Medicine and Health Sciences Commons^™

Event Adjudication Changes Key Results In Open-Label Trials: The Affirm Experience, Elaine M. Nasco, April Slee, Kent M. Koprowicz, Robert G. Hart

Kent M Koprowicz

Event Adjudication Changes Key Results in Open-Label Trials: The AFFIRM Experience Author Block: Elaine M. Nasco, April Slee, Kent Koprowicz, Robert G. Hart, Axio Research, LLC, Seattle, WA Abstract: Background: The value of central event adjudication of endpoints in multi-center randomized trials has recently been questioned. Methods: The NIH-sponsored Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) trial randomized 4,060 atrial fibrillation patients to antiarrhythmic drugs (rhythm control) vs. rate-controlling drugs, given open-label, at 213 clinical sites. While the primary outcome was mortality, a key secondary endpoint was ischemic stroke (IS), centrally adjudicated by those reviewing source documents from ...

“Nurses’ Station” Or “Nursing Station”? How To Appropriately Describe Our Workspace In Acute Care, Ashley Jarrell, Mona Shattell

Mona Shattell

No abstract provided.

Special Edition Editorial. Inpatient Psychiatric Treatment: Moving The Science Forward, Kathleen Delaney, Mona Shattell

Mona Shattell

No abstract provided.

Welcome To Tomorrow, Edward F. Rossomando

UCHC Articles - Research

It is always a delight to see an idea become a reality. We recognized that there was a need for a dental journal for those to publish a tentative explanation for a phenomenon, an explanation that could be used as a basis for further investigation. Early in the planning, it was necessary to address the question: Is there a need for a journal for dental hypothesis? A detailed examination of dental journals now published revealed that most if not all published research findings - this research might be in various scientific disciplines or in education but all contained results of testing ...

Should The Concentration Of Vitamin D Be Measured In All Patients With Hypertension?, Angela Boldo, Patrick Campbell, Pooja Luthra, William B. White

UCHC Articles - Research

With mounting evidence indicating the direct effect of vitamin D on the vascular smooth muscle cell, endothelial function and the renin-angiotensin-aldosterone system, it is clear that randomized trials of vitamin D replacement and renin and angiotensin inhibition in patients with hypertension and vitamin D deficiency are warranted. Preliminary research has shown an inverse relationship between BP and vitamin D levels, and supplementation appears promising. To that end, we have just initiated a randomized clinical trial evaluating the effects of vitamin D and/or a renin inhibitor on ambulatory and clinic BP in vitamin D deficient patients with hypertension (clinical trials ...

Genetic Influences On The Dynamics Of Pain And Affect In Fibromyalgia, Howard A. Tennen, Jonathan Covault

UCHC Articles - Research

Objective The purpose of the present investigation was to determine if variation in the catechol-O-methyltransferase (COMT) and mu-opioid receptor (OPRM1) genes is associated with pain-related positive affective regulation in fibromyalgia (FM). Design Forty-six female FM patients completed an electronic diary that included daily assessments of positive affect and pain. Between- and within-person analyses were conducted with multilevel modeling. Main Outcome Measure Daily positive affect was the primary outcome measure. Results Analyses revealed a significant gene × experience interaction for COMT, such that individuals with met/met genotype experienced a greater decline in positive affect on days when pain was elevated than ...

Feasibility Of Using Interactive Voice Response To Monitor Daily Drinking, Moods And Relationship Processes On A Daily Basis In Alcoholic Couples, Howard A. Tennen

UCHC Articles - Research

Background

Daily process research on alcohol involvement has used paper-and-pencil and electronic data collection methods, but no studies have yet tested the feasibility of using Interactive Voice Response (IVR) technology to monitor drinking, affective, and social interactional processes among alcoholic (ALC) couples. This study tested the feasibility of using IVR with n=54 ALC couples.

Methods

Participants were n=54 couples (probands who met criteria for a past one-year alcohol use disorder and their partners) recruited from a substance abuse treatment center and the local community. Probands and their partners reported on their daily drinking, marital interactions, and moods once ...

