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Regulation Of Runx Proteins In Human Cancers: A Dissertation, Sandhya Pande 2011 University of Massachusetts Medical School

Regulation Of Runx Proteins In Human Cancers: A Dissertation, Sandhya Pande

GSBS Dissertations and Theses

Runt related transcription factors (Runx) play an important role in mammalian development by regulating the expression of key genes involved in cell proliferation, differentiation and growth. The work described in this thesis details the mechanisms by which the activity of two members of this family are regulated in human cells. Chapter One provides a brief introduction of Runx transcription factors.

Chapter Two describes the regulation of Runx2 protein by the PI3 kinase/Akt pathway in human breast cancer cells. The PI3 kinase/Akt pathway is one of the major signal transduction pathways through which growth factors influence cell proliferation and ...


The Effects Of Meditation On Working Memory And Depression In An Older Adult: A Case Study, Alex R.Z. Bloom 2011 Pacific University

The Effects Of Meditation On Working Memory And Depression In An Older Adult: A Case Study, Alex R.Z. Bloom

School of Graduate Psychology

It is well-known that both short-term memory and levels of depression are a frequent problem in older adults. The current literature purports that mindfulness meditation can have salutary effects on both of these concerns. In particular, Mindfulness-Based Cognitive Therapy (MBCT) has demonstrated to be effective in treating depression; however, no data currently exists regarding the role of MBCT on both these variables in any population, let alone in older adults. Therefore, the purpose of this pilot case study was to explore the influence of MBCT on working memory and depression. The specific hypotheses tested were that a truncated, 4-week long ...


Effect Of Mindfulness-Based Cognitive Therapy On Self-Compassion, Satisfaction With Life, And Mindfulness, Theodore R. Askwith II 2011 Pacific University

Effect Of Mindfulness-Based Cognitive Therapy On Self-Compassion, Satisfaction With Life, And Mindfulness, Theodore R. Askwith Ii

School of Graduate Psychology

Growing evidence supports the effectiveness of mindfulness-based interventions for the treatment of depression and anxiety disorders, however, comparatively few studies have examined the effects of mindfulness-based interventions on positive variables such as mindfulness, self-compassion, and life satisfaction (Hofmann, Sawyer, Witt, & Oh, 2010; Chiesa & Serretti, 2010). This dissertation used a quasi-experimental design to examine the effects of mindfulness-based cognitive therapy (MBCT; Segal & Teasdale, 2002) on 21 psychology graduate students. The correlations between mindfulness, self-compassion, and satisfaction with life were also examined. Outcome measures include Mindful Attention Awareness Scale (MAAS-Brown & Ryan, 2003), Five Factor Mindfulness Questionnaire (FFMQ, Baer, Smith, Hopkins, Krietemeyer, & Toney, 2006), Self-Compassion Scale (SCS, Neff, 2003a), and Satisfaction with Life Scale (SWLS; Diener, Emmons, Larsen, & Griffin, 1985). Contrary to expectation, the results indicate no statistically significant differences between MBCT and control group on any of the outcome variables. Additional analyses indicated that the common humanity factor of self-compassion was significantly correlated with life satisfaction. Mindfulness and self-compassion also demonstrated positive significant correlations.


Habitat As A Source Of Intrapopulational Variation Of Ornament Size In Galápagos Lava Lizards (Microlophus Albemarlensis Complex), Mark Jordan, Jennifer Hollis, Paul Stone, Howard Stone 2011 Indiana University - Purdue University Fort Wayne

Habitat As A Source Of Intrapopulational Variation Of Ornament Size In Galápagos Lava Lizards (Microlophus Albemarlensis Complex), Mark Jordan, Jennifer Hollis, Paul Stone, Howard Stone

Mark A. Jordan

Gradients in habitat structure are expected to influence the outcome of selection on traits that contribute to communicative display. Galápagos lava lizards (Microlophus albemarlensis complex) on Isla Plaza Sur in the Galápagos Islands occur across a gradient of vegetative cover. Previous work in this population has shown that traits associated with predator avoidance are magnified in habitats with low vegetative cover. This pattern suggests that predation pressure differs by habitat and thus, may act to select against the elaboration of ornamentation. We measured the size of the chin patch, an ornament known to be used in intraspecific signaling, to test ...


