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D01. Bms Department Poster, University of Mississippi. Department of BioMolecular Sciences 2020 University of Mississippi

D01. Bms Department Poster, University Of Mississippi. Department Of Biomolecular Sciences

Annual Poster Session

Corresponding author (BioMolecular Sciences): Candace Lowstuter, candacel@olemiss.edu


Long Non-Coding Rna (Lncrna) As A New Biomarker For Hepatocellular Carcinoma (Hcc) Progression And Drug Resistance, Areeb Masood, Manish Tripathi, Sanjaya Satapathy 2020 The University of Texas Rio Grande Valley

Long Non-Coding Rna (Lncrna) As A New Biomarker For Hepatocellular Carcinoma (Hcc) Progression And Drug Resistance, Areeb Masood, Manish Tripathi, Sanjaya Satapathy

MEDI 9331 Scholarly Activities Clinical Years

Hepatocellular carcinoma (HCC) is a primary malignant liver tumor that commonly occurs as a progression of chronic liver inflammation due to long-standing viral hepatitis infection, toxins, metabolic conditions, and congenital disorders. In 2018, HCC was the 4th leading cause of cancer-related deaths worldwide, accounting for approximately 780,000 deaths in total.

HCC’s prognosis is directly correlated with early detection. Unfortunately, HCC has an asymptomatic pattern of growth in the early stages of the disease which makes early detection challenging. When HCC progresses to advanced stages, it leaves clinicians with limited therapeutic and curative options, leading to high rates of ...


R18. Preparation And Characterization Of Pegylated Nanostructured Lipid Carrier Systems For The Ocular Delivery Of Antineoplastic Agent, Sushrut Marathe, Narender Dudhipala, Soumyajit Majumdar 2020 University of Mississippi

R18. Preparation And Characterization Of Pegylated Nanostructured Lipid Carrier Systems For The Ocular Delivery Of Antineoplastic Agent, Sushrut Marathe, Narender Dudhipala, Soumyajit Majumdar

Annual Poster Session

Corresponding author (Pharmaceutics and Drug delivery): Sushrut Marathe, spmarath@go.olemiss.edu


Anesthetic Use In Status Epilepticus: A Concise Review, Furkan M. Yilmaz MD., Lauren A. Igneri PharmD, Yasir A. Yilmaz MD., Evren Burakgazi-Dalkilic MD. 2020 Cooper University Hospital, Department of Neurology

Anesthetic Use In Status Epilepticus: A Concise Review, Furkan M. Yilmaz Md., Lauren A. Igneri Pharmd, Yasir A. Yilmaz Md., Evren Burakgazi-Dalkilic Md.

Cooper Rowan Medical Journal

The purpose of this review is to summarize the recent literature focusing on intravenous (IV) administration of commonly used anesthetics, including midazolam, pentobarbital/ thiopental, propofol, and ketamine in the treatment of status epilepticus (SE). Anesthetics should be reserved as third-line therapy for the treatment of SE when benzodiazepines and other second-line agents fail to terminate the seizure. We have reviewed the literature related to the treatment of status epilepticus, refractory status epilepticus, super-refractory status epilepticus, anesthetics, midazolam, pentobarbital/thiopental, propofol, and ketamine. This paper focuses on the pharmacology, dosages, major side effects, and clinical use of IV anesthetics in the ...


Presence And Distress Of Chemotherapy-Induced Peripheral Neuropathy Symptoms In Upper Extremities Of Younger And Older Breast Cancer Survivors, Susan Storey, Andrea Cohee, Diane Von Ah, Eric Vachon, Noah R. Zanville, Patrick O. Monahan, Timothy E. Stump, Victoria L. Champion 2020 Indiana University School of Nursing

Presence And Distress Of Chemotherapy-Induced Peripheral Neuropathy Symptoms In Upper Extremities Of Younger And Older Breast Cancer Survivors, Susan Storey, Andrea Cohee, Diane Von Ah, Eric Vachon, Noah R. Zanville, Patrick O. Monahan, Timothy E. Stump, Victoria L. Champion

Journal of Patient-Centered Research and Reviews

Purpose: The purposes of this study were to determine whether the presence of upper extremity chemotherapy-induced peripheral neuropathy (CIPN) symptoms (burning, pins/needles, numbness, pain, and skin crawls) among breast cancer survivors (BCS) varied according to age (≤45 years or 55–70 years) and to examine age group differences in upper extremity CIPN symptom distress.