Update - March 2010, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- Glorifying God in Our Body: A Seventh-day Adventist Theological Foundation for Nursing
-- Editorial
-- New Beginning at the Center for Christian Bioethics

An In-Depth Look At Air Polishing, Caren M. Barnes

Faculty Publications, College of Dentistry

Air polishing has been available for four decades, however, the concept is based on a technology invented by Dr. Robert Black in 1945. Dr. Black invented the Air Dent, a device that used compressed air, water, and a highly abrasive powder to eliminate pain from cavity preparation, making anesthesia unnecessary. The Air Dent had numerous problems that could not be overcome, but Dr. Black never gave up on his idea. The technology he invented became the basis of air polishing and was first marketed in 1976. By the late 1970s, air polishing was readily available.

Air polishing represents the most ...

Human Performance Lab Newsletter, March 2010, St. Cloud State University

Human Performance Lab Newsletter

Contents of this issue include:

• Kelly's Corner by David Bacharach
• Evolution of an Ergometer by Eric Wright and Dennis Madden
• Physical Attributes of Youth in an Urban Tennis Program by Kate Kaufmann
• Stress and your Health by Ashlee Ford
• Fluid Intake and Athletic Performance by Ashley Davenport and Chad Johnson
• Improving Sudden Cardiac Arrest Survival Rate by April Kuschke

The Outcome Of Patients With Platinum-Resistant/Refractory Ovarian Cancer Treated With The Combination Of Pegylated Liposomal Doxorubicin And Gemcitabine, Vijaya Galic Md, Mba, Richard Boulay Md, M Bijoy Thomas Md, Cody Gillenwater, Christine C. Chen Md, Martin Martino Md

Department of Obstetrics & Gynecology

No abstract provided.

Latent Manifestations In The Us Congenital Rubella Syndrome (Crs) Population (Abstract 84.018), Normadeane Armstrong Ph.D, A.N.P.

Faculty Works: Nursing

Abstract from the 14th International Congress on Infectious Diseases

Pregnancy Outcome In Women With Antiphospholipid Syndrome On Low-Dose Aspirin And Heparin: A Retrospective Study., T. Naru, Rozilla Sadia Khan, R. Ali

Department of Obstetrics & Gynaecology

This retrospective review of hospital records analysed pregnancy outcome with 2 different treatments for women with recurrent miscarriage diagnosed with antiphospholipid syndrome in the index pregnancy. Of 64 women, 29 had received aspirin and 35 aspirin plus heparin. Pregnancy-induced hypertension, prematurity, intrauterine growth restriction and neonatal death were considered as maternal and fetal complications. There were no significant differences in antenatal and maternal complications between the groups. However, there were significant differences in mean anticardiolipin IgG antibody levels. Aspirin alone or in combination with parin was equally efficacious in women with antiphospholipid syndrome and recurrent miscarriage.

Aata Is A Novel Autotransporter And Virulence Factor Of Avian Pathogenic Escherichia Coli, Ganwu Li, Yaping Feng, Subhashinie Kariyawasam, Kelly A. Tivendale, Yvonne Wannemuehler, Fanghong Zhou, Catherine M. Logue, Cathy L. Miller, Lisa K. Nolan

Veterinary Microbiology and Preventive Medicine Publications

Autotransporters (AT) are widespread in Gram-negative bacteria, and many of them are involved in virulence. An open reading frame (APECO1_O1CoBM96) encoding a novel AT was located in the pathogenicity island of avian pathogenicEscherichia coli (APEC) O1's virulence plasmid, pAPEC-O1-ColBM. This 3.5-kb APEC autotransporter gene (aatA) is predicted to encode a 123.7-kDa protein with a 25-amino-acid signal peptide, an 857-amino-acid passenger domain, and a 284-amino-acid β domain. The three-dimensional structure of AatA was also predicted by the threading method using the I-TASSER online server and then was refined using four-body contact potentials. Molecular analysis of AatA revealed ...

