Evaluation Of Late-Onset Sepsis Antibiotic Utilization And Revision Of Empiric Late-Onset Sepsis Antibiotic Prescribing Guidelines, 2020 Providence St. Joseph Health, Portland, OR
Evaluation Of Late-Onset Sepsis Antibiotic Utilization And Revision Of Empiric Late-Onset Sepsis Antibiotic Prescribing Guidelines, Alex Creevan, Sara Clark, Anavice Jimenez, Michael Garcia
Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2020
Alex Creevan, PharmD
Michael Garcia, PharmD, Angela Roberti, PharmD, Sara Clark, PharmD, Anavice Jimenez, PharmD Candidate
Providence St. Joseph Health, Portland, OR
Evaluation of late-onset sepsis antibiotic utilization and revision of empiric late-onset sepsis antibiotic prescribing guidelines
Neonatal late-onset sepsis (LOS) is commonly defined as an infection occurring after the first 72 hours of life. Late onset sepsis is a common complication of prolonged admission to the neonatal intensive care unit (NICU) and is a major cause of morbidity and mortality. Due to risks associated with LOS, empiric antibiotics can be inappropriately prescribed, which may lead to multi-drug resistant bacteria, …
Pharmacoeconomic Impact Of Patient-Centric Oncology Service Model, 2020 Providence Health & Services, Portland Oregon
Pharmacoeconomic Impact Of Patient-Centric Oncology Service Model, Kasey Rubin, Samuel Jacobson, Shannon Buxell
Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2020
Kasey Rubin PharmD.
Samuel Jacobson PharmD. BCOP, Shannon Buxell PharmD.
Providence Health & Services, Portland Oregon
Pharmacoeconomic impact of patient-centric oncology service model
Providence Health & Services recently embedded ambulatory oncology pharmacists into the ambulatory oncology clinic setting. The overall purpose of this retrospective study is to quantify the financial benefits of ambulatory oncology pharmacists as well as quantify patient-centric factors through utilization of an onsite specialty pharmacy. This study was submitted and approved by Institutional Review Board. Electronic health records of patients who visited the ambulatory oncology clinic will be retrospectively reviewed over two time periods: 12 months preceding …
Pd-1 And Pd-L1 Inhibitors: A Single Center Medication Assistance Program (Map) Experience, 2020 Robert W. Franz Cancer Center, Providence Cancer Institute, Portland, OR, USA
Pd-1 And Pd-L1 Inhibitors: A Single Center Medication Assistance Program (Map) Experience, Sarah Tu, Shuntao Cai
Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2020
PD-1 and PD-L1 Inhibitors: A Single Center Medication Assistance Program (MAP) Experience
Sarah Tu, PharmD and Shuntao Cai, PharmD, BCOP
Robert W. Franz Cancer Center, Providence Cancer Institute, Portland, OR, USA
Background: PD-1 and PD-LI inhibitors are a large component of the growing immuno-oncology field and every year there are increasing studies investigating potential indications for these agents. This IRB approved retrospective chart review examines patients in the Medication Assistance Program (MAP) within a large tertiary medical center who are on PD-1 and PD-L1 medications due to financial barriers and/or non-FDA approved regimens (unlabeled indications). This study seeks to evaluate …
Evaluating Outcomes Of Medication-Related Interventions From The “Seniors At Risk For Falls After Emergency Room Visit” (Safer) Pilot Project, 2020 Providence Health & Services ・Portland, OR
Evaluating Outcomes Of Medication-Related Interventions From The “Seniors At Risk For Falls After Emergency Room Visit” (Safer) Pilot Project, Ling J. Zhan, Sharon Leigh, Mary E. Kuebrich, Clara Mikhaeil, Kevin Hom, Colleen M. Casey
Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2020
Primary Author: Ling J. Zhan, PharmD
Co-Authors: Sharon Leigh, PharmD BCPS, Mary Beth Kuebrich, MS, AGPCNP-BC, Clara Mikhaeil, PharmD, BCPS, Colleen M. Casey, PhD, ANP-BC
Location: Providence Health & Services, Portland, Oregon
Title: Evaluating outcomes of medication-related interventions from the “Seniors At risk for Falls after Emergency Room visit” (SAFER) pilot project
Purpose: Falls are the leading cause of injury in older adults, resulting in decreased mobility, loss of independence, and increased health care costs. Even a single fall puts an older adult at higher risk for future falls. Despite numerous studies showing evidence that multifactorial fall risk interventions are …
Safe Opioid Prescribing At Discharge, 2020 Providence St. Vincent Medical Center
