The Effect Of An Incline Walking Surface And The Contribution Of Balance On Spatiotemporal Gait Parameters Of Older Adults, Richard A. Ferraro
Seton Hall University Dissertations and Theses (ETDs)
Athlete And Coach Knowledge, Attitudes, And Perceptions Of Sickle Cell Trait And National Collegiate Athletic Association Mandated Testing: Recommendations For Intervention, 2010 Georgia Southern University
Athlete And Coach Knowledge, Attitudes, And Perceptions Of Sickle Cell Trait And National Collegiate Athletic Association Mandated Testing: Recommendations For Intervention, Raymona Holloway Lawrence
Electronic Theses and Dissertations
Individuals with Sickle Cell Trait have died suddenly after extreme exertion during military training, athletic practice or games (Kerle & Nishimura, 1996; Harrelson, Fincher & Robinson, 1995; Howe & Bowden, 2007). One of those deaths, Dale Lloyd, a football player at Rice University, prompted a change in the National Collegiate Athletic Association's (NCAA) Sports Medicine Handbook Guideline 3c: The Student Athlete with Sickle Cell Trait. Effective August 2010, the NCAA Division I Proposal No. 2009-75-B mandated sickle cell trait testing in all Division I athletes unless documented results of a prior test are provided to the institution or the student-athlete declines the test and signs a written release. It is well-documented that in the United States, Sickle Cell Disease/Sickle Cell Trait primarily affects African Americans more than any other race or ethnicity (NIH, 2008). Sickle cell screening programs have been scrutinized since the 1970s (Pemberton & Wailoo, 2006) because of insensitivity to race. The recent change in NCAA Guideline 3c has been scrutinized partially for the same reason. The purpose of this mixed methods study was threefold. It was necessary to 1) determine perceptions of SCT and NCAA mandated SCT testing from college coaches and athletes' points of view; 2) determine the necessary components of the Sickle Cell Orientation and Education (S.C.OR.E) intervention that will be developed to educate intercollegiate athletes, as well as their coaches, about sickle cell trait from pre-participation screening to sickle cell trait diagnosis, and 3) to highlight the potential implications of an NCAA policy that mandates SCT testing. The PRECEDE-PROCEED (PRE-PRO) model of program planning was utilized to determine the necessary components of the intervention (Green & Kreuter, 1999). Constructs ...
Leadership Safe Practices Snd Their Relationship With Hospital Deployment Of The Medication Reconciliation Innovation, Lance L. Roberts
Theses and Dissertations
Within the last decade there has been considerable national attention focused upon hospital quality and patient safety performance. Improvements in performance have been realized, but the rate of improvement has been slow. There is an increasing consensus that new ideas and national strategies are needed to accelerate improvement efforts in addressing quality/safety issues. Currently, within the hospital setting more attention is being paid to the role of leadership starting with the board of trustees in addressing gaps in performance. Organization-wide awareness of critical gaps in performance, accountability structures, and organizational ability are considered critical facilitators of improvement efforts. The ...
Dynamics Of The Rapsyn Scaffolding Protein At The Neuromuscular Junction Of Live Mice, 2010 University of Pennsylvania
Dynamics Of The Rapsyn Scaffolding Protein At The Neuromuscular Junction Of Live Mice, Emile Bruneau, Mohammed Akaaboune
Departmental Papers (ASC)
The efficacy of synaptic transmission depends on the maintenance of a high density of neurotransmitter receptors and their associated scaffold proteins in the postsynaptic membrane. While the dynamics of receptors has been extensively studied, the dynamics of the intracellular scaffold proteins that make up the postsynaptic density are largely unknown in vivo. Here, we focused on the dynamics of rapsyn, a protein required for the clustering and maintenance of acetylcholine receptor (AChR) density at postsynaptic sites. Using time-lapse imaging, we demonstrated that rapsyn is remarkably dynamic compared to AChRs at functional synapses, turning over 4–6 times more rapidly than ...
Economic Assessment Of Children’S Health And The Environment In Maine, 2010 Tufts University
Economic Assessment Of Children’S Health And The Environment In Maine, Mary E. Davis
Maine Policy Review
Reducing children’s exposure to environmental toxins is important for both moral and economic reasons. Mary Davis discusses the economic impact of environmentally related childhood illnesses in Maine, focusing on disease categories with fairly strong evidence connecting environmental pollution to childhood diseases: lead poisoning, asthma, neurobehavioral disorders, and cancer. Lead poisoning and neurobehavioral conditions are the most expensive because they lead to chronic diseases that are largely incurable and not easily treated. She concludes that state funding for initiatives aimed at reducing childhood exposure to environmental pollutants “would be money well spent.”
