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Comparative and Laboratory Animal Medicine Commons

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385 full-text articles. Page 10 of 10.

Diagnosis Of Aeromonas Hydrophila, Mycobacterium Species, And Batrachochytrium Dendrobatidis In An African Clawed Frog (Xenopus Laevis)., William Hill, Shelley Newman, Linden Craig, Chris Carter, Jane Czarra, Julie Brown 2010 University of Tennessee, Knoxville

Diagnosis Of Aeromonas Hydrophila, Mycobacterium Species, And Batrachochytrium Dendrobatidis In An African Clawed Frog (Xenopus Laevis)., William Hill, Shelley Newman, Linden Craig, Chris Carter, Jane Czarra, Julie Brown

William Allen Hill

Here we describe diagnosis of concurrent infection with Aeromonas hydrophila, Mycobacterium spp., and Batrachochytrium dendrobatidis in a wild female Xenopus laevis captured in Chile and transported to the United States. After approximately 130 d in the laboratory, the frog was presented for dysecdysis and obtundation. After euthanasia, tissues were submitted for histopathologic evaluation and PCR analysis for B. dendrobatidis and Ranavirus. Clinically significant gross lesions included cutaneous ulcerations on the lip, right forelimb, and ventral chest. Microscopic findings included regionally extensive splenic necrosis, diffuse pneumonia, and fibrinous coelomitis all containing intralesional bacteria. PCR analysis yielded positive results for B. dendrobatidis ...


Diversity In Laboratory Animal Science: Issues And Initiatives., L Alworth, K Ardayfio, A Blickman, L Greenhill, William Hill, P Sharp, R Talmage 2010 University of Tennessee, Knoxville

Diversity In Laboratory Animal Science: Issues And Initiatives., L Alworth, K Ardayfio, A Blickman, L Greenhill, William Hill, P Sharp, R Talmage

William Allen Hill

Since diversity in the workplace began receiving scholarly attention in the late 1980s, many corporations and institutions have invested in programs to address and manage diversity. We encourage laboratory animal science to address the challenges and to build on the strengths that personal diversity brings to our field and workplaces. Diversity is already becoming increasingly relevant in the workplace and the laboratory animal science field. By addressing issues related to diversity, laboratory animal science could benefit and potentially fulfill its goals more successfully. To date, diversity has received minimal attention from the field as a whole. However, many individuals, workplaces ...


Measurement Of C-Peptide Concentrations And Responses To Somatostatin, Glucose Infusion, And Insulin Resistance In Horses, F. Toth, N. Frank, Tomas Martin-Jimenez, S. Elliott, R. Geor, R. Boston 2010 University of Tennessee - Knoxville

Measurement Of C-Peptide Concentrations And Responses To Somatostatin, Glucose Infusion, And Insulin Resistance In Horses, F. Toth, N. Frank, Tomas Martin-Jimenez, S. Elliott, R. Geor, R. Boston

Tomás Martín-Jiménez

Reasons for performing study: Hyperinsulinaemia is detected in horses with insulin resistance (IR) and has previously been attributed to increased pancreatic insulin secretion. Connecting peptide (C-peptide) can be measured to assess pancreatic function because it is secreted in equimolar amounts with insulin and does not undergo hepatic clearance. Hypothesis: A human double antibody radioimmunoassay (RIA) detects C-peptide in equine serum and concentrations would reflect responses to different stimuli and conditions. Methods: A validation procedure was performed to assess the RIA. Six mature mares were selected and somatostatin administered i.v. as a primed continuous rate infusion, followed by 50 nmol ...


Systemic Myostatin Inhibition Via Liver-Targeted Gene Transfer In Normal And Dystrophic Mice, Kevin J. Morine, Lawrence T. Bish, Klara Pendrak, Margaret M. Sleeper, Elisabeth R. Barton, H. Lee Sweeney 2010 University of Pennsylvania

Systemic Myostatin Inhibition Via Liver-Targeted Gene Transfer In Normal And Dystrophic Mice, Kevin J. Morine, Lawrence T. Bish, Klara Pendrak, Margaret M. Sleeper, Elisabeth R. Barton, H. Lee Sweeney

Departmental Papers (Vet)

Background: Myostatin inhibition is a promising therapeutic strategy to maintain muscle mass in a variety of disorders, including the muscular dystrophies, cachexia, and sarcopenia. Previously described approaches to blocking myostatin signaling include injection delivery of inhibitory propeptide domain or neutralizing antibodies.

Methodology/Principal Findings: Here we describe a unique method of myostatin inhibition utilizing recombinant adeno-associated virus to overexpress a secretable dominant negative myostatin exclusively in the liver of mice. Systemic myostatin inhibition led to increased skeletal muscle mass and strength in control C57 Bl/6 mice and in the dystrophin-deficient mdx model of Duchenne muscular dystrophy. The mdx soleus ...


Grape Seed Proanthocyanidin Suppression Of Breast Cell Carcinogenesis Induced By Chronic Exposure To Combined 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone And Benzo[A]Pyrene, X Song, Kusum Rathore, N Siriwardhana, D Lin, Hwa-Chain Wang 2009 University of Tennessee - Knoxville

Grape Seed Proanthocyanidin Suppression Of Breast Cell Carcinogenesis Induced By Chronic Exposure To Combined 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone And Benzo[A]Pyrene, X Song, Kusum Rathore, N Siriwardhana, D Lin, Hwa-Chain Wang

Hwa-Chain Robert Wang

Breast cancer is the most common type of cancer among women in northern America and northern Europe; dietary prevention is a cost-efficient strategy to reduce the risk of this disease. To identify dietary components for the prevention of human breast cancer associated with long-term exposure to environmental carcinogens, we studied the activity of grape seed proanthocyanidin extract (GSPE) in suppression of cellular carcinogenesis induced by repeated exposures to low doses of environmental carcinogens. We used combined carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and benzo[a]pyrene (B[a]P), at picomolar concentrations, to repeatedly treat noncancerous, human breast epithelial ...


