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Incidence, Risk Factors, And Prediction Of Gastrointestinal And Intracranial Bleeding In A Cohort Of Older Veterans Prescribed Oral Anticoagulants, Angela Laurio 2018 City University of New York (CUNY)

Incidence, Risk Factors, And Prediction Of Gastrointestinal And Intracranial Bleeding In A Cohort Of Older Veterans Prescribed Oral Anticoagulants, Angela Laurio

Dissertations and Theses

ABSTRACT

Incidence, Risk Factors, and Prediction of Gastrointestinal and

Intracranial Bleeding in a Cohort of Older Veterans Prescribed Oral Anticoagulants

by

Angela L. Laurio

Advisor: Marianne (Mimi) C. Fahs, PhD, MPH

Objectives:

The objectives of this dissertation were to: (1) describe and compare the incidence and odds of gastrointestinal and intracranial bleeding in veterans age 50 to 89 who were prescribed warfarin, direct oral anticoagulants, or no oral anticoagulants; (2) identify risk factors for gastrointestinal and intracranial bleeding among older veterans prescribed oral anticoagulants, and to calculate the relative risk of bleeding over time through time-to-event analysis; and (3) develop ...


June 2018, SWOSU Bulldog Wellness Committee 2018 Southwestern Oklahoma State University

June 2018, Swosu Bulldog Wellness Committee

SWOSU BULLDOG WELLNESS

No abstract provided.


Adnexal Torsion In A Patient With Müllerian Agenesis Undergoing Ovarian Stimulation: A Case Report, Erika P. New, Adrianne R. Mallen, Abigail C. Mancuso, Bradley J. Van Voorhis 2018 Department of Obstetrics and Gynecology, University of South Florida, Tampa, FL

Adnexal Torsion In A Patient With Müllerian Agenesis Undergoing Ovarian Stimulation: A Case Report, Erika P. New, Adrianne R. Mallen, Abigail C. Mancuso, Bradley J. Van Voorhis

POG In Press

Background: As assisted reproductive technologies become increasingly available to patients, more women with Müllerian agenesis may undergo ovarian stimulation and oocyte retrieval to have genetically-related offspring. The risk of ovarian torsion is increased in patients utilizing assisted reproductive technologies compared to patients who do not undergo these treatments.

Case: A 25-year-old G0 with Mayer-Rokitansky-Kuster-Hauser syndrome presented to the emergency room two days after oocyte retrieval with an acute abdomen. During laparoscopy, she was found to have torsion of her left ovary.

Summary and Conclusion: As more young women with Müllerian agenesis present for fertility treatment, this anatomically unique patient cohort ...


Palina: A Phase Ii Safety Study Of Palbociclib In Combination With Letrozole Or Fulvestrant In African American Women With Hormone Receptor Positive Her2 Negative Advanced Breast Cancer, Filipa Lynce, Mervat Saleh, Ayesha Shajahan-Haq, Christopher Gallagher, Asma Dilawari, Olwen Hahn, Maysa Abu-Khalaf, Ling Cai, Paula Pohlmann, Mahsa Mohebtash, Lois Kamugisha, Claudine Isaacs 2018 MedStar Georgetown University Hospital

Palina: A Phase Ii Safety Study Of Palbociclib In Combination With Letrozole Or Fulvestrant In African American Women With Hormone Receptor Positive Her2 Negative Advanced Breast Cancer, Filipa Lynce, Mervat Saleh, Ayesha Shajahan-Haq, Christopher Gallagher, Asma Dilawari, Olwen Hahn, Maysa Abu-Khalaf, Ling Cai, Paula Pohlmann, Mahsa Mohebtash, Lois Kamugisha, Claudine Isaacs

Department of Medical Oncology Faculty Papers

Palbociclib has been shown to be a highly effective therapy in hormone receptor positive metastatic breast cancer when used in combination with letrozole or fulvestrant. Grade 3/4 neutropenia is a common side effect although febrile neutropenia is relatively uncommon. Insufficient data exist to describe the hematological safety of palbociclib in African American women (AAW) known to have a high incidence of benign ethnic neutropenia (BEN). PALOMA 1, 2 and 3, the initial phase II/III studies that led to the U.S. Food and Drug Administration (FDA) approval of palbociclib in metastatic breast cancer, only included participants with baseline ...


