Mental Disorders Commons^™

Development And Management Of Depression During And After Pregnancy, Alexa Bouts, Maria Patnella, Jourdan Ujlaki, Emily Wells, Hannah Lamb, Michelle Musser

Pharmacy and Wellness Review

Depression during pregnancy is common, whether it is a new onset of the disease or emerging symptoms of the already existent disease. Due to patient and prescriber concerns with antidepressant use during pregnancy, approximately three-quarters of those diagnosed with depression remain untreated. Furthermore, up to half of pregnant women with depression remain undiagnosed due to lack of recognition. As a result, both mother and fetus are at risk for negative health outcomes including substance abuse, functional impairment, increased risk of postnatal depression and poor pregnancy outcomes. Benefits must be balanced against the risks when considering pharmacologic treatment options to manage …

Prevalence Of Dementia And Mild Cognitive Impairment In Indigenous Bolivian Forager-Horticulturalists, Margaret Gatz, Wendy J. Mack, Helena C. Chui, E. Meng Law, Giuseppe Barisano, M. Linda Sutherland, James D. Sutherland, Daniel Eid Rodriguez, Raul Quispe Gutierrez, Juan Copajira Adrian, Jesus Bani Cuata, Amy R. Borenstein, Ellen E. Waters, Andrei Irimia, Christopher J. Rowan, L. Samuel Wann, Adel H. Allam, Randall C. Thompson, Michael I. Miyamoto, David E. Michalik, Daniel K. Cummings, Edmond Seabright, Angela R. Garcia, Paul L. Hooper, Thomas S. Kraft, Caleb E. Finch, Gregory S. Thomas, Jonathan Stieglitz, Benjamin C. Trumble, Michael D. Gurven, Hillard Kaplan

ESI Publications

Introduction

We evaluated the prevalence of dementia and mild cognitive impairment (MCI) in indigenous Tsimane and Moseten, who lead a subsistence lifestyle.

Methods

Participants from population-based samples ≥ 60 years of age (n = 623) were assessed using adapted versions of the Modified Mini-Mental State Examination, informant interview, longitudinal cognitive testing and brain computed tomography (CT) scans.

Results

Tsimane exhibited five cases of dementia (among n = 435; crude prevalence = 1.2%, 95% confidence interval [CI]: 0.4, 2.7); Moseten exhibited one case (among n = 169; crude prevalence = 0.6%, 95% CI: 0.0, 3.2), all age ≥ 80 years. …

Trauma In The Classroom, Dr. Kaylin Coody Coody

National Youth Advocacy and Resilience Conference

When looking at recent literature, it's clear that many students currently in school have experienced various levels of trauma, negatively impacting the social, emotional and academic progress. This session will review these specifics, with attendees have an understanding of trauma and strategies to support students in need.

Role Of Surgery In Multifocal Glioblastoma, Syeda Kubra Kishwar Jafri, Syed Sarmad Bukhari, Muhammad Shahzad Shamim

Section of Neurosurgery

The management of multifocal glioblastomas is a point of constant discussion amongst neuro-oncologists. Best outcomes in glioblastoma management come from gross total resection (GTR) followed by concomitant radiation and chemotherapy (CCRT). Multifocal disease is resistant to GTR. Conventional management of these lesion is usually biopsy only followed by CCRT. Recent evidence has shown that there may be some benefit to attempting GTR of the largest lesion whenever safe to do so.

Hallermann-Streiff Syndrome And Psychosis: A Case Report, Tarvis Peacock, Ubaid Khokhar, Jaclyn Murphy, Zach Murphy

HCA Healthcare Journal of Medicine

Hallermann-Streiff syndrome is a rare genetic congenital disorder, with fewer than 200 cases reported to date, that is characterized by brachycephaly with frontal bossing, micrognathia, a “bird-like” beaked nose, microphthalmia with congenital cataracts, dental abnormalities, hypotrichosis, skin atrophy, and short stature. There is limited data on psychosis in individuals with Hallermann-Streiff syndrome; the information available depicts mania rather than psychosis. This case report reviews the presentation and treatment of psychosis in a 32-year-old male with Hallermann-Streiff syndrome who was involuntarily admitted to an inpatient psychiatric unit for persecutory delusions and hallucinations. The patient’s psychosis responded well to risperidone with a …

Reducing Fear Overgeneralization With Safety Learning: Attention Bias As A Moderator, Boyang Fan

Dissertations, Theses, and Capstone Projects

Anxiety disorders are the most prevalent mental health condition and affect one out of nine individuals around the world. Fear generalization is a neurocognitive mechanism thought to maintain and exacerbate anxiety, and thus is an important target of therapeutic interventions. Yet, intervention research and practice place relatively little emphasis on its importance. Given that a significant proportion of individuals do not respond to extant treatments of anxiety disorders, a strengthened focus on fear generalization may inform the development and personalization of new treatment approaches. Recent notions have linked fear generalization to failures in distinguishing between signals that predict the occurrence …

Psilocybin Psychotherapy With Acceptance And Commitment Therapy: A Potential Treatment For Social Anxiety Disorder, Elliot Sandberg

