The Effect Of Pre-Extraction Preparation On Antioxidant Compounds Of Sauropus Androgynus (L.) Merr. Leaves Extracts,
2021
Faculty of Pharmacy Science, Universitas Muhammadiyah Prof. DR. HAMKA, Jakarta, Indonesia
The Effect Of Pre-Extraction Preparation On Antioxidant Compounds Of Sauropus Androgynus (L.) Merr. Leaves Extracts, Ni Putu Ermi Hikmawanti, Sofia Fatmawati, Zainal Arifin, Niken Cahyaningrum, Muhammad Arif Fauzan
Pharmaceutical Sciences and Research
Sauropus androgynus (L.) Merr. (Phyllanthaceae) is a green vegetable. It is rich in natural antioxidant compounds such as phenolics and flavonoids. The pre-extraction preparation can affect the results of extracting compounds from natural materials. This study aims to determine the effect of pre-extraction procedures, including sample form (fresh/dried), drying process (oven-drying/indirect sunlight-drying/air-drying), and particle size (ground/powdered) on total phenolic and flavonoid levels of ethanolic extracts of S. androgynus leaves and their antioxidant activity against DPPH radicals. S. androgynus leaves were extracted using the cold maceration method. The total phenolic and flavonoid contents of the extract were determined by the colorimetric …
Comparative Analytical Study Of Phytochemicals In Selected Antidiabetic Medicinal Plant Seeds In Sri Lanka,
2021
Department of Botany, Faculty of Science, University of Jaffna, Sri Lanka
Comparative Analytical Study Of Phytochemicals In Selected Antidiabetic Medicinal Plant Seeds In Sri Lanka, Gowri Rajkumar, Mihiri Rangika Jayasinghe, Vinotha Sanmugarajah
Pharmaceutical Sciences and Research
Medicinal plants are universally used in the management of various diseases in different medical practices. A varied diversity of compounds extracted from plants may show anticancer, antibacterial, and antidiabetic activities. Comparative laboratory studies and scientific approach of efficacy related to phytochemicals found in medicinal plants in Sri Lanka have not been reported yet. This study aims to evaluate the phytochemicals in selected four different plant seeds such as Syzygium cumini (L.) Skeels, Brassica alba (L.) Rabenh, Trigonella foenum-graecum L. and Nigella sativa L., which are used in the management of diabetes mellitus in Sri Lanka. The ethanol extracts of …
An Investigation Into The Use Of An Herbal Labor Induction Tincture Containing Black Cohosh, Cramp Bark, Partridgeberry, And Motherwort On Contractile Responses Produced From Isolated Strips Of Mouse Uterine Tissues,
2021
Bethel University
An Investigation Into The Use Of An Herbal Labor Induction Tincture Containing Black Cohosh, Cramp Bark, Partridgeberry, And Motherwort On Contractile Responses Produced From Isolated Strips Of Mouse Uterine Tissues, Clayton Neuenschwander, Katrina Wu, Teresa F. Degolier
Biological Sciences Faculty Publications
Introduction: Alternative solutions in the form of herbal remedies meant to ease or expedite the process of labor have often been pursued and administered but have seldom been quantitatively tested for efficacy. Published research has shown some validation for some commonly used herbs such as blue cohosh (Caulophyllum thalictroides), red raspberry (Rubus idaeus), castor bean (Ricinus communis) and evening primrose (Oenothera biennis) on isolated mouse uterine strips. Methods: This study tested an array of herbs used by midwives in a labor induction tincture, which included black cohosh (Actaea racemosa), cramp bark (Viburnum opulus), partridgeberry (Mitchella repens), and motherwort (Leonurus cardiaca). …
Modulating The Tumor Microenvironment To Improve Immunotherapy Treatments,
2021
University of Rhode Island
Modulating The Tumor Microenvironment To Improve Immunotherapy Treatments, Lleayem Nazario-Johnson, David Rowley
Senior Honors Projects
Advances in immunotherapy are revolutionizing the treatments of certain cancers, especially those in the blood. However, wider applications for eradicating solid tumors have been slow to emerge. A likely reason is the presence of myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment that secrete immunosuppressive molecules which attenuate the attack of immune cells. We hypothesize that small molecule Wnt/Beta- Catenin inhibitors can be used to modulate the immunosuppressive actions of MDSCs and increase the effectiveness of immunotherapy treatments, such as with chimeric antigen receptor (CAR) T-cells. The Wnt/Beta-Catenin Pathway has been shown to be a crucial driving force behind the …
