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Dietary Refinement And The Upper Gut Microbiota: The Starting Point For Obesity And Non-Communicable Diseases?, Ian Spreadbury 2017 Ancestral Health Society

Dietary Refinement And The Upper Gut Microbiota: The Starting Point For Obesity And Non-Communicable Diseases?, Ian Spreadbury

Journal of Evolution and Health

No abstract provided.


The Case For The Long Body, Frank Forencich 2017 Exuberant Animal

The Case For The Long Body, Frank Forencich

Journal of Evolution and Health

No abstract provided.


Mobile Health Interventions For Adult Obesity In The United States: Analysis Of Effectiveness And Efficacy, David P. Paul III, Keerthi Gochipathala, Alberto Coustasse, Bezawit Wodajo, Niharika Bhardwaj 2017 Marshall University

Mobile Health Interventions For Adult Obesity In The United States: Analysis Of Effectiveness And Efficacy, David P. Paul Iii, Keerthi Gochipathala, Alberto Coustasse, Bezawit Wodajo, Niharika Bhardwaj

Alberto Coustasse

The Unites States continues to struggle with the negative health effects associated with increasing population obesity, a problem which has been historically difficult, if not impossible, to solve. Mobile health applications represent a potential partial solution to this problem. We examine the existing literature on the effects of mobile health applications on body weight, waist circumference, BMI, and lifestyle, examining both physical findings as well as adherence, satisfaction and cost effectiveness. The use of mobile for weight reduction looks promising, but evidence is mixed, which is not surprising given the rapidly evolving nature of the mobile application field.


Electron Penetration Range For Diverse Materials, Anne C. Starley, Lisa M. Phillipps, JR Dennison 2017 Utah State University

Electron Penetration Range For Diverse Materials, Anne C. Starley, Lisa M. Phillipps, Jr Dennison

JR Dennison

The penetration range of energetic electrons into diverse materials can be modeled approximately with a simple fit. This fit is a function of a single parameter, Nv, which describes the effective number of valence electrons. Using the Continuous-Slow-Down-Approximation (CSDA) for energy deposition in a material, a composite analytical formula has been developed which estimates the range or maximum penetration depth of incident electrons for energies from10 MeV with an uncertainty of


Epigenetics And Shared Molecular Processes In The Regeneration Of Complex Structures, Labib Rouhana, Junichi Tasaki 2017 Wright State University - Main Campus

Epigenetics And Shared Molecular Processes In The Regeneration Of Complex Structures, Labib Rouhana, Junichi Tasaki

Labib Rouhana

The ability to regenerate complex structures is broadly represented in both plant and animal kingdoms. Although regenerative abilities vary significantly amongst metazoans, cumulative studies have identified cellular events that are broadly observed during regenerative events. For example, structural damage is recognized and wound healing initiated upon injury, which is followed by programmed cell death in the vicinity of damaged tissue and a burst in proliferation of progenitor cells. Sustained proliferation and localization of progenitor cells to site of injury give rise to an assembly of differentiating cells known as the regeneration blastema, which fosters the development of new tissue. Finally ...


Cellular And Molecular Dissection Of Pluripotent Adult Somatic Stem Cells In Planarians, Norito Shibata, Labib Rouhana, Kiyokazu Agata 2017 Wright State University - Main Campus

Cellular And Molecular Dissection Of Pluripotent Adult Somatic Stem Cells In Planarians, Norito Shibata, Labib Rouhana, Kiyokazu Agata

Labib Rouhana

Freshwater planarians, Plathelminthes, have been an intriguing model animal of regeneration studies for more than 100 years. Their robust regenerative ability is one of asexual reproductive capacity, in which complete animals develop from tiny body fragments within a week. Pluripotent adult somatic stem cells, called neoblasts, assure this regenerative ability. Neoblasts give rise to not only all types of somatic cells, but also germline cells. During the last decade, several experimental techniques for the analysis of planarian neoblasts at the molecular level, such as in situ hybridization, RNAi and fluorescence activated cell sorting, have been established. Moreover, information about genes ...


Piwi Homologs Mediate Histone H4 Mrna Localization To Planarian Chromatoid Bodies, Labib Rouhana, Jennifer A. Weiss, Ryan S. King, Phillip A. Newmark 2017 Wright State University - Main Campus

Piwi Homologs Mediate Histone H4 Mrna Localization To Planarian Chromatoid Bodies, Labib Rouhana, Jennifer A. Weiss, Ryan S. King, Phillip A. Newmark

Labib Rouhana

The well-known regenerative abilities of planarian flatworms are attributed to a population of adult stem cells called neoblasts that proliferate and differentiate to produce all cell types. A characteristic feature of neoblasts is the presence of large cytoplasmic ribonucleoprotein granules named chromatoid bodies, the function of which has remained largely elusive. This study shows that histone mRNAs are a common component of chromatoid bodies. Our experiments also demonstrate that accumulation of histone mRNAs, which is typically restricted to the S phase of eukaryotic cells, is extended during the cell cycle of neoblasts. The planarian PIWI homologs SMEDWI-1 and SMEDWI-3 are ...