Belmont University Research Symposium (BURS)

Individuals diagnosed with social anxiety disorder are in need of a more effective therapeutic intervention. Due to the nature of SAD, individuals tend to not seek care for their treatment, leading to the continuation of avoidance behaviors that significantly impact their daily existence. Psilocybin psychotherapy has the potential to lead to significant changes in the personality structure of individuals as well as reducing anxious responses to their environment in a relatively short period of time. Acceptance and commitment therapy can serve as the ideal therapeutic backing to psilocybin as it emphasizes mindfulness and psychological flexibility, both of which aid in …

Effects Of The Selective Gsk3b Inhibitor, Tideglusib, On Ethanol Consumption, Anxiety-Like Behavior, Taste Preference, And Downstream Proteins, Sam Gottlieb, Douglas Bledsoe, Jessica L. Maltman, Alanna Morgan, Jennifer T. Wolstenholme, Michael F. Miles

Graduate Research Posters

Background: We have shown modulations in glycogen synthase kinase 3 beta (GSK3B) abundance or activity regulate ethanol consumption, suggesting potential as a therapeutic target for alcohol use disorder (AUD). Here we report the GSK3B inhibitor tideglusib’s actions on ethanol consumption, basal behaviors, and modulation of GSK3B targets.

Methods: C57BL/6J males and females received i.g. 200mg/kg tideglusib, except drinking-in-the-dark (males;100mg/kg i.p.). Drinking-in-the-dark (DID): Mice given 20% ethanol 4-hours, 4-days/week x 3 weeks and then i.p. tideglusib or vehicle x 4 days in a Latin Square design with ethanol consumption measured daily. Light/Dark Box: Mice gavaged with tideglusib or vehicle …

Finding Benefit And Feeling Strain In Parenting A Child With Autism Spectrum Disorder, Haley C. Adams

Theses and Dissertations

Female caregivers of children with Autism Spectrum Disorder, often report higher levels of stress, anxiety, and depression which are often related to increased levels of caregiver strain, as well as the frequency and severity of child problem behaviors (CPB). Despite negative aspects of caring for a child with ASD, caregivers have also found benefit. The current study extended the caregiver benefit finding (CBF) and caregiver strain literature by exploring the role that these variables play in the mental health of female caregivers of children with ASD (n = 259), by assessing caregiver strain as a mediator between CPB and caregiver …

Is Exercise Effective In Improving The Cognitive And Behavioral Executive Functions In Children Diagnosed With Adhd?, Cara Scatena

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine “Is exercise effective in improving the cognitive and behavioral functions in children diagnosed with ADHD?”

Study Design: A systematic review of three randomized control trials (RCTs). All three of these studies were published between 2011 and 2016.

Data Sources: All three of the RCTs were found using PubMed. All of the studies were published in English in peer-reviewed journals and selected based on their relevance to the clinical question.

Outcome Measured: The outcome measured in these studies is the measurable improvement in executive functions related to the effects of …

Is Acupuncture Effective In Improving Pain In Patients With Knee Osteoarthritis?, Despina Lianidis

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not “Is acupuncture effective in improving pain in patients with knee osteoarthritis?”

Study design: A systematic review of three randomized controlled trials (RCTs) published in between 2015-2018.

Data sources: All three RCTs were discovered using PubMed. The articles were published in English in peer-reviewed journals and selected based on applicability to the clinical question.

Outcome measured: Based on the studies done by Lin et al. and Chen et al., using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), a self-reported measure of lower extremity pain, stiffness, …

Does Atomoxetine Improve Inattentiveness In Adults With Attention-Deficit Hyperactivity Disorder?, Sarah Defelice

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review of three composite studies is to determine whether or not atomoxetine improves inattentiveness in adults with attention-deficit hyperactivity disorder (ADHD)?

Study Design: A systematic review of three blinded randomized controlled trials (RCTs) published between 2011 and 2021.

Data Sources: Research was gathered from PubMed and Embase in December 2020-February 2021 for the three RCTs, and supplemental articles were found in September through November 2021 from PubMed. All three RCTs were published in English and found in peer-reviewed journals and were chosen based on their relevance to the topic question.

Outcome Measured: A …

Does Spaced Retrieval Therapy Help Improve Quality Of Life For Individuals With Dementia?, Simone E. Fleary

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this systematic EBM review is to determine “Does Spaced Retrieval Therapy Help Improve Quality of Life for Individuals with Dementia?”

Study Design: A systemic review of three peer-reviewed randomized controlled trials (RCT) published in English between 2016-2017.

Data Sources: All peer-reviewed articles were selected using PubMed. All articles were published in English and selected based on relevance to the clinical question. Exclusion criteria excluded studies with combined intervention methods.

Outcome Measured: Assessment of instrumental activities of daily living (IADL) was determined using the IADL task score assessed by the recruiter. Improvement of hyperphagic behavior assessed by …

Does The Use Of Blinatumomab Improve The Overall Survival Rate In Adults With Relapsed/Refractory Acute Lymphoblastic Leukemia?, Julia Colangeli

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review paper is to determine whether or not, “Does the use of blinatumomab improve the overall survival rate in adults with relapsed/refractory acute lymphoblastic leukemia?”