Hplc/Msn Profiling And Healing Activity Of A Muco-Adhesive Formula Of Salvadora Persica Against Acetic Acid-Induced Oral Ulcer In Rats,
2021
Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University (UQU), Makkah 21955, Saudi Arabia
Hplc/Msn Profiling And Healing Activity Of A Muco-Adhesive Formula Of Salvadora Persica Against Acetic Acid-Induced Oral Ulcer In Rats, Nahla Ayoub, Nadia Badr, Saeed S. Ai-Ghamdi, Safaa Alsanosi, Abdullah R. Alzahrani, Ashraf B. Abdel-Naim, Khaled Nematallah, Noha Swilam
Pharmacy
Salvadora persica L. (S. persica, Siwak) is an ethnic plant that is widely used for improving oral hygiene. ThisstudyaimedtoprovideaphytochemicalprofilingofS.persica ethylacetate fraction (SPEAF)and to evaluate the healing activity of a muco-adhesive formula of the fraction against acetic acid-induced oral ulcers in rats. HPLC-ESI-QTOF-MS-MS analysis of SPEAF resulted in the tentative identification of 56 metabolites containing fatty acids (23%), urea derivatives (10.5%) and sulphur compounds (10%), in addition to several amides, polyphenols and organic acids (6.5%, 5% and 2%, respectively). For the first time, 19 compounds were identified from S. persica. In vitro and in vivo experiments indicated that the extract is …
Collagen-Based Biomaterials With Possible Therapeutic Effects,
2021
CRAIOVA UNIVERSITY OF MEDICINE AND PHARMACY, DEPARTMENT OF PEDIATRICS, CRAIOVA, ROMANIA
Collagen-Based Biomaterials With Possible Therapeutic Effects, Ramona Mihaela Nedelcuţă, Gigi Călin, Mihai Cristian Nedelcuţă, Vlad Dumitru Baleanu, Dragos Virgil Davitoiu, Bogdan Socea, Bogdan-Petre Stănoiu
Journal of Mind and Medical Sciences
Epidermolysis bullosa (EB) is a rare, serious genetic disease, incurable through the current means. Apart from this initial definition, there was later some ease in the definition of the disease, including the manifestations of toxic epidermal necrolysis and Stevens Johnson syndrome in this entity. In medical practice, there are cases that do not overlap with the description in the literature, thus the treatment must be adapted and personalized to the particularities. We present the case of a female new-born, with "de novo" mutation for the early-onset antenatal epidermolysis and our personalized therapeutic management, based on collagen from bovine corneas by …
Validation Method For Simultaneous Analysis Of Betamethasone Dipropionate And Retinoic Acid In Cream Formulation By Ultra High-Performance Liquid Chromatography,
2021
Department of Pharmacy, Faculty of Health Sciences, Syarif Hidayatullah State Islamic University, Jakarta, Indonesia
Validation Method For Simultaneous Analysis Of Betamethasone Dipropionate And Retinoic Acid In Cream Formulation By Ultra High-Performance Liquid Chromatography, Supandi Supandi, Umar Mansyur, Annisa Ananda Ranie, Linda Mazroatul Ulya
Pharmaceutical Sciences and Research
A simple, precise and rapid reverse phase UHPLC-PDA method has been developed and validated for the simultaneous analysis of betamethasone dipropionate (BTM) and retinoic acid (REA) in whitening cream dosage form. The mixture of betamethasone dipropionate (BTM) and retinoic acid (REA) was separated on Phenomenex Bonclone 10 C18 (150 mm x 3.9 mm) column. All separations were performed with a Dionex 3000 Photodiode Array (PDA) detector on 240 nm and 340 nm wavelength, column temperature at 40oC, and flow rate at 1.0 ml/min. The mobile phase was methanol-acetic acid 0.1% (85:15) with pH 5. The retention times of BTM and …
Chemical Properties, Biological Activities And Poisoning Treatment Of Novichok: A Review,
2021
Faculty of Military Pharmacy, Indonesia Defense University, Bogor. West Java. Indonesia
Chemical Properties, Biological Activities And Poisoning Treatment Of Novichok: A Review, Tesia Aisyah Rahmania, Bantari Wisynu Kusuma Wardhani, Editha Renesteen, Yahdiana Harahap
