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A Polymerase Chain Reaction/Ligase Detection Reaction Fluorescent Microsphere Assay To Determine Plasmodium Falciparum Msp-119 Haplotypes, Arlene E. Dent, Christopher T. Yohn, Peter A. Zimmerman, John M. Vulule, James W. Kazura, Ann M. Moormann 2010 Case Western Reserve University

A Polymerase Chain Reaction/Ligase Detection Reaction Fluorescent Microsphere Assay To Determine Plasmodium Falciparum Msp-119 Haplotypes, Arlene E. Dent, Christopher T. Yohn, Peter A. Zimmerman, John M. Vulule, James W. Kazura, Ann M. Moormann

Ann M. Moormann

The merozoite surface protein-1 (MSP-1) is a blood stage antigen currently being tested as a vaccine against Plasmodium falciparum malaria. Determining the MSP-1(19) haplotype(s) present during infection is essential for assessments of MSP-1 vaccine efficacy and studies of protective immunity in human populations. The C-terminal fragment (MSP-1(19)) has four predominant haplotypes based on point mutations resulting in non-synonymous amino acid changes: E-TSR (PNG-MAD20 type), E-KNG (Uganda-PA type), Q-KNG (Wellcome type), and Q-TSR (Indo type). Current techniques using direct DNA sequencing are laborious and expensive. We present an MSP-1(19) allele-specific polymerase chain reaction (PCR)/ligase detection reaction-fluorescent ...


Alterations On Peripheral B Cell Subsets Following An Acute Uncomplicated Clinical Malaria Infection In Children, Amolo S. Asito, Ann M. Moormann, Kiprotich Chelimo, Zipporah W. Ng'ang'a, Robert Ploutz-Snyder, Rosemary A. Rochford 2010 Kenyatta University

Alterations On Peripheral B Cell Subsets Following An Acute Uncomplicated Clinical Malaria Infection In Children, Amolo S. Asito, Ann M. Moormann, Kiprotich Chelimo, Zipporah W. Ng'ang'a, Robert Ploutz-Snyder, Rosemary A. Rochford

Ann M. Moormann

BACKGROUND: The effects of Plasmodium falciparum on B-cell homeostasis have not been well characterized. This study investigated whether an episode of acute malaria in young children results in changes in the peripheral B cell phenotype. METHODS: Using flow-cytofluorimetric analysis, the B cell phenotypes found in the peripheral blood of children aged 2-5 years were characterized during an episode of acute uncomplicated clinical malaria and four weeks post-recovery and in healthy age-matched controls. RESULTS: There was a significant decrease in CD19+ B lymphocytes during acute malaria. Characterization of the CD19+ B cell subsets in the peripheral blood based on expression of ...


Exposure To Holoendemic Malaria Results In Elevated Epstein-Barr Virus Loads In Children, Ann M. Moormann, Kiprotich Chelimo, Peter Odada Sumba, Mary L. Lutzke, Robert Ploutz-Snyder, Duane Newton, James W. Kazura, Rosemary A. Rochford 2010 University of Massachusetts Medical School

Exposure To Holoendemic Malaria Results In Elevated Epstein-Barr Virus Loads In Children, Ann M. Moormann, Kiprotich Chelimo, Peter Odada Sumba, Mary L. Lutzke, Robert Ploutz-Snyder, Duane Newton, James W. Kazura, Rosemary A. Rochford

Ann M. Moormann

Perennial and intense malaria transmission (holoendemic malaria) and Epstein-Barr virus (EBV) infection are 2 cofactors in the pathogenesis of endemic Burkitt lymphoma (eBL). In the present study, we compared EBV loads in children living in 2 regions of Kenya with differing malaria transmission intensities: Kisumu District, where malaria transmission is holoendemic, and Nandi District, where malaria transmission is sporadic. For comparison, blood samples were also obtained from US adults, Kenyan adults, and patients with eBL. Extraction of DNA from blood and quantification by polymerase chain reaction give an EBV load estimate that reflects the number of EBV-infected B cells. We ...


Health Care Shortage Designations: Hpsa, Mua, And Tbd, Eileen Salinsky 2010 George Washington University

Health Care Shortage Designations: Hpsa, Mua, And Tbd, Eileen Salinsky

National Health Policy Forum

A wide variety of federal programs designed to improve access to health care services rely on specific criteria to designate areas and populations eligible for funding and other types of aid. Two related yet distinct designations, the Health Professional Shortage Area (HPSA) and the Medically Underserved Area (MUA), are most commonly used to identify underserved people or places. This background paper reviews the methodologies currently utilized in these designations, identifies the federal programs that use these designations to allocate resources, describes proposals that have been advanced to consolidate and improve these designations, and discusses key issues and challenges for future ...


