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Risk Factors For Endometritis After Low Transverse Cesarean Delivery, Margaret A. Olsen, Anne M. Butler, Denise M. Willers, Gilad A. Gross, Preetishma Devkota, Victoria J. Fraser 2010 Washington University School of Medicine in St. Louis

Risk Factors For Endometritis After Low Transverse Cesarean Delivery, Margaret A. Olsen, Anne M. Butler, Denise M. Willers, Gilad A. Gross, Preetishma Devkota, Victoria J. Fraser

Infectious Diseases Faculty Publications

No abstract provided.


Correlates Of Physical Activity In Black, Hispanic, And White Middle School Girls, Evelyn B. Kelly, Deborah Parra-Medina, Karin A. Pfeiffer, Marsha Dowda, Terry L. Conway, Larry S. Webber, Jared B. Jobe, Scott Going, Russell R. Pate 2010 University of South Carolina - Columbia

Correlates Of Physical Activity In Black, Hispanic, And White Middle School Girls, Evelyn B. Kelly, Deborah Parra-Medina, Karin A. Pfeiffer, Marsha Dowda, Terry L. Conway, Larry S. Webber, Jared B. Jobe, Scott Going, Russell R. Pate

Faculty Publications

Background: A need exists to better understand multilevel influences on physical activity among diverse samples of girls. This study examined correlates of moderate-to-vigorous physical activity (MVPA) among adolescent girls from different racial/ethnic backgrounds. Methods: 1,180 6th grade girls (24.5% black, 15.7% Hispanic, and 59.8% white) completed a supervised self-administered questionnaire that measured hypothesized correlates of PA. MVPA data were collected for 6 days using the ActiGraph accelerometer. Hierarchical regression analysis was used to examine correlates of PA in each racial/ethnic group. Results: Hispanic girls (n=185) engaged in 21.7 minutes of MVPA per ...


Changing Po2licy: The Elements For Improving Childhood Asthma Outcomes, Anne Rossier Markus, Meagan Lyon, Sara J. Rosenbaum 2010 George Washington University

Changing Po2licy: The Elements For Improving Childhood Asthma Outcomes, Anne Rossier Markus, Meagan Lyon, Sara J. Rosenbaum

Geiger Gibson/RCHN Community Health Foundation Research Collaborative

Childhood asthma is a serious and chronic health issue that affects one in seven U.S. children and their families, compromising their health and quality of life and placing a heavy financial burden on families as well as an enormous strain on the health care system. Treating, managing, and ultimately preventing and reducing the burden of asthma represents a critical test of the ability of the U.S. health system – health insurers, clinical care providers, and public health agencies – to work together. Our investigation found that, as a country, we already know enough to act and improve life for the ...


The Effect Of Medicare Part D On Pharmaceutical Prices And Utilization, Mark Duggan, Fiona S. morton 2010 University of Pennsylvania

The Effect Of Medicare Part D On Pharmaceutical Prices And Utilization, Mark Duggan, Fiona S. Morton

Health Care Management Papers

Medicare Part D began coverage of prescription drugs in 2006. Rather than setting pharmaceutical prices, the government contracted with private insurers to provide drug coverage. Theory suggests that additional insured consumers will raise the optimal price of a branded drug, while the insurer's ability to move demand to substitute treatments may lower prices. We estimate the program's effect on the price and utilization of pharmaceutical treatments. We find that Part D enrollees paid substantially lower prices than while uninsured, and increased their utilization of prescription drugs. We find relative price declines only for drugs with significant therapeutic competition.


Qrs Duration And Echocardiographic Evidence Of Left Ventricular Dyssynchrony In Patients With Left Ventricular Systolic Dysfunction., Hafeez Ahmed, Javed Majid Tai, Sohail Abrar Khan, Muniza Yousuf 2010 Aga Khan University

Qrs Duration And Echocardiographic Evidence Of Left Ventricular Dyssynchrony In Patients With Left Ventricular Systolic Dysfunction., Hafeez Ahmed, Javed Majid Tai, Sohail Abrar Khan, Muniza Yousuf

Department of Medicine

Objective: To determine the association between left ventricular (LV) dyssynchrony assessed by tissue Doppler imaging (TDI) in patients with left ventricular ejection fraction (LVEF) < 35% and prolonged ventricular depolarization on electrocardiography.

