Medicine and Health Sciences Commons^™

South, Lillian Harreld, 1879-1966 (Sc 2180), Manuscripts & Folklife Archives

MSS Finding Aids

Finding aid only for Manuscripts Small Collection 2180. Application to secure historical highway marker for Bowling Green, Kentucky native Lillian H. South, a female physician with a distinguished career as State Bacteriologist with the Kentucky State Board of Health. Includes application and supporting material.

2010 Weisser Et Al Only Slight Impace Of Predicted Rc.Pdf, M Tschochner

Monika Tschochner

No abstract provided.

Running Enhances Spatial Pattern Separation In Mice., David J Creer, Carola Romberg, Lisa M Saksida, Henriette Van Praag, Timothy J Bussey

Brain and Mind Institute Researchers' Publications

Increasing evidence suggests that regular exercise improves brain health and promotes synaptic plasticity and hippocampal neurogenesis. Exercise improves learning, but specific mechanisms of information processing influenced by physical activity are unknown. Here, we report that voluntary running enhanced the ability of adult (3 months old) male C57BL/6 mice to discriminate between the locations of two adjacent identical stimuli. Improved spatial pattern separation in adult runners was tightly correlated with increased neurogenesis. In contrast, very aged (22 months old) mice had impaired spatial discrimination and low basal cell genesis that was refractory to running. These findings suggest that the addition ...

Jual Obat Penggugur Kandungan Meulaboh 082328881996 Obat Aborsi Di Meulaboh, Dr Fitri

dr fitri

The Effect Of Patellar Taping On The Onset Of Vastus Medialis Obliquus And Vastus Lateralis Muscle Activity In Persons With Patellofemoral Pain, Wendy L. Gilleard, Jenny Mcconnell, David Parsons

Wendy L Gilleard

Background and Purpose. The purpose of this study was to investigate the effect of patellar taping on the onset of activity of the vastus medialis obliquus muscle (VMO) and the vastus lateralis muscle (VL). Subjects and Methods. Fourteen female subjects with patellar pain walked up and down stairs in two conditions: (1) with the patellofemoral joint of the painful lower extremity taped so that the pain was reduced by at least 50% on a pain provocation test and (2) without patellar taping. Results. When the patellofemoral joint was not taped, there was no difference in the onset of activity between ...

A Longitudinal Study Of The Effect Of Pregnancy On Rising To Stand From A Chair, Wendy L. Gilleard, Jack Crosbie, Richard Smith

Wendy L Gilleard

Rising to stand from a chair becomes more difficult to perform as pregnancy progresses, which may lead to altered biomechanics affecting the musculoskeletal demands on the body segments. The kinematic and kinetic adaptations in the lower limbs and trunk as pregnancy progresses are unknown. Nine maternal subjects were investigated using an eight-camera motion analysis system and two force plates, four times throughout pregnancy and once post-birth during rising to stand. Twelve nulliparous female subjects were used to establish natural variation with retesting over the time period. The maternal subjects used temporal–spatial, kinematic and kinetic strategies to widen the base ...

Microtensile Bond Strength Of Self-Adhesive Resin-Based Dental Cement, Selda Keskin

This study investigated the effectiveness of bleaching agents on the micro tensile bond strength (mTBS) of self-adhesive luting cement and enamel. A total of 126 samples were prepared from the labial surfaces of permanent human maxillary central incisors and assigned into three groups with 42 samples each as: control, enamel bleached with 10% hydrogen peroxide (HP), and enamel bleached with 10% carbamide peroxide (CP). Rely X Unicem1 (3 M, ESPE) was used as self-adhesive resin cement. The total testing period for bleaching was selected as 14 days and the bleaching agents were applied 8 hours a day. The statistical one-way ...

Impaired Wound Healing In Mouse Models Of Diabetes Is Mediated By Tnf-Α Dysregulation And Associated With Enhanced Activation Of Forkhead Box O1 (Foxo1), Michelle F. Siqueira, Jingyuan Li, Leena Chehab, Tesfahun Desta, Takahiro Chino, N. Krothpali, Yugal Behl, Mani Alikhani, Julia Yang, Cameron Braasch, Dana T. Graves

Departmental Papers (Dental)

Aims/hypothesis

The role of TNF-α in impaired wound healing in diabetes was examined by focusing on fibroblasts.

