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Optimization Of A Signal Transduction Model Of The Mitochondrial Apoptosis By Training To Multi-Cell Data., Jasmin Schmid 2010 Royal College of Surgeons in Ireland

Optimization Of A Signal Transduction Model Of The Mitochondrial Apoptosis By Training To Multi-Cell Data., Jasmin Schmid

MSc by research theses

Research in systems biology is a cycle of proposing and validating novel hypotheses through wet lab experiments and computational modelling. Hypotheses based on experimental data are tested in computational models and resulting model predictions propose further biochemical experiments which are once again basis for an improved and more broadly applicable model. Despite best experimental efforts and advances in biotechnology, essential parameters for deterministic models such as biochemical reaction kinetics are often not available in sufficient quality, and adapting these parameters through training of the model to control experiments remains the only alternative. Exemplified by our recently developed model of mitochondria1 ...


Effects Of Training On Physical Performance Wearing Personal Protective Equipment, David P. Swain, James A. Onate, Stacie I. Ringleb, Dayanand N. Naik, Marlene DeMaio 2010 Old Dominion University

Effects Of Training On Physical Performance Wearing Personal Protective Equipment, David P. Swain, James A. Onate, Stacie I. Ringleb, Dayanand N. Naik, Marlene Demaio

Human Movement Sciences Faculty Publications

We evaluated the effects of wearing a weighted vest during 6 weeks of military-style training. Forty-three subjects were randomly assigned to a control group or a vest group (carrying 4-5 kg for 2 weeks, and 8-10 kg for 4 weeks), with 37 completing the study (17 vest, 20 control). Both groups performed stair climbing in addition to standard Marine Corps training for 1 hour, four times per week. Pre- and post-tests were performed while wearing military personal protective equipment, with the exception of the Marine Physical Readiness Test (PRT). Both groups significantly improved PRT scores (8.4% 3-mile run, 28-38 ...


Educating Adolescents About Puberty: Are We Missing Something?, Hatim A. Omar 2010 University of Kentucky

Educating Adolescents About Puberty: Are We Missing Something?, Hatim A. Omar

Pediatrics Faculty Publications

Adolescents undergo significant physical and cognitive changes during their pubertal development. These changes contribute to and impact their future development. Educating adolescents at an early age about their expected development decreases the possible anxiety associated with this period of life and also helps adolescents make better choices in regards to their sexuality. In order to assess the degree of education regarding pubertal development and sexuality, we conducted a survey of late adolescents (median age 19 years) and parents of adolescents. A total of 409 adolescents (237 females, 172 males) and 124 parents completed the survey. 14.4% of teens (36 ...


Hyperandrogenism And Obesity, Amit M. Deokar, Shawn J. Smith, Amanda J. Goodwin, Hatim A. Omar 2010 University of Kentucky

Hyperandrogenism And Obesity, Amit M. Deokar, Shawn J. Smith, Amanda J. Goodwin, Hatim A. Omar

Pediatrics Faculty Publications

This chapter has a two-fold objective. One, ti addresses the association of hyperandrogenism and obesity and the complex metabolic derangements that are part of the problem. Clinical management of these co-morbidities is challenging and complex. Second, this chapter will aid health care providers with the key features to an early diagnosis and intervention to decrease the morbidities in the short as well as long term. Method: Systematic review of articles and information on the topic of interest that were published in the last 15 years. Conclusion: Obesity and hyperandrogenism are integral parts of Metabolic Syndrome/Polycystic Ovarian Syndrome (PCOS)/Hyperandrogenism ...


Pulmonary Embolism Presenting With Sudden Respiratory Failure In Two Previously Stable Neonates, Joseph Werthammer, Audra Pritt, Laura Reechi, Linda Brown, Mahmood Heydarian 2010 Marshall University

Pulmonary Embolism Presenting With Sudden Respiratory Failure In Two Previously Stable Neonates, Joseph Werthammer, Audra Pritt, Laura Reechi, Linda Brown, Mahmood Heydarian

Pediatrics

Pulmonary artery embolism (PE) is a rare and life-threatening complication in the neonate. We describe two previously stable infants who incurred respiratory failure from PE. The first case is a late preterm infant with gastroschisis with autopsy confirmation of PE presumably as a result of a central venous line (CVL) with thromboembolism. The second case is an extreme low birth weight infant with sudden onset of respiratory failure, abnormal chest x-ray, disseminated intravascular coagulation (DIC), and echocardiographic confirmation of a thrombus at the junction of the superior vena cava and right atrium (SVC/RA) at the site of a previous ...


