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Pharmacologic Responses Of The Mouse Urinary Bladder, A. Erdem, Christopher Chapple, Russ Chess-Williams 2010 Bond University

Pharmacologic Responses Of The Mouse Urinary Bladder, A. Erdem, Christopher Chapple, Russ Chess-Williams

Russ Chess-Williams

The aim of the study was to determine pathways involved in contraction and relaxation of the mouse urinary bladder. Mouse bladder strips were set up in gassed Krebs-bicarbonate solution and responses to various drugs and electrical field stimulation were obtained. Isoprenaline (b-receptor agonist) caused a 63% inhibition of carbachol precontracted detrusor (EC50=2nM). Carbachol caused contraction (EC50=0.3µM), responses were antagonised more potently by 4-DAMP (M3-antagonist) than methoctramine (M2-antagonist). Electrical field stimulation caused contraction, which was inhibited by atropine (60%) and less by guanethidine and α,β-methylene-ATP. The neurogenic responses were not potentiated by inhibition of nitric oxide synthase ...


Pharmacologic Responses Of The Mouse Urinary Bladder, A. Erdem, Christopher Chapple, Russ Chess-Williams 2010 Bond University

Pharmacologic Responses Of The Mouse Urinary Bladder, A. Erdem, Christopher Chapple, Russ Chess-Williams

Russ Chess-Williams

The aim of the study was to determine pathways involved in contraction and relaxation of the mouse urinary bladder. Mouse bladder strips were set up in gassed Krebs-bicarbonate solution and responses to various drugs and electrical field stimulation were obtained. Isoprenaline (b-receptor agonist) caused a 63% inhibition of carbachol precontracted detrusor (EC50=2nM). Carbachol caused contraction (EC50=0.3µM), responses were antagonised more potently by 4-DAMP (M3-antagonist) than methoctramine (M2-antagonist). Electrical field stimulation caused contraction, which was inhibited by atropine (60%) and less by guanethidine and α,β-methylene-ATP. The neurogenic responses were not potentiated by inhibition of nitric oxide synthase ...


Blood Kinetics Of Four Intraperitoneally Administered Therapeutic Candidate Bacteriophages In Healthy And Neutropenic Mice, Jumpei Uchiyama, Yoshihiro Maeda, Iyo Takemura, Russ Chess-Williams, Hiroshi Wakiguchi, Shigenobu Matsuzaki 2010 Bond University

Blood Kinetics Of Four Intraperitoneally Administered Therapeutic Candidate Bacteriophages In Healthy And Neutropenic Mice, Jumpei Uchiyama, Yoshihiro Maeda, Iyo Takemura, Russ Chess-Williams, Hiroshi Wakiguchi, Shigenobu Matsuzaki

Russ Chess-Williams

Due to multiple-drug resistant bacteria, phage therapy is being revisited. Although most animal experiments focus on therapeutic efficacy, the blood clearance kinetics of phages have not been well described. For further development of an efficient therapeutic strategy, information on phage blood kinetics is important. In this study, time-course concentration changes in peripheral blood of healthy and neutropenic mice were measured using four therapeutic phages (φMR11, KPP10, φEF24C, and KEP10). The results showed a two- to three-day rapid phage clearance, which fits a two-compartment model.


Mechanisms Of Rotator Cuff Disease: Alterations Of Scapular Kinematics On Subacromial Space, Amee Seitz 2010 Virginia Commonwealth University

Mechanisms Of Rotator Cuff Disease: Alterations Of Scapular Kinematics On Subacromial Space, Amee Seitz

Theses and Dissertations

Rotator cuff disease is multi-factored and has been attributed to both intrinsic and extrinsic factors. Extrinsic factors contribute to compression of the rotator cuff tendons. Intrinsic factors that contribute to rotator cuff tendon degradation with tensile/shear overload include alterations in biology, mechanical properties, morphology, and vascularity. Subacromial impingement is related to factors that encroach upon the subacromial space, while internal impingement affects the articular side of the tendons adjacent to glenoid. While the mechanisms of impingement are varied, further research is necessary to improve treatment and patient outcomes. Chapter 2 is a thorough review of literature on the mechanisms ...