Pharmaceutical Sciences and Research
Novichok is an organophosphate compound found as a nerve agent chemical weapon. However, the information about its chemical properties, biological activities, and molecular interactions in the body are still protected under the “top secret” security clearance. Novichok, with the codes A230, A232 and A234, is a compound whose structure has been successfully determined. The compound is synthesized from a precursor through a nucleophilic substitution reaction. Novichok agents are considered more potent than VX gas and can be applied in unitary and binary forms. This compound has ability for the binding with acetylcholinesterase (AChE) due to inability of acetylcholine metabolism. AChE …
The Effect Of Ethanol Extract Of Punica Granatum Linn. Leaves On Lipid Profiles Of Dyslipidemic Rat,
2021
Department of Pharmacology-Clinical Pharmacy, School of Pharmacy, Institut Teknologi Bandung, Bandung, Indonesia
The Effect Of Ethanol Extract Of Punica Granatum Linn. Leaves On Lipid Profiles Of Dyslipidemic Rat, Neng Fisheri Kurniati, Afrillia Nuryanti Garmana, Lia Nurul Sakinah
Pharmaceutical Sciences and Research
It has been reported that peel of Punica granatum has antidyslipidemic activity. The aim of this research was to investigate the antidyslipidemic activity of Punica granatum leaf. The dried Punica granatum leaves were extracted with 96% ethanol. Rats were divided into several groups, which were normal, positive control, simvastatin at a dose of 10 mg/kg bw as reference group, and Punica granatum extract at a dose of 100 mg/kg. Before treatment, male Wistar rats were fed with high cholesterol chow for 3 months, and then plant extract was given for 4 weeks. Blood samples were collected at week 0, 12, …
Complexation Of Glycoalkaloid Α- Tomatine With Sterols And Its Potential Application As An Anti-Cancer Drug,
2021
University of Missouri-St. Louis
Complexation Of Glycoalkaloid Α- Tomatine With Sterols And Its Potential Application As An Anti-Cancer Drug, Bishal Nepal
Dissertations
Glycoalkaloids (GAs) are secondary metabolites found mostly in higher plant species and some marine invertebrates. They are known to form complexes with 3β-hydroxy sterols such as cholesterol causing membrane disruption. So far the visual evidence showcasing the complexes formed between glycoalkaloids and sterols has been mainly restricted to some earlier studies using Brewster angle microscopy. This study aimed to develop a method for topographic and morphological analysis of sterol-glycoalkaloid complexes. Langmuir-Blodgett (LB) transfer of monolayers comprising of glycoalkaloid tomatine, sterols, and lipids in varying molar ratios onto mica followed by AFM examination was performed. The AFM method used required minimal …
Crohn’S Disease And Omega 3: Can It Decrease Crp? A Literature Review,
2021
Southeastern University - Lakeland
Crohn’S Disease And Omega 3: Can It Decrease Crp? A Literature Review, Ariana L. Vyvjala
Bachelors of Science in Nursing
The Crohn’s and Colitis foundation of America estimates that 70,000 Americans are diagnosed with inflammatory bowel disease (IBD) each year (2021). Crohn's disease is an inflammatory bowel disease characterized by periods of remission and exacerbation triggered by an increase in stress (Mackner et al., 2020). Patients can experience debilitating abdominal pain, diarrhea, fatigue, blood in the stool, and reduced appetite during an exacerbation period, all of which can lead to life-threatening complications (Mayo Clinic, 2020). In most cases, patients are diagnosed in their late teens or early adulthood years, and are prescribed anti-inflammatory drugs (Mayo Clinic, 2020). As there is …
Apigenin And Structurally Related Flavonoids Allosterically Potentiate The Function Of Human Α7-Nicotinic Acetylcholine Receptors Expressed In Sh-Ep1 Cells,
2021
University of California, San Francisco
Apigenin And Structurally Related Flavonoids Allosterically Potentiate The Function Of Human Α7-Nicotinic Acetylcholine Receptors Expressed In Sh-Ep1 Cells, Waheed Shabbir, Keun-Hang Susan Yang, Bassem Sadek, Murat Oz
