann, Albert Jergens 2016 Iowa State University

Alterations Of The Ileal And Colonic Mucosal Microbiota In Canine Chronic Enteropathies, Eric Cassmann, Robin White, Todd Atherly, Chong Wang, Yaxuan Sun, Samir Khoda, Curtis L. Mosher, Mark R. Ackermann, Albert Jergens

Chong Wang

Background

The intestinal microbiota is increasingly linked to the pathogenesis of chronic enteropathies (CE) in dogs. While imbalances in duodenal and fecal microbial communities have been associated with mucosal inflammation, relatively little is known about alterations in mucosal bacteria seen with CE involving the ileum and colon.

Aim

To investigate the composition and spatial organization of mucosal microbiota in dogs with CE and controls.

Methods

Tissue sections from endoscopic biopsies of the ileum and colon from 19 dogs with inflammatory bowel disease (IBD), 6 dogs with granulomatous colitis (GC), 12 dogs with intestinal neoplasia, and 15 controls were studied by ...


Effect Of Cold Compression Therapy On Postoperative Pain, Swelling, Range Of Motion, And Lameness After Tibial Plateau Leveling Osteotomy In Dogs, Kevin A. Drygas, Scott R. McClure, Robert L. Goring, Antonio Pozzi, Sheilah A. Robertson, Chong Wang 2016 Affiliated Veterinary Specialists

Effect Of Cold Compression Therapy On Postoperative Pain, Swelling, Range Of Motion, And Lameness After Tibial Plateau Leveling Osteotomy In Dogs, Kevin A. Drygas, Scott R. Mcclure, Robert L. Goring, Antonio Pozzi, Sheilah A. Robertson, Chong Wang

Chong Wang

Objective—To evaluate the effect of cold compression therapy (CCT) on postoperative pain, lameness, range of motion of the stifle joint, and swelling following tibial plateau leveling osteotomy (TPLO) in dogs. Design—Randomized, blinded, placebo-controlled clinical trial. Animals—34 client-owned dogs with unilateral deficiency of a cranial cruciate ligament undergoing TPLO. Procedures—Dogs were assigned to 2 groups. Group 1 (n = 17 dogs) received CCT in the 24-hour period following TPLO. Group 2 (n = 17 dogs) received no CCT. Degree of lameness, range of motion, and circumference of the stifle joint were measured before surgery and 1,14, and 28 ...


Influenza A Pandemic (H1n1) 2009 Virus Infection In Domestic Cat, Brett A. Sponseller, Erin Strait, Albert Jergens, Jesse Trujillo, Karen Harmon, Leo Koster, Melinda Jenkins-Moore, Mary Killian, Sabrina Swenson, Holly Bender, Ken Waller, Kristina Miles, Tracy Pearce, Kyoung-Jin Yoon, Peter Nara 2016 Iowa State University

Influenza A Pandemic (H1n1) 2009 Virus Infection In Domestic Cat, Brett A. Sponseller, Erin Strait, Albert Jergens, Jesse Trujillo, Karen Harmon, Leo Koster, Melinda Jenkins-Moore, Mary Killian, Sabrina Swenson, Holly Bender, Ken Waller, Kristina Miles, Tracy Pearce, Kyoung-Jin Yoon, Peter Nara

Holly Bender

Influenza A pandemic (H1N1) 2009 virus continues to rapidly spread worldwide. In 2009, pandemic (H1N1) 2009 infection in a domestic cat from Iowa was diagnosed by a novel PCR assay that distinguishes between Eurasian and North American pandemic (H1N1) 2009 virus matrix genes. Human-to-cat transmission is presumed.


A Clinical Index For Disease Activity In Cats With Chronic Enteropathy, Albert E. Jergens, J. M. Crandell, R. Evans, Mark R. Ackermann, Kristina G. Miles, Chong Wang 2016 Iowa State University

A Clinical Index For Disease Activity In Cats With Chronic Enteropathy, Albert E. Jergens, J. M. Crandell, R. Evans, Mark R. Ackermann, Kristina G. Miles, Chong Wang

Chong Wang

Background: There is a need for a clinically useful, quantitative index for measurement of disease activity in cats with chronic enteropathy (CE).

Objective: To develop a numerical activity index that is of practical value to clinicians treating CE in cats.

Animals: Eighty-two cats with CE.