Ultrasound-Guided Introital Drainage Of Pyometrocolpos, I Kim, Ranjith Vellody, Hans G. Pohl, Karun Sharma, Kabir Yadav 2018 George Washington University

Ultrasound-Guided Introital Drainage Of Pyometrocolpos, I Kim, Ranjith Vellody, Hans G. Pohl, Karun Sharma, Kabir Yadav

Radiology Faculty Publications

Pyometrocolpos can be caused by congenital malformations such as distal vaginal atresia and imperforate hymen. Patients usually present with obstructive urinary tract infections, acute kidney injury, or sepsis. Percutaneous drainage of the infected fluid can help treat the patient; however, recurrence is of concern. In this case report, we present a case of a child with recurrent pyometrocolpos due to distal vaginal atresia despite initial percutaneous drainage. To our knowledge, this is the first report of ultrasound-guided introital drainage of pyometrocolpos with relief of symptoms obviating the need for repeat drainage or immediate surgery. © 2017


Cime Newsletter : June 2018, CIME 2018 Aga Khan University

Cime Newsletter : June 2018, Cime

CIME Newsletter

- 13th AKU Ilizarov Course -Victoria
-Meet Our New Simulation Family Member
-Future Nurses and Doctors @ CIME
-Simulation in Action! -Basic Surgical Skills Workshop
-GI Endoscopy and ERCP Workshop
-Cardiology Survival Skills Workshop
-TED Talk by Sofia Babool, One of our Global Encounter students
-CIME Tours
-Clinical Simulation Educator Programme
-New Arrivals
-Breaking News!


Test Of An Interprofessional Collaborative Practice Model To Improve Obesity-Related Health Outcomes In Michigan, Jean Nagelkerk, Ramona Benkert, Brenda Pawl, Amber Myers, Lawrence J. Baer, Ann Rayford, Scott J. Berlin, Kimberly Fenbert, Holly Moore, Mark Armstrong, Drew Murray, Phyllis D. Boone, Sandra Masselink, Carly Jakstys 2018 Grand Valley State University

Test Of An Interprofessional Collaborative Practice Model To Improve Obesity-Related Health Outcomes In Michigan, Jean Nagelkerk, Ramona Benkert, Brenda Pawl, Amber Myers, Lawrence J. Baer, Ann Rayford, Scott J. Berlin, Kimberly Fenbert, Holly Moore, Mark Armstrong, Drew Murray, Phyllis D. Boone, Sandra Masselink, Carly Jakstys

Funded Articles

The purpose of the study was to test the effectiveness of an interprofessional collaborative practice (IPCP) education program on clinicians' and students' knowledge and attitudes toward IPCP and to determine the effectiveness of an IPCP weight loss program in two nurse-managed centers. The study team used the Midwest Interprofessional Practice, Education, and Research Center (MIPERC) collaborative practice education program that consists of online learning modules followed by daily huddles and collaborative care planning. The obesity intervention program was implemented by faculty and staff practitioners and students in two clinics with very different patient populations (community residents and college students). Staff ...


Letter From The Editors, Administrative Issues Journal Editors 2018 Southwestern Oklahoma State University

Letter From The Editors, Administrative Issues Journal Editors

Administrative Issues Journal

The Summer 2018 issue of the AIJ focuses on challenges and opportunities in our educational system.


School Board Governance In Changing Times: A School’S Transition To Policy Governance, Katherine Curry, Sean Kinder, Tania Benoiton, Jessica Noonan 2018 Oklahoma State University, Stillwater

School Board Governance In Changing Times: A School’S Transition To Policy Governance, Katherine Curry, Sean Kinder, Tania Benoiton, Jessica Noonan

Administrative Issues Journal

The expansion of the school choice movement and greater flexibility allowed by Every Student Succeeds Act (ESSA) means that education governance is emerging as an important issue for school effectiveness. This longitudinal case study sought to gain an understanding of the implementation of a new governance structure, Policy Governance, in a private, independent school with deeply entrenched culture and patterns of behavior. Findings suggest an immediate positive influence on leadership and culture in the district, including a “trickle down” effect on shared leadership. However, challenges to sustainability indicate that even strict adherence to the model, unanimous support among board members ...


