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Exploring The Associations Between Age Related Decline In Anti-Mullerian Hormone (Amh) And Physical Activity In The All Of Us Research Program, Robert J. Leone, Dr. Paige Coyne, Ze Meng, Dr. Sara Santarossa 2024 Wayne State University

Exploring The Associations Between Age Related Decline In Anti-Mullerian Hormone (Amh) And Physical Activity In The All Of Us Research Program, Robert J. Leone, Dr. Paige Coyne, Ze Meng, Dr. Sara Santarossa

Medical Student Research Symposium

Anti-Mullerian Hormone (AMH) is used to measure female fertility levels. Physical activity (PA) has previously been linked to increases in fertility rates. We explored associations between age related decline in AMH and PA, hypothesizing that consistent PA would lead to a lessened decline of AMH levels. This study is a secondary data analysis, sourced from the NIH’s All of Us Research Program database. Inclusion criteria for participant data : a) ≥1 AMH test record in their electronic health records, b) AMH level of < 7ng/ml, and c) ≥30 days of valid Fitbit data within 1 year prior to AMH test date. A series of generalized linear regression models were conducted between normalized AMH level and four different daily average activity intensity minutes based on metabolic equivalents (sedentary, lightly active, fairly active, and very active) and daily step count, adjusting for age at AMH test. The final dataset included 24 participants. Daily average of “very active” minutes had a strong positive effect on lessening the decline of AMH levels (β=0.0159, p=0.136). Two clusters (C1 and C2) were identified by applying the Kmeans method. C1 (N=9) has significantly higher daily “fairly active” minutes (C1: 19.61(8.05) vs C2: 7.59(3.81)) and daily “very active” minutes (C1: 22.81(10.23) vs C2: 8.95(5.12)) compared to C2 (N=15). In an association analysis, C1 AMH level is higher than C2 (0.35(-0.10,1.03), p=0.162. There may be an association between being very active and a preservation of AMH, which could be valuable to providers counseling women prolonging motherhood.


Breast Cancer And Colorectal Cancer Screening In Arab Americans From 2021-2023, Nicole Oska, Hasti Nema, Deni Peterson, Kendall Brothers, Mohammed Najeeb Al Hallek 2024 Wayne State University School of Medicine

Breast Cancer And Colorectal Cancer Screening In Arab Americans From 2021-2023, Nicole Oska, Hasti Nema, Deni Peterson, Kendall Brothers, Mohammed Najeeb Al Hallek

Medical Student Research Symposium

Breast Cancer and Colorectal Cancer Screening in Arab Americans from 2021-2023

Nicole Oska1, Hasti Nema1, Deni Peterson1, Kendall Brothers1, Mohammed Najeeb Al Hallak1,2

1Department of Oncology, School of Medicine, Wayne State University, Detroit, MI, USA; 2Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA


Introduction:

Breast cancer (BC) and colorectal cancer (CRC) are among the most commonly diagnosed cancers in the United States1,2; screening for these cancers is a pivotal component of preventative healthcare. Arab Americans represent a diverse, yet understudied, patient population that may encounter distinct barriers …


Efficacy Of Hypnosis As A Treatment For Alopecia, Haya Beydoun, Meena Moossavi 2024 Wayne State University

Efficacy Of Hypnosis As A Treatment For Alopecia, Haya Beydoun, Meena Moossavi

Medical Student Research Symposium

Title:

Efficacy of Hypnosis as a treatment for Alopecia

Introduction:

Hypnosis is an altered state of consciousness in which someone is more receptive to suggestions and modeling, and it can address psychological and physical symptoms that are aggravated by conscious and unconscious triggers.The intended outcome is a change in certain behaviors or patterns of thinking that patients have which can mitigate their stress load. Stress can induce and exacerbate alopecia, and patients often suffer increased stress due to the psychosocial burden of having a dermatological disease. A study showed that high levels of cortisol releasing hormones (CRH) were found to …


Tendon Rupture And Tendonitis In Low-Profile Dorsal Versus Volar Plating For Distal Radius Fractures: A Systematic Review And Meta-Analysis, Matthew Myhand, Shreya Balusu, Alex Lindahl BS, Hardy Evans MD, Charles Day Dr., Eric Jiang Dr. 2024 Wayne State University School of Medicine

Tendon Rupture And Tendonitis In Low-Profile Dorsal Versus Volar Plating For Distal Radius Fractures: A Systematic Review And Meta-Analysis, Matthew Myhand, Shreya Balusu, Alex Lindahl Bs, Hardy Evans Md, Charles Day Dr., Eric Jiang Dr.