Safe Opioid Prescribing At Discharge, Taylor Goodman, Elva Van Devender, Luetta Jones, Courtney Barber
Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2020
Safe Opioid Prescribing at Discharge Taylor Goodman, PharmD; Elva Van Devender, PharmD; Luetta Jones, PharmD; Courtney Barber
Background/Purpose: The opioid epidemic has led to devastating consequences, especially in Oregon, with an average of five Oregonians dying each week from opioid overdose. Opioid prescriptions at discharge are correlated with future continued opioid use. United States providers prescribe more opioids both inpatient and at discharge than other countries, and Oregon providers wrote more opioid prescriptions per person than the national average. Oversupplying prescription opioids can lead to reservoirs of unused medication, creating opportunities for non-medical use and overdose. Pharmacy interventions have …
Evaluating The Utility Of Cyp2c19 Genetic Testing For P2y12 Inhibitor Prescribing Within An Inpatient Setting, 2020 Providence Portland Medical Center, Portland, Oregon
Evaluating The Utility Of Cyp2c19 Genetic Testing For P2y12 Inhibitor Prescribing Within An Inpatient Setting, Thomas E. Maslo, Carolynn Null
Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2020
Thomas Maslo, PharmD, PGY-1 Pharmacy Resident
Carolynn Null, PharmD
Providence Portland Medical Center, Portland, Oregon
Evaluating the utility of CYP2C19 genetic testing for P2Y12 inhibitor prescribing within an inpatient setting
The emergence of pharmacogenomics offers the opportunity to practice precision medicine across health care. In patients presenting with acute coronary syndrome (ACS) and undergoing percutaneous coronary intervention (PCI), dual antiplatelet therapy (DAPT) is routinely prescribed for 12 months. DAPT consists of a P2Y12 inhibitor (clopidogrel, ticagrelor, or prasugrel) plus aspirin. Of the P2Y12 inhibitors, clopidogrel is uniquely impacted by CYP2C19 status. About 30% of the North American population carry at …
Evaluation Of A Two-Way, Hipaa-Compliant Text-Messaging Platform In A Health System Specialty Pharmacy, 2020 Providence St. Vincent Medical Center
Evaluation Of A Two-Way, Hipaa-Compliant Text-Messaging Platform In A Health System Specialty Pharmacy, Dj Clark, Adam Saulles, Tara Berkson
Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2020
PDJ Clark, PharmD, PGY1 Pharmacy Practice Resident
Adam Saulles, PharmD, CSP, BCACP; Tara Berkson, PharmD, BCACP
Providence Health and Services, Portland, Oregon
Evaluation of a two-way, HIPAA-compliant text-messaging platform in a health system specialty pharmacy
Specialty medications, including those used to treat Multiple Sclerosis (MS), represent a growing proportion of prescription drug expenditures in the United States. MS is a chronic, progressive condition that requires maintenance therapy with disease-modifying medications. Many patients with MS rely on specialty pharmacies to obtain, dispense, and perform the necessary monitoring for these complex medication regimens. A study performed in 2017 by Munsell et al, …
Implementing A Simplified Targeted Feedback Method To Reduce Fluoroquinolone Prescriptions In Emergency Departments, 2020 Providence St. Vincent Medical Center
Implementing A Simplified Targeted Feedback Method To Reduce Fluoroquinolone Prescriptions In Emergency Departments, Minh Le, Alyssa Christensen, Brent Footer
Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2020
Minh Le, PharmD
Alyssa Christensen, PharmD, BCIDP, Brent Footer, PharmD, BCPS
Providence Health System, Oregon
Implementing a simplified targeted feedback method to reduce fluoroquinolone prescriptions in emergency departments
Background: The CDC has proclaimed antibiotic resistance to be one of the biggest public health challenges of our time. Although fluoroquinolones (FQs) are among the most widely prescribed antibiotics in the ambulatory setting, there have been recent efforts to reduce their usage due to mounting concerns regarding their safety profile and resistance patterns. Provider audit-and-feedback has been shown to be among the most effective antimicrobial stewardship interventions, but the auditing process …
Implementation And Evaluation Of Pulmonary Arterial Hypertension Clinical Program And Pharmacist Education At A Health-System Specialty Pharmacy, 2020 Providence Health and Services, Portland, Oregon
Implementation And Evaluation Of Pulmonary Arterial Hypertension Clinical Program And Pharmacist Education At A Health-System Specialty Pharmacy, Timothy Cao, Adam Saulles, Tara Berkson
Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2020
Timothy Cao, PharmD, PGY-1 Pharmacy Resident
Preceptors: Adam Saulles, PharmD, CSP, BCACP and Tara Berkson, PharmD, BCACP
Providence Health and Services, Portland, Oregon
Implementation and evaluation of pulmonary arterial hypertension clinical program and pharmacist education at a health-system specialty pharmacy
Pulmonary Arterial Hypertension (PAH) is a progressive, debilitating, and costly disease, often resulting in poor prognosis when treatment is inadequate. With an exponential growth of specialty therapies, clinical pharmacists in specialty pharmacies are well-equipped to play an integral role in improving patient care outcomes and reducing overall healthcare costs. By incorporating a PAH-specific clinical program as part of the specialty …
Standardizing Specialty Pharmacist Follow-Up Frequency In Patients Prescribed Inflammatory Disease-Modifying Therapies, 2020 Providence Portland Medical Center
Standardizing Specialty Pharmacist Follow-Up Frequency In Patients Prescribed Inflammatory Disease-Modifying Therapies, Rochelle Castrillo, Linda Huynh, Tara Berkson, Adam Saulles
Providence Pharmacy PGY1 Program at Providence Portland and Providence St. Vincent Medical Centers 2020
Submission Category Specialty Pharmacy
Purpose Specialty medications for inflammatory conditions have demonstrated decreased effectiveness, safety, and quality of life, largely attributable to inadequate medication adherence. Furthermore, with poorer health outcomes, patients face greater healthcare costs associated with exacerbations, flares, and hospitalizations. Monitoring for non-adherence, side effects, and health status changes is essential for patients diagnosed with inflammatory conditions. The benefit of a standardized pharmacist clinical follow-up assessment is currently lacking in specialty pharmacy literature. This study will implement a standardized pharmacist follow-up frequency guide and determine its clinical value and utility for patient safety and therapeutic goals in newly established …
Education Of Heparin Per Pharmacy Guidelines To Increase Compliance, Safety, And Pharmacists’ Management Of Heparin Infusions, 2020 Providence Medford Medical Center
Education Of Heparin Per Pharmacy Guidelines To Increase Compliance, Safety, And Pharmacists’ Management Of Heparin Infusions, Christopher Truong, Braxton Mehl
Providence Pharmacy PGY1 Program at Providence Medford 2020
Presentation Title: Education of heparin per pharmacy guidelines to increase compliance, safety, and pharmacists’ management of heparin infusions
Authors: Christopher Truong, PharmD and Braxton Mehl, PharmD, BCCCP
Facility: Providence Medford Medical Center
Background: Element of Performance 4 of The Joint Commission’s National Patient Safety Goal 03.05.01 requires that hospitals have a written policy that addresses the need for baseline and ongoing laboratory tests to monitor and adjust anticoagulant therapy. Our hospital has a written Anticoagulation Management General Operating Policy for heparin orders managed through nursing or pharmacy. Currently, most heparin orders are nurse-managed and have resulted in lab and dosing …
Empowering Caregivers To Recognize, Support, And Treat Opioid Use Disorder: An Interdisciplinary Assessment Of Knowledge, Attitudes, And Comfort Level Pre And Post-Education, 2020 Providence Medford Medical Center
Empowering Caregivers To Recognize, Support, And Treat Opioid Use Disorder: An Interdisciplinary Assessment Of Knowledge, Attitudes, And Comfort Level Pre And Post-Education, Annette Sprankle, Mika Michaels
Providence Pharmacy PGY1 Program at Providence Medford 2020
Author: Annette Sprankle, PGY1 Pharmacy Resident, PMMC
Title: Empowering caregivers to recognize, support, and treat opioid use disorder: an interdisciplinary assessment of knowledge, attitudes, and comfort level pre and post-education
Background: Substance use disorder affects approximately one in every four hospitalized patients. These patients are often treated for the admitting medical issue without addressing their substance use disorder. A hospital admission provides an opportunity to connect patients to the medical system. Evidence demonstrates that starting medication-assisted treatment in the hospital reduces the risk of overdose upon discharge, rate of hospital readmission, length of stay, and hospital expenditures.
