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Michael J. Goodheart, Md, Kristina W. Thiel 2011 University of Iowa

Michael J. Goodheart, Md, Kristina W. Thiel

Proceedings in Obstetrics and Gynecology

Dr. Michael Goodheart is an Assistant Professor of Obstetrics and Gynecology in the Division of Gynecologic Oncology at the University of Iowa. In addition to clinical duties, Dr. Goodheart does research the focus of which is unraveling the role of the Wnt pathway in endometrial cancer.


Knockdown Of Mtdh Increases Drug Sensitivity To Hdac Inhibitor And Trail Combination Treatment In Endometrial Cancer Cells, Xiangbing Meng, Pavla Brachova, Shujie Yang, Zhi Xiong, Yuping Zhang, Kimberly K. Leslie 2011 University of Iowa

Knockdown Of Mtdh Increases Drug Sensitivity To Hdac Inhibitor And Trail Combination Treatment In Endometrial Cancer Cells, Xiangbing Meng, Pavla Brachova, Shujie Yang, Zhi Xiong, Yuping Zhang, Kimberly K. Leslie

Proceedings in Obstetrics and Gynecology

Understanding the molecular mechanisms of chemoresistance is vital to design therapies to restore chemosensitivity. MTDH mediates drug resistance by regulating expression of genes required for the control of apoptosis and cell cycle. These findings indicate that sensitivity to chemotherapy agents and combination treatment with HDAC inhibitor and TRAIL can be restored by manipulating MTDH, and hence depletion of MTDH is a potentially novel avenue for effective cancer therapy.


H19/Mir-675 Non-Coding Rna Expression Differentiates Among Cancers Of The Human Endometrium., Eric J. Devor, Jill N. DeMik, Brandon M. Schickling, Michael J. Goodheart, Kimberly K. Leslie 2011 University of Iowa

H19/Mir-675 Non-Coding Rna Expression Differentiates Among Cancers Of The Human Endometrium., Eric J. Devor, Jill N. Demik, Brandon M. Schickling, Michael J. Goodheart, Kimberly K. Leslie

Proceedings in Obstetrics and Gynecology

H19 is a maternally expressed non-coding RNA located at chromosome 11p15.5 near the reciprocally imprinted insulin-like growth factor 2 (IGF2) gene. Though the function of H19 is unknown, it is transcribed during embryonic development after which transcription is absent in all but a few tissues including cardiac muscle, breast, ovary, uterus, and placenta. Linking H19, miR-675 and RB1 expression with serous tumors of the endometrium suggests that RB1 suppression may be a differentiating event in serous tumorigenesis.


Lymphoid Enhancing Factor 1 (Lef-1) Overexpression In Epithelial Ovarian, Fallopian Tube And Peritoneal Cancer And Associations With Clinical Factors, Aine Clements, David Engle, Dawne Shelton, Traci Neff, Soo Park, David Bender, Amina Ahmed, Koen De Geest, Anna Button, John F. Engelhardt, Michael Goodheart 2011 University of Iowa

Lymphoid Enhancing Factor 1 (Lef-1) Overexpression In Epithelial Ovarian, Fallopian Tube And Peritoneal Cancer And Associations With Clinical Factors, Aine Clements, David Engle, Dawne Shelton, Traci Neff, Soo Park, David Bender, Amina Ahmed, Koen De Geest, Anna Button, John F. Engelhardt, Michael Goodheart

Proceedings in Obstetrics and Gynecology

Lef-1 mRNA levels were statistically elevated in cases of ovarian, fallopian tube or peritoneal cancer when compared to non-cancerous controls. Among cancer cases, levels of Lef-1 were statistically different between stage and histology. Lef-1 overexpression may be predictive of poor overall survival. These findings suggest that Lef-1 overexpression may contribute to ovarian, fallopian tube and peritoneal carcinogenesis, and that further investigation is warranted.