Phenomenology Of Embodied Dreamwork With Puerto Rican Women: A Dissertation, Lourdes F. Brache-Tabar 2010 Lesley University

Phenomenology Of Embodied Dreamwork With Puerto Rican Women: A Dissertation, Lourdes F. Brache-Tabar

Expressive Therapies Dissertations

The author investigated the experience of embodied dreamwork. Participants were eight Puerto Rican women who were chronically ill, of low socioeconomic status, who lived in Boston. The data were analyzed using transcendental phenomenology. Each participant engaged in one embodied dreamwork–unstructured interview session lasting approximately 1.5 hours. In addition, each participant drew a picture of how she felt after the dreamwork interview. This snowball, purposive sample gave detailed information about how they experienced embodied dreamwork. The participants’ statements were grouped into themes: (a) sense of place—environment, surroundings, spatiality; (b) the players—self, others; (c) plot; (d) in the ...


The Impact Of A Coordinated Care Program On Uninsured, Chronically Ill Patients, Jennifer Neimeyer 2010 Virginia Commonwealth University

The Impact Of A Coordinated Care Program On Uninsured, Chronically Ill Patients, Jennifer Neimeyer

Theses and Dissertations

This study explored how being enrolled in a program that both coordinates patient care and provides a medical home changes health care utilization for uninsured patients, more specifically those persons with chronic conditions, through the use of the Chronic Care Model and Andersen and Aday’s Behavioral Model for Access to Health Care. Uninsured patients typically seek out care in a fragmented manner, which may lead to ineffective and inefficient care, especially for conditions that may require ongoing treatment and monitoring such as chronic conditions. The methodology used to examine the relationship between the interaction of enrollment and chronic condition ...


Nursing Home Organizational Characteristics And Utilization Of Cancer-Related Medical Services, Chun-Chieh Lin 2010 Virginia Commonwealth University

Nursing Home Organizational Characteristics And Utilization Of Cancer-Related Medical Services, Chun-Chieh Lin

Theses and Dissertations

Cancer is the second leading cause of death in the U.S and is more common among the elderly. Since frailty and other age related conditions put the elderly at risk for nursing home care, nursing homes may be the site of care and death for many elderly cancer patients. However, there is a large gap in knowledge concerning cancer treatment of elderly nursing home residents. Since residents rely heavily on their nursing facilities, nursing homes might influence them in their treatment decisions. After controlling for resident and nursing home market characteristics, this study applies Andersen’s Behavioral Model to ...


Book Review Of, The Politics And History Of Aids Treatment In Brazil In Latin American Politics And Society, Shawn Smallman 2010 Portland State University

Book Review Of, The Politics And History Of Aids Treatment In Brazil In Latin American Politics And Society, Shawn Smallman

International & Global Studies Faculty Publications and Presentations

Reviews the book "The Politics and History of AIDS Treatment in Brazil," by Amy Nunn


Defining Acute Lung Disease In Children With The Oxygenation Saturation Index, Neal J. Thomas, Michele L. Shaffer, Douglas F. Willson, Mei-Chiung Shih, Martha A. Q. Curley 2010 University of Pennsylvania

Defining Acute Lung Disease In Children With The Oxygenation Saturation Index, Neal J. Thomas, Michele L. Shaffer, Douglas F. Willson, Mei-Chiung Shih, Martha A. Q. Curley

School of Nursing Departmental Papers

Objective: To evaluate whether a formula could be derived using oxygen saturation (Spo2) to replace Pao2 that would allow identification of children with acute lung injury and acute respiratory distress syndrome. Definitions of acute lung injury and acute respiratory distress syndrome require arterial blood gases to determine the Pao2/Fio2 ratio of 300 (acute lung injury) and 200 (acute respiratory distress syndrome).

Design: Post hoc data analysis of measurements abstracted from two prospective databases of randomized controlled trials.

Setting: Academic pediatric intensive care units.

Patients: A total of 255 children enrolled in two large prospective trials ...


Knowledge Of Stroke Warning Signs And Risk Factors : A Survey Of Irish Adults, Deirdre T. Holly 2010 Royal College of Surgeons in Ireland

Knowledge Of Stroke Warning Signs And Risk Factors : A Survey Of Irish Adults, Deirdre T. Holly

MSc by research theses

Background

Stroke is one of the leading causes of death and disability in Ireland. Access to high quality emergency and acute stroke care has beendemonstrated to reduce mortality and improve patient outcomes. Despite the introduction of clot-busting therapies such as thromboiysis, its use remains low in Ireland. Delay in the recognition of stroke warning signs and in seeking medical attention contribute to treatment delay. Previous studies indicate that knowledge of stroke risk factors and warning signs in the general public ispoor, resulting in delay in responding and seeking medical care.

