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Gene Delivery In The Equine Cornea: A Novel Therapeutic Strategy, Dylan G. Buss, Ajay Sharma, Elizabeth A. Giuliano, Rajiv R. Mohan 2010 University of Missouri, Columbia

Gene Delivery In The Equine Cornea: A Novel Therapeutic Strategy, Dylan G. Buss, Ajay Sharma, Elizabeth A. Giuliano, Rajiv R. Mohan

Pharmacy Faculty Articles and Research

Objective—To determine if hybrid adeno-associated virus serotype 2/5 (AAV5) vector can effectively deliver foreign genes into the equine cornea without causing adverse side effects. The aims of this study were to: (i) evaluate efficacy of AAV5 to deliver therapeutic genes into equine corneal fibroblasts (ECFs) using enhanced green fluorescent protein (EGFP) marker gene and (ii) establish the safety of AAV5 vector for equine corneal gene therapy.

Animal Material—Primary ECF cultures were harvested from healthy donor equine corneas. Cultures were maintained at 370C in humidified atmosphere with 5% CO2.

Procedure—AAV5 vector expressing EGFP under control of hybrid ...


Localization Of Angiotensin Converting Enzyme In Rabbit Cornea And Its Role In Controlling Corneal Angiogenesis In Vivo, Ajay Sharma, Daniel I. Bettis, John W. Cowden, Rajiv R. Mohan 2010 Chapman University

Localization Of Angiotensin Converting Enzyme In Rabbit Cornea And Its Role In Controlling Corneal Angiogenesis In Vivo, Ajay Sharma, Daniel I. Bettis, John W. Cowden, Rajiv R. Mohan

Pharmacy Faculty Articles and Research

Purpose: The renin angiotensin system (RAS) has been shown to modulate vascular endothelial growth factor and angiogenesis. In this study we investigated (i) the existence of the RAS components angiotensin converting enzyme (ACE) and angiotensin II receptors (AT1 and AT2) in the rabbit cornea using in vitro and ex vivo models and (ii) the effect of enalapril, an ACE inhibitor, to inhibit angiogenesis in rabbit cornea in vivo.

Methods: New Zealand White rabbits were used. Cultured corneal fibroblasts and corneal epithelial cells were used for RNA isolation and cDNA preparation using standard molecular biology techniques. PCR was performed to detect ...


Plasma Pharmacokinetics And Tissue Disposition Of Novel Dextran- Methylprednisolone Conjugates With Peptide Linkers In Rats, Suman Penugonda, Hitesh K. Agarwal, Keykavous Parang, Reza Mehvar 2010 Texas Tech University

Plasma Pharmacokinetics And Tissue Disposition Of Novel Dextran- Methylprednisolone Conjugates With Peptide Linkers In Rats, Suman Penugonda, Hitesh K. Agarwal, Keykavous Parang, Reza Mehvar

Pharmacy Faculty Articles and Research

The plasma and tissue disposition of two novel dextran prodrugs of methylprednisolone (MP) containing one (DMP-1) or five (DMP-5) amino acids as linkers were studied in rats. Single 5-mg/kg doses (MP equivalent) of each prodrug or MP were administered intravenously, and blood and tissue samples were collected. Prodrug and drug concentrations were quantitated using HPLC, and noncompartmental pharmacokinetic parameters were estimated. Whereas conjugation of MP with dextran in both prodrugs substantially decreased the clearance of the drug by ∼200-fold, the accumulations of the drug in the liver, spleen, and kidneys were significantly increased by conjugation. However, the extent of ...


Quantification Of Circulating Melanoma Cells, Jamie Freeman 2010 Edith Cowan University

Quantification Of Circulating Melanoma Cells, Jamie Freeman

Theses : Honours

Current prognostic techniques for Cutaneous Malignant Melanoma (CMM), a highly aggressive and drug resistant skin cancer, are inadequate at managing the disease and identifying early stage patients requiring treatment. It is thought that Circulating Tumour Cells (CTCs), which circulate in patient blood after being shed from solid tumours, may be useful in enhancing prognostic techniques and it has previously been shown in other malignancies that the presence of CTCs in patient blood is associated with poor prognosis. In CMM, CTCs can be detected through RT-PCR for melanoma associated markers, although this technique does not allow CTCs to be quantified. In ...


