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Excitoxicity In Retinal Ischemia And Treatment Using Non-Competitive Receptor Antagonists, Jacob Rube 2010 Touro College

Excitoxicity In Retinal Ischemia And Treatment Using Non-Competitive Receptor Antagonists, Jacob Rube

The Science Journal of the Lander College of Arts and Sciences

The following is an excerpt from the article: Ischemia is defined as an inadequacy of blood flow to tissue. Ischemia can deprive tissue of oxygen and metabolic substrates and it can also prevent the removal of waste products. If the ischemia is maintained over enough time the tissue will lose its homeostasis and eventually die causing an infarct. Retinal ischemia occurs when the blood supply to the retina does not meet the metabolic needs that are required to sustain the retina. This can lead to retinal damage and severe vision loss. Ischemia is caused by occluded blood vessels.


Cardiac Regeneration, Sara Leah Abraham 2010 Touro College

Cardiac Regeneration, Sara Leah Abraham

The Science Journal of the Lander College of Arts and Sciences

The following is an excerpt from the introduction to this article: Cardiovascular disease is a generic term that refers to any illness or disorder that involves the heart and its vessels or the blood vessels of the body. Cardiovascular disease has been accepted as the leading cause of death worldwide. According to the Centers for Disease Control’s National Vital Statistics Reports, twenty six percent of deaths in 2006, 631,636 in total, were caused by diseases of the heart (Heron et al. 2009).

One of the most common of all cardiovascular diseases is Ischaemic Heart Disease. This coronary artery ...


Benefits Of Breastfeeding, Renee Chill 2010 Touro College

Benefits Of Breastfeeding, Renee Chill

The Science Journal of the Lander College of Arts and Sciences

When a child is born, a mother can choose to breastfeed her infant or to use an alternative source of nutrition such as formula. To choose properly, the mother must be informed about the pros and cons of each method of feeding. This paper will elaborate on the process of breastfeeding and present some of the benefits that are conferred to both infant and mother through the act of breastfeeding, benefits that formula does not provide. Breastfeeding positively affects infants in both the short- and long-term by providing protection from infectious diseases, fostering the psychological bond with their mothers, and ...


Pompe’S Disease And The Effects Of Alpha-Glucosidase Deficiency, Aaron Richler 2010 Touro College

Pompe’S Disease And The Effects Of Alpha-Glucosidase Deficiency, Aaron Richler

The Science Journal of the Lander College of Arts and Sciences

The following is an excerpt from the introduction of this article: The energy that the body needs in order to function is obtained from carbohydrates that we get through our diet. These carbohydrates are monosacharides, disaccharides and polysacharides. The polysaccharides and disaccharides are hydrolyzed to monosaccharide’s such glucose (which comprises roughly 80%) fructose and galactose. Most cells convert the fructose and galactose to glucose. The body can use the glucose or store it. If energy is needed, glucose can be oxidized through the many reactions of glycolysis which gives a net production of 2 ATP and 2 NADH from ...


The Peanut Allergy Epidemic, Rivky Sachs 2010 Touro College

The Peanut Allergy Epidemic, Rivky Sachs

The Science Journal of the Lander College of Arts and Sciences

Peanut allergy is one of the most predominant food allergies. It accounts for majority of the highly severe and fatal allergic reactions to food. Peanut allergy is generally detected early in life and is commonly associated with other atopic disorders such as asthma, eczema, and rhinitis. The prevalence and pervasiveness of peanut allergies is increasing worldwide, and most peanut allergic patients have lifelong sensitivities to peanuts (de Leon et al, 2008). Patients with severe allergies must stringently avoid any contact with peanuts and depend on intramuscular epinephrine (EpiPen) to counteract the reaction caused by intake of peanuts. Much research is ...


Plasma Pharmacokinetics And Tissue Disposition Of Novel Dextran- Methylprednisolone Conjugates With Peptide Linkers In Rats, Suman Penugonda, Hitesh K. Agarwal, Keykavous Parang, Reza Mehvar 2010 Texas Tech University

Plasma Pharmacokinetics And Tissue Disposition Of Novel Dextran- Methylprednisolone Conjugates With Peptide Linkers In Rats, Suman Penugonda, Hitesh K. Agarwal, Keykavous Parang, Reza Mehvar

Pharmacy Faculty Articles and Research

The plasma and tissue disposition of two novel dextran prodrugs of methylprednisolone (MP) containing one (DMP-1) or five (DMP-5) amino acids as linkers were studied in rats. Single 5-mg/kg doses (MP equivalent) of each prodrug or MP were administered intravenously, and blood and tissue samples were collected. Prodrug and drug concentrations were quantitated using HPLC, and noncompartmental pharmacokinetic parameters were estimated. Whereas conjugation of MP with dextran in both prodrugs substantially decreased the clearance of the drug by ∼200-fold, the accumulations of the drug in the liver, spleen, and kidneys were significantly increased by conjugation. However, the extent of ...