Neuromuscular Adaptations During Perturbations In Individuals With And Without Bilateral Vestibular Loss, Nora Havlik Riley
Theses and Dissertations
Approximately 20% of the general population is affected by a vestibular disorder. Vestibular dysfunction is recognized as an important intrinsic factor leading to falls. Despite research on balance strategies with platform perturbations, limited information exists on neuromuscular performance of the knee with perturbations during functional tasks. Improved understanding of the effects of BVL on neuromuscular control of the knee will aid researchers and clinicians in developing rehabilitation programs that address the adaptations and balance deficits that occur with vestibular loss. Hence, the main purpose was to examine accuracy of performance, knee muscle activation patterns and long latency responses in response ...
Comparative Validity Of Mmpi-A Scales Scores In African American And Caucasian Male Juvenile Delinquents, 2010 Old Dominion University
Comparative Validity Of Mmpi-A Scales Scores In African American And Caucasian Male Juvenile Delinquents, Stacy Natasha Wilson
Psychology Theses & Dissertations
This study examined comparative validity of the MMPI-A scale scores of African American and Caucasian male juvenile delinquents utilizing a step down hierarchical regression procedure proposed by Laughtenschlager & Mendoza (1986). The MMPI-A (Butcher et al., 1992) was administered to 281 African American and Caucasian juvenile delinquents while their caretakers filled out the CBCL (Achenbach, 1991; Achenbach & Rescorla, 2001) and DBRS (Barkley & Murphy, 1998), which were used as extra-test measures. Significant overall prediction bias was detected in 15 out of 56 regressions. Statistically significant prediction bias was found for a subset of criterion variables for Clinical Scales 2, 4, and 9, as well as Content Scales A-dep, A-hea, A-ang, and A-con and Supplementary Scale IMM. Slope bias was found for A-hea with "DSM-Oriented Somatic Problems". Statistically significant intercept ...
Inpatient Group Psychotherapy: Predicting Attendance And Participation, 2010 Old Dominion University
Inpatient Group Psychotherapy: Predicting Attendance And Participation, Sharon E. Silverberg
Counseling & Human Services Theses & Dissertations
Inpatient group psychotherapy is one of the primary talk therapy interventions offered to patients necessitating acute psychiatric treatment. Research indicates that patients who attend and participate in group psychotherapy sessions while admitted to psychiatric hospitals have a lower rate of recidivism and are more successful in the community utilizing lower levels of psychiatric care. Unfortunately, not all patients attend group psychotherapy while admitted to a psychiatric facility and therefore do not benefit, possibly contributing to non-compliance with community-based treatment and readmissions to inpatient psychiatric institutions for stabilization and safety. This lack of participation in group psychotherapy deprives the patient the ...
Student Empathy: A Learning Experience, 2010 Western Kentucky University
Student Empathy: A Learning Experience, Sherry R. Lovan
Nursing Faculty Publications
A class of senior students in a community nursing course wrote Dear Diary journal entries that conveyed a deep understanding of empathy. This assignment served to connect the students with people in different stages of life. The Dear Diary journal entries provide an example to effectively demonstrate how classroom assignments can encourage students to place themselves in another’s shoes, the basis for empathy.
The Association Between Parental Perceptions Of Children's Residential Mental Health Treatment And The Parent-Child Relationship, Susanne Elizabeth Preston
Counseling & Human Services Theses & Dissertations
Residential mental health treatment for children as an intervention for children is increasing, potentially affecting the relationship within families. The purpose of this study was to examine the parental perspectives of the associations between the parent-child relationship and children's residential mental health treatment. This study explored parental perspectives of specific aspects of the parent-child relationship: parental support, satisfaction with parenting, parental involvement, communication, and limit setting-and the association between these aspects and the child's residential mental health treatment. Paired samples t-tests were conducted; resulting in statistically significant changes on all scales measured, with varying effect sizes. Results ...
Purines And The Anti-Epileptic Actions Of Ketogenic Diets, 2010 Trinity College
Purines And The Anti-Epileptic Actions Of Ketogenic Diets, Susan A. Masino, Masahito Kawamura Jr., David N. Ruskin, Jeremy Gawryluk, Xuesong Chen, Jonathan D. Geiger
Ketogenic diets are high in fat and low in carbohydrates and represent a well-established and effective treatmentalternative to anti-epileptic drugs. Ketogenic diets are used for the management of a variety of difficult-to-treat or intractableseizure disorders, especially pediatric refractory epilepsy. However, it has been shown that this dietary therapycan reduce seizures in people of all ages, and ketogenic diets are being applied to other prevalent medical conditions suchas diabetes. Although used effectively to treat epilepsy for nearly 90 years, the mechanism(s) by which ketogenic dietswork to reduce seizures remain ill-understood. One mechanism receiving increased attention is based on findings that ...