The Relationship Between Vascularity, P53 Gene Mutations And Distant Metastatic Disease In Epithelial Ovarian Carcinoma, Janna Girardi, Megan Samuelson, Anna Button, Koen De Geest, David P. Bender, Amina Ahmed, Michael Goodheart 2011 University of Iowa

The Relationship Between Vascularity, P53 Gene Mutations And Distant Metastatic Disease In Epithelial Ovarian Carcinoma, Janna Girardi, Megan Samuelson, Anna Button, Koen De Geest, David P. Bender, Amina Ahmed, Michael Goodheart

Proceedings in Obstetrics and Gynecology

Mutations of the p53 tumor suppressor gene are associated with large differences (>7 vessels/HPF) in Microvessel density (MVD) counts between primary and metastatic tumor sites in patients with epithelial ovarian cancer. These data are consistent with models demonstrating p53 mutation functions directly to influence angiogenesis. This information supports continued therapy and research involving angiogenesis inhibitors in patients with ovarian cancer, especially in the setting of increased differences in MVD between primary and metastatic sites.


Zmiz1 Is Overexpressed In Epithelial Ovarian Cancer And Associated With P53 Gene Mutations, Niyati J. Nadkarni, Laura M. Rogers, Megan Samuelson, Traci Neff, David P. Bender, Amina Ahmed, Koen De Geest, Anna Button, Adam Dupuy, Michael Goodheart 2011 University of Iowa

Zmiz1 Is Overexpressed In Epithelial Ovarian Cancer And Associated With P53 Gene Mutations, Niyati J. Nadkarni, Laura M. Rogers, Megan Samuelson, Traci Neff, David P. Bender, Amina Ahmed, Koen De Geest, Anna Button, Adam Dupuy, Michael Goodheart

Proceedings in Obstetrics and Gynecology

Zmiz1 staining is elevated in patients with epithelial ovarian cancer. Tumors that are Zmiz1 positive are associated with mutations of the p53 gene. Zmiz1 overexpression may be associated with decreased survival in patients with epithelial ovarian cancer. Additional studies are needed to more clearly determine the role of Zmiz1 in patients with epithelial ovarian cancer.


Diagnosis Of Endometrial Cancer Complicated By Morbid Obesity—A Case Report, Janna Girardi, Michael Goodheart 2011 University of Iowa

Diagnosis Of Endometrial Cancer Complicated By Morbid Obesity—A Case Report, Janna Girardi, Michael Goodheart

Proceedings in Obstetrics and Gynecology

A 47 year old morbidly obesity nulligravid female presented to a local hospital with chest pain and shortness of breath, CT of the chest confirmed pulmonary embolism, and endometrial biopsy performed showed grade 1 endometrioid adenocarcinoma with squamous differentiation. CT scan performed demonstrated pelvic, retroperitoneal, inguinal and right axillary lymphadenopathy, and hepatomegaly with grossly unremarkable uterus and ovaries. Due to the burden of disease, axillary and inguinal lymph node biopsy was attempted, however due to depth of nodes, the tissue was not reached and biopsy efforts were abandoned. It required a great deal of discussion with the radiology department to ...


Toward A Microrna Signature Of Endometrial Cancer, Eric J. Devor, Michael J. Goodheart, Kimberly K. Leslie 2011 University of Iowa

Toward A Microrna Signature Of Endometrial Cancer, Eric J. Devor, Michael J. Goodheart, Kimberly K. Leslie

Proceedings in Obstetrics and Gynecology

A simple meta-analysis of eight microRNA (miRNA) expression surveys of endometrial cancers reveals a panel of sixteen miRNAs that are significantly over-expressed (n = 15) or under-expressed (n = 1) in at least three surveys. Examination of these miRNAs indicates that they target mRNAs involved in a number of basic cellular processes including the crucial epithelial to mesenchymal transition (EMT) and hypoxia response. The central role played by these miRNAs is reinforced by the demonstration that they are all among the most ancient of all animal miRNAs. This suggests that they are members of a core set of miRNAs dysregulated as part ...