A Phenomenological Description Of The Lived Experience Of Creating Art For Women With Breast Cancer, Laurie Stark 2010 University of Central Florida

A Phenomenological Description Of The Lived Experience Of Creating Art For Women With Breast Cancer, Laurie Stark

Electronic Theses and Dissertations

Conventional approaches to cancer treatment typically do not address the personal experiences of the women with breast cancer. The aim of this study was to develop a structural description of the lived experience of women with breast cancer who create art, specifically through painting, sketching or drawing. A phenomenological approach was employed to explore the meaning of creating art for four women with a diagnosis of breast cancer. The philosophical underpinnings for this study were based on the phenomenological method of bracketing which allows the researcher and subjects to focus on lived experience. This qualitative methodology provided a means to ...


Comparison Of Arnp And Physician Malpractice In States With And Without Controlled Substance Prescribing Authority, Deborah Chandler 2010 University of Central Florida

Comparison Of Arnp And Physician Malpractice In States With And Without Controlled Substance Prescribing Authority, Deborah Chandler

Electronic Theses and Dissertations

Florida is one of two states that do not allow ARNPs to prescribe controlled substances. The Florida Legislature has expressed concern regarding the safety of ARNPs prescribing controlled substances. The purpose of this study was to compare malpractice rates of ARNPs and physicians in states with and without controlled substance prescribing. The design was a direct comparison of malpractice rates in states with and without ARNP controlled substance prescriptive authority. Comparison of malpractice claims was made between physicians (MDs and DOs collectively) and ARNPs in the United States and by state ARNP prescribing authority. Comparison of malpractice claims was also ...


Effectiveness Of Probiotics In Preventing Antibiotic Associated Diarrhea And Clostridium Difficile In Long Term Care, Marva Edwards-Marshall 2010 University of Central Florida

Effectiveness Of Probiotics In Preventing Antibiotic Associated Diarrhea And Clostridium Difficile In Long Term Care, Marva Edwards-Marshall

Electronic Theses and Dissertations

Problem/Purpose: Antibiotic associated diarrhea (AAD) and clostridium-difficile diarrhea (CDAD) are the most common forms of infectious diarrhea in long-term care facilities. The purpose of this study was to determine the effectiveness of probiotics in preventing AAD and CDAD in the long term care geriatric population, and to identify interventions that can be used to improve clinical practice. Background/Significance: Prophylactic use of probiotics have been purported to decrease the incidences of AAD and CDAD. Previous studies have yielded contradictory results on the efficacy of probiotics. The objective of this study was to evaluate the impact of administration of probiotics ...


The Impact Of Pre-Operative Mupirocin Prophylaxis On Surgical Site Infections In Same-Day Admission Open Heart Patients, Joanna Gerry 2010 University of Central Florida

The Impact Of Pre-Operative Mupirocin Prophylaxis On Surgical Site Infections In Same-Day Admission Open Heart Patients, Joanna Gerry

Electronic Theses and Dissertations

The CDC estimates that one in 20 patients admitted to the hospital is a carrier of methicillin-resistant Staphylococcus aureus (MRSA). Staphylococci are commonly found on the skin and mucous membranes within the anterior nares, which provides the principle reservoir for this organism. These organisms can go on to cause surgical site infections in hospitalized patients. Mupirocin is an effective topical medication used to eliminate nasal carriage of Staphylococcus aureus (S. aureus). Based on Level A evidence, the 2007 Society of Thoracic Surgeons has made a Class I recommendation for the use of mupirocin for all patients undergoing cardiac surgery in ...