Time Of Day Regulates Subcellular Trafficking, Tripartite Synaptic Localization, And Polyadenylation Of The Astrocytic Fabp7 Mrna, Jason R. Gerstner, William M. Vanderheyden, Timothy LaVaute, Cara J. Westmark, Labib Rouhana, Allan I. Pack, Marvin Wickens, Charles F. Landry 2017 Wright State University - Main Campus

Time Of Day Regulates Subcellular Trafficking, Tripartite Synaptic Localization, And Polyadenylation Of The Astrocytic Fabp7 Mrna, Jason R. Gerstner, William M. Vanderheyden, Timothy Lavaute, Cara J. Westmark, Labib Rouhana, Allan I. Pack, Marvin Wickens, Charles F. Landry

Labib Rouhana

The astrocyte brain fatty acid binding protein (Fabp7) has previously been shown to have a coordinated diurnal regulation of mRNA and protein throughout mouse brain, and an age-dependent decline in protein expression within synaptoneurosomal fractions. Mechanisms that control time-of-day changes in expression and trafficking Fabp7 to the perisynaptic process are not known. In this study, we confirmed an enrichment of Fabp7 mRNA and protein in the astrocytic perisynaptic compartment, and observed a diurnal change in the intracellular distribution of Fabp7 mRNA in molecular layers of hippocampus. Northern blotting revealed a coordinated time-of-day-dependent oscillation for the Fabp7 mRNA poly(A) tail ...


Germline Defects Caused By Smed-Boule Rna-Interference Reveal That Egg Capsule Deposition Occurs Independently Of Fertilization, Ovulation, Mating, Or The Presence Of Gametes In Planarian Flatworms, Jessica Kathryne Steiner, Junichi Tasaki, Labib Rouhana 2017 Wright State University - Main Campus

Germline Defects Caused By Smed-Boule Rna-Interference Reveal That Egg Capsule Deposition Occurs Independently Of Fertilization, Ovulation, Mating, Or The Presence Of Gametes In Planarian Flatworms, Jessica Kathryne Steiner, Junichi Tasaki, Labib Rouhana

Labib Rouhana

Few animals are known to lay eggs in the absence of ovulation or copulation, as it is presumably energetically wasteful and subjected to negative selection. Characterization of Smed-boule, a member of the DAZ family of germline RNA-binding proteins, revealed that egg capsule (or capsule) production and deposition occurs independently of the presence of gametes in the planarian flatworm Schmidtea mediterranea. Reduction of Smed-boule expression by RNA-interference (RNAi) causes ablation of spermatogonial stem cells and the inability of ovarian germline stem cells to undergo oogenesis. Although animals subjected to Smed-boule RNAi lose their gametes and become sterile, they continue to lay ...


Prmt5 And The Role Of Symmetrical Dimethylarginine In Chromatoid Bodies Of Planarian Stem Cells, Labib Rouhana, Ana P. Vieira, Rachel H. Roberts-Galbraith, Phillip A. Newmark 2017 Wright State University - Main Campus

Prmt5 And The Role Of Symmetrical Dimethylarginine In Chromatoid Bodies Of Planarian Stem Cells, Labib Rouhana, Ana P. Vieira, Rachel H. Roberts-Galbraith, Phillip A. Newmark

Labib Rouhana

Planarian flatworms contain a population of adult stem cells (neoblasts) that proliferate and generate cells of all tissues during growth, regeneration and tissue homeostasis. A characteristic feature of neoblasts is the presence of chromatoid bodies, large cytoplasmic ribonucleoprotein (RNP) granules morphologically similar to structures present in the germline of many organisms. This study aims to reveal the function, and identify additional components, of planarian chromatoid bodies. We uncover the presence of symmetrical dimethylarginine (sDMA) on chromatoid body components and identify the ortholog of protein arginine methyltransferase PRMT5 as the enzyme responsible for sDMA modification in these proteins. RNA interference-mediated depletion ...