Aim

To study knowledge of risk factors and warning signs ...


Gossypol Induced Cell Death In Du 145 Prostate Cancer Cells, Susan Kennelly 2010 Royal College of Surgeons in Ireland

Gossypol Induced Cell Death In Du 145 Prostate Cancer Cells, Susan Kennelly

MSc by research theses

Cancer Biology

Tumourigenesis is a multistep process which includes the transformation of healthy cells into extremely malignant cells, caused by the disruption of normal tissue homeostasis. Hanahan and Weinberg propose that there are a common set of 'acquired capabilities' that most if not all cancers posses's in order to survive and proliferate despite changes in their normal cell physiology during cancer development (Hanahan and Weinberg, 2000). These "Hallmarks of Cancer", according to Hanahan and Weinberg, are the six essential physiological alterations which lead to malignant growth: self-sufficiency in growth signals, insensitivity to growth inhibitory signals, evasion of apoptosis, limitless ...


Aspirin "Resistance" : An Evaluation And Explanation, Meadhbh McCall 2010 Royal College of Surgeons in Ireland

Aspirin "Resistance" : An Evaluation And Explanation, Meadhbh Mccall

MSc by research theses

Background: Low-dose aspirin is used for the prevention of thrombosis in the treatment of cardiovascular disease. Patients failing to respond to their aspirin are classified as Aspirin Resistant (AR) and are at a greater risk of having a cardiovascular event (CVE). Our study sets out to: evaluate aspirin response in a real world cardiovascular population, assess the utility of Platelet Function Tests (PFT's) in the clinic and identify causes of AR, with the overall aim of improving patient clinical outcomes.

Methods: Aspirin non-responding patients were identified using laboratory based methods (Light Transmission Aggregometry with arachidonic acid, VerifyNow™-Aspirin, serum ...


In-Vitro Osteogenesis Is Affected By Composition And Stiffness Of Collagen-Gag Scaffold., Claire M. Tierney 2010 Royal College of Surgeons in Ireland

In-Vitro Osteogenesis Is Affected By Composition And Stiffness Of Collagen-Gag Scaffold., Claire M. Tierney

PhD theses

Collagen-glycosaminoglycan (GAG) scaffolds were initially designed for use in skin regeneration and have since been utilised in cartilage, nerve and muscle tissue engineering. The FDA-approved formulation contains a ratio of 0.5% collagen to 0.044% GAG. However, the composition and stiffness of the collagen-GAG scaffold has never been optimised to sustain a particular cell phenotype or designed with tissue-specific applications in mind. This study sought to investigate the effect of varying the composition and stiffness of the scaffold on the material andstructural properties, in addition to cell behaviour, with a view to developing an optimised collagen-GAG scaffold for use ...


Bidirectional Receptor Crosstalk In Breast Cancer: The Role Of C-Myc And Coregulatory Proteins And Future Implications For Cancer Treatment., Dearbhaile C. Collins 2010 Royal College of Surgeons in Ireland

Bidirectional Receptor Crosstalk In Breast Cancer: The Role Of C-Myc And Coregulatory Proteins And Future Implications For Cancer Treatment., Dearbhaile C. Collins

PhD theses

Background

Progression of breast cancer despite hormonal and biological treatments continues to pose a therapeutic challenge. Receptor crosstalk is a resistant mechanism that can occur between the estrogen receptor (ER) and the receptor tyrosine kinases, such as HER2, in response to inhibition by anti-endocrine treatments. Briefly, tumours can overactivate growth factor signalling cascades and give rise to an endocrine independent tumour. Wehypothesized that treatment with tyrosine kinase receptor inhibitors (TKIs), trastuzumab (Herceptin®) and lapatinib (Tyverb®), could induce similar receptor crosstalk by overactivating endocrine-driven tumour growth.

Methods

Proteomic analysis (LC-Mass Spectrometry) was used to assess proteins that interact with the proto-oncogene ...