The Combination Of Paclitaxel And Gefitinib Inhibits Endometrial Cancer Cells By Inducing Mitotic Catastrophe: Proof Of Principle For Dual Therapy In Endometrial Cancer, Xiangbing Meng, Laura L. Laidler, Lina Albitar, Anna M. Holmes, Donghai Dai, Thomas E. Buekers, David P. Bender, Kimberly K. Leslie 2011 University of Iowa

The Combination Of Paclitaxel And Gefitinib Inhibits Endometrial Cancer Cells By Inducing Mitotic Catastrophe: Proof Of Principle For Dual Therapy In Endometrial Cancer, Xiangbing Meng, Laura L. Laidler, Lina Albitar, Anna M. Holmes, Donghai Dai, Thomas E. Buekers, David P. Bender, Kimberly K. Leslie

Proceedings in Obstetrics and Gynecology

Serous uterine endometrial cancer is a lethal disease for which new therapeutic regimens are urgently needed. Combinations of chemotherapeutic agents and small molecule growth factor inhibitors have demonstrated activity in cancers from other sites. Our objective was to determine whether such a combination using Paclitaxel and Gefitinib could be active in serous endometrial cancer cells.


Combination Therapy With Mtor And Pi3 Kinase Inhibitors Is Broadly Synergistic In A Wide Variety Of Endometrial Cancer Cells, Shujie Yang, Xue Xiao, Xiangbing Meng, Kimberly K. Leslie 2011 University of Iowa

Combination Therapy With Mtor And Pi3 Kinase Inhibitors Is Broadly Synergistic In A Wide Variety Of Endometrial Cancer Cells, Shujie Yang, Xue Xiao, Xiangbing Meng, Kimberly K. Leslie

Proceedings in Obstetrics and Gynecology

Dysregulation of mammalian target of rapamycin (mTOR) signaling has been found in many human tumors, including endometrial cancer, and mTOR inhibitors have been utilized in clinical trials as targeted therapies with only limited success. Herein we identify a viable treatment alternative that overcomes temsirolimus-induced AKT phosphorylation in endometrial cancer. Our data suggest temsirolimus and BEZ235 inhibit different components of the AKT/mTOR signaling pathway to accomplish synergistic pathway inhibition, which is necessary for therapeutic efficacy to abrogate the increased signaling through AKT that occurs with mTOR inhibition alone


Mir-888: A Newly Identified Mirna Significantly Over-Expressed In Endometrial Cancers, Adriann M. Hovey, Eric J. Devor, Kimberly K. Leslie 2011 University of Iowa

Mir-888: A Newly Identified Mirna Significantly Over-Expressed In Endometrial Cancers, Adriann M. Hovey, Eric J. Devor, Kimberly K. Leslie

Proceedings in Obstetrics and Gynecology

Endometrial cancer is the most common gynecological malignancy and the fourth most common cancer in women. With accumulating evidence, microRNAs have emerged as significant players in the development and progression of cancers. The data points to miR-888 playing an important functional role in the development of aggressive endometrial tumors. Future research will focus on identifying and validating the targets of miR-888 to elucidate its mechanism of action and support this hypothesis


Comparison Of P53 Mutation Status, Primary Cytoreductive Surgical Outcomes, And Overall Survival In Patients With Ovarian Cancer, David Engle, Hubert Fornalik, Traci Neff, Anna Button, K Collins, Amina Ahmed, David Bender, Susan Lutgendorf, Michael Goodheart 2011 University of Iowa

Comparison Of P53 Mutation Status, Primary Cytoreductive Surgical Outcomes, And Overall Survival In Patients With Ovarian Cancer, David Engle, Hubert Fornalik, Traci Neff, Anna Button, K Collins, Amina Ahmed, David Bender, Susan Lutgendorf, Michael Goodheart

Proceedings in Obstetrics and Gynecology

Optimal surgical cytoreduction continues to be an important prognostic variable in patients with ovarian cancer independent of p53 mutational status. Among patients with suboptimal cytoreduction a p53 mutation may offer a survival advantage.