Vertebrate Gld2 Poly(A) Polymerases In The Germline And The Brain, Labib Rouhana, Liaoteng Wang, Natascha Buter, Jae Eun Kwak, Craig A. Schiltz, Tania Gonzalez, Ann E. Kelley, Charles F. Landry, Marvin Wickens 2017 Wright State University - Main Campus

Vertebrate Gld2 Poly(A) Polymerases In The Germline And The Brain, Labib Rouhana, Liaoteng Wang, Natascha Buter, Jae Eun Kwak, Craig A. Schiltz, Tania Gonzalez, Ann E. Kelley, Charles F. Landry, Marvin Wickens

Labib Rouhana

Cytoplasmic polyadenylation is important in the control of mRNA stability and translation, and for early animal development and synaptic plasticity. Here, we focus on vertebrate poly(A) polymerases that are members of the recently described GLD2 family. We identify and characterize two closely related GLD2 proteins in Xenopus oocytes, and show that they possess PAP activity in vivo and in vitro and that they bind known polyadenylation factors and mRNAs known to receive poly(A) during development. We propose that at least two distinct polyadenylation complexes exist in Xenopus oocytes, one of which contains GLD2; the other, maskin and Pumilio ...


De Novo Alignment Of Girardia Dorotocephala Transcriptome, Labib Rouhana, Eugene M. P. Almazan 2017 Wright State University - Main Campus

De Novo Alignment Of Girardia Dorotocephala Transcriptome, Labib Rouhana, Eugene M. P. Almazan

Labib Rouhana

De novo alignment of a Girardia dorotocephala (2n = 16) transcriptome using the Trinity platform.


Autoregulation Of Gld-2 Cytoplasmic Poly(A) Polymerase, Labib Rouhana, Marvin Wickens 2017 Wright State University - Main Campus

Autoregulation Of Gld-2 Cytoplasmic Poly(A) Polymerase, Labib Rouhana, Marvin Wickens

Labib Rouhana

Cytoplasmic polyadenylation regulates mRNA stability and translation and is required for early development and synaptic plasticity. The GLD-2 poly(A) polymerase catalyzes cytoplasmic polyadenylation in the germline of metazoa. Among vertebrates, the enzyme is encoded by two isoforms of mRNA that differ only in the length of their 3′-UTRs. Here we focus on regulation of vertebrateGLD-2 mRNA. We show that the 3′-UTR of GLD-2 mRNA elicits its own polyadenylation and translational activation during frog oocyte maturation. We identify the sequence elements responsible for repression and activation, and demonstrate that CPEB and PUF proteins likely mediate repression in ...


It Always Seems Too Early, Until It’S Too Late, Marie Eaton 2017 Western Washington University

It Always Seems Too Early, Until It’S Too Late, Marie Eaton

Palliative Care Institute

What is Palliative Care?

  • Specialized care for people living with chronic and serious illness.
  • Goal is to improve quality of life for both the patient and the family when cure is not possible.
  • Focuses on providing relief from the symptoms and stress of a serious illness
  • Provided by an interdisciplinary team of palliative care doctors, nurses, social workers, chaplains, family members and others who work together to provide an extra layer of support.
  • Appropriate at any age and at any stage in a serious illness and can be provided along with curative treatment


Screening, Brief Intervention And Referral To Treatment Implementation In The Emergency Department, Arvind Venkat MD, Gary Shank PhD, Sherry Rickard-Aasen, Janice Pringle PhD, William Johnjulio MD 2017 Allegheny General Hospital

Screening, Brief Intervention And Referral To Treatment Implementation In The Emergency Department, Arvind Venkat Md, Gary Shank Phd, Sherry Rickard-Aasen, Janice Pringle Phd, William Johnjulio Md

The Qualitative Report

We sought to qualitatively evaluate impediments in implementing a novel Screening, Brief Intervention and Referral to Treatment (SBIRT) protocol into normal emergency department (ED) workflow for patients with at-risk drug/alcohol behavior. From 2010, administrative and nursing champions trained nurses at a single ED (census: 50,000 visits/yr) in SBIRT and incorporated SBIRT into normal ED nursing workflow in 2012. To qualitatively analyze impediments in SBIRT implementation, we created a semi-structured questionnaire for protocol champions with subsequent follow-up. Investigators analyzed responses using qualitative methodology based on a modified grounded theory framework. In 2012, 47693 visits by 31525 patients met ...


“It’S Not A Life Or Death Thing”: A Grounded Theory Study Of Smoking Decisions Among Chinese Americans, Yu Lu 2017 Ohio University - Main Campus

“It’S Not A Life Or Death Thing”: A Grounded Theory Study Of Smoking Decisions Among Chinese Americans, Yu Lu

The Qualitative Report

Smoking results in a high mortality rate for Chinese Americans. Little is known, however, about the decisions members of this group make that lead to these unhealthy behaviors. Examining smoking decisions could help us understand these choices as well as develop effective prevention strategies. This grounded theory study was conducted to understand Chinese Americans’ smoking decisions. Fifty-four individual interviews and three focus groups were conducted with Chinese Americans of different smoking statuses. The findings describe five smoking decisions including the trajectory of these behaviors. Optimistic bias is identified as one of the main reasons that regular smokers decide not to ...