Fk228 And Oncogenic H-Ras Synergistically Induce Mek1/2 And Nox-1 To Generate Reactive Oxygen Species For Differential Cell Death, SHAMBHUNATH CHOUDHARY, Kusum Rathore, Hwa-Chain Robert Wang 2009 University of Tennessee - Knoxville

Fk228 And Oncogenic H-Ras Synergistically Induce Mek1/2 And Nox-1 To Generate Reactive Oxygen Species For Differential Cell Death, Shambhunath Choudhary, Kusum Rathore, Hwa-Chain Robert Wang

Shambhunath Choudhary DVM, PhD

To investigate the mechanism behind the pro-apoptotic ability of oncogenic H-Ras to enhance FK228-induced apoptosis, we primarily used the 10T1/2-TR-H-Ras cell line, in which ectopic expression of oncogenic H-Ras(V12) is controlled by the addition of tetracycline into cultures, and secondarily used oncogenic H-Ras-expressing MCF10A cells in our studies. Our results showed the pro-apoptotic roles of Mek1/2 activation, nicotinamide adenine dinucleotide phosphate-oxidase 1 (Nox-1) elevation, and reactive oxygen species (ROS) production in FK228-induced selective cell death of oncogenic H-Ras-expressing cells versus counterpart cells. We found that although Nox-1 elevation and ROS production played essential roles in oncogenic H-Ras-induced ...


Serum Concentrations Of Methimazole In Cats After A Single Oral Dose Of Controlled-Release Carbimazole Or Sugar-Coated Methimazole (Thiamazole)., S. Longhofer, Tomas Martin-Jimenez, J. Soni-Gupta 2009 University of Tennessee, Knoxville

Serum Concentrations Of Methimazole In Cats After A Single Oral Dose Of Controlled-Release Carbimazole Or Sugar-Coated Methimazole (Thiamazole)., S. Longhofer, Tomas Martin-Jimenez, J. Soni-Gupta

Tomás Martín-Jiménez

No abstract provided.


Fk228 And Oncogenic H-Ras Synergistically Induce Mek1/2 And Nox-1 To Generate Reactive Oxygen Species For Differential Cell Death, Shambhunath Choudhary, K Rathore, Hwa-Chain Wang 2009 University of Tennessee - Knoxville

Fk228 And Oncogenic H-Ras Synergistically Induce Mek1/2 And Nox-1 To Generate Reactive Oxygen Species For Differential Cell Death, Shambhunath Choudhary, K Rathore, Hwa-Chain Wang

Hwa-Chain Robert Wang

To investigate the mechanism behind the pro-apoptotic ability of oncogenic H-Ras to enhance FK228-induced apoptosis, we primarily used the 10T1/2-TR-H-Ras cell line, in which ectopic expression of oncogenic H-Ras(V12) is controlled by the addition of tetracycline into cultures, and secondarily used oncogenic H-Ras-expressing MCF10A cells in our studies. Our results showed the pro-apoptotic roles of Mek1/2 activation, nicotinamide adenine dinucleotide phosphate-oxidase 1 (Nox-1) elevation, and reactive oxygen species (ROS) production in FK228-induced selective cell death of oncogenic H-Ras-expressing cells versus counterpart cells. We found that although Nox-1 elevation and ROS production played essential roles in oncogenic H-Ras-induced ...


Grape Seed Proanthocyanidin Suppression Of Breast Cell Carcinogenesis Induced By Chronic Exposure To Combined 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone And Benzo[A]Pyrene, X Song, Kusum Rathore, N Siriwardhana, D Lin, Hwa-Chain Wang 2009 University of Tennessee - Knoxville

Grape Seed Proanthocyanidin Suppression Of Breast Cell Carcinogenesis Induced By Chronic Exposure To Combined 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone And Benzo[A]Pyrene, X Song, Kusum Rathore, N Siriwardhana, D Lin, Hwa-Chain Wang

Kusum Rathore MS, PhD, College of Veterinary Medicine

Breast cancer is the most common type of cancer among women in northern America and northern Europe; dietary prevention is a cost-efficient strategy to reduce the risk of this disease. To identify dietary components for the prevention of human breast cancer associated with long-term exposure to environmental carcinogens, we studied the activity of grape seed proanthocyanidin extract (GSPE) in suppression of cellular carcinogenesis induced by repeated exposures to low doses of environmental carcinogens. We used combined carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and benzo[a]pyrene (B[a]P), at picomolar concentrations, to repeatedly treat noncancerous, human breast epithelial ...


Atlas Of Surgical Approaches To The Bones And Joints Of The Dog And Cat, R Latorre Reviriego, F Gil Cano, S Climent Peris, O Lopez Albors, Robert Henry, MD Ayala Florenciano, G Ramirez Zarzosa, F Martinez Gomariz, J Vazquez Auton 2009 University of Tennessee, Knoxville

Atlas Of Surgical Approaches To The Bones And Joints Of The Dog And Cat, R Latorre Reviriego, F Gil Cano, S Climent Peris, O Lopez Albors, Robert Henry, Md Ayala Florenciano, G Ramirez Zarzosa, F Martinez Gomariz, J Vazquez Auton

Robert W Henry

No abstract provided.


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