Study Design: A cross-sectional study.

Place and Duration of Study: The Aga Khan University, Karachi, from June to September 2007.

Methodology: All patients with LVEF < 35% were included. Apical 2-D images were obtained in 4 chamber and 2 chamber views. TDI pulse wave Doppler parameters were measured from these 2 color-coded images. Time interval between the onset of QRS complex and the peak systolic velocity per region was derived. Patients with valvular heart disease, mitral annular calcification, atrial fibrillation and paced rhythm were excluded. Fischer’s exact test was used to determine the association between QRS duration and left ventricular dyssynchrony.

Results: A total of 60 patients were included. Twenty one patients had QRS duration of > 120 msec. Out of those 21 patients, a total of 6 patients (28.6%) had evidence of dyssynchrony on TDI. Five patients (23.8%) had dyssynchrony on the basis of basal septal and basal lateral velocity ...


Comparison Of Nine Different Real-Time Pcr Chemistries For Qualitative And Quantitative Applications In Gmo Detection, Torstein Tengs 2010 Norwegian Veterinary Institute

Comparison Of Nine Different Real-Time Pcr Chemistries For Qualitative And Quantitative Applications In Gmo Detection, Torstein Tengs

Dr. Torstein Tengs

Several techniques have been developed for detection and quantification of genetically modified organisms, but quantitative real-time PCR is by far the most popular approach. Among the most commonly used realtime PCR chemistries are TaqMan probes and SYBR green, but many other detection chemistries have also been developed. Because their performance has never been compared systematically, here we present an extensive evaluation of some promising chemistries: sequenceunspecific DNA labeling dyes (SYBR green), primer-based technologies (AmpliFluor, Plexor, Lux primers), and techniques involving double-labeled probes, comprising hybridization (molecular beacon) and hydrolysis (TaqMan, CPT, LNA, and MGB) probes, based on recently published experimental data ...


Scar Less: A Review Of Methods Of Scar Reduction At Sites Of Peripheral Nerve Repair, W.C. Ngeow 2010 Univ. Malaya

Scar Less: A Review Of Methods Of Scar Reduction At Sites Of Peripheral Nerve Repair, W.C. Ngeow

Wei Cheong Ngeow

Scar formation is important for normal wound healing but proliferation of scar tissue from the epineurium in response to a nerve injury will result in impediment to the regenerating axons that need to traverse the repaired site. This article reviews the events that occur after peripheral nerve transection and the challenges that need to be addressed to reduce scarring in order to improve nerve regeneration. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 109: 357-366)


Prevalence, Incidence, And Persistence Of Major Depressive Symptoms In The Cardiovascular Health Study, Stephen M. Thielke MD, MS, Paula Diehr PhD 2010 University of Washington

Prevalence, Incidence, And Persistence Of Major Depressive Symptoms In The Cardiovascular Health Study, Stephen M. Thielke Md, Ms, Paula Diehr Phd

Paula Diehr

PURPOSE: To explore the association of major depressive symptoms with advancing age, sex, and self-rated health among older adults. DESIGN AND METHODS: We analyzed 10 years of annual assessments in a longitudinal cohort of 5888 Medicare recipients in the Cardiovascular Health Study. Self-rated health was assessed with a single question, and subjects categorized as healthy or sick. Major depressive symptoms were assessed using the Center for Epidemiologic Studies Short Depression Scale, with subjects categorized as nondepressed (score < 10) or depressed (> or =10). Age-, sex-, and health-specific prevalence of depression and the probabilities of transition between depressed and nondepressed states were estimated. RESULTS: The ...


A Mixture Model Based Approach For Estimating The Fdr In Replicated Microarray Data, SHUO JIAO, Shunpu Zhang 2010 Fred Hutchinson Cancer Research Center

A Mixture Model Based Approach For Estimating The Fdr In Replicated Microarray Data, Shuo Jiao, Shunpu Zhang

Shuo Jiao

One of the mostly used methods for estimating the false discovery rate (FDR) is the permutation based method. The permutation based method has the well-known granularity problem due to the discrete nature of the permuted null scores. The granularity problem may produce very unstable FDR estimates. Such instability may cause scientists to over- or under-estimate the number of false positives among the genes declared as significant, and hence result in inaccurate interpretation of biological data. In this paper, we propose a new model based method as an improvement of the permutation based FDR estimation method of SAM [1] The new ...