Enhancing The Cultural Competency Of Prospective Leaders Via A Study Abroad Experience, Douglas Hermond, Mathias R. Vairez, Jr., Tyrone Tanner 2018 Prairie View A&M University, TX

Enhancing The Cultural Competency Of Prospective Leaders Via A Study Abroad Experience, Douglas Hermond, Mathias R. Vairez, Jr., Tyrone Tanner

Administrative Issues Journal

The purpose of this investigation was to determine whether an experiential learning opportunity, specifically a study tour experience, would improve the cultural intelligence of prospective educational leaders and would challenge them to expand their own cultural understanding and behavior. Several prospective leaders who enrolled in a graduate program in Educational Leadership volunteered to attend a study abroad program that was intended, in part, to enhance their cultural competence. They were then asked to complete a survey that measured the four domains of cultural intelligence, namely metacognition, cognition, motivation and behavior. They were also asked to respond to prompts about how ...


Developing The Capacity Of Culturally Competent Leaders To Redress Inequitable Outcomes: Increasing Opportunities For Historically Marginalized Students, Sheri Williams 2018 University of New Mexico, Albuquerque

Developing The Capacity Of Culturally Competent Leaders To Redress Inequitable Outcomes: Increasing Opportunities For Historically Marginalized Students, Sheri Williams

Administrative Issues Journal

Objective: This study investigated the practices and impact of interdisciplinary faculty at a flagship university in the American Southwest who were engaged in the process of redesigning curriculum in order to center candidates on what they need to know and do as culturally competent school leaders.

Method: Participants were 31 interdisciplinary faculty involved in preparing candidates for leadership in early childhood and elementary and secondary education, in diverse contexts including high need and Native American-serving schools. The qualitative study utilized document analysis of faculty’s multi-year work in developing the capacity of candidates to increase opportunities for historically marginalized students ...


Pituitary Tuberculoma, Amir Humza Sohail, Umar Farooq Bhatti, Najmul Islam 2018 Aga Khan University

Pituitary Tuberculoma, Amir Humza Sohail, Umar Farooq Bhatti, Najmul Islam

Section of Diabetes, Endocrinology and Metabolism

Tuberculosis rarely involves the hypothalamo-pituitary region and constitutes only 1% of the lesions involving the sellar and/or suprasellar region. Coleman and Meredith first reported pituitary tuberculosis in 1940, and only a handful of cases have been reported ever since. It may manifest as a chiasmal syndrome due to compression of the optic chiasm or as hypopituitarism due to pituitary destruction. It has a characteristic radiological appearance and can mimic a pituitary adenoma. Diagnostic procedures, such as trans-sphenoidal biopsy, are crucial for accurate diagnosis. We report a case of a 32-year male, who presented with complaints of headache and decreased ...


“Your Fears Are Appreciated Here”: Exploring A Humanistic Approach To Public Speaking Instruction, Justin D. Walton 2018 Cameron University, OK

“Your Fears Are Appreciated Here”: Exploring A Humanistic Approach To Public Speaking Instruction, Justin D. Walton

Administrative Issues Journal

Communication teachers have long been concerned with the development of students’ oral communication competencies. Regrettably, public speaking remains one of the most feared communicative contexts. Though there has been extensive interest in cognitive/behavioral strategies for alleviating communication apprehension, there has been surprisingly little descriptive pedagogical research conducted on the subject within actual classroom settings. This qualitative case study examines the way one communication teacher dealt with issues of student reticence and fear in her introductory public speaking courses through the use of humanistic, student-centered principles. Findings reveal that her pedagogy emphasized (a) the expression of feelings and emotions, (b ...