Anemia Infecciosa Del Salmón, Iowa State University Center For Food Security And Public Health

CFSPH fichas de las enfermedades

La anemia infecciosa del salmón (AIS) es una de las enfermedades virales más importantes del salmón del Atlántico criado en granjas. Esta enfermedad altamente contagiosa puede ser insidiosa, con un índice de mortalidad bajo al inicio; sin embargo, el índice de mortalidad acumulativo a veces puede superar el 90% si la enfermedad no se controla. La AIS se describió por primera vez en Noruega en 1984, y continúa siendo un problema en dicho país a pesar de las medidas de control. Desde fines de la década de 1990, también se han registrado brotes en otros lugares. Esta enfermedad devastó la ...

Mycotoxin Contamination Of Corn: What It Is, What It Does To Pigs And What Can Be Done About It, John F. Patience, Steven M. Ensley, Sherry Hoyer

Iowa Pork Industry Center Fact Sheets

Mycotoxins in corn are produced by certain molds which infect the ears of corn. Molds may be present without the production of mycotoxins, but mycotoxins cannot be produced in the absence of molds

Schedule For Ct Image Guidance In Treating Prostate Cancer With Helical Tomotherapy., G Beldjoudi, S Yartsev, G Bauman, Jerry J. Battista Dr., Jacob Van Dyk

Oncology Publications

The aim of this study was to determine the effect of reducing the number of image guidance sessions and patient-specific target margins on the dose distribution in the treatment of prostate cancer with helical tomotherapy. 20 patients with prostate cancer who were treated with helical tomotherapy using daily megavoltage CT (MVCT) imaging before treatment served as the study population. The average geometric shifts applied for set-up corrections, as a result of co-registration of MVCT and planning kilovoltage CT studies over an increasing number of image guidance sessions, were determined. Simulation of the consequences of various imaging scenarios on the dose ...

Development Of Hong Kong Chinese Materia Medica (Hkcmm) Standards = 香港中藥材標準的制訂與發展, Hu-Biao Chen, Tao Yi

HKBU Staff Publication

The development of HKCMM standards is one of the achievements of developing Hong Kong into an international centre for Chinese medicine. In order to enable more people concerned to have an intimate knowledge of this standard, the author was invited to introduce the development of HKCMM standards to readers, including: 1) the history of the project and the basis for legislative supports; 2) the composition and operation of the regulatory division, the research institution and the evaluation committee; 3) the progress of HKCMM standards; 4) the contents and features of HKCMM standards.

在發展香港成為國際中醫藥中心的眾多成果中,香港中藥材標準(港標)的制訂是其中成果之一。為了讓更多相關人士了解和熟悉這個標準,本文作者應邀向讀者介紹港標制訂的以下內容,包括:1 ...

Comparison Of The Anti-Inflammatory And Anti-Nociceptive Effects Of Three Medicinal Plants Known As “Snow Lotus” Herb In Traditional Uighur And Tibetan Medicines, Tao Yi, Zhong-Zhen Zhao, Zhi-Ling Yu, Hu-Biao Chen

HKBU Staff Publication

Ethnopharmacological relevance: Saussurea involucrata (Kar. et Kir.) Sch.-Bip. (Compositae) has long been used under the herbal name "Snow Lotus" for the treatment of rheumatoid arthritis, stomachache and dysmenorrhea in Uighur folk medicine. In traditional Tibetan medicine, Saussurea laniceps Hand.-Mazz. and Saussurea medusa Maxim. have also been used under the name "Snow Lotus" and prescribed for the treatment of pain and inflammatory conditions. Aim of the study: The present study evaluated the pharmacological effects of three species of "Snow Lotus" in experimental inflammation and pain models, and determined the chemical compounds that may correlate with their pharmacological activities. Materials ...

Lymphocytic Choriomeningitis, Iowa State University Center For Food Security And Public Health

Center for Food Security and Public Health Technical Factsheets

Lymphocytic choriomeningitis virus (LCMV) is a pathogen, normally carried in rodents, which can cause aseptic meningitis and other conditions in humans. Most people experience a relatively mild illness and fatal infections are rare; however, pregnant women may give birth to congenitally infected infants with severe defects of the brain and eye. In a few instances, this virus has been transmitted in transplanted organs, usually resulting in fatal disease. LCMV infections in rodents are often subclinical, although acute clinical signs or chronic effects may be seen in some animals. Some strains of this virus can cause life-threatening illness in New World ...