Heath Care Spending: Why Is Miami An Outlier?, Laura A. Dummit, Mary Ellen Stahlman 2010 George Washington University

Heath Care Spending: Why Is Miami An Outlier?, Laura A. Dummit, Mary Ellen Stahlman

National Health Policy Forum

The National Health Policy Forum’s site visit to Miami focused on the complex factors that drive health care spending and is the latest in a series on the dynamics of health care markets. Miami has long been recognized as having among the highest Medicare per capita spending in the country, along with high rates of uninsured, strong managed care presence, and a history of health care fraud. This colorful health care market brings into stark relief many of the reasons for high and growing health care spending across the country. It also highlights several issues involved in building and ...


A Tale Of Two American Cities: A Look At Lifestyles, Jaclyn Thompson 2010 Western Oregon University

A Tale Of Two American Cities: A Look At Lifestyles, Jaclyn Thompson

Honors Senior Theses/Projects

No abstract provided.


Chhs June Enewsletter, Dr. John Bonaguro, Dean, VaShon S. Wells, editor 2010 College of Health & Human Services, WKU

Chhs June Enewsletter, Dr. John Bonaguro, Dean, Vashon S. Wells, Editor

College of Health & Human Services Publications

No abstract provided.


Childhood Obesity: Prevention & Intervention, Carrie Beth Lossing 2010 California Polytechnic State University - San Luis Obispo

Childhood Obesity: Prevention & Intervention, Carrie Beth Lossing

Psychology and Child Development

Childhood obesity rates have skyrocketed in the recent years. These trends are alarming since childhood obesity has been linked to numerous health conditions, socioemotional consequences, and academic consequences. This project examines the factors that have been associated with childhood obesity and the consequences of being obese or overweight for children. This project also presents lifestyle changes that parents can make to reduce the likelihood of their children becoming overweight or obese.


Evaluating Microfossil Content Of Dental Calculus From Brazilian Sambaquis, Verônica Wesolowski, Sheila Maria Ferraz Mendonça de Souza, Karl Reinhard, Gregório Ceccantini 2010 Escola Nacional de Saúde Pública Sérgio Arouca/Fiocruz

Evaluating Microfossil Content Of Dental Calculus From Brazilian Sambaquis, Verônica Wesolowski, Sheila Maria Ferraz Mendonça De Souza, Karl Reinhard, Gregório Ceccantini

Karl Reinhard Papers/Publications

To date, limited numbers of dental calculus samples have been analyzed by researchers in diverse parts of the world. The combined analyses of these have provided some general guidelines for the analysis of calculus that is non-destructive to archaeological teeth. There is still a need for a quantitative study of large numbers of calculus samples to establish protocols, assess the level of contamination, evaluate the quantity of microfossils in dental calculus, and to compare analysis results with the literature concerning the biology of calculus formation. We analyzed dental calculus from 53 teeth from four Brazilian sambaquis. Sambaquis are the shellmounds ...


Prevalence Of Obesity, Type Ii Diabetes Mellitus, Hyperlipidemia, And Hypertension In The United States: Findings From The Ge Centricity Electronic Medical Record Database., Albert G Crawford, Christine Cote, Joseph Couto, Mehmet Daskiran, Candace Gunnarsson, Kara Haas, Sara Haas, Somesh C Nigam, Rob Schuette 2010 Thomas Jefferson University School of Population Health

Prevalence Of Obesity, Type Ii Diabetes Mellitus, Hyperlipidemia, And Hypertension In The United States: Findings From The Ge Centricity Electronic Medical Record Database., Albert G Crawford, Christine Cote, Joseph Couto, Mehmet Daskiran, Candace Gunnarsson, Kara Haas, Sara Haas, Somesh C Nigam, Rob Schuette

College of Population Health Faculty Papers

This study analyzed GE Centricity Electronic Medical Record (EMR) data to examine the effects of body mass index (BMI) and obesity, key risk factor components of metabolic syndrome, on the prevalence of 3 chronic diseases: type II diabetes mellitus, hyperlipidemia, and hypertension. These chronic diseases occur with high prevalence and impose high disease burdens. The rationale for using Centricity EMR data is 2-fold. First, EMRs may be a good source of BMI/obesity data, which are often underreported in surveys and administrative databases. Second, EMRs provide an ideal means to track variables over time and, thus, allow longitudinal analyses of ...