Methods

Small excisional wounds were created in the db/db mice model of type 2 diabetes and normoglycaemic littermates, and in a streptozotocin-induced type 1 diabetes mouse model and control mice. Fibroblast apoptosis was measured by the TUNEL assay, proliferation by detection of proliferating cell nuclear antigen, and forkhead box O1 (FOXO1) activity by DNA binding and nuclear translocation. TNF-α was specifically inhibited by pegsunercept.

Results

Diabetic wounds had increased TNF-α, fibroblast apoptosis, caspase-3/7 activity and activation of the pro-apoptotic transcription ...

Increased Incidence And Size Of The Cavum Septum Pellicidum In Children With Chromosome 22q11.2 Deletion Syndrome, Elliott A. Beaton, Y Qin, V Nguyen, J Stoddard, J D. Pinter, T J. Simon

Psychology Faculty Publications

Chromosome 22q11.2 deletion syndrome (22q11.2DS) is a result of a hemizygotic microdeletion that results in a variety of impairments in children including greater risk for psychiatric ailments in adulthood. We used high-resolution magnetic resonance imaging to accurately quantify the length and, for the first time, volume, of the cavum septum pellucidum (CSP) in children aged 7 to 14years with 22q11.2DS and typically developing (TD) controls. Significantly greater anteroposterior length and greater CSP volumes were found in children with 22q11.2DS compared with controls. Furthermore, the largest CSP were found only in the 22q11.2DS group and with ...

Input Constraints And The Efficiency Of Entry: Lessons From Cardiac Surgery, David M. Cutler, Robert S. Huckman, Jonathan T. Kolstad

Health Care Management Papers

Prior studies suggest that with elastically supplied inputs free entry may lead to an inefficiently high number of firms in equilibrium. Under input scarcity, however, the welfare loss from free entry is reduced. Further, free entry may increase use of high-quality inputs, as oligopolistic firms underuse these inputs when entry is constrained. We assess these predictions by examining how the 1996 repeal of certificate-of-need (CON ) legislation in Pennsylvania affected the market for cardiac surgery in the state. We show that entry led to a redistribution of surgeries to higher quality surgeons, and that this entry was approximately welfare neutral.

Microstructural Characteristics Of Functionally Graded Materials Designed As Dental Post, Ahmed A. Madfa

Ahmed A. Madfa

To study the interfaces and microstructure of multilayered materials fabricated based on functionally graded concept for use as dental posts.

Social Inequalities And The Decline Of Stroke Mortality In The City Of Sao Paulo, Brazil, Paulo A. Lotufo

Paulo A Lotufo

No abstract provided.

Inhibitory Role Of Sphingosine 1-Phosphate Receptor 2 In Macrophage Recruitment During Inflammation, Jason Michaud, Timothy Hla, Dong-Soon Im

UCHC Articles - Research

Macrophage recruitment to sites of inflammation is an essential step in host defense. However, the mechanisms preventing excessive accumulation of macrophages remain relatively unknown. The lysophospholipid sphingosine 1-phosphate (S1P) promotes T and B cell egress from lymphoid organs by acting on S1P receptor 1 (S1P₁R). More recently, S1P₅R was shown to regulate NK cell mobilization during inflammation, raising the possibility that S1P regulates the trafficking of other leukocyte lineages. In this study, we show that S1P₂R inhibits macrophage migration in vitro and that S1P₂R-deficient mice have enhanced macrophage recruitment during thioglycollate peritonitis ...

Clock In Breast Tumorigenesis: Evidence From Genetic, Epigenetic, And Transcriptional Profiling Analyses, Richard G. Stevens

UCHC Articles - Research

As transcriptional regulators, the genes responsible for maintaining circadian rhythm exert influence in a variety of biological processes. Recently, it has been suggested that the core circadian genes may play a role in breast tumorigenesis, possibly by influencing hormone regulation or other cancer-relevant pathways. Here, we examine the role of the central circadian regulator CLOCK in breast cancer by conducting a genetic and epigenetic association study, as well as transcriptional profiling arrays and a pathway-based network analysis. Significant associations were detected between CLOCK tagging SNPs and breast cancer risk, with apparent effect modification by ER/PR status. Furthermore, hypermethylation in ...