Biology, Chemistry, and Environmental Sciences Faculty Articles and Research
Phytochemicals, such as monoterpenes, polyphenols, curcuminoids, and flavonoids, are known to have anti-inflammatory, antioxidant, neuroprotective, and procognitive effects. In this study, the effects of several polyhydroxy flavonoids, as derivatives of differently substituted 5,7-dihydroxy-4H-chromen-4-one including apigenin, genistein, luteolin, kaempferol, quercetin, gossypetin, and phloretin with different lipophilicities (cLogP), as well as topological polar surface area (TPSA), were tested for induction of Ca2+ transients by α7 human nicotinic acetylcholine (α7 nACh) receptors expressed in SH-EP1 cells. Apigenin (10 μM) caused a significant potentiation of ACh (30 μM)-induced Ca2+ transients, but did not affect Ca2+ transients induced by high K+ …
Psychedelics Can Save: The Scientific And Social Case For Rescheduling Psychedelic Compounds,
2021
University of Tennessee, Knoxville
Psychedelics Can Save: The Scientific And Social Case For Rescheduling Psychedelic Compounds, Galen M. Fader
Chancellor’s Honors Program Projects
No abstract provided.
Identification Of Adverse Drug Reactions In Congestive Heart Failure Patients In A Tertiary Care Hospital, West Nusa Tenggara, Indonesia,
2021
University of Qamarul Huda Badaruddin, Central Lombok
Identification Of Adverse Drug Reactions In Congestive Heart Failure Patients In A Tertiary Care Hospital, West Nusa Tenggara, Indonesia, Dita Marina Lupitaningrum, Putri Ramdaniah, Depi Yuliana
Pharmaceutical Sciences and Research
Congestive Heart Failure (CHF) is a progressive health problem with high mortality and morbidity and has the potential to develop adverse drug reactions (ADRs). This study was conducted to determine the prevalence of potential ADRs, the types of drugs that cause ADRs, the types of ADRs, and the risk factors that affect the ADRs in CHF patients. Data were collected using medical record of hospitalized patient at the West Nusa Tenggara (NTB) Provincial Hospital, Indonesia, in 2017 to 2019. The assessment of the causality and severity of ADRs used the Naranjo algorithm and the Hartwig and Siegel scale. This study …
Comprehensive In Silico Analysis Of Christinin Molecular Behaviour From Ziziphus Spina-Christi Leaves On Propionibacterium Acnes,
2021
Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Islam Bandung, West Java, Indonesia
Comprehensive In Silico Analysis Of Christinin Molecular Behaviour From Ziziphus Spina-Christi Leaves On Propionibacterium Acnes, Fitrianti Darusman, Taufik Muhammad Fakih
Pharmaceutical Sciences and Research
The role of in silico studies in the discovery of new drugs is very important and interesting in the recent years, where the results can be used as confirmation of the results of in vitro tests carried out experimentally in the laboratory. One of the herbal ingredients is Ziziphus spina-christi leaves with effective antibacterial activity, such as for acne-causing bacteria, namely Propionibacterium acnes. This is because it contains main secondary metabolites with saponins as the major components which contain christinin as its active compound. There are four known types of christinin, namely christinin-A, christinin-B, christinin-C, and christinin-D. In this …
A Review: Composition Of Neonatal Meconium Microbiota And Its Role For Potential Probiotic,
2021
Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, Indonesia
A Review: Composition Of Neonatal Meconium Microbiota And Its Role For Potential Probiotic, Devi Oktaviyani, Raden Zulfa 'Alawiyyah, Putri Nusaiba, Amarila Malik
Pharmaceutical Sciences and Research
Early-life period (≤ 1 month after birth) is critical for determining long- and short-term health of neonates. Composition of neonates’ gut microbiota varies greatly between individuals whose development is influenced by various factors including differences in maternal diet and lifestyle during pregnancy, related to population and ethnicity. Balanced microbial composition can create symbiosis among commensal microbes, immunomodulatory compound production, and subsequent immune response regulation. Unbalanced microbiota composition, characterized by more pathogenic organism, less diversity, and less resistance to disease, is called dysbiosis. Probiotic bacteria are a bacteria group contributing to the balance of neonates’ gut microbiota. Probiotic bacterial strains, such …