Medical Student Research Symposium

Tendon Rupture and Tendonitis in Low-Profile Dorsal versus Volar Plating for Distal Radius Fractures: A Systematic Review and Meta-Analysis

Background: Dorsal plating of distal radius fractures has historically been associated with high rates of hardware removal, tendonitis, and tendon rupture. Newer generation low-profile dorsal plates are thinner (<1.6mm thick) with improved characteristics. We examine whether low-profile dorsal plates still have higher rates of tendon complications than volar locking plates.

Methods: We searched Ovid MEDLINE, Web of Science, and EMBASE for published literature describing tendon complications in association with plating of distal radius fractures. Inclusion criteria encompasses any primary study of low-profile dorsal plates that included data on tendon complications. Studies that included both low-profile dorsal and volar plating arms were included …


Biological Sex Is A Predictor Of Pretibial Subcutaneous Tissue Depth For Intraosseous Catheter Insertion, Alex DuVall, Thomas Sprys-Tellner, Tristan Lemon, Ryan Kelly, Andrew Stefan, James Paxton 2024 Wayne State University

Biological Sex Is A Predictor Of Pretibial Subcutaneous Tissue Depth For Intraosseous Catheter Insertion, Alex Duvall, Thomas Sprys-Tellner, Tristan Lemon, Ryan Kelly, Andrew Stefan, James Paxton

Medical Student Research Symposium

Introduction

Intraosseous (IO) vascular access is most commonly used when critical patients need rapid establishment of vascular access. They have shown high rates of successful placement, with the proximal tibia showing the highest first-attempt success rates. Proper establishment of vascular access requires a needle properly sized to enter the bony cortex and stay there. In this study, we analyzed demographic associations with pre-tibial subcutaneous tissue depth (PTSTD).

Methods

The PTSTD was calculated using computed tomography (CT) images of adult (³ 18 years old) patients. Variables including side, age, sex, height, weight, BMI, hypertension, diabetes mellitus, atherosclerosis, coronary artery disease, and …


Utilizing Bibliometrics To Understand The Role Of Machine Learning In The Current Orthopedic Arthroplasty Literature, Matthew Corsi BS., Fong Nham MD., Mouhanad El-Othmani MD 2024 Wayne State University School of Medicine, Detroit, Michigan, USA

Utilizing Bibliometrics To Understand The Role Of Machine Learning In The Current Orthopedic Arthroplasty Literature, Matthew Corsi Bs., Fong Nham Md., Mouhanad El-Othmani Md

Medical Student Research Symposium

Background: Machine learning technology has been demonstrated to be a very useful tool in current orthopedic research. Furthermore, machine learning has shown to be quite impactful in the field of arthroplasty solving many clinical and scientific problems, leading to greater utilization in retrospective studies. This current study aims to identify machine learning arthroplasty research and predict future hotspots. We hypothesize that the production of current scientific literature on machine learning will be produced by US-based national institutions and will have exponentially grown in the past 5 years.

Methods: Machine learning arthroplasty publications between 1996 and 2023 were identified using the …


Assessing Mentor And Coordinator Professional Development In The Context Of Medical School Learning Communities, Chelsea Yu, Alyssa Fabrizio, Gretchen Swift, Brianna Regan, Jack Considine, Carline Dugue 2024 MS3

Assessing Mentor And Coordinator Professional Development In The Context Of Medical School Learning Communities, Chelsea Yu, Alyssa Fabrizio, Gretchen Swift, Brianna Regan, Jack Considine, Carline Dugue

Medical Student Research Symposium

Background
Learning communities (LCs) create a bridge for senior students to engage with peers to provide advice and support. Anecdotally, LC leaders gain confidence in communication, empathy, and leadership - well received traits for residency. We aim to describe and quantify the growth of LC leaders over time.