Long-Term Outcomes Among Women With Cervical Cancer Treated From 1960-1987, Christopher Yopp, Jo Benda, Colleen Stockdale, Jami L. Shepard, Amina Ahmed 2011 University of Iowa

Long-Term Outcomes Among Women With Cervical Cancer Treated From 1960-1987, Christopher Yopp, Jo Benda, Colleen Stockdale, Jami L. Shepard, Amina Ahmed

Proceedings in Obstetrics and Gynecology

To determine long term survival among women treated for cervical cancer and to provide long-term information regarding mortality and morbidity following treatment. Among a cohort of young women treated for cervical cancer over a 27 year period, with survival available up to 48 years from initial diagnosis, there were no variables identified which impacted the duration of survival beyond the initial stage of cervical cancer at presentation.


Positron Emission Tomography In Detection Of Metastatic Leiomyosarcoma In A Postoperative Patient: A Case Report, David B. Engle, Linda M. Smiley, Scott L. Baum, Greg P. Wellman 2011 University of Iowa

Positron Emission Tomography In Detection Of Metastatic Leiomyosarcoma In A Postoperative Patient: A Case Report, David B. Engle, Linda M. Smiley, Scott L. Baum, Greg P. Wellman

Proceedings in Obstetrics and Gynecology

In leiomyosarcoma (LMS) abnormal vaginal bleeding is the most common reported symptom in patients (56%), followed by pelvic mass (54%), and pain (22%). LMS is often hard to diagnosis on a uterine biopsy because it does not originate in the endometrium and may not invade into the cavity. Non-specific symptoms as well as difficulty in diagnosis being made by biopsy, means that many LMS tumors are often mistaken for fibroids preoperatively. To our knowledge this is the only reported case of FDG-PET being used in the postoperative evaluation of a patient with LMS and a suspicious lung mass. Our case ...


Wnt/ß-Catenin/Lef-1 Signaling In The Uterus And Its Implications In Uterine Gland Formation And Cancer Development, Dawne N. Shelton, Michael J. Goodheart 2011 University of Iowa

Wnt/ß-Catenin/Lef-1 Signaling In The Uterus And Its Implications In Uterine Gland Formation And Cancer Development, Dawne N. Shelton, Michael J. Goodheart

Proceedings in Obstetrics and Gynecology

Wnt/b-catenin signaling appears to be important in a multitude of cancers. This review article details current knowledge of the Wnt/b-catenin/Lef1 pathway in generalized gland regulation and formation in addition to endometrial cancer. Wnt signaling is critical for the development of the female urogenital system, in particular mullerian duct formation. Dysregulation of this signaling pathway at multiple nodes has been observed in numerous tumor types, including endometrial cancer. In particular, nuclear accumulation of b-catenin correlates with tumor severity. As such, therapeutic modulation of Wnt signaling represents an emerging avenue for the treatment of cancers that rely on this ...


Prehabilitation For Total Knee Arthroplasty: A Patient-Centred Approach To Maximizing Surgical Outcomes, Carly D. McKay 2011 University of Western Ontario

Prehabilitation For Total Knee Arthroplasty: A Patient-Centred Approach To Maximizing Surgical Outcomes, Carly D. Mckay

Electronic Thesis and Dissertation Repository

The purpose of this dissertation was to investigate the role of prehabilitation in post-operative recovery for patients undergoing total knee arthroplasty (TKA) for osteoarthritis. Study one was a meta-analysis that aimed to consolidate the body of knowledge regarding prehabilitation for TKA patients. Study two compared the Lower Limb Tasks Questionnaire (LLTQ) to the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) in terms of agreement and responsiveness. Study three investigated the effect of a six-week pre-surgical strength training program on post-operative outcomes (quadriceps strength, mobility, pain, self-reported function, health-related quality of life, arthritis self efficacy) for TKA patients. Finally, study ...