Methods: Retrospective case review of 59 cats diagnosed with inflammatory bowel disease (IBD). Prospective validation study of 23 cats having either IBD or food-responsive enteropathy (FRE). Multivariate regression analysis was used to identify which combination of clinical and laboratory variables were best associated with intestinal inflammation of IBD. This combination of variables was expressed in ...


Identification Of Feline Tritrichomonas Foetus Surface Epitopes: Putative Targets For Development Of A Novel Diagnostic Test For Feline Trichomonosis, Emily Nissa Gould 2016 University of Tennessee - Knoxville

Identification Of Feline Tritrichomonas Foetus Surface Epitopes: Putative Targets For Development Of A Novel Diagnostic Test For Feline Trichomonosis, Emily Nissa Gould

Masters Theses

BACKGROUND: Tritrichomonas foetus (T. foetus) is a flagellated protozoa that infects the distal ileum and proximal colon of domestic cats and also induces reproductive failure in cattle. Although feline trichomonosis is recognized to have a global prevalence of up to 30%, it still poses a diagnostic and therapeutic challenge to veterinarians; thus, there is a need for both improved diagnostics and therapeutics. Despite differing organ tropism between genotypes, evidence exists for conserved virulence factors between feline and bovine T. foetus. Two epitopes (1.15 and 1.17) of the bovine T. foetus glycosylated surface antigen 1.15-1.17 have been ...


Cinv Survey, Lauren Hackbarth 2016 Iowa State University

Cinv Survey, Lauren Hackbarth

Honors Projects and Posters

Introduction: Chemotherapy-induced nausea and vomiting (CINV) is a common side effect of chemotherapeutic treatment experienced by dogs that can lower quality of life and functionality. These symptoms are likewise found in people receiving chemotherapy; however, human oncology has well-established protocols for preventing these side effects, while veterinary medicine does not. The objective of this research is to establish a baseline regarding current standard of care to determine how veterinary specialists are managing CINV in dogs receiving chemotherapy.

Introduction: Chemotherapy-induced nausea and vomiting (CINV) is a common side effect of chemotherapeutic treatment experienced by dogs that can lower quality of life ...


Animal-Assisted Therapy For Military Veterans With Posttraumatic Stress Disorder: An Investigation On The Positive Effects Of Attachment And Affiliation Behaviors, Sara Miele 2016 Dominican University of California

Animal-Assisted Therapy For Military Veterans With Posttraumatic Stress Disorder: An Investigation On The Positive Effects Of Attachment And Affiliation Behaviors, Sara Miele

Scholarly & Creative Works Conference 2017

Posttraumatic stress disorder (PTSD) develops in people who have experienced a traumatic event (nimh.nih.gov, 2016). Because PTSD is a chronic disorder, it is associated with impaired quality of life (Stern et al., 2013). A specific population at high risk for developing PTSD is military veterans. It is estimated over half a million military veterans suffer from PTSD (Stern et al., 2013). Although there are psychological services and treatments for veterans, many do not seek help because fear of the negative stigma associated with mental illness (Lanning & Krenek, 2013). Recently, efforts have been made to implement veteran friendly treatment ...


Alterations Of The Ileal And Colonic Mucosal Microbiota In Canine Chronic Enteropathies, Eric Cassmann, Robin White, Todd Atherly, Chong Wang, Yaxuan Sun, Samir Khoda, Curtis L. Mosher, Mark R. Ackermann, Albert Jergens 2016 Iowa State University

Alterations Of The Ileal And Colonic Mucosal Microbiota In Canine Chronic Enteropathies, Eric Cassmann, Robin White, Todd Atherly, Chong Wang, Yaxuan Sun, Samir Khoda, Curtis L. Mosher, Mark R. Ackermann, Albert Jergens

Veterinary Clinical Sciences Publications

Background

The intestinal microbiota is increasingly linked to the pathogenesis of chronic enteropathies (CE) in dogs. While imbalances in duodenal and fecal microbial communities have been associated with mucosal inflammation, relatively little is known about alterations in mucosal bacteria seen with CE involving the ileum and colon.

Aim

To investigate the composition and spatial organization of mucosal microbiota in dogs with CE and controls.

Methods

Tissue sections from endoscopic biopsies of the ileum and colon from 19 dogs with inflammatory bowel disease (IBD), 6 dogs with granulomatous colitis (GC), 12 dogs with intestinal neoplasia, and 15 controls were studied by ...


