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Bioelectric Applications For Treatment Of Melanoma, Stephen J. Beebe, Karl H. Schoenbach, Richard Heller 2010 Old Dominion University

Bioelectric Applications For Treatment Of Melanoma, Stephen J. Beebe, Karl H. Schoenbach, Richard Heller

Bioelectrics Publications

Two new cancer therapies apply bioelectric principles. These methods target tumor structures locally and function by applying millisecond electric fields to deliver plasmid DNA encoding cytokines using electrogene transfer (EGT) or by applying rapid rise-time nanosecond pulsed electric fields (nsPEFs). EGT has been used to locally deliver cytokines such as IL-12 to activate an immune response, resulting in bystander effects. NsPEFs locally induce apoptosis-like effects and affect vascular networks, both promoting tumor demise and restoration of normal vascular homeostasis. EGT with IL-12 is in melanoma clinical trials and nsPEFs are used in models with B16F10 melanoma in vitro and in ...


Variable Number Of Tandem Repeat Polymorphisms (Vntrs) In The Acan Gene Associated With Pectus Excavatum, Michael W. Stacey, Serina Neumann, Ashley Dooley, Kara Segna, Robert Kelly, Donald Nuss, Anne Kuhn, Michael Goretsky, Annie Fecteau, Aimee Pastor, Virginia Proud 2010 Old Dominion University

Variable Number Of Tandem Repeat Polymorphisms (Vntrs) In The Acan Gene Associated With Pectus Excavatum, Michael W. Stacey, Serina Neumann, Ashley Dooley, Kara Segna, Robert Kelly, Donald Nuss, Anne Kuhn, Michael Goretsky, Annie Fecteau, Aimee Pastor, Virginia Proud

Bioelectrics Publications

No abstract provided.


Folic Acid Source, Usual Intake, And Folate And Vitamin B-12 Status In Us Adults: National Health And Nutrition Examination Survey (Nhanes) 2003–2006, Quanhe Yang, Mary E. Cogswell, Heather C. Hamner, Alicia L. Carriquiry, Christine M. Pfeiffer, Robert J. Berry 2010 Centers for Disease Control and Prevention

Folic Acid Source, Usual Intake, And Folate And Vitamin B-12 Status In Us Adults: National Health And Nutrition Examination Survey (Nhanes) 2003–2006, Quanhe Yang, Mary E. Cogswell, Heather C. Hamner, Alicia L. Carriquiry, Christine M. Pfeiffer, Robert J. Berry

Statistics Publications

Background: US adults have access to multiple sources of folic acid. The contribution of these sources to usual intakes above the tolerable upper intake level (UL) (1000 ug/d) and to folate and vitamin B-12 status is unknown. Objective: The objective was to estimate usual folic acid intake above the UL and adjusted serum and red blood cell folate, vitamin B-12, methylmalonic acid, and homocysteine concentrations among US adults by 3 major folic acid intake sources - enriched cereal-grain products (ECGP), ready-to-eat cereals (RTE), and supplements (SUP) - categorized into 4 mutually exclusive consumption groups. Design: We used data from the National ...


Three-Phase Model Harmonizes Estimates Of The Maximal Suppression Of Parathyroid Hormone By 25-Hydroxyvitamin D In Persons 65 Years Of Age And Older, Ramon A. Durazo-Arvizu, Bess Dawson-Hughes, Christopher T. Sempos, Elizabeth A. Yetley, Anne C. Looker, Guichan Cao, Susan S. Harris, Vicki L. Burt, Alicia L. Carriquiry, Mary Frances Picciano 2010 Loyola University Chicago

Three-Phase Model Harmonizes Estimates Of The Maximal Suppression Of Parathyroid Hormone By 25-Hydroxyvitamin D In Persons 65 Years Of Age And Older, Ramon A. Durazo-Arvizu, Bess Dawson-Hughes, Christopher T. Sempos, Elizabeth A. Yetley, Anne C. Looker, Guichan Cao, Susan S. Harris, Vicki L. Burt, Alicia L. Carriquiry, Mary Frances Picciano

Statistics Publications

The concentration or threshold of 25-hydroxyvitamin D [25(OH)D] needed to maximally suppress intact serum parathyroid hormone (iPTH) has been suggested as a measure of optimal vitamin D status. Depending upon the definition of maximal suppression of iPTH and the 2-phase regression approach used, 2 distinct clusters for a single 25(OH)D threshold have been reported: 16-20 ng/mL (40-50 nmol/L) and 30-32 ng/mL (75-80 nmol/L). To rationalize the apparently disparate published results, we compared thresholds from several regression models including a 3-phase one to estimate simultaneously 2 thresholds before and after adjusting for possible ...