Comparison Of Ge Centricity Electronic Medical Record Database And National Ambulatory Medical Care Survey Findings On The Prevalence Of Major Conditions In The United States., Albert G. Crawford, Christine Cote, Joseph Couto, Mehmet Daskiran, Candace Gunnarsson, Kara Haas, Sara Haas, Somesh C Nigam, Rob Schuette, Joseph Yaskin 2010 Department of Health Policy, Jefferson Medical College

Comparison Of Ge Centricity Electronic Medical Record Database And National Ambulatory Medical Care Survey Findings On The Prevalence Of Major Conditions In The United States., Albert G. Crawford, Christine Cote, Joseph Couto, Mehmet Daskiran, Candace Gunnarsson, Kara Haas, Sara Haas, Somesh C Nigam, Rob Schuette, Joseph Yaskin

College of Population Health Faculty Papers

The study objective was to facilitate investigations by assessing the external validity and generalizability of the Centricity Electronic Medical Record (EMR) database and analytical results to the US population using the National Ambulatory Medical Care Survey (NAMCS) data and results as an appropriate validation resource. Demographic and diagnostic data from the NAMCS were compared to similar data from the Centricity EMR database, and the impact of the different methods of data collection was analyzed. Compared to NAMCS survey data on visits, Centricity EMR data shows higher proportions of visits by younger patients and by females. Other comparisons suggest more acute ...


Beverage Consumption Among Low-Income Hispanics With Uncontrolled Type 2 Diabetes, Milagros C. Rosal, Stephenie C. Lemon, Barbara C. Olendzki 2010 University of Massachusetts Medical School

Beverage Consumption Among Low-Income Hispanics With Uncontrolled Type 2 Diabetes, Milagros C. Rosal, Stephenie C. Lemon, Barbara C. Olendzki

Preventive and Behavioral Medicine Publications and Presentations

This study sought to describe beverage consumption, caloric contribution of beverages to total caloric intake, and associations between beverage consumption and metabolic factors among a sample of low-income Hispanics participating in a trial of a diabetes self-management intervention. Findings: Treatment strategies to improve glucose control and reduce diabetes complications among Hispanics are needed. There is a high consumption of calories from beverages, accounting for one-fifth of total caloric intake, among this high-risk Hispanic population. Milk, juices, fruit drinks and regular soda are particular sources of calories. Beverage consumption is associated with metabolic markers, including HbA1c, cholesterol, blood pressure, BMI and ...


A Comparison Of 1978 And 2006 Peak Pollen Seasons And Sampling Methods In Missoula, Montana, Kelly L. Crispen, Donald N. Gillespie, Emily C. Weiler, Curtis W. Noonan, Raymond F. Hamilton, Tony Ward 2010 University of Montana - Missoula

A Comparison Of 1978 And 2006 Peak Pollen Seasons And Sampling Methods In Missoula, Montana, Kelly L. Crispen, Donald N. Gillespie, Emily C. Weiler, Curtis W. Noonan, Raymond F. Hamilton, Tony Ward

Public and Community Health Sciences Faculty Publications

A study was conducted in Missoula, Montana to compare local pollen counts from 1978 with those measured nearly 30 years later in 2006 using two different measurement techniques (Durham gravimetric sampler and a Burkard volumetric sampler). Trends in peak pollen times measured during the spring, summer and autumn, respectively, were compared between the two years by Pearson’s correlation and frequency of occurrence of plant genus. Meteorological conditions were also examined during each of the two study periods.

In comparing the two years, there was a statistically significant linear association between the different counts for the months of April through ...


Urinary Levoglucosan As A Biomarker For Wood Smoke: Results Of Human Exposure Studies, Megan Ann Bergauff, Tony Ward, Curtis W. Noonan, Christopher T. Migliaccio, Christopher D. Simpson, Ashley R. Evanoski, Christopher P. Palmer 2010 The University of Montana

Urinary Levoglucosan As A Biomarker For Wood Smoke: Results Of Human Exposure Studies, Megan Ann Bergauff, Tony Ward, Curtis W. Noonan, Christopher T. Migliaccio, Christopher D. Simpson, Ashley R. Evanoski, Christopher P. Palmer

Public and Community Health Sciences Faculty Publications

Urinary levoglucosan was investigated as a potential biomarker for wood smoke exposure in two different controlled experimental settings. Nine subjects were exposed to smoke from a campfire in a controlled setting and four were exposed to smoke from an older model wood stove. All subjects were asked to provide urine samples before and after exposure, and to wear personal PM2.5 monitors during the exposure. Urinary levoglucosan measurements from both studies showed no consistent response to the smoke exposure. A third experiment was conducted to assess the contribution of dietary factors to urinary levoglucosan levels. Nine subjects were asked ...