What Is The Evidence For Using Family Based Interventions To Prevent Stroke Recurrence?, Maggie Lawrence, Caroline McVey, Susan M. Kerr 2010 Glasgow Caledonian University

What Is The Evidence For Using Family Based Interventions To Prevent Stroke Recurrence?, Maggie Lawrence, Caroline Mcvey, Susan M. Kerr

Dr. Maggie Lawrence

Stroke has a devastating impact on individuals and families. Risk factors for recurrence include lifestyle behaviours such as smoking, excessive alcohol consumption, an unhealthy diet and physical inactivity. This article describes a programme of research that aims to gather and synthesise the evidence required to inform the development and evaluation of a family centred, behavioural intervention designed to address lifestyle risk factors for recurrent stroke. We present an overview of the research undertaken to develop the evidence base. This included a survey of stroke nurse practice, a focus group study with people who had had a stroke as well as ...


Young Adults’ Experience Of Stroke: A Qualitative Review Of The Literature, Maggie Lawrence 2010 Glasgow Caledonian University

Young Adults’ Experience Of Stroke: A Qualitative Review Of The Literature, Maggie Lawrence

Dr. Maggie Lawrence

Stroke is a life-threatening event that has a devastating impact on young adults and their families. The author conducted a systematic review of the qualitative literature to explore the experience of stroke from the perspective of young adults. Four primary research 'papers' were analyzed using the Qualitative Assessment and Review Instrument; 60 findings were extracted from the papers and merged into 13 categories, from which three synthesized findings were developed - disorientation, disrupted sense of self, and roles and relationships.


Survivors On The Edge: The Lived Experience Of Professional Musicians With Playing-Related Injuries, Christine A. Guptill 2010 Western University

Survivors On The Edge: The Lived Experience Of Professional Musicians With Playing-Related Injuries, Christine A. Guptill

Christine A Guptill

The purpose of this study was to understand the lived-experience of professional instrumental musicians who have experienced playing-related injuries. This study used a hermeneutic phenomenological methodology developed to examine this lived-experience. In-depth interviews were conducted with ten professional musicians. This was followed by a focus group where preliminary findings were presented to participants and their feedback was sought. Other sources of lived-experience included participant-observation by the researcher, who is a musician and has experienced injuries; and biographic and artistic representations of musical performance and its loss, including literature, films and television. The findings were summarized in a visual representation unique ...


Event Adjudication Changes Key Results In Open-Label Trials: The Affirm Experience, Elaine M. Nasco, April Slee, Kent M. Koprowicz, Robert G. Hart 2010 Axio Research

Event Adjudication Changes Key Results In Open-Label Trials: The Affirm Experience, Elaine M. Nasco, April Slee, Kent M. Koprowicz, Robert G. Hart

Kent M Koprowicz

Event Adjudication Changes Key Results in Open-Label Trials: The AFFIRM Experience Author Block: Elaine M. Nasco, April Slee, Kent Koprowicz, Robert G. Hart, Axio Research, LLC, Seattle, WA Abstract: Background: The value of central event adjudication of endpoints in multi-center randomized trials has recently been questioned. Methods: The NIH-sponsored Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) trial randomized 4,060 atrial fibrillation patients to antiarrhythmic drugs (rhythm control) vs. rate-controlling drugs, given open-label, at 213 clinical sites. While the primary outcome was mortality, a key secondary endpoint was ischemic stroke (IS), centrally adjudicated by those reviewing source documents from ...


“Nurses’ Station” Or “Nursing Station”? How To Appropriately Describe Our Workspace In Acute Care, Ashley Jarrell, Mona Shattell 2010 DePaul University

“Nurses’ Station” Or “Nursing Station”? How To Appropriately Describe Our Workspace In Acute Care, Ashley Jarrell, Mona Shattell

Mona Shattell

No abstract provided.


Special Edition Editorial. Inpatient Psychiatric Treatment: Moving The Science Forward, Kathleen Delaney, Mona Shattell 2010 Rush University

Special Edition Editorial. Inpatient Psychiatric Treatment: Moving The Science Forward, Kathleen Delaney, Mona Shattell

Mona Shattell

No abstract provided.