The Protective Effects A Full-Term Pregnancy Plays Against Mammary Carcinoma, Matthew p. Carter 2010 University of Massachusetts Amherst

The Protective Effects A Full-Term Pregnancy Plays Against Mammary Carcinoma, Matthew P. Carter

Masters Theses 1911 - February 2014

No abstract provided.


Relationships Between Jump Characteristics Of Collegiate Female Athletes Competing In Different Disciplines, Christopher J. MacDonalds, Hugh S. Lamont, John C. Garner, Jeremy A. Gentles, Ashley A. Kavanaugh, Michael H. Stone 2010 East Tennessee State University

Relationships Between Jump Characteristics Of Collegiate Female Athletes Competing In Different Disciplines, Christopher J. Macdonalds, Hugh S. Lamont, John C. Garner, Jeremy A. Gentles, Ashley A. Kavanaugh, Michael H. Stone

ETSU Faculty Works

No abstract provided.


Encapsulation Of Curcumin In O/W Nanoemulsions And Its Bioaccessibility After In Vitro Digestion, Kashif Ahmed 2010 University of Massachusetts Amherst

Encapsulation Of Curcumin In O/W Nanoemulsions And Its Bioaccessibility After In Vitro Digestion, Kashif Ahmed

Masters Theses 1911 - February 2014

The functional ingredient curcumin has a variety of biological and pharmacological actions, such as anti-tumor, anti-inflammatory, anti-virus, anti-oxidant, and anti-HIV properties coupled with low toxicity. However, curcumin possesses low bioavailability due to its poor solubility in water. The purpose of this study was to investigate the impact of different lipid-based formulations of curcumin on in vitro solubilization and bioaccessibility. Oils representing LCT, MCT, LCT:SCT mix and SCT were used to prepare O/W (nano)emulsions with droplet sizes as low as 174 nm. An in vitro digestion model simulating the small intestine milieu in the fasted and fed state ...


Athlete And Coach Knowledge, Attitudes, And Perceptions Of Sickle Cell Trait And National Collegiate Athletic Association Mandated Testing: Recommendations For Intervention, Raymona Holloway Lawrence 2010 Georgia Southern University

Athlete And Coach Knowledge, Attitudes, And Perceptions Of Sickle Cell Trait And National Collegiate Athletic Association Mandated Testing: Recommendations For Intervention, Raymona Holloway Lawrence

Electronic Theses and Dissertations

Individuals with Sickle Cell Trait have died suddenly after extreme exertion during military training, athletic practice or games (Kerle & Nishimura, 1996; Harrelson, Fincher & Robinson, 1995; Howe & Bowden, 2007). One of those deaths, Dale Lloyd, a football player at Rice University, prompted a change in the National Collegiate Athletic Association's (NCAA) Sports Medicine Handbook Guideline 3c: The Student Athlete with Sickle Cell Trait. Effective August 2010, the NCAA Division I Proposal No. 2009-75-B mandated sickle cell trait testing in all Division I athletes unless documented results of a prior test are provided to the institution or the student-athlete declines the test and signs a written release. It is well-documented that in the United States, Sickle Cell Disease/Sickle Cell Trait primarily affects African Americans more than any other race or ethnicity (NIH, 2008). Sickle cell screening programs have been scrutinized since the 1970s (Pemberton & Wailoo, 2006) because of insensitivity to race. The recent change in NCAA Guideline 3c has been scrutinized partially for the same reason. The purpose of this mixed methods study was threefold. It was necessary to 1) determine perceptions of SCT and NCAA mandated SCT testing from college coaches and athletes' points of view; 2) determine the necessary components of the Sickle Cell Orientation and Education (S.C.OR.E) intervention that will be developed to educate intercollegiate athletes, as well as their coaches, about sickle cell trait from pre-participation screening to sickle cell trait diagnosis, and 3) to highlight the potential implications of an NCAA policy that mandates SCT testing. The PRECEDE-PROCEED (PRE-PRO) model of program planning was utilized to determine the necessary components of the intervention (Green & Kreuter, 1999). Constructs ...