Meeting Summary: Embracing Mental Health Care: Lessons Learned For Success, Jeffrey Brown, David M. Keller 2011 University of Massachusetts Medical School

Meeting Summary: Embracing Mental Health Care: Lessons Learned For Success, Jeffrey Brown, David M. Keller

General Pediatrics

The American Academy of Pediatrics (AAP) is a national organization comprising more than 62,000 members, 66 state and local chapters, 29 national committees, 49 sections, 9 councils, and staff of approximately 400. On July 28, 2011, the AAP Mental Health Initiatives hosted a preconference on “Embracing Mental Health Care: Lessons Learned for Success” in Chicago, IL. The goal was to empower pediatricians to address the health and well-being of children and youth with mental health concerns.


Identifying Unique Neighborhood Characteristics To Guide Health Planning For Stroke And Heart Attack: Fuzzy Cluster And Discriminant Analyses Approaches, Ashley Pedigo, William Seaver, Agricola Odoi 2011 University of Tennessee, Knoxville

Identifying Unique Neighborhood Characteristics To Guide Health Planning For Stroke And Heart Attack: Fuzzy Cluster And Discriminant Analyses Approaches, Ashley Pedigo, William Seaver, Agricola Odoi

Agricola Odoi

Background: Socioeconomic, demographic, and geographic factors are known determinants of stroke and myocardial infarction (MI) risk. Clustering of these factors in neighborhoods needs to be taken into consideration during planning, prioritization and implementation of health programs intended to reduce disparities. Given the complex and multidimensional nature of these factors, multivariate methods are needed to identify neighborhood clusters of these determinants so as to better understand the unique neighborhood profiles. This information is critical for evidence-based health planning and service provision. Therefore, this study used a robust multivariate approach to classify neighborhoods and identify their socio-demographic characteristics so as to provide ...


A Comparative Study Of A Pathogenic Versus A Nonpathogenic Naegleria Species, Melissa Jamerson 2011 Virginia Commonwealth University

A Comparative Study Of A Pathogenic Versus A Nonpathogenic Naegleria Species, Melissa Jamerson

Theses and Dissertations

Naegleria fowleri (N. fowleri) and Naegleria lovaniensis (N. lovaniensis) are closely related amebae found in the environment. N. fowleri causes Primary Amebic Meningoencephalitis (PAM), a fatal disease of the central nervous system, while N. lovaniensis is nonpathogenic. N. fowleri infection occurs when amebae enter the nasal passages, and migrate to the brain. The molecular mechanisms involved in the pathogenesis of PAM are not well-defined. Therefore, the purpose of this study was to define phenotypic characteristics that may be functionally linked to the pathogenicity associated with N. fowleri. Studies revealed that N. fowleri has a faster growth rate and is more ...


Effectiveness Of A Combined Home Visiting And Group Intervention For Low Income African American Mothers: The Pride In Parenting Program, Kathy S. Katz, Marian H. Jarrett, Ayman El-Mohandes, Susan Schneider, Doris McNeely-Johnson, Michele Kiely 2011 Georgetown University

Effectiveness Of A Combined Home Visiting And Group Intervention For Low Income African American Mothers: The Pride In Parenting Program, Kathy S. Katz, Marian H. Jarrett, Ayman El-Mohandes, Susan Schneider, Doris Mcneely-Johnson, Michele Kiely

Publications and Research

Intervention strategies are needed to improve maternal and infant outcomes in minority populations living in poverty. Home visiting by nurses has improved outcomes for mothers and young children, but use of professional staff makes these programs expensive. Pride in Parenting was a randomized controlled trial of paraprofessional home visitation to provide health and developmental intervention for high-risk African American mothers in Washington, DC. This study proposed to test whether paraprofessional visitors drawn from the community could effectively influence health and mothers; parenting behaviors and attitudes. African American mothers with inadequate prenatal care were recruited at delivery and randomized to intervention ...


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