Unique Genome-Wide Transcriptome Profiles Of Chicken Macrophages Exposed To Salmonella-Derived Endotoxin, Ceren Ciraci, Christopher K. Tuggle, Michael J. Wannemeuhler, Dan Nettleton, Susan J. Lamont 2010 Iowa State University

Unique Genome-Wide Transcriptome Profiles Of Chicken Macrophages Exposed To Salmonella-Derived Endotoxin, Ceren Ciraci, Christopher K. Tuggle, Michael J. Wannemeuhler, Dan Nettleton, Susan J. Lamont

Statistics Publications

Background: Macrophages play essential roles in both innate and adaptive immune responses. Bacteria require endotoxin, a complex lipopolysaccharide, for outer membrane permeability and the host interprets endotoxin as a signal to initiate an innate immune response. The focus of this study is kinetic and global transcriptional analysis of the chicken macrophage response to in vitro stimulation with endotoxin from Salmonella typhimurium-798.

Results: The 38535-probeset Affymetrix GeneChip Chicken Genome array was used to profile transcriptional response to endotoxin 1, 2, 4, and 8 hours post stimulation (hps). Using a maximum FDR (False Discovery Rate) of 0.05 to declare genes as ...


Investigating Compassion Fatigue And Burnout Rates Among Mental Health Professionals At Sioux Trails Mental Health Center, Lora Schoewe 2010 Minnesota State University - Mankato

Investigating Compassion Fatigue And Burnout Rates Among Mental Health Professionals At Sioux Trails Mental Health Center, Lora Schoewe

All Theses, Dissertations, and Other Capstone Projects

The purpose of this research is to explore the existence of compassion fatigue and burnout among mental health professionals at Sioux Trails Mental Health Center, which is a community based mental health center in located in various rural communities in Southern Minnesota. The research also sought to identify what the professional and agency can do to reduce burnout rates.

Research Questions: Does compassion fatigue and burnout exist among the mental health professionals at Sioux Trails Mental Health Center? What professional and personal resources do the mental health professionals use to reduce the risk of compassion fatigue an burnout?


The Role Of Chemotherapy In The Management Of Newly Diagnosed Brain Metastases: A Systematic Review And Evidence-Based Clinical Practice Guideline., Minesh P Mehta, Nina A Paleologos, Tom Mikkelsen, Paula D Robinson, Mario Ammirati, David W Andrews, Anthony L Asher, Stuart H Burri, Charles S Cobbs, Laurie E Gaspar, Douglas Kondziolka, Mark E Linskey, Jay S Loeffler, Michael McDermott, Jeffrey J Olson, Roy A Patchell, Timothy C Ryken, Steven N Kalkanis 2010 University of Wisconsin School of Public Health and Medicine

The Role Of Chemotherapy In The Management Of Newly Diagnosed Brain Metastases: A Systematic Review And Evidence-Based Clinical Practice Guideline., Minesh P Mehta, Nina A Paleologos, Tom Mikkelsen, Paula D Robinson, Mario Ammirati, David W Andrews, Anthony L Asher, Stuart H Burri, Charles S Cobbs, Laurie E Gaspar, Douglas Kondziolka, Mark E Linskey, Jay S Loeffler, Michael Mcdermott, Jeffrey J Olson, Roy A Patchell, Timothy C Ryken, Steven N Kalkanis

Department of Neurosurgery Faculty Papers

TARGET POPULATION: This recommendation applies to adults with newly diagnosed brain metastases; however, the recommendation below does not apply to the exquisitely chemosensitive tumors, such as germinomas metastatic to the brain.

RECOMMENDATION: Should patients with brain metastases receive chemotherapy in addition to whole brain radiotherapy (WBRT)? Level 1 Routine use of chemotherapy following WBRT for brain metastases has not been shown to increase survival and is not recommended. Four class I studies examined the role of carboplatin, chloroethylnitrosoureas, tegafur and temozolomide, and all resulted in no survival benefit. Two caveats are provided in order to allow the treating physician to ...