Island Fragmentation Drives Evolutionary Diversification Of Galápagos Lava Lizards (Microlophus Spp.), Mark Jordan, H. Snell 2011 Indiana University - Purdue University Fort Wayne

Island Fragmentation Drives Evolutionary Diversification Of Galápagos Lava Lizards (Microlophus Spp.), Mark Jordan, H. Snell

Mark A. Jordan

No abstract provided.


Phenotypic Divergence Despite High Levels Of Gene Flow In Galapagos Lava Lizards (Microlophus Albemarlensis), Mark Jordan, H. Snell, H. Snell, W. Jordan 2011 Indiana University - Purdue University Fort Wayne

Phenotypic Divergence Despite High Levels Of Gene Flow In Galapagos Lava Lizards (Microlophus Albemarlensis), Mark Jordan, H. Snell, H. Snell, W. Jordan

Mark A. Jordan

The extent of evolutionary divergence of phenotypes between habitats is predominantly the result of the balance of differential natural selection and gene flow. Lava lizards (Microlophus albemarlensis) on the small island of Plaza Sur in the Galápagos archipelago inhabit contrasting habitats: dense vegetation on the western end of the island thins rapidly in a transitional area, before becoming absent on the eastern half. Associated with these habitats are phenotypic differences in traits linked to predator avoidance (increased wariness, sprint speed, and endurance in lizards from the sparsely vegetated habitat). This population provides an opportunity to test the hypothesis that reduced ...


Historical Fragmentation And Genetic Drift In Populations Of Galápagos Lava Lizards (Microlophus Albemarlensis Complex), Mark Jordan, H. Snell 2011 Indiana University - Purdue University Fort Wayne

Historical Fragmentation And Genetic Drift In Populations Of Galápagos Lava Lizards (Microlophus Albemarlensis Complex), Mark Jordan, H. Snell

Mark A. Jordan

No abstract provided.


Meningitis Presenting As Depression: A Case Report, Karl Doghramji, MD 2011 Thomas Jefferson University

Meningitis Presenting As Depression: A Case Report, Karl Doghramji, Md

Jefferson Journal of Psychiatry

The relationship between psychiatric and medical illness has long been recognized by clinicians. Of special importance to psychiatrists are the diagnostic dilemmas posed by medical illnesses presenting as psychiatric disorders. In a review of recent studies, LaBruzza found that "at least one out of every twenty patients receiving an initial psychiatric evaluation may have an underlying medical illness which accounts for the psychiatric symptoms." This was especially true with inpatients, where between 5% and 30% of patients, with a weighted average of 12%, had medical illnesses accounting for their psychiatric complaints 11). One medical illness which can resemble psychiatric illness ...


Attention Deficit Disorder, Residual Type- A Case Study, James Stanch, MD 2011 Thomas Jefferson University

Attention Deficit Disorder, Residual Type- A Case Study, James Stanch, Md

Jefferson Journal of Psychiatry

The syndrome of Minimal Brain Dysfunction (MBD) in children has been well described by a number of authors. Such children were first described in 1941 by Werner and Strauss(1) who made a distinction between brain injury and -simple- mental retardation. In the past such terms as Hyperactive Child Syndrome, Minimal Brain Damage, and Hyperkinetic Behavior Syndrome have been used to describe this syndrome.