The Experiences Of Health Care Providers Providing Comfort For Nursing Home Patients At The End Of Life, Herma Baker 2010 University of Central Florida

The Experiences Of Health Care Providers Providing Comfort For Nursing Home Patients At The End Of Life, Herma Baker

Electronic Theses and Dissertations

Research shows that healthcare providers (HCPs) are not adequately prepared to provide comfort care for patients who are at the end of life. Since the 1990s, numerous legislative, research, and clinical initiatives have addressed concerns about improving care at the end of life. The purpose of this study was to describe the experiences of HCPs providing comfort for patients in the nursing home who are at the end of life. This study focused on physicians, nurse practitioners, nurses and nurses' aides at a central Florida nursing home. A descriptive qualitative design was done utilizing a focus group discussion, individual interviews ...


Advanced Practice Nursing In The Faith Community Setting: A Case Study, Chianta Lindsey 2010 University of Central Florida

Advanced Practice Nursing In The Faith Community Setting: A Case Study, Chianta Lindsey

Electronic Theses and Dissertations

The purpose of this case study is to demonstrate the effectiveness of an Advanced Practice Nurse in providing spiritual and nursing care within a faith community setting. The study will describe the process of developing a Parish Nurse program using a Nurse Practitioner to offer wholistic health care to parishioners. It will also illustrate the collaborative process of developing a free health center within a faith based organization, using the Nurse Practitioner to manage the health center and deliver health care services. In order to demonstrate the need for parish nurse care, the case study used an anonymous survey to ...


Assessing Adult Attitudes Toward End-Of-Life Issues And Advanced Directives After Implementing An Educational Intervention In A, Marchina Tolbert-Jones 2010 University of Central Florida

Assessing Adult Attitudes Toward End-Of-Life Issues And Advanced Directives After Implementing An Educational Intervention In A, Marchina Tolbert-Jones

Electronic Theses and Dissertations

Purpose: There is a lack of discussion regarding end-of-life care planning which results in low advanced directive execution (AD) rates. This can lead to decision making by family, friends, and the health care team on behalf of patients whose end-of-life care wishes are unknown. The purpose of this study was to determine the effectiveness of an educational intervention in the work setting to increase end-of-life discussions and the execution of advanced directives. Methods: A descriptive design was used in an occupational workplace setting at a local bottling company after appropriate IRB approval was obtained. An educational intervention based on the ...


The Effect Of Combat Exercises On Cardiovascular Response: An Exploratory Study, MeLisa Gantt 2010 University of Central Florida

The Effect Of Combat Exercises On Cardiovascular Response: An Exploratory Study, Melisa Gantt

Electronic Theses and Dissertations

PURPOSE: Hypertension (HTN) affects one in every three adults in the United States. Often associated with the older population, this silent killer has emerged in an unsuspecting group, young military soldiers. With the rapid succession of multiple deployments, long intervals between blood pressure (BP) assessments, and the absence of cardiovascular (CV) measures during the pre and post deployment health screenings; soldiers may be at higher risk for HTN than their civilian counterparts of the same age. The purpose of this study was to explore real-time continuous CV measures of soldiers before, during, and after exposure to a simulated combat stressor ...


Prevalence Of And Risk Factors For Intraoperative Non-Euglycemia Events In Premature Neonates >2500 Grams, Zulay Ritrosky 2010 University of Central Florida

Prevalence Of And Risk Factors For Intraoperative Non-Euglycemia Events In Premature Neonates >2500 Grams, Zulay Ritrosky

Electronic Theses and Dissertations

This study examined the rates and risks of premature neonates >2500grams developing intraoperative non-euglycemia events (IONEE). A retrospective chart review of 26 premature neonates >2500 grams who underwent surgical procedures between January 1 and December 31, 2009 was conducted. Statistical analysis was done using Chi square and t-tests. Ten of the 26 subjects (38%) experienced an IONEE. Hyperglycemia was the primary IONEE that was noted in the neonates. (Mean: 143.19; sd: 56.041) Length of surgery was significantly longer in those premature neonates with IONEE than those with euglycemia (71.7 0± 27.03 vs. 45.62 ± 17.98 ...