Interpersonal Relationship And Its Effect On Treatment Compliance In Patients With Type-2 Diabetes Mellitus,
2021
Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, Indonesia
Interpersonal Relationship And Its Effect On Treatment Compliance In Patients With Type-2 Diabetes Mellitus, Fransiskus Samuel Renaldi, Woro Riyadina, Muhammad Qamar, Rani Sauriasari
Pharmaceutical Sciences and Research
Type-2 diabetes mellitus has become a chronic disease that can lead to serious complications and can only be prevented by compliant treatment of the patients. Compliance can be influenced by various factors, one of which is interpersonal factors. This study aimed to identify various interpersonal relationship problems between patients and healthcare workers that can affect their treatment compliance behavior. This study employed a qualitative design with phenomenological methods. This research was conducted in Central Bogor City in March-August 2020. The data were collected by conducting in-depth interviews with 20 type-2 diabetes mellitus patients who had been confirmed by the Community …
Preliminary Characterization, Antioxidant And Antiproliferative Properties Of Polysaccharide From Caulerpa Taxifolia,
2021
College of Pharmacy, Adamson University, 900 San Marcelino Ermita, Manila Philippines
Preliminary Characterization, Antioxidant And Antiproliferative Properties Of Polysaccharide From Caulerpa Taxifolia, Ariane Marie Bayro, Joanne Katherine Manlusoc, Renaliza Alonte, Catherine Caniel, Patrick Conde, Carlo Embralino
Pharmaceutical Sciences and Research
Macroalgae are abundant sources of bioactive polysaccharides and prospective candidates for effective and non-toxic substances. This study aims to preliminary characterize and determine the in vitro antioxidant activity and cancer cell growth inhibitory activity against human lung adenocarcinoma cell (A549) of the polysaccharide from an invasive green alga, Caulerpa taxifolia. Crude polysaccharide (CP) was extracted from the dried algal sample of C. taxifolia by hot water extraction followed by absolute ethanol precipitation. CP was subjected to preliminary chemical characterization, including protein, carbohydrate, and sulfate content analysis by Kjeldahl titrimetry, acid hydrolysis, gravimetry, and ashing-acid water digestion ion chromatography, respectively. …
B6: In- Vitro Anticancer Effects Of Cinnamomum Verum J. Presl, Cinnamaldeyde, 4 Hydroxyvcinnamic Acid And Eugenol On An Oral Squamous Cell Carcinoma Cell Line,
2021
Department of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital, Chennai, India.
B6: In- Vitro Anticancer Effects Of Cinnamomum Verum J. Presl, Cinnamaldeyde, 4 Hydroxyvcinnamic Acid And Eugenol On An Oral Squamous Cell Carcinoma Cell Line, Saranya Varadarajan, Thodur Madapusi Balaji, Malathi Narasimhan, Durai Pandian Chamundeeswari, Dhanapal Sakthisekaran
Annual Research Symposium
No abstract provided.
Effects Of Strong Oxidants Present In Acer Spp. On Hemolysis Methemoglobin Production In Equine Erythrocytes,
2021
Otterbein
Effects Of Strong Oxidants Present In Acer Spp. On Hemolysis Methemoglobin Production In Equine Erythrocytes, Gabrielle Mcgeorge, Jeffrey Lehman
Undergraduate Honors Thesis Projects
Maple toxicosis is a deadly condition affecting equines after they have ingested wilted leaves of the genus Acer (i.e., maple species). It is characterized by hemolytic anemia and methemoglobinemia. Although the toxins responsible for causing toxicosis have not been identified, they are thought to be strong oxidants. The objective of this study is to determine the effect of eight compounds (galloyl derivatives) found in Acer spp. on hemolysis and methemoglobin production in bioassays with equine erythrocytes. Seven of the compounds are known constituents of Acer spp. that are commercially available. One of the compounds--acertannin--was isolated and characterized from leaf extracts …