A Case Of Recurrent Dissociative Episodes In A Patient With Congenital Defects, Mark Miller, MD 2011 Thomas Jefferson University

A Case Of Recurrent Dissociative Episodes In A Patient With Congenital Defects, Mark Miller, Md

Jefferson Journal of Psychiatry

Case Report

Marie, a 30 year old American-born Hispanic female, was first seen in the emergency room with suicidal ideation (the impulse to jump in front of an oncoming car), depression, anxiety, and distress about "always getting attacked so much."


Interpersonal Relationships As Sources Of Medical Student Stress, Beverly Jones, MD 2011 Thomas Jefferson University

Interpersonal Relationships As Sources Of Medical Student Stress, Beverly Jones, Md

Jefferson Journal of Psychiatry

Introduction

The issue of physician impairment, that is , decreased ability or quality of functioning due to intemperate use of drugs or alcohol, emotional or psychiatric dysfunction, has recently received attention (1,5) . Studies have indicated the risks physicians face of substance abuse problems(6,7), marital discord(8,9), suicide (lO,ll), and psychiatric problems (l2-14). studies have also addressed the difficulties faced by medical students (15-20).

A group of medical students at the University of North Carolina came together to investigate the subject of medical student impairment . A survey was constructed in order to ascertain the sources of stress ...


Olfaction And Sexuality, Michael Buxbaum, MD 2011 Thomas Jefferson University

Olfaction And Sexuality, Michael Buxbaum, Md

Jefferson Journal of Psychiatry

A patient who describes himself as "sanitary" told me of his concern with odors. Whenever he thinks about establishing a sexual relationship , he develops a fear that his partner may smell offensive, especially around her genital area. He describes signs and symptoms of sympathetic overactivity when he engages in foreplay, and is afraid that he might be impotent if he smells anything offensive. In fact, he has to insert a finger into his partner's vagina during foreplay, to test the nature of the odor. He feels relieved when the smell is neutral or perfumed, and demonstrates enhanced sexual performance ...


Editors' Column, 2011 Thomas Jefferson University

Editors' Column

Jefferson Journal of Psychiatry

With this issue, The Jefferson Journal of Psychiatry , a Resident Publication, comes into being.

The purpose of this journal is to provide a forum for the presentation of ideas, data, and discussion. We are trying to give residents a setting in which to communicate in a way more formal than the seminars of residency training, but less forbidding than national journals.


Introduction, Harvey J. Schwartz, MD 2011 Thomas Jefferson University

Introduction, Harvey J. Schwartz, Md

Jefferson Journal of Psychiatry

It is with great pride that we introduce our new resident JOURNAL. This unique forum was created to allow our resident s the opportunity to explore the challenges and pleasures to writing and publishing. Putting one's thoughts and experiences on paper demands a clarity of thinking and a willingness to share what is otherwise private.

For the resident this becomes a valuable educational enterprise. For the faculty this is an opportunity to view first hand the work of our trainees . Not limited to reading course descriptions of clinical service schedules, our staff can now get to know t he ...


Camptothecin Analogs And Methods Of Preparation Thereof, Dennis P. Curran, David Bom, Thomas Burke 2011 University of Kentucky

Camptothecin Analogs And Methods Of Preparation Thereof, Dennis P. Curran, David Bom, Thomas Burke

Pharmaceutical Sciences Faculty Patents

To read this abstract, please download this patent.


Racial Differences In The Genetics Of Preeclampsia, Lori Hill 2011 Virginia Commonwealth University

Racial Differences In The Genetics Of Preeclampsia, Lori Hill

Theses and Dissertations

Preeclampsia (PE), characterized by hypertension and proteinuria after 20 weeks of gestation, affects 5-8% of pregnancies worldwide. Although preeclampsia is a significant cause of maternal and perinatal mortality and morbidity, its etiology remains to be elucidated. Racial differences have been observed for preeclampsia, with U.S. Blacks having higher rates and more severe disease, compared to U.S. Whites and Hispanics. One potential source of racial differences in preeclampsia is genetic variation between populations. Genetic susceptibility to preeclampsia is well established, but the specific contributions of maternal vs. fetal genes, and how these vary among racial groups is poorly understood ...


