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Neuroaids In Africa, Kevin Robertson, Jeff Liner, James Hakim, Jean-Louis Sankalé, Igor Grant, Scott Letendre, David Clifford, Amadou Gallo Diop, Assan Jaye, Georgette Kanmogne, Alfred Njamnshi, T. Dianne Langford, Tufa Gemechu Weyessa, Charles Wood, Mwanza Banda, Mina Hosseinipour, Ned Sacktor, Noeline Nakasuja, Paul Bangirana, Robert Paul, John Joska, Joseph Wong, Michael Boivin, Penny Holding, Betsy Kammerer, Annelies Van Rie, Prudence Ive, Avindra Nath, Kathy Lawler, Clement Adebamowo, Walter Royal III, Jeymohan Joseph 2010 University of North Carolina

Neuroaids In Africa, Kevin Robertson, Jeff Liner, James Hakim, Jean-Louis Sankalé, Igor Grant, Scott Letendre, David Clifford, Amadou Gallo Diop, Assan Jaye, Georgette Kanmogne, Alfred Njamnshi, T. Dianne Langford, Tufa Gemechu Weyessa, Charles Wood, Mwanza Banda, Mina Hosseinipour, Ned Sacktor, Noeline Nakasuja, Paul Bangirana, Robert Paul, John Joska, Joseph Wong, Michael Boivin, Penny Holding, Betsy Kammerer, Annelies Van Rie, Prudence Ive, Avindra Nath, Kathy Lawler, Clement Adebamowo, Walter Royal Iii, Jeymohan Joseph

Virology Papers

In July 2009, the Center for Mental Health Research on AIDS at the National Institute of Mental Health organized and supported the meeting “NeuroAIDS in Africa.” This meeting was held in Cape Town, South Africa, and was affiliated with the 5th IAS Conference on HIV Pathogenesis, Treatment and Prevention. Presentations began with an overview of the epidemiology of HIV in sub-Saharan Africa, the molecular epidemiology of HIV, HIV-associated neurocognitive disorders (HANDs), and HAND treatment. These introductory talks were followed by presentations on HAND research and clinical care in Botswana, Cameroon, Ethiopia, The Gambia, Kenya, Malawi, Nigeria, Senegal, South Africa, Uganda ...


An Intervention To Prevent Symptoms Associated With Hepatitis C: A Pilot Study, Donna M. Zucker 2010 University of Massachusetts - Amherst

An Intervention To Prevent Symptoms Associated With Hepatitis C: A Pilot Study, Donna M. Zucker

College of Nursing Faculty Publication Series

The objectives of this study were to (a) pilot test instruments measuring fatigue and quality of life (QOL); (b) pilot test an exercise intervention; and (c) estimate the effect size of this intervention relative to completion of combination therapy, fatigue, QOL, and walking distance in 20 patients with chronic hepatitis C about to begin interferon alpha and ribavirin treatment. Alpha reliabilities for both the Schwartz Cancer Fatigue Scale and Hepatitis Quality of Life Questionnaire were moderately high. Power analyses of all outcome measures indicated a small effect size and sample size estimate of 30–40 per group to achieve power ...


The Complete Ethical Framework For End-Of-Life Care, Joan McCarthy, Mary Donnelly, Dolores Dooley, Louise Campbell, David Smith, Catherine O'Neill, Christina Quinlan, John Weafer 2010 University College Cork

The Complete Ethical Framework For End-Of-Life Care, Joan Mccarthy, Mary Donnelly, Dolores Dooley, Louise Campbell, David Smith, Catherine O'Neill, Christina Quinlan, John Weafer

General Practice Reports

The Ethical Framework for End-of-life Care is part of a national programme, the Hospice Friendly Hospitals Programme (HfH) of the Irish Hospice Foundation, which is intended to improve the culture of care and organization regarding dying, death and bereavement in Irish hospitals. The Framework is an educational resource that consists of eight Modules of Learning for health professionals, patients, families and the general public. The Framework is the outcome of a unique collaboration between University College Cork, the Royal College of Surgeons in Ireland and the Irish Hospice Foundation, with contributions from ethicists, legal experts, theologians, sociologists and clinicians. It ...


H1n1 2009 In Karachi: A Situational Analysis, Bushra Jamil, Syed Faisal Mahmood 2010 Aga Khan University

H1n1 2009 In Karachi: A Situational Analysis, Bushra Jamil, Syed Faisal Mahmood

Department of Medicine

No abstract provided.