Methods
This study aims to elucidate an objective measure of student leader growth and development. We will evaluate opinions on the LC’s ability to foster professional and personal growth, and we will assess areas for improvement. Through Qualtrics self-rated queries using a Likert scale, we will survey 32 Coordinators from classes 2023-2026 …


Fueling Survival: Adipocyte-Mediated Modulation Of Iron Metabolism And Oxidative Stress Pathways In Bone Metastatic Prostate Cancer, Shrila Rajendran, Alexis Wilson, Shane Mecca, Mackenzie Herroon, Laimar Garmo, Izabela Podgorski 2024 Wayne State University

Fueling Survival: Adipocyte-Mediated Modulation Of Iron Metabolism And Oxidative Stress Pathways In Bone Metastatic Prostate Cancer, Shrila Rajendran, Alexis Wilson, Shane Mecca, Mackenzie Herroon, Laimar Garmo, Izabela Podgorski

Medical Student Research Symposium

Fueling survival: Adipocyte-mediated modulation of iron metabolism and oxidative stress pathways in bone metastatic prostate cancer

Authors: Shrila Rajendran1*, Alexis Wilson1,2, Shane Mecca1, Mackenzie Herroon1, Laimar Garmo1, and Izabela Podgorski1,2

Department of Pharmacology, Wayne State University School of Medicine1 and Cancer Biology Graduate Program, Wayne State University School of Medicine and Karmanos Cancer Institute2

Prostate cancer (PCa) commonly metastasizes to the bone marrow, where cancer cells interact with a variety of cell types that compose the bone tumor microenvironment. The interaction of interest for this research is …


A Systematic Review Of The Social Determinants Of Health In Shoulder Arthroplasty Outcomes, Allison Boland, John Pum, Michael Gaudiani, Matthew A. Gasparro 2024 Wayne State University

A Systematic Review Of The Social Determinants Of Health In Shoulder Arthroplasty Outcomes, Allison Boland, John Pum, Michael Gaudiani, Matthew A. Gasparro

Medical Student Research Symposium

This systematic review investigates the impact of social determinants of health (SDOH) on outcomes in shoulder arthroplasty (SA). SA, a common orthopedic procedure, has seen an increasing focus on SDOH influencing postoperative results. The study aims to comprehensively assess this impact on both surgical and patient-reported outcomes.

Through a systematic search of databases, 34 studies (2011-2021) met the inclusion criteria, involving 4,825,547 patients. Explored SDOH included insurance status, race/ethnicity, age, sex, income, social support, and veteran status. Outcomes considered were length of stay, American Shoulder and Elbow Surgeons scores, total SA rates, revision rates, complication rates, and discharge status.

Findings …


Exploring The Effects Of Amniotic Bladder Therapy On Female Sexual Dysfunction In Interstitial Cystitis/Bladder Pain Syndrome Patients, Jonathan D. Lutchka, Jack Vercnocke MD, David Pearlman MD, Aron Liaw MD, Nivedita Dhar MD 2024 Wayne State University

Exploring The Effects Of Amniotic Bladder Therapy On Female Sexual Dysfunction In Interstitial Cystitis/Bladder Pain Syndrome Patients, Jonathan D. Lutchka, Jack Vercnocke Md, David Pearlman Md, Aron Liaw Md, Nivedita Dhar Md

Medical Student Research Symposium

Introduction and Objectives: Female sexual dysfunction (FSD) is commonly associated with Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS). FSD manifests as abnormalities in sexual desire, arousal, orgasm, pain, distress, and satisfaction. Our primary objective was to assess the impact of micronized amniotic membrane injections (AM) on FSD and lower urinary tract symptoms using comprehensive measures, including the multi-domain Female Sexual Function Index (FSFI), the Pain Visual Analog Scale (VAS), and the Interstitial Cystitis Symptom Index (ICSI) and Interstitial Cystitis Problem Index (ICPI).