Methods: The study was a secondary analysis of younger (n = 505) and older (n = 622) BCS. Inclusion criteria were age of ≤45 years or 55–70 years; patient at 3–8 years postdiagnosis; patient received the chemotherapy regimen of paclitaxel, doxorubicin, and cyclophosphamide; and patient ...


Validation Of An Endometrial Tumor Diameter Model For Risk Assessment In The Absence Of Lymph Node Mapping, McKayla J. Riggs, Callie M. Cox Bauer, Caela R. Miller, James K. Aden, Scott A. Kamelle 2020 Brooke Army Medical Center

Validation Of An Endometrial Tumor Diameter Model For Risk Assessment In The Absence Of Lymph Node Mapping, Mckayla J. Riggs, Callie M. Cox Bauer, Caela R. Miller, James K. Aden, Scott A. Kamelle

Journal of Patient-Centered Research and Reviews

Purpose: This study aimed to assess the optimal tumor diameter for predicting lymphatic metastasis and to determine intraoperatively the need for lymph node dissection in patients with endometrioid endometrial cancer.

Methods: Military beneficiaries diagnosed with stage I–III endometrioid endometrial cancer during 2003–2016 who had at least 7 pelvic and/or paraaortic lymph nodes removed during the time of hysterectomy were studied. Tumor diameter was compared against the presence of positive nodes, using the prior models of 20 mm (ie, Mayo model) and 50 mm (ie, Milwaukee model), to determine the false-negative rate of each threshold. A separate analysis ...


A Prospective Study Of Patterns Of Regret In The Year After Hysterectomy, Roopina Sangha, Andrew Bossick, Wan-Ting K. Su, Chad Coleman, Neha Chavali, Ganesa Wegienka 2020 Henry Ford Health System

A Prospective Study Of Patterns Of Regret In The Year After Hysterectomy, Roopina Sangha, Andrew Bossick, Wan-Ting K. Su, Chad Coleman, Neha Chavali, Ganesa Wegienka

Journal of Patient-Centered Research and Reviews

Purpose: This study sought to identify patterns of self-reported regret after hysterectomy.

Methods: Women undergoing hysterectomy for a benign indication were recruited in the 2 weeks prior to surgery. Women reported demographics and completed validated questionnaires (Decisional Regret Scale, Patient Health Questionnaire-9, Decisional Conflict Scale, and the Comprehensive Score for Financial Toxicity) up to 7 times over the first year postsurgery. Medical records were reviewed for clinical and operative details. Latent class growth mixture models were applied to the repeated regret scores to identify patterns after hysterectomy. Clinical and other participant characteristics were compared across the classes.

Results: Three latent ...


Discordance In Perceptions Of Barriers To Breast Cancer Treatment Between Hispanic Women And Their Providers, Swapna Reddy, Mary Saxon, Nina Patel, Matthew Speer, Tiffany Ziegler, Nirali Patel, Madison Ziegler, Stephany Esquivel, Andrea Daniella Mata, Asha Devineni, Pooja Paode, Nitika Thawani, Subhakar Mutyala 2020 Arizona State University

Discordance In Perceptions Of Barriers To Breast Cancer Treatment Between Hispanic Women And Their Providers, Swapna Reddy, Mary Saxon, Nina Patel, Matthew Speer, Tiffany Ziegler, Nirali Patel, Madison Ziegler, Stephany Esquivel, Andrea Daniella Mata, Asha Devineni, Pooja Paode, Nitika Thawani, Subhakar Mutyala

Journal of Patient-Centered Research and Reviews

Despite comparable screening and incidence rates that are 26% below that of non-Hispanic Whites, Hispanic women present with breast cancer at more advanced stages of disease, representing a continuing and troubling health disparity for this population. Reducing these disparities warrant more innovative research approaches to better understand perspectives of Hispanic patients regarding barriers to treatment and how these perspectives compare to those of their providers. A pilot qualitative study was conducted at a major urban cancer center in Arizona that measured both patient and provider perspectives regarding barriers to treatment. Through a multimethod qualitative analysis, researchers surveyed patients and providers ...