Bioengineered Microparticles For Controlled Drug Delivery To The Lungs, Neeraj Sivadas 2010 Royal College of Surgeons in Ireland

Bioengineered Microparticles For Controlled Drug Delivery To The Lungs, Neeraj Sivadas

PhD theses

Traditional formulations for pulmonary drug delivery mainly focused on two approaches: (i) Dissolving or suspending the drug in a solvent or propellant to produce liquid aerosols or (ii) Blending drug particulates with dry carrier particles typically composed of sugars. Although effective for localised delivery of small drug molecules, these methods did not meet the complex formulation and delivery challenges posed by the newer biotechnology-derived medicines. One of the many avenues being explored to overcome these issues is the use of novel controlled drug release technologies. While such systems are available in the market for the oral and the parenteral routes ...


Defining Exemplary Children's Mental Health Services In Minnesota's Rural Communities, Melanie Wurtzberger 2010 Minnesota State University - Mankato

Defining Exemplary Children's Mental Health Services In Minnesota's Rural Communities, Melanie Wurtzberger

All Theses, Dissertations, and Other Capstone Projects

Research shows that children’s mental health services in rural areas are not likely to meet all the qualities to be determined ‘exemplary’ with regards to diverse groups and at-risk populations due to: limited community resources, decreased funding and reimbursement rates, geographic distance from consumers, lack of collaborations from primary care physicians, and sparse number of adequately trained mental health (Fenell & Hovestadt, 2005; Gamm, Stone & Pittman, 2003; Moore et al., 2005; Powell & Dunlap, 2005) The purpose of the research was to define exemplary services as it applies to rural county children’s mental health services so as to assist county agencies in identifying exemplary ...


The Effect Of Ultraviolet Radiation (Type B) On Decubitus Ulcers, Ayodele Teslim Onigbinde, Kehinde Foyeke Olafimihan, Adesola Ojoawo, Rufus Adesoji Adedoyin, Oluwabunmi Omiyale, Joyce Mothabeng 2010 Obafemi Awolowo University

The Effect Of Ultraviolet Radiation (Type B) On Decubitus Ulcers, Ayodele Teslim Onigbinde, Kehinde Foyeke Olafimihan, Adesola Ojoawo, Rufus Adesoji Adedoyin, Oluwabunmi Omiyale, Joyce Mothabeng

Internet Journal of Allied Health Sciences and Practice

Pressure ulcers heal slowly and this often results in prolonged hospitalization. Wound infection delays healing in decubitus ulcers and standard treatment include wound dressing and use of antibiotics. However, there is increasing resistance of bacteria to antibiotics. The purpose of this study was to determine the effects of ultraviolet radiation (UVB) on the healing of decubitus ulcers. The study was also designed to learn the effect of UVR (Type B) on bacteria. Methods: Ten subjects with ascertained bilateral pressure sores (6 at the gluteal region and 4 at the heels) on the left lower extremities were recruited for this study ...


Measuring The Quality Of Rural-Based, Government Health Care Workers In Nepal, Stephen J. Knoble, Anil Pandit, Bibek Koirala, Laxmi Ghimire 2010 University of Utah,

Measuring The Quality Of Rural-Based, Government Health Care Workers In Nepal, Stephen J. Knoble, Anil Pandit, Bibek Koirala, Laxmi Ghimire

Internet Journal of Allied Health Sciences and Practice

A representative, cross-sectional clinical skills assessment of 163 mid-level, rural-based, government health care workers was conducted in four districts of Nepal in June 2007. All Health Assistants and Auxiliary Healthcare Workers within the target districts were scored using checklists of standardized key skills in clinical encounters with model patients or clinical models. Participant scores were reported as a mean percentage in adult medicine 28(%), pediatric medicine 56(%), maternity medicine 35(%), orthopedic medicine 45(%), clinical procedures 59(%), and management 46(%). This was measured against the government’s 60(%) standard on clinical skills. There was little significant difference between categories of health ...


Day Therapy Programs For Adolescents With Mental Health Problems: A Systematic Review, Yamini Deenadayalan, Saravana Kumar, Zuzana Machotka, Luke Perraton 2010 International Centre for Allied Health Evidence

Day Therapy Programs For Adolescents With Mental Health Problems: A Systematic Review, Yamini Deenadayalan, Saravana Kumar, Zuzana Machotka, Luke Perraton

Internet Journal of Allied Health Sciences and Practice

Day therapy programs are one of many interventions available for adolescents with mental health issues. Day therapy programs utilise a multi-disciplinary community-based approach to the treatment of mental health issues and allow adolescents to remain under the care of their family. To date, no review has specifically investigated the effectiveness of day therapy programs for adolescents. This review aims to investigate both the effectiveness of day therapy programs for adolescents with mental health problems and highlight the key components underpinning these programs. A systematic review of peer- reviewed literature was undertaken, using recognised processes. Eight studies were included in this ...


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