Methods: Study participants included patients diagnosed with IC/BPS and FSD refractory to traditional therapies. Under general anesthesia, these …


Flash Radiation Ultra-High Dose Rate Radiation With Potential For Sensitization By Platinum, Abigail A. Jaczkowski, Stephen Brown Ph.D. 2024 Wayne State University

Flash Radiation Ultra-High Dose Rate Radiation With Potential For Sensitization By Platinum, Abigail A. Jaczkowski, Stephen Brown Ph.D.

Medical Student Research Symposium

External beam radiation therapy, a cornerstone in cancer treatment for 50% of patients, poses challenges due to its toxicity to both cancer and healthy cells. Seeking to mitigate side effects, the emerging FLASH radiation technology employs ultra-high dose rates, promising quicker treatments with reduced impact on surrounding normal tissue. Platinum, recognized as a radiation sensitizer, enhances the effectiveness of radiation therapy by increasing sensitization at higher energy levels through pair-production.

This study explores the hypothesis that Cisplatin, a platinum-based chemotherapy agent, will exhibit a synergistic effect when combined with FLASH radiation. Using A549 cells from non-small cell lung cancer, the …


The Efficacy And Frequency Of Early Left Heart Catheterization After Out Of Hospital Cardiac Arrest Over The Last Decade, Shobi Mathew, Robert Welch, Robert Swor, Robert R. Ehrman, Anthony Lagina, Brian O'Neil 2024 Wayne State University School of Medicine

The Efficacy And Frequency Of Early Left Heart Catheterization After Out Of Hospital Cardiac Arrest Over The Last Decade, Shobi Mathew, Robert Welch, Robert Swor, Robert R. Ehrman, Anthony Lagina, Brian O'Neil

Medical Student Research Symposium

Introduction:

The efficacy of early coronary intervention after return of spontaneous circulation (ROSC) from out of hospital cardiac arrest (OHCA) is debated. We aimed to nationally study the effect of early LHC on survival with good neurological outcome and describe the rate and timing of LHC in OHCA.

Methods:

The observational study included patients enrolled in the national CARES registry from 2013-21. Outcome was cerebral performance category, (CPC) (good <3 vs. poor > 3) at hospital discharge. For the outcome of LHC by year, chi square analysis was performed. A propensity score (PS) model was constructed using variables predictive of LHC and good outcome …


Exploring The Relationship Of Varying Hydrocephalus Severity On Csf Dynamics In A Pediatric Hydrocephalus Rodent Model, Parker R. Fitzgerald, Grant Zydeck, Jeff Horbatiuk, Enoch Kim, Arjun Muralidharan, Carolyn A. Harris PhD 2024 Wayne State University

Exploring The Relationship Of Varying Hydrocephalus Severity On Csf Dynamics In A Pediatric Hydrocephalus Rodent Model, Parker R. Fitzgerald, Grant Zydeck, Jeff Horbatiuk, Enoch Kim, Arjun Muralidharan, Carolyn A. Harris Phd

Medical Student Research Symposium

Hydrocephalus causes neurological effects and high intracranial pressure (ICP) in the pediatric condition. Studies observing the relationship between ICP and cerebrospinal fluid (CSF) production in an electrical resistance model have been performed, but less has been done to define this relationship in living organisms. This study explored CSF flow dynamics as a consequence of hydrocephalus severity utilizing a novel model.