Conference Proceedings: Aurora Scientific Day 2020, 2020 Advocate Aurora Health

Conference Proceedings: Aurora Scientific Day 2020

Journal of Patient-Centered Research and Reviews

Abstracts published in this supplement were among those presented at the 46th annual Aurora Scientific Day research symposium, held virtually on May 20, 2020. The symposium provides a forum for describing research studies conducted by faculty, fellows, residents, and allied health professionals affiliated with Wisconsin-based Aurora Health Care, a part of the Advocate Aurora Health health system, which publishes the Journal of Patient-Centered Research and Reviews.


Evaluation Of A Mobile Health Intervention To Improve Wellness Outcomes For Breast Cancer Survivors, Jamie Cairo, Laurie Williams, Lisa Bray, Katrina Goetzke, Ana Cristina Perez 2020 Aurora Cancer Care, Advocate Aurora Health

Evaluation Of A Mobile Health Intervention To Improve Wellness Outcomes For Breast Cancer Survivors, Jamie Cairo, Laurie Williams, Lisa Bray, Katrina Goetzke, Ana Cristina Perez

Journal of Patient-Centered Research and Reviews

Purpose: Breast cancer survivors are at increased risk of cancer recurrence, second malignancies, and other comorbid conditions. This study examined if use of a convenient, commercially available, $65 per month app that gives breast cancer survivors access to a health and wellness coach is more effective than a self-guided toolkit and one-time health education session at achieving the following goals: 1) improving adherence to a plant-based diet, 2) increasing physical activity, 3) assisting with weight loss and reduction in body mass index, 4) reducing elevated depression and fatigue scores, and 5) leading to sustained adherence to lifestyle and wellness plan ...


Cole Relaxation Frequency As A Prognostic Parameter For Breast Cancer, William D. Gregory, Shahila Mehboob Christie, John Shell, Georges J. Nahhas, Maharaj Singh, Wendy Mikkelson 2020 NovaScan, Inc.; University of Wisconsin-Milwaukee

Cole Relaxation Frequency As A Prognostic Parameter For Breast Cancer, William D. Gregory, Shahila Mehboob Christie, John Shell, Georges J. Nahhas, Maharaj Singh, Wendy Mikkelson

Journal of Patient-Centered Research and Reviews

We previously reported successful classification of breast cancer versus benign tissue using the Cole relaxation frequency measured on tissue excised during breast surgery as part of a study at two urban hospitals in the U.S. Midwest. Using that health system’s cancer registry, we have discovered retrospectively that outcomes for patients who participated in the initial study can be classified correctly in 3 well-differentiated categories: nonrecurrent (NR); recurrent with no metastasis (RNM); and recurrent with metastasis (RM). As Cole relaxation frequency increases, the classification moves from NR to RNM and finally to RM. Multivariate analysis showed a significant association ...


A History Of #Bcsm And Insights For Patient-Centered Online Interaction And Engagement, Matthew S. Katz, Alicia C. Staley, Deanna J. Attai 2020 Department of Radiation Medicine, Lowell General Hospital

A History Of #Bcsm And Insights For Patient-Centered Online Interaction And Engagement, Matthew S. Katz, Alicia C. Staley, Deanna J. Attai

Journal of Patient-Centered Research and Reviews

Purpose: Participation in cancer support groups can provide a sense of community and may better prepare patients for interactions with their health care team. Online interactions may overcome some barriers to in-person support group participation. #BCSM (breast cancer social media), the first cancer support community established on Twitter, was founded in 2011 by two breast cancer survivors. The aims of this study are to describe the growth and changes in this community and to discuss future directions and lessons that may apply to other online support communities.

Methods: Symplur Signals was used to obtain all #BCSM Twitter data from January ...