Microarray Analysis Of Paramecium Bursaria Chlorella Virus 1 Transcription, 2010 University of Nebraska-Lincoln
Microarray Analysis Of Paramecium Bursaria Chlorella Virus 1 Transcription, Giane M. Yanai-Balser, Garry A. Duncan, James D. Eudy, Dong Wang, Xiao Li, Irina V. Agarkova, David D. Dunigan, James L. Van Etten
James Van Etten Publications
Paramecium bursaria chlorella virus 1 (PBCV-1), a member of the family Phycodnaviridae, is a large doublestranded DNA, plaque-forming virus that infects the unicellular green alga Chlorella sp. strain NC64A. The 330-kb PBCV-1 genome is predicted to encode 365 proteins and 11 tRNAs. To monitor global transcription during PBCV-1 replication, a microarray containing 50-mer probes to the PBCV-1 365 protein-encoding genes (CDSs) was constructed. Competitive hybridization experiments were conducted by using cDNAs from poly(A)- containing RNAs obtained from cells at seven time points after virus infection. The results led to the following conclusions: (i) the PBCV-1 replication cycle is temporally ...
Crystal Structure Of A Virus-Encoded Putative Glycosyltransferase, 2010 Purdue University
Crystal Structure Of A Virus-Encoded Putative Glycosyltransferase, Yi Xiang, Ulrich Baxa, Ying Zhang, Alasdair C. Steven, Gentry L. Lewis, James L. Van Etten, Michael G. Rossmann
James Van Etten Publications
The chloroviruses (family Phycodnaviridae), unlike most viruses, encode some, if not most, of the enzymes involved in the glycosylation of their structural proteins. Annotation of the gene product B736L from chlorovirus NY-2A suggests that it is a glycosyltransferase. The structure of the recombinantly expressed B736L protein was determined by X-ray crystallography to 2.3-Å resolution, and the protein was shown to have two nucleotide-binding folds like other glycosyltransferase type B enzymes. This is the second structure of a chlorovirus-encoded glycosyltransferase and the first structure of a chlorovirus type B enzyme to be determined. B736L is a retaining enzyme and belongs ...
Human Platelets Recognize A Novel Surface Protein, Pada, On Streptococcus Gordonii Through A Unique Interaction Involving Fibrinogen Receptor Gpiibiiia., Helen J. Petersen, Ciara Keane, Howard F. Jenkinson, M Margaret Vickerman, Amy Jesionowski, Janet C. Waterhouse, Dermot Cox, Steven W. Kerrigan
School of Pharmacy Articles
The concept of an infectious agent playing a role in cardiovascular disease is slowly gaining attention. Among several pathogens identified, the oral bacterium Streptococcus gordonii has been implicated as a plausible agent. Platelet adhesion and subsequent aggregation are critical events in the pathogenesis and dissemination of the infective process. Here we describe the identification and characterization of a novel cell wall-anchored surface protein, PadA (397 kDa), of S. gordonii DL1 that binds to the platelet fibrinogen receptor GPIIbIIIa. Wild-type S. gordonii cells induced platelet aggregation and supported platelet adhesion in a GPIIbIIIa-dependent manner. Deletion of the padA gene had no ...
Differential Growth Of The Frontonasal Suture In Rabbits, 2010 University of Iowa
Differential Growth Of The Frontonasal Suture In Rabbits, Maura Josephine Vroman
Theses and Dissertations
The purpose of this study was to substantiate previous claims that differential growth across the frontonasal suture occurs and if this differential growth pattern is caused by an increased mitotic rate of the nasal bone.
Two six week old New Zealand White Rabbits were given calcein 20mg/kg IA, demeclocycline 20mg/kg IA, and BrdU 40mg/kg IA on Days 1, 11, and 14, respectively. The animals were euthanized using Ketamine 31.6mg/kg IM and Pentobarbital 100mg/kg IV. The frontonasal suture was removed from the rabbit and divided into hemisections. The right hemisection was histologically processed using standard ...