The model induced hydrocephalus in rats through injecting 30-50 micrometers of 25% (w/v) kaolin into the cisterna magna to obstruct CSF outflow. After 15-16 days of acclimation, the rats were anesthetized with isoflurane. A Transonic SP200 pressure transducer was inserted …


A Pilot Study Assessing The Efficacy Of Amniotic Bladder Therapy In Spinal Cord Injury Patients With Female Sexual Dysfunction, Kyle P. O'Hollaren, Emma Ross, Codrut Radoiu, Lincoln Erickson, Michael Bush-Arnold, Ali Bitar, Steven Lucas, Nivedita Dhar 2024 Wayne State University School of Medicine

A Pilot Study Assessing The Efficacy Of Amniotic Bladder Therapy In Spinal Cord Injury Patients With Female Sexual Dysfunction, Kyle P. O'Hollaren, Emma Ross, Codrut Radoiu, Lincoln Erickson, Michael Bush-Arnold, Ali Bitar, Steven Lucas, Nivedita Dhar

Medical Student Research Symposium

Introduction and Objectives: Female sexual dysfunction (FSD) following spinal cord injury (SCI) presents with abnormalities in sexual desire, arousal, orgasm, pain, distress, and dissatisfaction. FSD negatively impacts quality of life and is often refractory to available treatment options. Previously, we reported preliminary benefits of intra-detrusor micronized amniotic membrane (AM) on detrusor dysfunction following SCI. In this study, we evaluated the effect of intra-detrusor micronized AM injection on FSD symptoms in SCI patients using the multi-domain female sexual function index (FSFI) and pain visual analog scale (VAS).

Methods: Five SCI females (mean age: 32 ± 12 years) with FSD recalcitrant to …


Examining Vaccine Hesitancy Trends In An Underserved Population At A Student-Run Free Clinic, John Pum, Cameron Bear, Dhiraj Tadikamalla, Hasti Nema 2024 Wayne State University School of Medicine

Examining Vaccine Hesitancy Trends In An Underserved Population At A Student-Run Free Clinic, John Pum, Cameron Bear, Dhiraj Tadikamalla, Hasti Nema

Medical Student Research Symposium

Title: Examining Vaccine Hesitancy Trends in an Underserved Population at a Student-Run Free Clinic

Authors: John Pum, Cameron Bear, Dhiraj Tadikamalla, Hasti Nema, Robert Sherwin M.D.

Introduction:

The global debate surrounding the safety and efficacy of COVID-19 vaccines has triggered widespread vaccination hesitancy, impacting not only COVID-19 immunizations but also other vaccines. This study investigates whether a parallel trend exists within a Student-Run Free Clinic (SRFC), focusing on an underserved population disproportionately affected by the pandemic.

Methods:

Retrospective analysis was conducted by coordinators of Cass Clinic, a Detroit-based SRFC. Patients included were individuals 18 or older who received the influenza …


Six- Month Report Assessing The Feasibility And Effectiveness Of Amniotic Bladder Therapy In Patients With Chronic Radiation Cystitis, Samy Shelbaya, Raghav Madan, Nick Pryde, Jack Vercnocke, Codrut Radoiu, Julian Julian Jeberaeel, Nitin Vaishampayan, Nivedita Dhar 2024 Wayne State University

Six- Month Report Assessing The Feasibility And Effectiveness Of Amniotic Bladder Therapy In Patients With Chronic Radiation Cystitis, Samy Shelbaya, Raghav Madan, Nick Pryde, Jack Vercnocke, Codrut Radoiu, Julian Julian Jeberaeel, Nitin Vaishampayan, Nivedita Dhar

Medical Student Research Symposium

Introduction: In view of the pathophysiology of chronic radiation cystitis (CRC) that is mainly caused by activation of an inflammatory cascade leading to chronic inflammation, vascular damage and fibrosis, amniotic membrane (AM) based therapy has emerged as a potential therapeutic approach for radiation-induced tissue injury due to its immunomodulatory, vasculogenic and anti-fibrotic properties. We have previously reported that amniotic bladder therapy (ABT) provides symptomatic improvement in refractory CRC patients for up to 3 months. Herein, we evaluated the durability of ABT up to 6 months.