Alterations Of The Ileal And Colonic Mucosal Microbiota In Canine Chronic Enteropathies, Eric Cassmann, Robin White, Todd Atherly, Chong Wang, Yaxuan Sun, Samir Khoda, Curtis L. Mosher, Mark R. Ackermann, Albert E. Jergens 2016 Iowa State University

Alterations Of The Ileal And Colonic Mucosal Microbiota In Canine Chronic Enteropathies, Eric Cassmann, Robin White, Todd Atherly, Chong Wang, Yaxuan Sun, Samir Khoda, Curtis L. Mosher, Mark R. Ackermann, Albert E. Jergens

Veterinary Diagnostic and Production Animal Medicine Publications

Background

The intestinal microbiota is increasingly linked to the pathogenesis of chronic enteropathies (CE) in dogs. While imbalances in duodenal and fecal microbial communities have been associated with mucosal inflammation, relatively little is known about alterations in mucosal bacteria seen with CE involving the ileum and colon.

Aim

To investigate the composition and spatial organization of mucosal microbiota in dogs with CE and controls.

Methods

Tissue sections from endoscopic biopsies of the ileum and colon from 19 dogs with inflammatory bowel disease (IBD), 6 dogs with granulomatous colitis (GC), 12 dogs with intestinal neoplasia, and 15 controls were studied by ...


Meningeal Worm In Central Iowa Goat Herds, Kelly Still Brooks 2016 Iowa State University

Meningeal Worm In Central Iowa Goat Herds, Kelly Still Brooks

Animal Industry Report

Aberrant migration of the deer meningeal worm, Parelaphostrongylus tenuis, is a commonly recognized cause of neurologic disease in South American camelids but is less frequently considered in other small ruminant species. After an unusually cool and wet summer season, central Iowa goat herds serviced by Iowa State University’s Veterinary Field Services have been increasingly affected by P. tenuis, with clinical cases presenting as early as August. Most caprine cases present with progressive neurologic deficits, starting with hind-end weakness and ataxia which may lead to complete paresis and death. Both sporadic cases and herd outbreaks involving as much as 15 ...


Clinical Study Of Canine Tear Lacritin As A Treatment For Dry Eye, Katherine E. Kelly 2016 James Madison University

Clinical Study Of Canine Tear Lacritin As A Treatment For Dry Eye, Katherine E. Kelly

Senior Honors Projects

Keratoconjunctivitis sicca (KCS), the deficiency of tears also known as dry eye, is a prevalent disease that affects both humans and canines. The current treatment for dye eye, cyclosporine (Restatis®), only provides temporary relief, is often associated with discomfort and is inconsistently effective. Lacritin is a naturally occurring tear glycoprotein secreted from the human and canine lacrimal glands. It has been shown that lacritin stimulates basal tearing in rabbits when applied topically. This study characterized the amount and form of lacritin found in the tears of dogs with healthy and dry eyes—information which may be applied to the development ...


Canine Peripheral Blood Lymphocyte Phenotyping By 7-Color Multiparameter Flow Cytometry, Ratree Platt, Terry Ng, Sherry Glover, Michael Roof, Kayoko Kimura, James A. Roth 2015 Iowa State University

Canine Peripheral Blood Lymphocyte Phenotyping By 7-Color Multiparameter Flow Cytometry, Ratree Platt, Terry Ng, Sherry Glover, Michael Roof, Kayoko Kimura, James A. Roth

James A. Roth

Objective: To characterize baseline canine lymphocyte phenotypes including lymphocytes coexpressing multiple markers by novel 7-color multiparameter flow cytometry. Study Design: Fresh canine peripheral blood lymphocytes of 79 healthy 26-week-old Beagle or Beagle-mix dogs were stained and analyzed. Results: The high number of samples and acquired flow data (averaging 1.9x105 cells/sample) allowed the detection of minor lymphocyte subsets coexpressing multiple lymphocyte markers. The averaged percentages of major lymphocyte subsets of CD3+, CD4+, CD8+, CD21+ and gd TCR+ cells from this study were 74.0, 43.6, 14.3, 9.6, and 0.2, respectively, which were comparable but uniquely ...


Images Of Emerging And Exotic Diseases Of Animals, Steven D. Sorden, Claire B. Andreasen 2015 Iowa State University

Images Of Emerging And Exotic Diseases Of Animals, Steven D. Sorden, Claire B. Andreasen

Claire B. Andreasen

The chapter contains annotated color images of emerging diseases and exotic diseases in wild and domesticated animals.