Impaired M3 And Enhanced M2 Muscarinic Receptor Contractile Function In A Streptozotocin Model Of Mouse Diabetic Urinary Bladder, K. J. Pak, Rennolds S. Ostrom, M. Matsui, F. J. Ehlert 2010 University of California, Irvine

Impaired M3 And Enhanced M2 Muscarinic Receptor Contractile Function In A Streptozotocin Model Of Mouse Diabetic Urinary Bladder, K. J. Pak, Rennolds S. Ostrom, M. Matsui, F. J. Ehlert

Pharmacy Faculty Articles and Research

We investigated the contractile roles of M2 and M3 muscarinic receptors in urinary bladder from streptozotocin-treated mice. Wild-type and M2 muscarinic receptor knockout (M2 KO) mice were given a single injection of vehicle or streptozotocin (125 mg kg−1) 2–24 weeks prior to bladder assays. The effect of forskolin on contractions elicited to the muscarinic agonist, oxotremorine-M, was measured in isolated urinary bladder (intact or denuded of urothelium). Denuded urinary bladder from vehicle-treated wild-type and M2 KO mice exhibited similar contractile responses to oxotremorine-M, when contraction was normalized relative to that elicited by KCl (50 mM). Eight to 9 ...


Prospects And Pits On The Path Of Biomimetics: The Case Of Tooth Enamel, Vuk Uskoković 2010 Chapman University

Prospects And Pits On The Path Of Biomimetics: The Case Of Tooth Enamel, Vuk Uskoković

Pharmacy Faculty Articles and Research

This review presents a discourse on challenges in understanding and imitating the process of amelogenesis in vitro on the molecular scale. In light of the analysis of imitation of the growth of dental enamel, it also impends on the prospects and potential drawbacks of the biomimetic approach in general. As the formation of enamel proceeds with the protein matrix guiding the crystal growth, while at the same time conducting its own degradation and removal, it is argued that three aspects of amelogenesis need to be induced in parallel: a) crystal growth; b) protein assembly; c) proteolytic degradation. A particular emphasis ...


Vector Delivery Technique Affects Gene Transfer In The Cornea In Vivo, Rajiv R. Mohan, Ajay Sharma, Tyler C. Cebulko, Ashish Tandon 2010 University of Missouri-Columbia

Vector Delivery Technique Affects Gene Transfer In The Cornea In Vivo, Rajiv R. Mohan, Ajay Sharma, Tyler C. Cebulko, Ashish Tandon

Pharmacy Faculty Articles and Research

Purpose: This study tested whether controlled drying of the cornea increases vector absorption in mouse and rabbit corneas in vivo and human cornea ex vivo, and studied the effects of corneal drying on gene transfer, structure and inflammatory reaction in the mouse cornea in vivo.

Methods: Female C57 black mice and New Zealand White rabbits were used for in vivo studies. Donor human corneas were used for ex vivo experiments. A hair dryer was used for drying the corneas after removing corneal epithelium by gentle scraping. The corneas received no, once, twice, thrice, or five times warm air for 10 ...


"Transduction Efficiency Of Aav 2/6, 2/8 And 2/9 Vectors For Delivering Genes In Human Corneal Fibroblasts ", Ajay Sharma, Arkasubhra Ghosh, Eric T. Hansen, Jason M. Newman, Rajiv R. Mohan 2010 Chapman University

"Transduction Efficiency Of Aav 2/6, 2/8 And 2/9 Vectors For Delivering Genes In Human Corneal Fibroblasts ", Ajay Sharma, Arkasubhra Ghosh, Eric T. Hansen, Jason M. Newman, Rajiv R. Mohan

Pharmacy Faculty Articles and Research

In the present study, cellular tropism and relative transduction efficiency of AAV2/6, AAV2/8 and AAV2/9 vectors have been tested for the cornea using primary cultures of human corneal fibroblasts. The AAV6, AAV8 and AAV9 serotypes having AAV2 ITR plasmid encoding for alkaline phosphatase (AP) gene were generated by transfecting HEK293 cell line with pHelper, pARAP4 and pRep/Cap plasmids. Primary cultures of human corneal fibroblasts were exposed to AAV infectious particles at two different doses (1×105 and 2×105 MOI). Cytochemistry and enzyme assays were used to measure delivered transgene expression in samples collected at 4 ...


Defining The Plasticity Of Transcription Factor Binding Sites By Deconstructing Dna Consensus Sequences: The Phop-Binding Sites Among Gamma/Enterobacteria, Oscar Harari, Sun-Yang Park, Henry Huang, Eduardo A. Groisman, Igor Zwir 2010 Washington University School of Medicine in St. Louis

Defining The Plasticity Of Transcription Factor Binding Sites By Deconstructing Dna Consensus Sequences: The Phop-Binding Sites Among Gamma/Enterobacteria, Oscar Harari, Sun-Yang Park, Henry Huang, Eduardo A. Groisman, Igor Zwir

Open Access Publications

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