Periodontal Disease And Adverse Pregnancy Outcomes: Treatment Recommendations For The Pregnant Patient, Tabitha Price 2010 East Tennessee State University

Periodontal Disease And Adverse Pregnancy Outcomes: Treatment Recommendations For The Pregnant Patient, Tabitha Price

ETSU Faculty Works

No abstract provided.


Private Sector's Role In Health Service Provision In Senegal, Population Council 2010 Population Council

Private Sector's Role In Health Service Provision In Senegal, Population Council

Reproductive Health

In Senegal, private providers are a major source of health services, including contraceptive services, and private sector partnerships are a key component of the Ministry of Health strategy toward achieving national health objectives. This brief reports on SMNI/PF/PALU—a five-year USAID-bilateral project aiming to foster high-quality service delivery, and build strong links between all levels of the health system and communities, including between private and public health sectors. In Senegal, private businesses have hosted innovative advocacy activities, committed to health supplies and information management, and demonstrated a general interest in supporting a collaborative movement toward national health objectives ...


Otterfit News February 2010, Department of Health and Sport Sciences 2010 Otterbein University

Otterfit News February 2010, Department Of Health And Sport Sciences

Health and Sport Sciences Newsletter

Health, Wellness, & Programming Information for OtterFit participants


Hss Departmental Developments Winter 2010, Department of Health and Sport Sciences 2010 Otterbein University

Hss Departmental Developments Winter 2010, Department Of Health And Sport Sciences

Health and Sport Sciences Newsletter

  • Nutrition Counseling Sessions
  • HSS Annual Recognition Night
  • OtterFit
  • Updates from the Majors


Stroke Protocol And Patient Outcomes, Patricia A. Nielsen 2010 Olivet Nazarene University

Stroke Protocol And Patient Outcomes, Patricia A. Nielsen

Faculty Scholarship – Nursing

Stroke is the third leading cause of death in the United States, ranking behind “diseases of the heart” and all forms of cancer (American Stroke Association, 2007). It is also a leading cause of serious long-term disability in the United States. Despite these statistics, there is poor knowledge among both the general community and health care professionals about the nature of stroke, signs and symptoms of a stroke, and what to do in the event of a stroke. Early treatment is crucial in maximizing the benefit of stroke intervention. The purpose of this evidence-based project (EBP) at PSMH was to ...


Factors Affecting Enrolment Of Plhiv Into Art Services In India, Avina Sarna, Damodar Bachani, Mary Philip Sebastian, Ruchi Sogarwal, Madhusudana Battala 2010 Population Council

Factors Affecting Enrolment Of Plhiv Into Art Services In India, Avina Sarna, Damodar Bachani, Mary Philip Sebastian, Ruchi Sogarwal, Madhusudana Battala

HIV and AIDS

At the end of 2007, India had an estimated 2.31 million people living with HIV, and an HIV prevalence of 0.34 percent. Despite the low HIV prevalence, these statistics place India among countries with a large number of people living with HIV (PLHIV). To address the care and support needs of PLHIV, the Ministry of Health and Family Welfare, Government of India, initiated a national program in 2004 to provide free antiretroviral therapy (ART) for PLHIV. By March 2009, there were 211 functioning Antiretroviral Treatment Centers and 254 Community Care Centers across the country, and to date 217 ...


Monitoring And Evaluation Of The Emergency Plan Progress (Meepp): End-Of-Project Evaluation, Sam Kalibala 2010 Population Council

Monitoring And Evaluation Of The Emergency Plan Progress (Meepp): End-Of-Project Evaluation, Sam Kalibala

HIV and AIDS

This report evaluates the scope of the Monitoring and Evaluation of the Emergency Plan Progress (MEEPP) and the lessons learned from the project in Uganda, which aims to improve availability and quality of PEPFAR data.