A History And One Or Two Things I’Ve Learned, Irvin Sam Schonfeld 2010 CUNY Graduate Center

A History And One Or Two Things I’Ve Learned, Irvin Sam Schonfeld

Publications and Research

No abstract provided.


Promoting Physical Activity In Afterschool Programs, Aaron Beighle, Michael W. Beets, Heather E. Erwin, Jennifer Huberty, Justin B. Moore, Megan Stellino 2010 University of South Carolina - Columbia

Promoting Physical Activity In Afterschool Programs, Aaron Beighle, Michael W. Beets, Heather E. Erwin, Jennifer Huberty, Justin B. Moore, Megan Stellino

Faculty Publications

No abstract provided.


Workers Killed While Collecting Solid Waste, Kentucky Injury Prevention and Research Center 2010 University of Kentucky

Workers Killed While Collecting Solid Waste, Kentucky Injury Prevention And Research Center

Kentucky Haz Alerts--Motor Vehicle

To prevent solid waste collection injuries:

  • An applicable worker safety program should be established
  • Before the solid waste truck is moved, visible hand signal communication between the driver and tipper should be established
  • A standard operating procedure (SOP) should be established for stacking dumpsters as a result of a job hazard analysis
  • A drug testing program should be incorporated in a worker safety program
  • Pre-trip and post-trip vehicle inspections should be performed
  • An ANSI ISEA 107-1999 safety vest should be worn at all times when on duty
  • Do not ride on the steps if the truck is going faster than ...


Coffee And Tea Intake And Risk Of Breast Cancer, Awang Bulgiba Awang Mahmud 2010 Department of Social and Preventive Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA

Coffee And Tea Intake And Risk Of Breast Cancer, Awang Bulgiba Awang Mahmud

Awang Bulgiba Awang Mahmud

Known risk factors account for about 10-15% of breast cancer incidence suggesting that lifestyle exposures are crucial in its etiology. Previous epidemiological studies on the association between coffee and tea consumption and breast cancer risk have been inconsistent. We investigated the association of coffee and tea consumption with the risk of breast cancer among women in EPIC-NL cohort, a population-based prospective cohort in Netherlands with 27,323 participants. Exposure was measured by a validated food frequency questionnaire, and the outcome was verified by direct linkage with the Netherlands Cancer Registry. A total of 681 invasive primary breast cancers were diagnosed ...


'Slowing Down When You Should': Initiators And Influences Of The Transition From The Routine To The Effortful, Carol-anne Moulton, Glenn Regehr, Lorelei Lingard, Catherine Merritt, Helen Macrae 2010 University of Toronto

'Slowing Down When You Should': Initiators And Influences Of The Transition From The Routine To The Effortful, Carol-Anne Moulton, Glenn Regehr, Lorelei Lingard, Catherine Merritt, Helen Macrae

Lorelei Lingard

BACKGROUND: 'Slowing down when you should' has been described as marking the transition from 'automatic' to 'effortful' functioning in professional practice. The ability to 'slow down' is hypothesized as an important factor in expert judgment. This study explored the nature of the 'slowing down' phenomenon intraoperatively and its link to surgical judgment.

METHODS: Twenty-eight surgeons across different surgical specialties were interviewed from four hospitals affiliated with a large urban university. In grounded theory tradition, data were collected and analyzed in an iterative design, using a constant comparative approach. Emergent themes were identified and a conceptual framework was developed.

RESULTS: Surgeons ...


Otseeker Helps Library And Allied Health Professionals To Find Quality Evidence Efficiently, Annie McCluskey, Sally Bennett, Tammy Hoffmann, Leigh Tooth 2010 University of Sydney

Otseeker Helps Library And Allied Health Professionals To Find Quality Evidence Efficiently, Annie Mccluskey, Sally Bennett, Tammy Hoffmann, Leigh Tooth

Tammy Hoffmann

Background:  Research is essential for evidence-based practice yet many health professionals do not have enough time to find research. Studies relevant to occupational therapists can be particularly difficult to find. Most search engines are broad and return a large number of irrelevant articles. Occupational Therapy Systematic Evaluation of Evidence (OTseeker) is an occupational therapy database available at http://www.otseeker.com. Developed by Australian occupational therapists, the resource aims to increase access to research and support clinical decision making. This discipline-specific database contains pre-appraised information from a variety of sources and decreases the time required to locate best evidence.

Objectives ...


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