Validation Of C-Reactive Protein In The Early Diagnosis Of Neonatal Sepsis In A Tertiary Care Hospital In Kenya., Rashim Kumar, Rachel Musoke, William Macharia, Gunturu Revathi 2010 Gertrude’s Children’s Hospital

Validation Of C-Reactive Protein In The Early Diagnosis Of Neonatal Sepsis In A Tertiary Care Hospital In Kenya., Rashim Kumar, Rachel Musoke, William Macharia, Gunturu Revathi

Paediatrics and Child Health, East Africa

Objective: To evaluate utility of C-reactive protein (CRP) in the early diagnosis of neonatal sepsis in a tertiary care Newborn Unit in Kenya.

Design: Cross-sectional study.

Setting: Newborn Unit, Kenyatta National Hospital.

Subjects: All neonates admitted to Newborn Unit, Kenyatta National Hospital during the study period with suspected sepsis based on specified clinical criteria.

Results: Of the 310 infants, there were 83 episodes of proven sepsis and 94 episodes of probable sepsis. Using the standard CRP cut-off value of 5 mg/dl, a sensitivity of 95.2% in proven sepsis and 98.9% for probable septic episodes were noted. In ...


Predictors Of Emotional Problems And Physical Aggression Among Children Of Hong Kong Chinese, Mainland Chinese And Filipino Immigrants To Canada, Morton Beiser, Hayley Hamilton, Joanna Anneke Rummens, Jacqueline Oxman-Martinez, Linda Ogilvie, Chuck Humphrey, Robert Armstrong 2010 Ryerson University,

Predictors Of Emotional Problems And Physical Aggression Among Children Of Hong Kong Chinese, Mainland Chinese And Filipino Immigrants To Canada, Morton Beiser, Hayley Hamilton, Joanna Anneke Rummens, Jacqueline Oxman-Martinez, Linda Ogilvie, Chuck Humphrey, Robert Armstrong

Paediatrics and Child Health, East Africa

Background and study aims: Data from the New Canadian Children and Youth Study (NCCYS), a national study of immigrant children and youth in Canada, are used to examine the mental health salience of putatively universal determinants, as well as of immigration-specific factors. Universal factors (UF) include age, gender, family and neighbourhood characteristics. Migration-specific (MS) factors include ethnic background, acculturative stress, prejudice, and the impact of region of resettlement within Canada.

Methods: In a sample of children from Hong Kong, the Philippines and Mainland China, the study examined the determinants of emotional problems (EP), and physical aggression (PA). A two-step regression ...


The Neighborhood Cancer Center, Gregory R. Harper MD, PhD, Debbie Salas-Lopez MD, MPH, Keith J. Weinhold MHA, Elliot J. Sussman MD, MBA 2010 Lehigh Valley Health Network

The Neighborhood Cancer Center, Gregory R. Harper Md, Phd, Debbie Salas-Lopez Md, Mph, Keith J. Weinhold Mha, Elliot J. Sussman Md, Mba

Administration & Leadership

No abstract provided.


Clinical, Radiological And Cognitive Features Of Arteriovenous Malformations Of The Brain: A Prospective Study Of Consecutive Patients Presenting To Beaumont Hospital., Patrick Leo Galvin 2010 Royal College of Surgeons in Ireland

Clinical, Radiological And Cognitive Features Of Arteriovenous Malformations Of The Brain: A Prospective Study Of Consecutive Patients Presenting To Beaumont Hospital., Patrick Leo Galvin

MD theses

No abstract provided.


Induction Of Epidermal Growth Factor Receptor Family And Mucin Expression By Eosinophil Granule Proteins In Epithelial Cells., Mohamed Amin 2010 Royal College of Surgeons in Ireland

Induction Of Epidermal Growth Factor Receptor Family And Mucin Expression By Eosinophil Granule Proteins In Epithelial Cells., Mohamed Amin

MD theses

Objectives

To determine the effect of the eosinophil cationic granule proteins Major Basic Protein (MBP) and Eosinophil Peroxidase (EPO) on expression of the epidermal growth factor receptors (EGFR) HER1 and HER2 and consequently mucin gene expression in bronchial epithelial cells. Eosinophil accumulation and degranulation at local inflammatory sites is a feature of asthma, allergic rhinitis and nasal polyposis. Eosinophils and their granule proteins have been implicated in cell and tissue remodelling and have been shown to communicate with other cell types at inflammatory sites, including epithelial cells and nerve cells. The HER family of receptors, including HER1 and HER2 are ...