Genetics And Criminal Responsibility, Stephen J. Morse 2011 University of Pennsylvania

Genetics And Criminal Responsibility, Stephen J. Morse

Faculty Scholarship at Penn Law

Some believe that genetics threatens privacy and autonomy and will eviscerate the concept of human nature. Despite the astonishing research advances, however, none of these dire predictions and no radical transformation of the law have occurred.


Counting The Cost: Estimating The Number Of Deaths Among Recently Released Prisoners In Australia, Stuart A. Kinner, David B. Preen, Azar Kariminia, Tony Butler, Jessica Y. Andrews, Mark Stoové, Matthew Law 2011 Western University

Counting The Cost: Estimating The Number Of Deaths Among Recently Released Prisoners In Australia, Stuart A. Kinner, David B. Preen, Azar Kariminia, Tony Butler, Jessica Y. Andrews, Mark Stoové, Matthew Law

Aboriginal Policy Research Consortium International (APRCi)

Objective: To estimate the number of deaths among people released from prison in Australia in the 2007–08 financial year, within 4 weeks and 1 year of release. Design, participants and setting: Application of crude mortality rates for ex-prisoners (obtained from two independent, state-based record-linkage studies [New South Wales and Western Australia]) to a national estimate of the number and characteristics of people released from prison in 2007–08. Main outcome measures: Estimated number of deaths among adults released from Australian prisons in 2007–08, within 4 weeks and 1 year of release, classified by age, sex, Indigenous status and ...


The Use Of Imputed Values In The Meta-Analysis Of Genome-Wide Association Studies., SHUO JIAO, Li Hsu, Carolyn Hutter, Ulrike Peters 2011 Fred Hutchinson Cancer Research Center

The Use Of Imputed Values In The Meta-Analysis Of Genome-Wide Association Studies., Shuo Jiao, Li Hsu, Carolyn Hutter, Ulrike Peters

Shuo Jiao

In genome-wide association studies (GWAS), it is a common practice to impute the genotypes of untyped single nucleotide polymorphism (SNP) by exploiting the linkage disequilibrium structure among SNPs. The use of imputed genotypes improves genome coverage and makes it possible to perform meta-analysis combining results from studies genotyped on different platforms. A popular way of using imputed data is the "expectation-substitution" method, which treats the imputed dosage as if it were the true genotype. In current practice, the estimates given by the expectation-substitution method are usually combined using inverse variance weighting (IVM) scheme in meta-analysis. However, the IVM is not ...


Regulation Of Cytosolic Phospholipase A2 (Cpla2) And Its Association With Cell Proliferation In Human Lens Epithelial Cells, Yin Wang, Kui-Yi Xing, Marjorie F. Lou 2011 University of Nebraska- Lincoln & School of Veterinary Medicine and Biomedical Sciences

Regulation Of Cytosolic Phospholipase A2 (Cpla2) And Its Association With Cell Proliferation In Human Lens Epithelial Cells, Yin Wang, Kui-Yi Xing, Marjorie F. Lou

Papers in Veterinary and Biomedical Science

PURPOSE. To investigate the molecular mechanism for cytosolic phospholipase A2 (cPLA2) regulation and its association to platelet-derived growth factor (PDGF)-induced cell proliferation.

METHODS. cPLA2 was examined using human lens epithelial (HLE) B3 cells. Reactive oxygen species (ROS) generation induced by PDGF was analyzed by luminescence assay. Cell proliferation was measured by cell counting and by BrdU assay. Human cPLA2 gene was cloned via RT-PCR followed by sitedirected mutagenesis to construct HLE B3 cells expressing either inactive cPLA2 enzyme with S228A mutation (S228A), or cPLA2 truncated at the calcium-binding C2 domain (C2D). Activity of cPLA2 was measured by arachidonic acid ...


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