Welcome To Tomorrow, Edward F. Rossomando 2010 University of Connecticut School of Medicine and Dentistry

Welcome To Tomorrow, Edward F. Rossomando

UCHC Articles - Research

It is always a delight to see an idea become a reality. We recognized that there was a need for a dental journal for those to publish a tentative explanation for a phenomenon, an explanation that could be used as a basis for further investigation. Early in the planning, it was necessary to address the question: Is there a need for a journal for dental hypothesis? A detailed examination of dental journals now published revealed that most if not all published research findings - this research might be in various scientific disciplines or in education but all contained results of testing ...


Should The Concentration Of Vitamin D Be Measured In All Patients With Hypertension?, Angela Boldo, Patrick Campbell, Pooja Luthra, William B. White 2010 University of Connecticut School of Medicine and Dentistry

Should The Concentration Of Vitamin D Be Measured In All Patients With Hypertension?, Angela Boldo, Patrick Campbell, Pooja Luthra, William B. White

UCHC Articles - Research

With mounting evidence indicating the direct effect of vitamin D on the vascular smooth muscle cell, endothelial function and the renin-angiotensin-aldosterone system, it is clear that randomized trials of vitamin D replacement and renin and angiotensin inhibition in patients with hypertension and vitamin D deficiency are warranted. Preliminary research has shown an inverse relationship between BP and vitamin D levels, and supplementation appears promising. To that end, we have just initiated a randomized clinical trial evaluating the effects of vitamin D and/or a renin inhibitor on ambulatory and clinic BP in vitamin D deficient patients with hypertension (clinical trials ...


Genetic Influences On The Dynamics Of Pain And Affect In Fibromyalgia, Howard A. Tennen, Jonathan Covault 2010 University of Connecticut School of Medicine and Dentistry

Genetic Influences On The Dynamics Of Pain And Affect In Fibromyalgia, Howard A. Tennen, Jonathan Covault

UCHC Articles - Research

Objective The purpose of the present investigation was to determine if variation in the catechol-O-methyltransferase (COMT) and mu-opioid receptor (OPRM1) genes is associated with pain-related positive affective regulation in fibromyalgia (FM). Design Forty-six female FM patients completed an electronic diary that included daily assessments of positive affect and pain. Between- and within-person analyses were conducted with multilevel modeling. Main Outcome Measure Daily positive affect was the primary outcome measure. Results Analyses revealed a significant gene × experience interaction for COMT, such that individuals with met/met genotype experienced a greater decline in positive affect on days when pain was elevated than ...


Feasibility Of Using Interactive Voice Response To Monitor Daily Drinking, Moods And Relationship Processes On A Daily Basis In Alcoholic Couples, Howard A. Tennen 2010 University of Connecticut School of Medicine and Dentistry

Feasibility Of Using Interactive Voice Response To Monitor Daily Drinking, Moods And Relationship Processes On A Daily Basis In Alcoholic Couples, Howard A. Tennen

UCHC Articles - Research

Background

Daily process research on alcohol involvement has used paper-and-pencil and electronic data collection methods, but no studies have yet tested the feasibility of using Interactive Voice Response (IVR) technology to monitor drinking, affective, and social interactional processes among alcoholic (ALC) couples. This study tested the feasibility of using IVR with n=54 ALC couples.

Methods

Participants were n=54 couples (probands who met criteria for a past one-year alcohol use disorder and their partners) recruited from a substance abuse treatment center and the local community. Probands and their partners reported on their daily drinking, marital interactions, and moods once ...


Primary Health Care Models And Suitability For Provision Of E-Services: An Overview., Borislav D. Dimitrov, Tom Fahey 2010 Royal College of Surgeons in Ireland

Primary Health Care Models And Suitability For Provision Of E-Services: An Overview., Borislav D. Dimitrov, Tom Fahey

General Practice Conference Proceedings and Posters

We present an overview of the most frequently distributed types of primary health care (PHC) models of delivery across different countries and cultural environments. We summarise and describe most important definitions, principles of classification, attributes, necessary conditions (e.g., patient-management systems, electronic health records, ICT platforms) and organisation and key performance indicators (KPI) for functioning of the primary health care systems. We review and explore the suitability of different PHC models for provision of electronic (e-)services.


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