Service Organisation For The Secondary Prevention Of Ischaemic Heart Disease In Primary Care., Brian S. Buckley, Mary C. Byrne, Susan M. Smith 2010 National University of Ireland, Galway

Service Organisation For The Secondary Prevention Of Ischaemic Heart Disease In Primary Care., Brian S. Buckley, Mary C. Byrne, Susan M. Smith

General Practice Articles

BACKGROUND: Ischaemic heart disease (IHD) is a major cause of mortality and morbidity and its prevalence is set to increase. Secondary prevention aims to prevent subsequent acute events in people with established IHD. While the benefits of individual medical and lifestyle interventions is established, the effectiveness of interventions which seek to improve the way secondary preventive care is delivered in primary care or community settings is less so.

OBJECTIVES: To assess the effectiveness of service organisation interventions, identifying which types and elements of service change are associated with most improvement in clinician and patient adherence to secondary prevention recommendations relating ...


Maternal Age At Birth And Childhood Type 1 Diabetes: A Pooled Analysis Of 30 Observational Studies, Chris R. Cardwell, Lars C. Stene, Geir Joner, Max K. Bulsara, Ondrej Cinek, Joachim Rosenbauer, Johnny Ludvigsson, Mireia Jané, Jannet Svensson, Michael J. Goldacre, Thomas Waldhoer, Przamyslawa Jarosz-Chobot, Suely GA Gimeno, Lee-Ming Chuang, Roger C. Parslow, Emma JK Wadsworth, Amanda Chetwynd, Paolo Pozzilli, Girts Brigis, Brone Urbonaitė, Sandra Sipetic, Edith Schober, Gabriele Devoti, Constantin Ionescu-Tirgoviste, Carine E. de Beaufort, Denka Stoyanov, Karsten Buschard, Chris C. Patterson 2010 University of Notre Dame Australia

Maternal Age At Birth And Childhood Type 1 Diabetes: A Pooled Analysis Of 30 Observational Studies, Chris R. Cardwell, Lars C. Stene, Geir Joner, Max K. Bulsara, Ondrej Cinek, Joachim Rosenbauer, Johnny Ludvigsson, Mireia Jané, Jannet Svensson, Michael J. Goldacre, Thomas Waldhoer, Przamyslawa Jarosz-Chobot, Suely Ga Gimeno, Lee-Ming Chuang, Roger C. Parslow, Emma Jk Wadsworth, Amanda Chetwynd, Paolo Pozzilli, Girts Brigis, Brone Urbonaitė, Sandra Sipetic, Edith Schober, Gabriele Devoti, Constantin Ionescu-Tirgoviste, Carine E. De Beaufort, Denka Stoyanov, Karsten Buschard, Chris C. Patterson

Medical Papers and Journal Articles

Objective: To investigate whether children born to older mothers have an increased risk of type 1 diabetes by performing a meta-analysis using individual patient data to adjust for recognised confounders.

Research design and methods: Relevant studies published before June 2009 were identified from MEDLINE, Web of Science and EMBASE. Authors of studies were contacted and asked to provide individual patient data or conduct pre-specified analyses. Risk estimates of type 1 diabetes by category of maternal age were calculated for each included study, before and after adjustment for potential confounders. Meta-analysis techniques were used to derive combined odds ratios, and investigate ...


Vascular Pharmacotherapy And Dementia, Oliver Piguet, Brett Garner 2010 Prince of Wales Medical Research Institute

Vascular Pharmacotherapy And Dementia, Oliver Piguet, Brett Garner

Illawarra Health and Medical Research Institute

The incidence of dementia is increasing dramatically with the ageing population. Increasing evidence indicates that vascular disease is associated with cognitive decline and with the most common form of dementia, Alzheimer's disease (AD). Cardiovascular risk factors such as hyperlipidaemia, hypertension and type 2 diabetes have attracted attention as potential targets in the prevention of dementia. The present review aims to provide a concise overview of the recent advances linking vascular disease with dementia (with a particular focus on AD) and to examine the evidence for efficacy, where possible, for utilising vascular pharmacotherapy as a treatment option for dementia. © 2010 ...