Pk/Pd Modelling Of Comb-Shaped Pegylated Salmon Calcitonin Conjugates Of Differing Molecular Weights, 2010 Technological University Dublin
Pk/Pd Modelling Of Comb-Shaped Pegylated Salmon Calcitonin Conjugates Of Differing Molecular Weights, Sinead Ryan, Jesus Maria Frias, David H. Haddleton, David J. Brayden
Salmon calcitonin (sCT) was conjugated via cysteine-1 to novel combed-shaped end-functionalised poly(PEG) methyl ether methacrylate) (sCT-P) comb-shaped polymers, to yield conjugates of total molecular weights (MW) inclusive of sCT: 6.5, 9.5, 23 and 40 kDa. The conjugates were characterised by HPLC and their in vitro and in vivo bioactivity was measured by cAMP assay on human T47D cells and following intravenous (i.v.) injection to rats, respectively. Stability against endopeptidases, rat serum and liver homogenates was assessed. There were linear and exponential relationships between conjugate MW with potency and efficacy respectively, however the largest MW conjugate still ...
Successful Use Of Rituximab In Evans Syndrome And Refractory Immune Thrombocytopenic Purpura, 2010 Aga Khan University
Successful Use Of Rituximab In Evans Syndrome And Refractory Immune Thrombocytopenic Purpura, Muhammad Kashif, Adnan Qureshi, Salman Naseem Adil, Mohammad Khurshid
Department of Pathology and Laboratory Medicine
Immune cytopenias are mediated by auto-antibodies produced by B-lymphocytes. Conventional treatment of immune-mediated haematological disorders includes immunosuppression with steroids and other immune modulating therapies and in some refractory cases, splenectomy. Response rates to conventional and second-line agents are variable and a proportion of patients require lifelong immunosuppression to maintain the disease in remission. Rituximab, an anti- CD 20 monoclonal antibody has gained widespread acceptance in the management of B-cell malignancies. Additionally, it has been used to treat the disorders associated with autoantibody production. We report herein the successful use of Rituximab in the treatment of two patients with autoimmune cytopenias ...
Genetic Diversity Among Plasmodium Falciparum Field Isolates In Pakistan Measured With Pcr Genotyping Of The Merozoite Surface Protein 1 And 2, Najia Ghanchi, Andreas Martensson, Johan Ursing, Sana Jafri, Sandor Bereczky, Rabia Hussain, Mohammad Asim Beg
Department of Pathology and Laboratory Medicine
Background:The genetic diversity of Plasmodium falciparum has been extensively studied in various parts of the world. However, limited data are available from Pakistan. This study aimed to establish molecular characterization of P. falciparum field isolates in Pakistan measured with two highly polymorphic genetic markers, i.e. the merozoite surface protein 1 (msp-1) and 2 (msp-2).
Methods:Between October 2005 and October 2007, 244 blood samples from Patients with symptomatic blood-slide confirmed P. falciparum mono-infections attending the Aga Khan University Hospital, Karachi, or its collection units located in Sindh and Baluchistan provinces, Pakistan were collected. The genetic diversity of P ...
Resolution Of Clinical Signs In Trauma Intensive Care Unit Patients Following Diagnosis Of Ventilator-Associated Pneumonia, Kathryn A. Connor, Joseph M. Swanson, G. Christopher Wood, Bradley A. Boucher, Louis J. Magnotti
Pharmacy Faculty/Staff Publications
PURPOSE: The ATS/IDSA Ventilator-Associated Pneumonia (VAP) guidelines suggest that clinical improvement of VAP should be apparent within 3-6 days. Anecdotally, such improvement has not been noted in trauma patients at our institution. The current study was conducted to evaluate resolution of clinical signs of VAP following diagnosis.
METHODS: Critically injured adults admitted to the trauma intensive care unit (TICU) from 6/1/06-12/31/07 and subsequently diagnosed with VAP were retrospectively reviewed. Clinical signs, including derangements of maximum temperature (Tmax), white blood cell (WBC) count and Pa02/FiO2, were evaluated on days 1-16 following VAP diagnosis. Data are ...
Hormone And Adpokine Alterations Across Eleven Weeks Of Training In Division I Collegiate Throwers: An Exploratory Study, 2010 West Virginia University
Hormone And Adpokine Alterations Across Eleven Weeks Of Training In Division I Collegiate Throwers: An Exploratory Study, W. Guy Hornsby, Christian R. Carter, Guy Gregory Haff, Micheal R. Ramsey, Andy R. Dotterweich, N. Travis Triplett, Charles A. Stuart, Margaret E. Stone, Michael H. Stone
ETSU Faculty Works
Conceptually, it is important to understand the underlying physiological mechanisms of any training program model. This understanding aids the coach/sport scientist in making better choices in manipulating variables in formulating the training model. These underlying mechanisms can be associated with training variable manipulation and fatigue management aspects as well as the overall health of the athlete. Hormone and cytokine concentrations can be linked to alterations resulting from the manipulation of training variables and to subsequent alterations in performance (Haff et al., 2008; Ishigaki et al., 2005; Jurimae et al., 2010; Stone et al., 2007). For example, alterations in the ...