The Role Of Surgical Resection In The Management Of Newly Diagnosed Brain Metastases: A Systematic Review And Evidence-Based Clinical Practice Guideline., Steven N Kalkanis, Douglas Kondziolka, Laurie E Gaspar, Stuart H Burri, Anthony L Asher, Charles S Cobbs, Mario Ammirati, Paula D Robinson, David W Andrews, Jay S Loeffler, Michael McDermott, Minesh P Mehta, Tom Mikkelsen, Jeffrey J Olson, Nina A Paleologos, Roy A Patchell, Timothy C Ryken, Mark E Linskey 2010 Henry Ford Health System, 2799 West Grand Blvd, K-11, Detroit, MI

The Role Of Surgical Resection In The Management Of Newly Diagnosed Brain Metastases: A Systematic Review And Evidence-Based Clinical Practice Guideline., Steven N Kalkanis, Douglas Kondziolka, Laurie E Gaspar, Stuart H Burri, Anthony L Asher, Charles S Cobbs, Mario Ammirati, Paula D Robinson, David W Andrews, Jay S Loeffler, Michael Mcdermott, Minesh P Mehta, Tom Mikkelsen, Jeffrey J Olson, Nina A Paleologos, Roy A Patchell, Timothy C Ryken, Mark E Linskey

Department of Neurosurgery Faculty Papers

QUESTION: Should patients with newly-diagnosed metastatic brain tumors undergo open surgical resection versus whole brain radiation therapy (WBRT) and/or other treatment modalities such as radiosurgery, and in what clinical settings? Target population These recommendations apply to adults with a newly diagnosed single brain metastasis amenable to surgical resection. Recommendations Surgical resection plus WBRT versus surgical resection alone Level 1 Surgical resection followed by WBRT represents a superior treatment modality, in terms of improving tumor control at the original site of the metastasis and in the brain overall, when compared to surgical resection alone. Surgical resection plus WBRT versus SRS ...


The Role Of Stereotactic Radiosurgery In The Management Of Patients With Newly Diagnosed Brain Metastases: A Systematic Review And Evidence-Based Clinical Practice Guideline., Mark E Linskey, David W Andrews, Anthony L Asher, Stuart H Burri, Douglas Kondziolka, Paula D Robinson, Mario Ammirati, Charles S Cobbs, Laurie E Gaspar, Jay S Loeffler, Michael McDermott, Minesh P Mehta, Tom Mikkelsen, Jeffrey J Olson, Nina A Paleologos, Roy A Patchell, Timothy C Ryken, Steven N Kalkanis 2010 Department of Neurosurgery, University of California-Irvine Medical Center

The Role Of Stereotactic Radiosurgery In The Management Of Patients With Newly Diagnosed Brain Metastases: A Systematic Review And Evidence-Based Clinical Practice Guideline., Mark E Linskey, David W Andrews, Anthony L Asher, Stuart H Burri, Douglas Kondziolka, Paula D Robinson, Mario Ammirati, Charles S Cobbs, Laurie E Gaspar, Jay S Loeffler, Michael Mcdermott, Minesh P Mehta, Tom Mikkelsen, Jeffrey J Olson, Nina A Paleologos, Roy A Patchell, Timothy C Ryken, Steven N Kalkanis

Department of Neurosurgery Faculty Papers

QUESTION: Should patients with newly-diagnosed metastatic brain tumors undergo stereotactic radiosurgery (SRS) compared with other treatment modalities? Target population These recommendations apply to adults with newly diagnosed solid brain metastases amenable to SRS; lesions amenable to SRS are typically defined as measuring less than 3 cm in maximum diameter and producing minimal (less than 1 cm of midline shift) mass effect. Recommendations SRS plus WBRT vs. WBRT alone Level 1 Single-dose SRS along with WBRT leads to significantly longer patient survival compared with WBRT alone for patients with single metastatic brain tumors who have a KPS > or = 70.Level 1 ...


Different Training Volumes Yield Equivalent Increases In Bmd, R. A. Pierce, L. C. Lee, C. P. Ahles, S. M. Shdo, S. V. Jaque, Ken D. Sumida 2010 Chapman University

Different Training Volumes Yield Equivalent Increases In Bmd, R. A. Pierce, L. C. Lee, C. P. Ahles, S. M. Shdo, S. V. Jaque, Ken D. Sumida

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

The purpose of this study was to determine if an exercise threshold existed in stimulating an elevation in bone mineral density (BMD), via resistance training, during the growth period in male rats. 27 male rats were randomly divided into Control (Con, n = 9), 3 ladder climb resistance trained group (3LC, n = 9), and 6 ladder climb resistance trained group (6LC, n = 9). The 3LC and 6LC groups were conditioned to climb a vertical ladder with weights appended to their tail 3 days/wk for a total of 6 wks, but the 6LC group performed significantly more work than the 3LC ...