Racial And Ethnic Disparities In Low Birth Weight Delivery Associated With Maternal Occupational Characteristics, John D. Meyer, Nicholas D. Warren, Susan T. Reisine

UCHC Articles - Research

Objectives

Work characteristics and maternal education have both been associated with low birth weight (LBW) delivery. We sought to examine the relative contribution of these two factors to LBW delivery and determine whether ethnic/racial differentials in educational attainment and work characteristics might play a role in well-described disparities in LBW.

Methods

Scores for work substantive complexity (SC) derived from the O*NET were imputed to maternal occupation for Connecticut singleton births in 2000. Risks for LBW were estimated separately for black, Hispanic, and white mothers using logistic regression controlling for maternal covariates.

Results

Using white mothers as a referent ...

White Matter Hyperintensities Predict Functional Decline In Voiding, Mobility And Cognition In Older Persons, Dorothy B. Wakefield, George A. Kuchel, Richard F. Kaplan, Leslie I. Wolfson

UCHC Articles - Research

Objective

To compare MRI data to functional assessments of mobility, urinary control, and cognition to determine common or distinctive features in the distribution of brain white matter hyperintensities (WMHs) associated with functional decline/impairment.

Design

Baseline data from subjects 75-89 years enrolled in a longitudinal study. Assessors and subjects were blinded to group assignment.

Participants

99 subjects were enrolled using a balanced 3×3 matrix stratified by age and mobility performance. Exclusion criteria included: medication, systemic conditions, and neurologic diseases which can compromise mobility.

Setting

Healthy community-dwelling volunteers.

Measurements

WMHs were identified using semi-automated segmentation method and regional burdens were ...

Prognostic Value Of Ishak Fibrosis Stage: Findings From The Halt-C Trial, Herbert L. Bonkovsky

UCHC Articles - Research

Background and Aims

Studies of the prognostic value of Ishak fibrosis stage are lacking. We utilized multi-year follow-up of the Hepatitis C Antiviral Long Term Treatment Against Cirrhosis (HALT-C) Trial to determine whether individual Ishak fibrosis stages predicted clinical outcomes in patients with chronic hepatitis C.

Methods

Baseline liver biopsies from 1,050 patients with compensated chronic hepatitis C who had failed combination peginterferon and ribavirin were reviewed by a panel of expert hepatopathologists. Fibrosis was staged with the Ishak scale (ranging from 0=no fibrosis to 6=cirrhosis). Biopsy fragmentation and length as well as number of portal tracts ...

Immunologic Indicators Of Clinical Progression During Canine Leishmania Infantum Infection, Paola M. Boggiatto, Amanda E. Ramer-Tait, Erin E. Kramer, Kyle Metz, Katherine Gibson-Corley, Kathleen Mullin, Jesse M. Hosterner, Jack M. Gallup, Douglas E. Jones, Christine A. Petersen

Dr. Amanda Ramer-Tait Publications

In both dogs and humans Leishmania infantum infection is more prevalent than disease, as infection often does not equate with clinical disease. Previous studies additively indicate that advanced clinical visceral leishmaniasis is characterized by increased production of anti-Leishmania antibodies, Leishmania-specific lymphoproliferative unresponsiveness, and decreased production of gamma interferon (IFN-γ) with a concomitant increase of interleukin-10 (IL-10). In order to differentiate infection versus progressive disease for better disease prognostication, we temporally evaluated humoral and cellular immunologic parameters of naturally infected dogs. The work presented here describes for the first time the temporal immune response to natural autochthonous L. infantum ...

Collaborating With A Financial Therapist: The Why, Who, What And How, Cicily Maton, Michelle Maton, William Martin

Publications – Dreihaus College of Business

Financial planning clients are seeking holistic solutions to their financial opportunities and challenges. Yet, few financial planners and mental health professionals work together to benefit clients. This article showcases a partnership between a financial therapist, trained as a psychologist, and two financial planners who have implemented an evidence-based model of financial planning drawing upon the behavioral finance, neureconomics, evolutionary psychology, and coaching literature.

Evaluation Of Enteral Feeding Success In Head Injured Patients Placed In Pentobarbital Induced Comas, Jane M. Gervasio, Jonathan Egel, Joshua Mcgehee, Gabriel Drew Stillabower, Nicole Ponton, Lawrence Bortenschlager, Timothy Pohlman

Scholarship and Professional Work – COPHS

Abstract of Distinction from Clinical Nutrition Week, Las Vegas, NV, February 8-10, 2010.