Executive Summary: A Step-By-Step Guide To Strengthening Sexual Violence Services In Public Health Facilities, Jill Keesbury, Jill Thompson 2010 Population Council

Executive Summary: A Step-By-Step Guide To Strengthening Sexual Violence Services In Public Health Facilities, Jill Keesbury, Jill Thompson

Reproductive Health

This document contains an executive summary of “A step-by-step guide to strengthening sexual violence services in public health facilities: Lessons and tools from sexual violence services in Africa.” Sexual violence (SV) is a serious health and human rights problem across Africa that disproportionately affects women and girls. Survivors require comprehensive and sensitive care to mitigate the negative health consequences of SV, minimize psychological trauma, and promote long-term reintegration and recovery. Despite high levels of sexual violence and a growing recognition of the need to improve the management of rape and sexual assault, many public health facilities in Africa do not ...


Friendship's 3-Tier Healthcare System: An Innovative Approach To Delivering Healthcare To Geographically And Socially Remote Areas, Runa Khan 2010 Singapore Management University

Friendship's 3-Tier Healthcare System: An Innovative Approach To Delivering Healthcare To Geographically And Socially Remote Areas, Runa Khan

Social Space

The hardest communities to reach and treat often live in the most remote, harsh landscapes. On the nomadic islands of the Brahmaputra in Bangladesh, poor migratory communities are so cut off from urban centres that medical treatment is virtually unheard of. Runa Khan, Executive Director of Bangladeshi NGO Friendship, shares the difficult and inspired journey to build a mobile healthcare system using hospital ships, mobile clinics and community medics.


A Lifestyle Modification Program For Community Dwelling Adults With Obesity, Ashlee M. Lee, Julie A. Stolt 2010 University of North Dakota

A Lifestyle Modification Program For Community Dwelling Adults With Obesity, Ashlee M. Lee, Julie A. Stolt

Occupational Therapy Capstones

Obesity is significantly rising among adults in the United States. The Center for Disease Control (CDC, 2009e), estimates that obesity increased by 15% to 32.9% within a 20 year span (1985 – 2008). Clinical obesity is defined as having a BMI 30 and over; it is correlated with secondary complications that include hypertension, type II diabetes, osteoarthritis, cardiovascular diseases, cancers, cerebral vascular accidents, sleep apnea, and respiratory illnesses (CDC, 2009d; World Health Organization [WHO], 2009). Beyond the many health consequences caused by obesity, there are also psychosocial, genetic, and discriminatory aspects of this disease that negatively impact the quality of ...


Differentiating Dementia From Mental Illness In The Elderly: An Occupational Therapy Process, Michelle Halsted 2010 University of North Dakota

Differentiating Dementia From Mental Illness In The Elderly: An Occupational Therapy Process, Michelle Halsted

Occupational Therapy Capstones

The purpose of this product is to provide those persons admitted to a hospital setting with an unclear diagnosis the opportunity to be efficiently and accurately diagnosed, thus allowing proper treatment, medications, and placement, if needed. Often, . there is confusion amongst professionals in the treatment team as to whether an older adult may have a developing dementia versus symptoms of a mental illness. Through the evaluation process, individuals will engage in a balance of evaluative activities that may improve physical, social, emotional, spiritual, occupational, and cognitive focus areas. These evaluations are primarily based on Allen's Cognitive Model and The ...


Use Of Myofascial Release And Proprioceptive Neuromuscular Facilitation In Combination With A Rehabilitation Protocol For A Patient Following A Massive Rotator Cuff Tear And Repair: A Case Report, Bryan L. Arroyo 2010 University of North Dakota

Use Of Myofascial Release And Proprioceptive Neuromuscular Facilitation In Combination With A Rehabilitation Protocol For A Patient Following A Massive Rotator Cuff Tear And Repair: A Case Report, Bryan L. Arroyo

Physical Therapy Scholarly Projects

Background and Purpose. This case report describes the use of postoperative treatments incorporating myofascial release and proprioceptive neuromuscular techniques, on a 59-year-old male who underwent a left open rotator cuff repair following a massive rotator cuff tear. This was after an 8 week passive motion phase. The goals of this case report were to evaluate the feasibility of these techniques and to examine improvements in shoulder range of motion, function of the involved extremity, and pain reduction.

Case Description. The patient suffered a massive rotator cuff tear at work after falling on his shoulder. The patient started with an 8 ...


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