Amniotic Fluid Embolism, Nadia Nawaz, Ahmed Raheem Buksh 2018 Aga Khan University

Amniotic Fluid Embolism, Nadia Nawaz, Ahmed Raheem Buksh

Department of Obstetrics & Gynaecology

Amniotic fluid embolism is a rare and severe problem in obstetric patients. We experienced a 21-year primigravida who underwent emergency cesarean section due to sudden collapse and fetal distress after rupture of membranes in labour. Subsequently, she developed intraoperative coagulopathy, hemorrhage, hypotension, and respiratory collapse requiring ventilation. Both maternal and neonatal lives were saved with full recovery and discharged in stable condition. The clinical diagnosis of amniotic fluid embolism (AFE) was made, which is a very rare complication of pregnancy/puerperium with varying presentation, ranging from cardiac arrest, circulatory collapse and death through mild degrees of organ system dysfunction with ...


Triad3a Induces The Degradation Of Early Necrosome To Limit Ripk1-Dependent Cytokine Production And Necroptosis., Norah A. Alturki, Scott McComb, Ardeshir Ariana, Dikchha Rijal, Robert G. Korneluk, Shao-Cong Sun, Emad S Alnemri, Subash Sad 2018 University of Ottawa; King Saud University

Triad3a Induces The Degradation Of Early Necrosome To Limit Ripk1-Dependent Cytokine Production And Necroptosis., Norah A. Alturki, Scott Mccomb, Ardeshir Ariana, Dikchha Rijal, Robert G. Korneluk, Shao-Cong Sun, Emad S Alnemri, Subash Sad

Department of Biochemistry and Molecular Biology Faculty Papers

Understanding the molecular signaling in programmed cell death is vital to a practical understanding of inflammation and immune cell function. Here we identify a previously unrecognized mechanism that functions to downregulate the necrosome, a central signaling complex involved in inflammation and necroptosis. We show that RipK1 associates with RipK3 in an early necrosome, independent of RipK3 phosphorylation and MLKL-induced necroptotic death. We find that formation of the early necrosome activates K48-ubiquitin-dependent proteasomal degradation of RipK1, Caspase-8, and other necrosomal proteins. Our results reveal that the E3-ubiquitin ligase Triad3a promotes this negative feedback loop independently of typical RipK1 ubiquitin editing enzymes ...


Effect Of Putative Mitokatp Channel Blocker On Lipopolysaccharide-Induced Effects In Human Umbilical Vein Endothelial Cells, Indranie Ramsaroop 2018 Philadelphia College of Osteopathic Medicine

Effect Of Putative Mitokatp Channel Blocker On Lipopolysaccharide-Induced Effects In Human Umbilical Vein Endothelial Cells, Indranie Ramsaroop

PCOM Biomedical Studies Student Scholarship

Heart failure and high mortality rates are associated with severe sepsis. Recently, focus has been on mitochondrial ultrastructural changes and function due to sepsis and sepsis-related pathologies. Chopra et al. (2011) has provided data showing the involvement of the mitochondrial-mediated intrinsic apoptosis cascade in regulating adult rat ventricular myocyte (ARVM) dysfunction in sepsis. Experimental endotoxemia has shown mitochondrial membrane potential collapse, membrane permeability changes and release of cytochrome C to be indicators of mitochondrial dysfunction. Outer mitochondrial membrane (OMM) permeability is controlled by Bax translocation, resulting Voltage Dependent Anion Channels (VDACs) pores in the OMM and activation of mitoKATP channels ...


Quantifying Bias In Measuring Insecticide-Treated Bednet Use: Meta-Analysis Of Self-Reported Vs Objectively Measured Adherence, Paul J. Krezanoski, David R. Bangsberg, Alexander C. Tsai 2018 Zuckerberg San Francisco General Hospital

Quantifying Bias In Measuring Insecticide-Treated Bednet Use: Meta-Analysis Of Self-Reported Vs Objectively Measured Adherence, Paul J. Krezanoski, David R. Bangsberg, Alexander C. Tsai

OHSU-PSU School of Public Health Faculty Publications and Presentations

Background Insecticide-treated bednets (ITNs) are recommended for use by 3.4 billion people at risk of malaria world-wide. Policy makers rely on measurements of ITN use to optimize malaria prevention efforts. Self-reports are the most common means of assessing ITN use, but self-reports may be biased in a way that reduces their reliability as a proxy for ITN adherence. This meta-analysis compared self-reported and two methods which are more objective measures of ITN use to explore whether self-reports overestimate actual ITN adherence.