Methods: CRC patients recalcitrant to multiple therapies were eligible for the study and …


Preventing And Responding To Workplace Violence In The Emergency Department, Stefanie Lai, Alicia Rodriguez 2024 Providence

Preventing And Responding To Workplace Violence In The Emergency Department, Stefanie Lai, Alicia Rodriguez

Providence Nursing Research Conference 2023 – Present

Background: Workplace violence (WPV) is defined as physical violence or verbal threats of physical violence, regardless of whether an employee sustains an injury. Emergency department (ED) staff are at high risk of exposure to WPV, which can lead to burnout, job dissatisfaction, and secondary stress. Effective preparation for and response to WPV incidents can help mitigate these negative effects. Multicomponent interventions, including education, safety huddles, behavioral health rapid response teams, and environmental modifications, have been shown to reduce WPV incidents and increase staff perceptions of safety.

Purpose: The purpose of this evidence informed-quality improvement project was to increase knowledge of …


Peer-To-Peer Model To Educate And Spread Awareness Of Vaccines In Detroit, Sofia Howson, Jennifer Schmidt, Catherine Maples, Jack Mcconnell, Soham Desai, Rebekah Pitpitan, Teena Chopra, Matthew W. Seeger 2024 Wayne State University

Peer-To-Peer Model To Educate And Spread Awareness Of Vaccines In Detroit, Sofia Howson, Jennifer Schmidt, Catherine Maples, Jack Mcconnell, Soham Desai, Rebekah Pitpitan, Teena Chopra, Matthew W. Seeger

Medical Student Research Symposium

Since the COVID-19 pandemic, national vaccination rates show a dangerous decline with Detroit being amongst the lowest with only 41.3% of adolescents completing the vaccine series. The Vaccine Ambassador program was created to mitigate the decline in vaccination rates through the education and empowerment of youth via train-the-trainer model of education.

The program was implemented over the course of two years with a total of 28 high school students who received education on the history and mechanism of vaccines, herd immunity, and how to effectively communicate. The program was created in collaboration with physicians in Infectious Diseases and a professor …


Active Surveillance Vs. Curative Treatment: Longitudinal Quality Of Life 2-Years After Low-Risk Prostate Cancer Diagnosis, Emma Streveler, Cathryn Bock, Jinping Xu, James Janisse, Justin Woo 2024 Wayne State University

Active Surveillance Vs. Curative Treatment: Longitudinal Quality Of Life 2-Years After Low-Risk Prostate Cancer Diagnosis, Emma Streveler, Cathryn Bock, Jinping Xu, James Janisse, Justin Woo

Medical Student Research Symposium

Background: Active surveillance (AS) allows patients with low-risk prostate cancer (LRPC) to be monitored for disease progression, thereby avoiding or delaying invasive curative treatment (CT) (i.e., surgery or radiation) and related side effects. Here we compare quality of life (QOL) two-years after diagnosis between men who underwent CT overall and by race.

Methods: Black and white men with LRPC were recruited through population-based cancer registries in metropolitan Detroit and Georgia. Participants were grouped by their treatment type (CT or AS). QOL measures SF-12 and EPIC-26 were assessed at baseline and 2-year follow up using mailed surveys. Differences between groups at …


Analysis Of Antibody Drug Conjugate On Cellular Senescent Human Glioblastoma, Ariel P. Walker, Renee Hirte, Cecile Riviere-Cazaux, Authur Warrington, Terry Burns 2024 Wayne State University

Analysis Of Antibody Drug Conjugate On Cellular Senescent Human Glioblastoma, Ariel P. Walker, Renee Hirte, Cecile Riviere-Cazaux, Authur Warrington, Terry Burns

Medical Student Research Symposium

Background: Glioblastoma Multiforme (GBM) is an aggressive and malignant brain tumor known for its rapid progression and unfavorable prognosis. The standard treatment options primarily involve radiation and temozolomide, however recurrence is inevitable.

B7H3/CD276, an immunomodulatory transmembrane glycoprotein, demonstrates tumor-specific expression, with limited presence in normal healthy tissue, making it a promising and attractive treatment target in GBM. AbbV155 is an antibody drug conjugate that inhibits BCL-XL and specifically targets B7H3 (CD276) on GBM cells with the goal of selectively eliminating viable tumor cells.

Objectives: First, we sought to confirm the presence of B7H3/CD276 in our selected cell line via …


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