Sex Related Differences In Skeletal Muscle Subcutaneous Adipose Tissue, Cross-Sectional Area, And Grayscale, Christina Sullivan 2020 University of Nebraska - Lincoln

Sex Related Differences In Skeletal Muscle Subcutaneous Adipose Tissue, Cross-Sectional Area, And Grayscale, Christina Sullivan

Honors Theses, University of Nebraska-Lincoln

Previous studies have demonstrated the efficacy of ultrasonography to assess subcutaneous adipose tissue, cross-sectional area (CSA), and grayscale for muscle. The purpose of the present study was to examine the sex-related differences in subcutaneous adipose tissue, as well as cross-sectional area and grayscale for the rectus femoris (RF) and vastus lateralis (VL). Five recreationally trained males (mean ± SD: age= 25.6 ± 1.9 years; height= 182.29 ± 5.88 cm; body mass= 84.67 ± 9.88 kg) and five recreationally trained females (mean ± SD: age= 21 ± .71 years; height= 162.71 ± 12.41 cm; body mass= 77.02 ± 14.91 ...


The Effect Of High School Disability-Based Peer Mentoring On Perspectives Toward People With Disabilities, Caroline Jacobs 2020 University of Nebraska - Lincoln

The Effect Of High School Disability-Based Peer Mentoring On Perspectives Toward People With Disabilities, Caroline Jacobs

Honors Theses, University of Nebraska-Lincoln

Negative perspectives towards people with disabilities have been shown to lead to discrimination, prejudice, and an overall decreased quality of life. One way to possibly improve attitudes and interactions with students with disabilities could be implementing peer mentoring programs for special education students in high school. Research presented in this thesis examines the difference in perspectives toward people with disabilities between people who have or have not participated as a mentor in a disability-based peer mentoring program in high school. Data were collected through an online survey that assessed peer mentoring experiences as well as a scale to measure comfort ...


Dancing During Labor: Are Women Down To Boogie?, Drew A. Horter, Kayla Heslin, Marie Forgie, Emily Malloy, Jessica J. F. Kram 2020 Advocate Aurora Health; Center for Urban Population Health

Dancing During Labor: Are Women Down To Boogie?, Drew A. Horter, Kayla Heslin, Marie Forgie, Emily Malloy, Jessica J. F. Kram

Journal of Patient-Centered Research and Reviews

Recent social media trends have demonstrated increased interest in dancing during the final weeks of pregnancy and labor. However, there is limited evidence about dancing during labor and its impact on labor pain and duration as well as patient satisfaction. Before conducting a prospective study, given that enrollment is often challenging, our feasibility study aimed to assess the willingness of pregnant women to participate in a future study evaluating low-impact dance during labor. We anonymously surveyed a convenience sample of English-speaking/reading pregnant women who presented for prenatal care at 1 of 3 clinics from June 2019 to July 2019 ...


Optimizing Wellness In Academic Emergency Medicine, Kristen E. Nordenholz, Al'ai Alvarez, Michelle D. Lall, Christine Stehman, Cindy C. Bitter, Emily L. Hirsh, Rita Manfredi, Rosanna D. Sikora, Dave W. Lu, Leon D. Sanchez, Matthew L. Wong, Steven Bird, Andra L. Blomkalns 2020 University of Colorado School of Medicine

Optimizing Wellness In Academic Emergency Medicine, Kristen E. Nordenholz, Al'ai Alvarez, Michelle D. Lall, Christine Stehman, Cindy C. Bitter, Emily L. Hirsh, Rita Manfredi, Rosanna D. Sikora, Dave W. Lu, Leon D. Sanchez, Matthew L. Wong, Steven Bird, Andra L. Blomkalns

Journal of Wellness

Introduction

Academic Emergency Physicians (EPs) face additional unique challenges in optimizing wellness compared to community EPs.

Objective

Our objective was to explore specific individual and systems challenges that academic EPs encounter that affect their wellbeing and professional fulfillment in emergency medicine (EM).

Methods

An expert group of academic EPs convened in 2019 at the annual meeting of the Society of Academic Emergency Medicine to investigate the overall causes of burnout in healthcare providers, the effects of burnout on the healthcare system, specific causes of burnout in EM, and the distinct challenges facing academic emergency physicians.

Results

We outline specific causes ...