Methods A comprehensive search of electronic databases and hand searching reference lists resulted in screening 2885 records and ...


Fracture Liaison Services Improve Outcomes Of Patients With Osteoporosis-Related Fractures: A Systematic Literature Review And Meta-Analysis, Chih-Hsing Wu, Shih-Te Tu, Yin-Fan Chang, Ding-Cheng Chan, Jui-Teng Chien, Chih-Hsueh Lin, Sonal Singh, Manikanta Dasari, Jung-Fu Chen, Keh-Sung Tsai 2018 National Cheng Kung University

Fracture Liaison Services Improve Outcomes Of Patients With Osteoporosis-Related Fractures: A Systematic Literature Review And Meta-Analysis, Chih-Hsing Wu, Shih-Te Tu, Yin-Fan Chang, Ding-Cheng Chan, Jui-Teng Chien, Chih-Hsueh Lin, Sonal Singh, Manikanta Dasari, Jung-Fu Chen, Keh-Sung Tsai

Open Access Articles

OBJECTIVES: This systematic review and meta-analysis evaluated the outcomes of patients with osteoporosis-related fractures managed through fracture liaison services (FLS) programs.

METHODS: Medline, PubMed, EMBASE, and the Cochrane Library were searched (January 2000-February 2017 inclusive) using the keywords 'osteoporosis', 'fractures', 'liaison', and 'service' to identify randomised controlled trials and observational studies of patients aged > /=50years with osteoporosis-related fractures in hospital, clinic, community, or home-based settings who were managed using FLS. Risk of bias was assessed at outcome level. Meta-analysis followed a random-effects and fixed-effects model. Outcomes of interest were incidence of bone mineral density (BMD) testing, treatment initiation, adherence, re-fractures ...


Global Surgery – Informing National Strategies For Scaling Up Surgery In Sub-Saharan Africa., Jakub Gajewski, Leon Bijlmakers, Ruairi F. Brugha 2018 Royal College of Surgeons in Ireland

Global Surgery – Informing National Strategies For Scaling Up Surgery In Sub-Saharan Africa., Jakub Gajewski, Leon Bijlmakers, Ruairi F. Brugha

Epidemiology and Public Health Medicine Articles

Surgery has the potential to address one of the largest, neglected burdens of disease in low- and middle-income countries (LMICs), especially in sub-Saharan Africa (SSA). The Lancet Commission on Global Surgery (LCoGS) has provided a blueprint for a systems approach to making safe emergency and elective surgery accessible and affordable and has started to enable African governments to develop national surgical plans. This editorial outlines an important gap, which is the need for surgical systems research, especially at district hospitals which are the first point of surgical care for rural communities, to inform the implementation of country plans. Using the ...


Ephrinb3 Modulates Hippocampal Neurogenesis And The Reelin Signaling Pathway In A Pilocarpineinduced Model Of Epilepsy, Tian-Tian Liu, Yi Li, Yi Shu, Bo Xiao, Li Feng 2018 Central South University

Ephrinb3 Modulates Hippocampal Neurogenesis And The Reelin Signaling Pathway In A Pilocarpineinduced Model Of Epilepsy, Tian-Tian Liu, Yi Li, Yi Shu, Bo Xiao, Li Feng

Open Access Articles

EphrinB3 is important in the regulation of cell proliferation, differentiation and migration via cellcell contact, and can activate the reelin pathway during brain development. However, the effect of ephrinB3 on hippocampal neurogenesis and the reelin pathway in epilepsy remains to be fully elucidated. In the present study, the expression of ephrinB3 in pilocarpineinduced status epilepticus (SE) rats was investigated. SYBR Greenbased reverse transcriptionquantitative polymerase chain reaction analysis, immunohistochemical labeling and western blot analysis were used to detect the gene and protein expression levels of ephrinB3 and reelin pathway proteins. Immunofluorescence staining of doublecortin (DCX) was utilized to analyze hippocampal neurogenesis ...


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