Chemosensitization Of Cancer Cells By Sirna Using Targeted Nanogel Delivery, Erin B. Dickerson, William H. Blackburn, Michael H. Smith, Laura B. Kapa, L. Andrew Lyon, John F. McDonald 2010 Georgia Institute of Technology

Chemosensitization Of Cancer Cells By Sirna Using Targeted Nanogel Delivery, Erin B. Dickerson, William H. Blackburn, Michael H. Smith, Laura B. Kapa, L. Andrew Lyon, John F. Mcdonald

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Background: Chemoresistance is a major obstacle in cancer treatment. Targeted therapies that enhance cancer cell sensitivity to chemotherapeutic agents have the potential to increase drug efficacy while reducing toxic effects on untargeted cells. Targeted cancer therapy by RNA interference (RNAi) is a relatively new approach that can be used to reversibly silence genes in vivo by selectively targeting genes such as the epidermal growth factor receptor (EGFR), which has been shown to increase the sensitivity of cancer cells to taxane chemotherapy. However, delivery represents the main hurdle for the broad development of RNAi therapeutics.

Methods: We report here the use ...


Chronic Inflammatory Responses To Microgel-Based Implant Coatings, Amanda W. Bridges, Rachel E. Whitmire, Neetu Singh, Kellie L. Templeman, Julia E. Babensee, L. Andrew Lyon, Andrés J. García 2010 Georgia Institute of Technology

Chronic Inflammatory Responses To Microgel-Based Implant Coatings, Amanda W. Bridges, Rachel E. Whitmire, Neetu Singh, Kellie L. Templeman, Julia E. Babensee, L. Andrew Lyon, Andrés J. García

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Inflammatory responses to implanted biomedical devices elicit a foreign body fibrotic reaction that limits device integration and performance in various biomedical applications. We examined chronic inflammatory responses to microgel conformal coatings consisting of thin films of poly(N-isopropylacrylamide) hydrogel microparticles cross-linked with poly(ethylene glycol) diacrylate deposited on poly(ethylene terephthalate) (PET). Unmodified and microgel-coated PET disks were implanted subcutaneously in rats for 4 weeks and explants were analyzed by histology and immunohistochemistry. Microgel coatings reduced chronic inflammation and resulted in a more mature/organized fibrous capsule. Microgel-coated samples exhibited 22% thinner fibrous capsules that contained 40% fewer cells compared ...


The Nonpsychoactive Cannabinoid Cannabidiol Inhibits 5-Hydroxytryptamine3a Receptor-Mediated Currents In Xenopus Laevis Oocytes, Keun-Hang Susan Yang, Sehamuddin Galadari, Dmytro Isaev, Georg Petroianu, Toni S. Shippenberg, Murat Oz 2010 Chapman University

The Nonpsychoactive Cannabinoid Cannabidiol Inhibits 5-Hydroxytryptamine3a Receptor-Mediated Currents In Xenopus Laevis Oocytes, Keun-Hang Susan Yang, Sehamuddin Galadari, Dmytro Isaev, Georg Petroianu, Toni S. Shippenberg, Murat Oz

Mathematics, Physics, and Computer Science Faculty Articles and Research

The effect of the plant-derived nonpsychotropic cannabinoid, cannabidiol (CBD), on the function of hydroxytryptamine (5-HT)3A receptors expressed in Xenopus laevis oocytes was investigated using two-electrode voltage-clamp techniques. CBD reversibly inhibited 5-HT (1 μM)-evoked currents in a concentration-dependent manner (IC50 = 0.6 μM). CBD (1 μM) did not alter specific binding of the 5-HT3A antagonist [3H]3-(5-methyl-1H-imidazol-4-yl)-1-(1-methylindol-3-yl)propan-1-one (GR65630), in oocytes expressing 5-HT3A receptors. In the presence of 1 μM CBD, the maximal 5-HT-induced currents were also inhibited. The EC50 values were 1.2 and 1.4 μM, in the absence and presence of CBD, indicating ...


A Descriptive Analysis Of Bookings In Sibley County Jail Between January 1, 2008 And December 31, 2009, DeAnna Aufderheide 2010 Minnesota State University - Mankato

A Descriptive Analysis Of Bookings In Sibley County Jail Between January 1, 2008 And December 31, 2009, Deanna Aufderheide

All Theses, Dissertations, and Other Capstone Projects

Each year approximately 12 million admissions and releases occur in U.S. jails (Solomon, A. L., Osborne, J. W. L, LoBuglio, S. F., Mellow, J., & Mukamal, D. A.). Those that cycle in and out of jail often times are unstable. These instabilities include: substance abuse, lack of housing and employment, mental illness, and health concerns. More than 80 percent of offenders are incarcerated for less than one month; some for a few hours or a few days (Solomon, et. al.). This concern was identified by the Public Health Nurse (PHN) who has seen the same offenders being booked in, time after time. The PHN and the Jail Administrator wanted to find out what caused these individuals to return and how could recidivism be decreased. In order to address this concern, information needed to be analyzed to find out the trends and patterns of ...