Study Design: A systematic review of two RCTs and one case-based series were utilized. All studies were published between 2014-2019.

Data Sources: The two RCTs were found through PubMed and the case-based series was obtained through CINAHL Plus. All the studies were published in peer-reviewed journals.

Outcomes Measured: The main outcome measured in all the studies was overall survival. Both RCTs defined overall survival as the time from …

Does Administration Of An Anterior Suprascapular Nerve Block Improve Post-Operative Pain And Reduce Opioid Consumption When Compared To Traditional Interscalene Nerve Plexus Block In Adults Undergoing Arthroscopic Shoulder Surgery?, Tyler Trobetsky

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not “Does administration of an anterior suprascapular nerve block improve post-operative pain and reduce opioid consumption when compared to traditional interscalene nerve plexus block in adults undergoing arthroscopic shoulder surgery.”

Study Design: A review of three randomized controlled trials (RCTs) published in English between 2017-2020.

Data Sources: All three articles used are peer-reviewed RCTs that were discovered using PubMed. The articles were evaluated and selected based on their ability to answer the proposed clinical question.

Outcome Measured: All three articles measured and compared post-operative pain using numerical …

Quality Of Life Before And After Cosmetic Surgery: Should Body Dysmorphic Disorder Be Considered An Absolute Or Relative Contraindication For Cosmetic Surgery?, Lindsay Conlisk

Capstone Showcase

Body Dysmorphic Disorder (BDD) has historically been regarded as a strong contraindication for cosmetic plastic surgery. New research now suggests that the contraindications to cosmetic surgery in patients with BDD may not be so absolute. This paper reviews diagnostic criteria, diagnostic challenges, and current standard of treatment of BDD. It then presents the idea of insight analysis in the BDD patient as a significant factor in determining if patients with BDD may or may not benefit from cosmetic surgery or procedures.

Bolstering The Effectiveness Of Exposure-Response Prevention In The Treatment Of Obsessive-Compulsive Disorder: Using Self-Compassion As An Adjunctive Intervention, Whitney E. Dyer

DSW Capstone Projects

Individuals suffering with Obsessive-Compulsive Disorder (OCD) face many challenges receiving proper diagnostics and evidence-based treatment. Furthermore, Exposure-Response Prevention (ERP), the empirically supported gold standard approach for targeting OCD, presents its own challenges. Examining the influences of ERP treatment reluctance is paramount to bolstering the effectiveness of outcomes and safeguarding participant adherence and ultimate success. This Capstone highlights the overlooking of addressing shame within traditional ERP protocol and posits a practice application model that supports the adjunctive use of self-compassion, a potent antidote for shame, within the use of ERP. As treatment hesitation is an inhibitor to relief for OCD sufferers, …

Physiological Effects Of Activity-Based Anorexia In Female Rats And An Overview Of Eating Disorders, Madelyn Uyemura

Regis University Student Publications (comprehensive collection)

The aim of this thesis is to bring AN to the foreground of conversation both in a scientific and sociological framework. Nearly 40 million Americans suffer from anxiety disorders, which is characterized by the feeling of a loss of control. In some cases, another disorder called anorexia nervosa (AN) can codevelop. AN is characterized by a refusal, and inability, to maintain a healthy body weight. Some suffering from anxiety may restrict caloric intake and increase exercise to cope with stress. This results in extreme caloric deprivation. AN can be modeled in rats using an activity-based anorexia (ABA) method. In …

Auto- Ethnography With A Deep Dive Into Changes Mental Health During The Pandemic And A Look Into The Way The Pandemic Has Shaped Nursing Protocols For Recent Nursing College Graduates, Audrey Shaffer, Sarah Bereznay

Williams Honors College, Honors Research Projects

In this project we completed a deep dive into how the Covid-19 pandemic reshaped our mental health and has affected our preparation for careers as registered nurses through a series of auto- ethnographic narrative journals using scholarly articles to support this idea. By utilizing personal narratives, we analyzed and reflected upon the cognitive and mental changes we experienced throughout this pandemic. We fulfilled this by comprising two personal narratives with inquiries pertaining to each shared narrative by utilizing the common themes of being nursing students and living through a pandemic. Within these personal narratives, we discussed how the pandemic influenced …

An Examination Of The Relationship Between Fear Of Evaluation, Social Anxiety, And Depression, Michelle Ingraffia

Masters Theses

This study explores fear of negative evaluation (FNE) and fear of positive evaluation (FPE) across social anxiety and depression. The following assessment tools were used to measure fear of positive evaluation, fear of negative evaluation, social anxiety, and depression: Fear of Positive Evaluation Scale, Brief Fear of Negative Evaluation - Straightforward, Liebowitz Social Anxiety Scale – Self Report, The Center for Epidemiological Studies Depression Scale – Revised. A sample of two hundred and thirty-one participants completed forms online via Amazon Mechanical Turk. Social anxiety was correlated positively with both FNE and FPE; likewise, depression was correlated positively with both FNE …