Dynamic Transcriptomes Identify Biogenic Amines And Insect-Like Hormonal Regulation For Mediating Reproduction In Schistosoma Japonicum., Jipeng Wang, Ying Yu, Haimo Shen, Tao Qing, Yuanting Zheng, Qing Li, Xiaojin Mo, Shuqi Wang, Nana Li, Riyi Chai, Bin Xu, Mu Liu, Paul J Brindley, Donald P McManus, Zheng Feng, Leming Shi, Wei Hu 2017 George Washington University

Dynamic Transcriptomes Identify Biogenic Amines And Insect-Like Hormonal Regulation For Mediating Reproduction In Schistosoma Japonicum., Jipeng Wang, Ying Yu, Haimo Shen, Tao Qing, Yuanting Zheng, Qing Li, Xiaojin Mo, Shuqi Wang, Nana Li, Riyi Chai, Bin Xu, Mu Liu, Paul J Brindley, Donald P Mcmanus, Zheng Feng, Leming Shi, Wei Hu

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Eggs produced by the mature female parasite are responsible for the pathogenesis and transmission of schistosomiasis. Female schistosomes rely on a unique male-induced strategy to accomplish reproductive development, a process that is incompletely understood. Here we map detailed transcriptomic profiles of male and female Schistosoma japonicum across eight time points throughout the sexual developmental process from pairing to maturation. The dynamic gene expression pattern data reveal clear sex-related characteristics, indicative of an unambiguous functional division between males and females during their interplay. Cluster analysis, in situ hybridization and RNAi assays indicate that males likely use biogenic amine neurotransmitters through the ...


Is A Students’ Ability To Critically Self-Reflect, Related To Their Performance On Physiotherapy Clinical Placements?, Sarah Brooks, Nikki Milne, Rob Marc Orr, Rebecca Terry 2017 Bond University

Is A Students’ Ability To Critically Self-Reflect, Related To Their Performance On Physiotherapy Clinical Placements?, Sarah Brooks, Nikki Milne, Rob Marc Orr, Rebecca Terry

Australian Journal of Clinical Education

Background. The relationship between students’ reflective ability and performance on physiotherapy clinical placement is currently unclear.

Objectives. To investigate: i) if a relationship exists between students’ critical reflective ability and performance on physiotherapy clinical placement; and whether these relationships differ by ii) Critical reflective task (CRT) rank grade or, iii) by gender.

Design. An observational cohort study design.

Methods. Critical Reflection Task (CRT) marks and clinical placement (APP) scores from 196 (F=94; M=102) post-graduate, entry-level physiotherapy students were analyzed.

Results. A significant moderate predictive relationship was found between CRT marks and APP scores (r=.411, p2=.169, SEE ...


Marijuana Regulation And Federalism, John M. Greabe 2017 University of New Hampshire School of Law

Marijuana Regulation And Federalism, John M. Greabe

Legal Scholarship

[Excerpt] "Federal law makes the cultivation and use of marijuana illegal for all purposes. Yet, over the past two decades, 28 states plus the District of Columbia have legalized marijuana for medicinal purposes, and eight states plus the District of Columbia have legalized it for recreational purposes. Marijuana regulation thus provides a useful and timely example for exploring the ways in which the distribution of power between the federal government and the states can facilitate policy change."


Usage Of 3d Models Of Tetralogy Of Fallot For Medical Education: Impact On Learning Congenital Heart Disease., Yue-Hin Loke, Ashraf S Harahsheh, Axel Krieger, Laura J Olivieri 2017 George Washington University

Usage Of 3d Models Of Tetralogy Of Fallot For Medical Education: Impact On Learning Congenital Heart Disease., Yue-Hin Loke, Ashraf S Harahsheh, Axel Krieger, Laura J Olivieri

Pediatrics Faculty Publications

BACKGROUND: Congenital heart disease (CHD) is the most common human birth defect, and clinicians need to understand the anatomy to effectively care for patients with CHD. However, standard two-dimensional (2D) display methods do not adequately carry the critical spatial information to reflect CHD anatomy. Three-dimensional (3D) models may be useful in improving the understanding of CHD, without requiring a mastery of cardiac imaging. The study aimed to evaluate the impact of 3D models on how pediatric residents understand and learn about tetralogy of Fallot following a teaching session.

METHODS: Pediatric residents rotating through an inpatient Cardiology rotation were recruited. The ...


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