The Heart And Soul Of Change: Delivering What Works In Therapy, Second Edition (Book Review), B. F. S. Grenyer 2010 University of Wollongong

The Heart And Soul Of Change: Delivering What Works In Therapy, Second Edition (Book Review), B. F. S. Grenyer

Illawarra Health and Medical Research Institute

In 1936 Saul Rosenzweig (19072004) published a scientific paper concluding that psychotherapies of different theoretical and practical orientations all produce equivalent effectiveness-a conclusion that remains unchanged today despite 75 years of empirical research seeking to find differential effectiveness for different forms of psychotherapy treatment. What is less well know, however, is that despite equivalent effectiveness of therapy brand names, there is considerable variation in effectiveness between individual therapists. It is therefore fitting that this book begins with a message from Rosenzweig, which sets the scene for a very different volume from the first edition. The first edition (1999), edited by ...


The Possible Role Of Il-17 In Obesity-Associated Cancer, Tiphaine Gislette, Jiezhong Chen 2010 University of Wollongong

The Possible Role Of Il-17 In Obesity-Associated Cancer, Tiphaine Gislette, Jiezhong Chen

Illawarra Health and Medical Research Institute

Obesity and overweight have become major medical and social problems. Both are increasing worldwide; two-thirds of the population in developed countries is obese or overweight. Obesity has been associated with many comorbidities, including diabetes and heart disease. Studies have also found that obesity is one of the risk factors involved in increased cancer incidence. Many obesity-related factors are responsible, including increased blood levels of insulin/IGF, IL-6, TNF-alpha, and leptin, and decreased blood levels of adiponectin. Recently, it has been shown that IL-17 levels increase in obese patients. IL-17 is well known to increase carcinogenesis; thus, increased IL-17 levels in ...


Changes In Colon Gene Expression Associated With Increased Colon Inflammation In Interleukin-10 Gene-Deficient Mice Inoculated With Enterococcus Species, Matthew PG Barnett, Warren C. McNabb, Adrian L. Cookson, Shuotun Zhu, Marcus Davy, Bianca Knoch, Katie Nones, Alison J. Hodgkinson, Nicole Roy 2010 AgResearch Grasslands

Changes In Colon Gene Expression Associated With Increased Colon Inflammation In Interleukin-10 Gene-Deficient Mice Inoculated With Enterococcus Species, Matthew Pg Barnett, Warren C. Mcnabb, Adrian L. Cookson, Shuotun Zhu, Marcus Davy, Bianca Knoch, Katie Nones, Alison J. Hodgkinson, Nicole Roy

Illawarra Health and Medical Research Institute

Background: Inappropriate responses to normal intestinal bacteria may be involved in the development of Inflammatory Bowel Diseases (IBD, e.g. Crohn's Disease (CD), Ulcerative Colitis (UC)) and variations in the host genome may mediate this process. IL-10 gene-deficient (Il10-/-) mice develop CD-like colitis mainly in the colon, in part due to inappropriate responses to normal intestinal bacteria including Enterococcus strains, and have therefore been used as an animal model of CD. Comprehensive characterization of changes in cecum gene expression levels associated with inflammation in the Il10-/- mouse model has recently been reported. Our aim was to characterize changes in ...


Molecular Characterization Of The Onset And Progression Of Colitis In Inoculated Interleukin-10 Gene-Deficient Mice: A Role For Pparcx, Bianca Knoch, Matthew Barnett, Janine Cooney, Warren McNabb, Diane Barraclough, William Laing, Shuotun Zhu, Zaneta A. Park, Paul MacLean, Scott O. Knowles, Nicole Roy 2010 University of Wollongong

Molecular Characterization Of The Onset And Progression Of Colitis In Inoculated Interleukin-10 Gene-Deficient Mice: A Role For Pparcx, Bianca Knoch, Matthew Barnett, Janine Cooney, Warren Mcnabb, Diane Barraclough, William Laing, Shuotun Zhu, Zaneta A. Park, Paul Maclean, Scott O. Knowles, Nicole Roy

Illawarra Health and Medical Research Institute

The interleukin-10 gene-deficient (Il10−/−) mouse is a model of human inflammatory bowel disease and Ppara has been identified as one of the key genes involved in regulation of colitis in the bacterially inoculated Il10−/− model. The aims were to (1) characterize colitis onset and progression using a histopathological, transcriptomic, and proteomic approach and (2) investigate links between PPARα and IL10 using gene network analysis. Bacterial inoculation resulted in severe colitis in Il10−/− mice from 10 to 12 weeks of age. Innate and adaptive immune responses showed differences in gene expression relating to colitis severity. Actin cytoskeleton dynamics, innate immunity, and ...