Computer Based Training: Understanding Schizophrenia, Elli Marie Bach 2010 Minnesota State University - Mankato

Computer Based Training: Understanding Schizophrenia, Elli Marie Bach

All Theses, Dissertations, and Other Capstone Projects

The purpose of this capstone project was to research, design and implement a computer based training module for staff who work with individuals experiencing mental illness. This training focused directly on schizophrenia, which is the most common mental health disorder treated at the Community Behavioral Health Hospital in St. Peter.


Mindfulness Based Stress Reduction And Chronic Illness, Kelly Dulohery 2010 Minnesota State University - Mankato

Mindfulness Based Stress Reduction And Chronic Illness, Kelly Dulohery

All Theses, Dissertations, and Other Capstone Projects

The Minnesota Department of Health (n.d.) defines a chronic health condition as having an extended course, does not resolve suddenly, and complete cure is a rarity. The literature suggests that stress can exacerbate the symptoms of chronic health condition (Roth and Robins, 2004). Addressing the biopsychosocial needs of individuals with chronic health conditions pushes the limits of conventional medicine (Grossman, Niemann, Schmidt, & Walach, 2004). A chronic health condition, if left untreated can lead to additional physical and psychological conditions (e.g. contributing to the development of anxiety, depression, and feelings of isolation, hopelessness, and helplessness) (Ledesma & Kumano, 2009); (Reibel, Greeson, Brainard, & Rosenzweig, 2001). One way to reduce stress is through the Mindfulness Based Stress Reduction (MBSR) a program developed to address the biospychosocial needs of an individual with chronic health conditions by providing training in ...


Evidence Based Practices For Sensory Stimulation Seeking Impulsive Diagnosis, Sheena Gasner 2010 Minnesota State University - Mankato

Evidence Based Practices For Sensory Stimulation Seeking Impulsive Diagnosis, Sheena Gasner

All Theses, Dissertations, and Other Capstone Projects

The purpose of this project is to identify evidence based practices that can be used in the treatment of Sensory Stimulation Seeking Impulsive Disorder (430.0). Identification of these practices will more effectively meet the therapeutic needs of the children diagnosed with this disorder.


Improving Organizational Practices: Learning From Direct Care Staff And Team Leads, Abigail Helget 2010 Minnesota State University - Mankato

Improving Organizational Practices: Learning From Direct Care Staff And Team Leads, Abigail Helget

All Theses, Dissertations, and Other Capstone Projects

The purpose in completing this needs assessment was to pinpoint inconsistencies or unclear aspects of the direct care provided to clients served by H.S.I. staff. This understanding can then assist H.S.I. in providing the necessary support for direct care staff and also allow for H.S.I to provide more adequate support for their clients. All information gathered from the focus groups will be disseminated to support departments and Team Leads through a written report. Based upon these results H.S.I. may choose to implement new or revised trainings, conduct meetings or enact companywide policies.


Social And Family Support For Individuals With Mental Illness, Beth Filzen 2010 Minnesota State University - Mankato

Social And Family Support For Individuals With Mental Illness, Beth Filzen

All Theses, Dissertations, and Other Capstone Projects

Though the patient remains the primary focus throughout the hospital stay, family members of the patient play a crucial role in the patient’s healing process and in helping them to maintain independent living in the community following a hospital stay.

The purpose of this project is to provide family members of individuals hospitalized with information regarding mental illness that is concise and easy to understand. The information will also include resources and supports for family members as they continue to support their loved one.


Stigma Reduction Techniques/Campaigns For Practitioners In A Rural Community Mental Health Practice, Becky Mensing 2010 Minnesota State University - Mankato

Stigma Reduction Techniques/Campaigns For Practitioners In A Rural Community Mental Health Practice, Becky Mensing

All Theses, Dissertations, and Other Capstone Projects

The purpose of this project was to systematically review the literature on the negative effects of stigma on the therapy seeking clients of rural mental health centers. Also to provide information on anti-stigma campaign efforts. The goal of anti-stigma programs are to create awareness about how stigma affects people with mental illnesses, and to have participants develop a sense of what it means to walk in the shoes of a person with mental illness (Corrigan, 2004, p. 19). The research question was how do we help people from being victimized by the prejudice and discrimination that arises from stigma?


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