Purpose: The purpose …
Incorporating A Clinical Pharmacist In An Outpatient Palliative Care Team, 2020 Providence Milwaukie Hospital
Incorporating A Clinical Pharmacist In An Outpatient Palliative Care Team, Crystal Rim, Sharon Leigh, Linda Desitter, Mary Grant, Dana Nguyen
Providence Pharmacy PGY1 Program at Providence Milwaukie and Providence Newberg Medical Centers 2020
Title: Incorporating a clinical pharmacist in an outpatient palliative care team
Crystal Rim, PharmD; Sharon Leigh, PharmD, BCPS; Linda De Sitter MD, MPH; Mary Grant, ANP; Dana Nguyen, PharmD
Palliative care is a growing field in medicine that focuses on delivering care that improves quality of life for patients with serious illnesses. Often, the goals of palliative care differ from traditional goals of medicine. Currently, there is limited data demonstrating the integration of pharmacists in the palliative care setting. The purpose of this quality improvement is to evaluate the clinical pharmacist’s role within an outpatient palliative care team when performing …
Evaluation Of Transitional Care Interventions From A Decentralized Clinical Pharmacist In A Small Inpatient Geriatric Psychiatry Unit, 2020 Providence Newberg Medical Center
Evaluation Of Transitional Care Interventions From A Decentralized Clinical Pharmacist In A Small Inpatient Geriatric Psychiatry Unit, Nathan Wong, Michael Brown
Providence Pharmacy PGY1 Program at Providence Milwaukie and Providence Newberg Medical Centers 2020
Evaluation of Transitional Care Interventions from a Decentralized Clinical Pharmacist in a Small Inpatient Geriatric Psychiatry Unit
Nathan Wong, PharmD; Michael Brown, RPh, BCPS, BCPP
Background: Transitioning between healthcare settings increases the risk for medication errors. A systematic review of 26 studies comparing various medication reconciliation interventions demonstrated consistent reductions in adverse drug events. Intensive pharmacist involvement and focus on high risk populations were the most successful. 1 Geriatric and behavioral health populations are especially vulnerable with polypharmacy and cognitive impairment often complicating the picture. Providence Milwaukie Hospital (PMH) houses a small unit tailored to provide mental health care …
Impact Of Academic Detailing On Clinical Pharmacy Specialist Involvement In Medication Assisted, 2020 Providence Medical Group, Oregon
Impact Of Academic Detailing On Clinical Pharmacy Specialist Involvement In Medication Assisted, Lindsey M. Bartos, Kristin A. Tallman, Dara L. Johnson
Providence Pharmacy PGY2 Program at Providence Medical Group 2020
Title: Impact of academic detailing on clinical pharmacy specialist involvement in medication assisted treatment for opioid use disorder in a primary care setting
Lindsey Bartos, PharmD; Kristin Tallman, PharmD, BCPS, BCACP; Dara Johnson, PharmD, BCPP, BCACP
Introduction: Opioid prescribing and opioid overdose deaths have increased steadily since the 1990s, reaching a 6-fold increase between 1999 and 2017. The opioid crisis, as it became known, was declared a public health emergency in 2017. In 2018 alone, an estimated two million people had a diagnosed opioid use disorder (OUD). The use of medication-assisted treatment (MAT) for OUD reduces the use …
Impact Of Pharmacist-Led Appointments For Hypertension Management In A Primary Care Setting: A Retrospective Analysis, 2020 Providence Medical Group
Impact Of Pharmacist-Led Appointments For Hypertension Management In A Primary Care Setting: A Retrospective Analysis, Anne Marie Thibodeaux, Christine Doran, Ben Rosati
Providence Pharmacy PGY2 Program at Providence Medical Group 2020
Impact of pharmacist-led appointments for hypertension management in a primary care setting: a retrospective analysis
Introduction: High blood pressure is a major risk factor for heart disease and stroke, two of the leading causes of death for Americans.1 Evidence supports the idea that pharmacist-led hypertension management can result in overall blood pressure reduction; however, it remains unclear whether pharmacist-led initiatives can also improve performance metrics.2-5
Research question: Can pharmacist-led appointments for blood pressure management positively impact hypertension metrics?