Current State Of Sleep-Related Performance Optimization Interventions For The E-Sports Industry, Allison Joy Brager, Guido Simonelli 2020 United States Army Recruiting Command

Current State Of Sleep-Related Performance Optimization Interventions For The E-Sports Industry, Allison Joy Brager, Guido Simonelli

NeuroSports

Abstract: The e-sports industry is rapidly expanding but despite industry growth, there are existing gaps in knowledge regarding holistic and pharmacological performance enhancement strategies. The current commentary focuses on the current state of performance intervention strategies that target sleep/wake and circadian timing systems. These performance intervention strategies are based on the current state of sleep/wake health and research portfolios of Army research laboratories. The intent is to provide a foundation for future research efforts directly targeting sleep/wake and circadian timing systems in order to optimize and enhance e-sports performance at both the individual and group levels.


Updates In Cervical Cancer Screening, Sarah Cokenakes (Hirsh), MD - PGY 3 2020 Thomas Jefferson University

Updates In Cervical Cancer Screening, Sarah Cokenakes (Hirsh), Md - Pgy 3

Department of Family & Community Medicine Presentations and Grand Rounds

Learning Objectives:

  • To review the incidence of cervical cancer in the United States and the relationship between the HPV virus and invasive cervical cancer.
  • To review the 2019 ASCCP guidelines and how they differ from 2012 guidelines.
  • To discuss use of technology to aid in appropriate decision making and management.


Identifying Genetic Factors That Contribute To The Increased Risk Of Congenital Heart Defects In Infants With Down Syndrome., Cristina E. Trevino, Aaron M. Holleman, Holly Corbitt, Cheryl L. Maslen, Tracie C. Rosser, David J. Cutler, H Richard Johnston, Benjamin L. Rambo-Martin, Jai Oberoi, Kenneth J. Dooley, George T. Capone, Roger H. Reeves, Heather J. Cordell, Bernard D. Keavney, A J Agopian, Elizabeth Goldmuntz, Peter J. Gruber, James O'Brien, Douglas C. Bittel, Lalita Wadhwa, Clifford L. Cua, Jennifer G. Mulle, Michael P. Epstein, Stephanie L. Sherman, Michael E. Zwick 2020 Children's Mercy Hospital

Identifying Genetic Factors That Contribute To The Increased Risk Of Congenital Heart Defects In Infants With Down Syndrome., Cristina E. Trevino, Aaron M. Holleman, Holly Corbitt, Cheryl L. Maslen, Tracie C. Rosser, David J. Cutler, H Richard Johnston, Benjamin L. Rambo-Martin, Jai Oberoi, Kenneth J. Dooley, George T. Capone, Roger H. Reeves, Heather J. Cordell, Bernard D. Keavney, A J Agopian, Elizabeth Goldmuntz, Peter J. Gruber, James O'Brien, Douglas C. Bittel, Lalita Wadhwa, Clifford L. Cua, Jennifer G. Mulle, Michael P. Epstein, Stephanie L. Sherman, Michael E. Zwick

Manuscripts, Articles, Book Chapters and Other Papers

Atrioventricular septal defects (AVSD) are a severe congenital heart defect present in individuals with Down syndrome (DS) at a > 2000-fold increased prevalence compared to the general population. This study aimed to identify risk-associated genes and pathways and to examine a potential polygenic contribution to AVSD in DS. We analyzed a total cohort of 702 individuals with DS with or without AVSD, with genomic data from whole exome sequencing, whole genome sequencing, and/or array-based imputation. We utilized sequence kernel association testing and polygenic risk score (PRS) methods to examine rare and common variants. Our findings suggest that the Notch pathway ...


Hiv Basics: Common Clinical Scenarios, Steven C. Hatch 2020 University of Massachusetts Medical School

Hiv Basics: Common Clinical Scenarios, Steven C. Hatch

PEER Liberia Project

This is a lecture in the PEER Liberia Infectious Diseases Lecture Series. The goals of this presentation are to: review some (not all) clinical scenarios involving advanced HIV infection; consider some (not all) opportunistic infection (OI) scenarios; discuss OI prophylaxis; discuss alternative HIV regimens; and briefly review most pertinent data regarding TB/HIV coinfection.


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