What's Your Radiographic Diagnosis?, James Roth 2015 Iowa State University

What's Your Radiographic Diagnosis?, James Roth

James A. Roth

On May 11, 1973 a nine-year-old male Chesapeake Bay Retriever was admitted to the Stange Memorial clinic as a referral case with a tentative diagnosis of a diaphragmatic hernia.


Preventing Zoonotic Canine Leishmaniasis In Northeastern Brazil: Pet Attachment And Adoption Of Community Leishmania Prevention, Kevin J. Esch, Nubia N. Pontes, Paulo Elias Arruda, Annette M. O'Connor, Lorena Morais, Selma M.B. Jeronimo, Christine A. Petersen 2015 Iowa State University

Preventing Zoonotic Canine Leishmaniasis In Northeastern Brazil: Pet Attachment And Adoption Of Community Leishmania Prevention, Kevin J. Esch, Nubia N. Pontes, Paulo Elias Arruda, Annette M. O'Connor, Lorena Morais, Selma M.B. Jeronimo, Christine A. Petersen

Annette O'Connor

Visceral leishmaniasis (VL), caused by Leishmania infantum chagasi (L.i. chagasisyn. infantum) in northeastern Brazil, was responsible for 51,000 new VL cases from 1980 to 2003. Household presence of L. infantum-infected dogs is a major risk factor for human infection. Despite culling of dogs based on seropositivity, canine L. infantum seroprevalence remains near 20%, suggesting that dog culling is ineffective for preventing VL spread. We administered a cross-sectional survey to 224 households within 300 m of the homes of VL human patients diagnosed within the last year. The goal was to develop a model for voluntary preventative ...


Preparatory Work For The Future Development Of Scientific Opinions On Animal Health, Annette M. O'Connor, Rungano Stan Dzikamunhenga, D. Wolfe, Jan M. Sargeant, J. Glanville, J Wood 2015 Iowa State University

Preparatory Work For The Future Development Of Scientific Opinions On Animal Health, Annette M. O'Connor, Rungano Stan Dzikamunhenga, D. Wolfe, Jan M. Sargeant, J. Glanville, J Wood

Annette O'Connor

This final report summarizes the results of two reviews and a scoping study related to Canine leishmaniosis (CanL). Three objectives were addressed in this project. Objective 1 was to summarize relative sensitivity and specificity estimates of assays used to detect infection in dogs with Leishmania infantum in studies of naïve dogs in areas where Leishmania infantum infection is endemic. Objective 2 was to summarize data available to estimate the prevalence of parasitological cure (failure to detect organism) after a 12-month follow-up period in animals treated with meglumine antimoniate, miltefosine, and allopurinol or combinations of these drugs for canine leishmaniosis. Objective ...


Color Images For Zoonotic Diseases Of Companion Animals, Steven D. Sorden, Claire B. Andreasen, Molly D. Murphy 2015 Iowa State University

Color Images For Zoonotic Diseases Of Companion Animals, Steven D. Sorden, Claire B. Andreasen, Molly D. Murphy

Claire B. Andreasen

The chapter contains annotated color images of diseases in or caused from companion animals.


Experimental Canine Leptospirosis Caused By Leptospira Interrogans Servars Pomona And Bratislava, Justin Jay Greenlee, David P. Alt, Carole Ann Bolin, Richard L. Zuerner, Claire B. Andreasen 2015 Iowa State University

Experimental Canine Leptospirosis Caused By Leptospira Interrogans Servars Pomona And Bratislava, Justin Jay Greenlee, David P. Alt, Carole Ann Bolin, Richard L. Zuerner, Claire B. Andreasen

Claire B. Andreasen

Objective—To evaluate gross, histopathologic, and serum biochemical findings caused by Leptospira interrogans serovars pomona and bratislava inoculated in dogs. Animals—Twenty-seven 8-week-old female Beagles. Procedure—Dogs were randomly assigned to challenge or control groups. Challenge groups were conjunctivally inoculated on 3 successive days with 5 X 107 L interrogans serovar pomona (n = 12) or serovar bratislava (11). Clinical signs were recorded throughout the experiment, and clinical pathology assays, bacteriologic culture, and necropsies (6 or 7 dogs necropsied at each time point) were done on postinoculation day (PID) 7, 10, 14, and 20. Results—Infection could not be confirmed in ...


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