Study design: Retrospective chart review
Methods: Primary outcome data was measured via metric inventory, defined as percentage of …
Clinical Pharmacist-Led Intervention To Improve Statin Metric For Secondary Prevention At Providence Medical Group – Southern Oregon Region, 2020 Providence Medical Group, Oregon
Clinical Pharmacist-Led Intervention To Improve Statin Metric For Secondary Prevention At Providence Medical Group – Southern Oregon Region, Chloe Nguyen, Judy Wong, Karen White
Providence Pharmacy PGY2 Program at Providence Medical Group 2020
Clinical Pharmacist-Led Intervention to Improve Statin Metric for Secondary Prevention at Providence Medical Group – Southern Oregon Region
Chloe Nguyen, PharmD, Judy Wong, PharmD, BCACP, and Karen White, PharmD, BCACP
Background: Currently, there is a gap in meeting the statin metric at Providence Medical Group in Southern Oregon Region. The purpose of this project is to identify intervention strategies to improve statin metric for secondary prevention among patients with clinical atherosclerotic cardiovascular disease (ASCVD).
Methods: This quality improvement project was approved by the system’s Institutional Review Board. Patients at least 18 years of age with diagnosis of clinical ASCVD not …
Effect Of A Pharmacist-Led Antimicrobial Stewardship (Ams) Program On Outpatient Fluoroquinolone Prescribing In The Elderly, 2020 Providence Medical Group
Effect Of A Pharmacist-Led Antimicrobial Stewardship (Ams) Program On Outpatient Fluoroquinolone Prescribing In The Elderly, Katie Larue, Chelsea Mannebach, Bonnie Jiron
Providence Pharmacy PGY2 Program at Providence Medical Group 2020
Title: Effect of a pharmacist-led antimicrobial stewardship (AMS) program on outpatient fluoroquinolone prescribing in the elderly
Authors: LaRue, Katie PharmD; Mannebach, Chelsea PharmD, BCPS, BCACP; Jiron, Bonnie, PharmD, BCACP
Introduction: The Center for Disease Control and Prevention, the Society of Infectious Diseases Pharmacists, and American Pharmacists Association recognize the need for outpatient AMS programs and the important role pharmacists play in appropriate prescribing. Fluoroquinolones (FQ) pose many risks, highlighted by U.S Food and Drug Administration safety warnings, including aortic dissection, hypoglycemia, mental health side effects, and tendonitis, along with the risk of Clostridium difficile infections, particularly in …
Development And Characterization Of Selective Cb2r Inverse Agonists As A Novel Anti-Inflammatory Therapy For Neuroinflammation – Mechanisms Of Action In Murine And Human Microglia Models Provide Valuable Insights Into Their Therapeutic Potential, 2020 University of Tennessee Health Science Center
Development And Characterization Of Selective Cb2r Inverse Agonists As A Novel Anti-Inflammatory Therapy For Neuroinflammation – Mechanisms Of Action In Murine And Human Microglia Models Provide Valuable Insights Into Their Therapeutic Potential, Sahar Saleh Alghamdi
Theses and Dissertations (ETD)
Introduction: Recently, research has revealed the presence of cannabinoid receptor 2 (CB2R) in the central nervous system (CNS); since then, the receptor has emerged as a promising therapeutic target for treating multiple neurodegenerative diseases (NDD) such as Alzheimer’s (AD), Parkinson’s (PD), Human Immunodeficiency Virus (HIV) and Multiple Sclerosis (MS). The restricted and upregulated expression of CB2R in activated microglia and lack of psychotropic activity make this receptor an attractive target for discovering novel therapy to treat neuroinflammatory diseases for which there is currently no curative treatment. Methodology: A library of compounds were synthesized and evaluated in ACTOne and TANGO-bla functional …
Demographics Of Opioid Prescriptions, 2020 West Chester University of Pennsylvania
Demographics Of Opioid Prescriptions, Isaac Linton, Simon Condliffe
Economics & Finance Student Work
The author ran Linear Probability Model and Logistic Model regressions on data from the 2017 Medical Expenditures Panel Survey to determine demographics of opioid prescriptions. The dependent variable was opioid prescription received (Y/N) and independent variables included age, education level, relative income, race, insurance status, etc. Results of the regressions showed that people with public or private insurance are more likely to be prescribed an opioid, that the problem mainly affects white people, and that as educational attainment increases, likelihood of opioid prescription decreases.