Moral Distress And Avoidance Behavior In Nurses Working In Critical Care And Non-Critical Care Units, Mary Jo De Villers 2010 Loyola University Chicago

Moral Distress And Avoidance Behavior In Nurses Working In Critical Care And Non-Critical Care Units, Mary Jo De Villers

Dissertations

Significance: Nurses facing impediments to what they perceive as moral practice may experience inner turmoil, frustration, and moral distress. These scenarios may culminate in resignation from employment at the individual level, increased attrition at the systems level, and poor patient outcomes, including increased morbidity and mortality.

Purpose: To explore the relationships between moral distress and avoidance thoughts and behavior between nurses currently practicing in critical care and non-critical care settings.

Methods: A descriptive cross-sectional comparative design was used. The sample was comprised of a randomized subset of 370 critical care nurses, a convenience sample of 87 nurses from a nursing ...


Using Matching Methods From Both Fisher's Experimental Design And Rubin's Causal Model To Compare Between Two Medical Facilities With Extremely Skewed Number Of Subjects, Gideon D. Bahn 2010 Loyola University Chicago

Using Matching Methods From Both Fisher's Experimental Design And Rubin's Causal Model To Compare Between Two Medical Facilities With Extremely Skewed Number Of Subjects, Gideon D. Bahn

Dissertations

The present study deals with the problem of comparison between a two medical facilities' with extremely skewed sample sizes from non-experimental study. The data came from a study of rehabilitation interventions with patients diagnosed with cardiac and pulmonary issues who received treatment either in inpatient rehabilitation facilities (IRFs) or in skilled nursing facilities (SNFs). Due to inclusion and exclusion criteria, however, the study had failed to recruit sufficient number of participants between two comparison groups: 319 from IRFs and 27 from SNFs. As a result, the main hypothesis of the study was not tested due to the disparity of the ...


Hormone Induction Of Gamete Release And In-Vitro Fertilization In The Critically Endangered Corroboree Frog, Phillip G. Byrne, A J Silla 2010 University of Wollongong

Hormone Induction Of Gamete Release And In-Vitro Fertilization In The Critically Endangered Corroboree Frog, Phillip G. Byrne, A J Silla

Illawarra Health and Medical Research Institute

Background: Conservation Breeding Programs (CBP's) are playing an important role in the protection of critically endangered anuran amphibians, but for many species recruitment is not successful enough to maintain captive populations, or provide individuals for release. In response, there has been an increasing focus on the use of Assisted Reproductive Technologies (ART), including the administration of reproductive hormones to induce gamete release followed by in vitro fertilisation. The objective of this study was to test the efficacy of two exogenous hormones to induce gamete release, for the purpose of conducting in vitro fertilisation (IVF), in one of Australia's ...


Assessing The Risks Of Recycling Urban Stormwater For Potable Supply Via An Aquifer, Joanne Vanderzalm, Kerry Levett, Declan Page, Peter Dillon, Simon Toze, Konrad Miotlinski, Jatinder Sidhu, Karen Barry, Kim Alexander 2010 CSIRO Land and Water

Assessing The Risks Of Recycling Urban Stormwater For Potable Supply Via An Aquifer, Joanne Vanderzalm, Kerry Levett, Declan Page, Peter Dillon, Simon Toze, Konrad Miotlinski, Jatinder Sidhu, Karen Barry, Kim Alexander

Illawarra Health and Medical Research Institute

Urbanisation and the subsequent increase in impervious land use generate increased urban stormwater which can be recycled viamanaged aquifer recharge (MAR) to supplement more traditional surface or ground water supplies. This paper compares the quality of stormwater from two urban catchments in South Australia to assess the risks, in accordance with the Australian Guidelines for Water Recycling, of recycling stormwater via a limestone aquifer for potable water use. In the regional city of Mount Gambier, stormwater MARin a karstic aquifer has been used to supplement the city's drinking water supply for over 100 years. The source water was generally ...


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