Identification Of Methylated Genes Associated With Aggressive Bladder Cancer, Carmen J. Marsit, E. Andres Houseman, Brock C. Christensen, Luc Gagne, Margaret R. Wrensch, Heather H. Nelson, Joseph Weimels, Shichun Zheng, John K. Wiencke, Angeline S. Andrew, Alan R. Schned, Margaret R. Karagas, Karl T. Kelsey 2010 Brown University

Identification Of Methylated Genes Associated With Aggressive Bladder Cancer, Carmen J. Marsit, E. Andres Houseman, Brock C. Christensen, Luc Gagne, Margaret R. Wrensch, Heather H. Nelson, Joseph Weimels, Shichun Zheng, John K. Wiencke, Angeline S. Andrew, Alan R. Schned, Margaret R. Karagas, Karl T. Kelsey

Open Dartmouth: Faculty Open Access Articles

Approximately 500,000 individuals diagnosed with bladder cancer in the U.S. require routine cystoscopic follow-up to monitor for disease recurrences or progression, resulting in over $ 2 billion in annual expenditures. Identification of new diagnostic and monitoring strategies are clearly needed, and markers related to DNA methylation alterations hold great promise due to their stability, objective measurement, and known associations with the disease and with its clinical features. To identify novel epigenetic markers of aggressive bladder cancer, we utilized a high-throughput DNA methylation bead-array in two distinct population-based series of incident bladder cancer (n = 73 and n = 264, respectively). We ...


Studies On Antidyslipidemic Effects Of Morinda Citrifolia (Noni) Fruit, Leaves And Root Extracts., Saf-ur Rehman Mandukhail, Nauman Aziz, Anwar Gilani 2010 Aga Khan University

Studies On Antidyslipidemic Effects Of Morinda Citrifolia (Noni) Fruit, Leaves And Root Extracts., Saf-Ur Rehman Mandukhail, Nauman Aziz, Anwar Gilani

Department of Biological & Biomedical Sciences

Background: The objective of present study was to provide the pharmacological basis for the medicinal use of Morinda citrifolia Linn in dyslipidemia using the aqueous-ethanolic extracts of its fruits (Mc.Cr.F), leaves (Mc.Cr.L) and roots (Mc.Cr.R). Results: Mc.Cr.F, Mc.Cr.L and Mc.Cr.R showed antidyslipidemic effects in both triton (WR-1339) and high fat diet-induced dyslipidemic rat models to variable extents. All three extracts caused reduction in total cholesterol and triglyceride levels in triton-induced dyslipidemia. In high fat diet-induced dyslipidemia all these extracts caused significant reduction in total cholesterol, triglyceride, low density ...


Mechanical Flow Restoration In Acute Ischemic Stroke: A Model System Of Cerebrovascular Occlusion: A Dissertation, Juyu Chueh 2010 University of Massachusetts Medical School

Mechanical Flow Restoration In Acute Ischemic Stroke: A Model System Of Cerebrovascular Occlusion: A Dissertation, Juyu Chueh

GSBS Dissertations and Theses

Stroke is the third most common cause of death and a leading cause of disability in the United States. The existing treatments of acute ischemic stroke (AIS) involve pharmaceutical thrombolytic therapy and/or mechanical thrombectomy. The Food and Drug Administration (FDA)-approved recombinant tissue plasminogen activator (tPA) administration for treatment of stroke is efficacious, but has a short treatment time window and is associated with a risk of symptomatic hemorrhage. Other than tPA, the Mechanical Embolus Removal in Cerebral Ischemia (MERCI) retriever system and the Penumbra Aspiration system are both approved by the FDA for retrieval of thromboemboli in AIS ...


Dissecting The Role Of Innate Pattern Recognition Receptors And Interferon Regulatory Factor-5 In The Immune Response To Human Metapneumovirus And Other Pathogens: A Dissertation, Zhaozhao Jiang 2010 University of Massachusetts Medical School

Dissecting The Role Of Innate Pattern Recognition Receptors And Interferon Regulatory Factor-5 In The Immune Response To Human Metapneumovirus And Other Pathogens: A Dissertation, Zhaozhao Jiang

GSBS Dissertations and Theses

The Innate immune system is the first line of defense against invading microbial pathogens. It is a fast-acting and non-antigen-specific defense system, which employs germline encoded surveillance systems capable of responding to a broad-spectrum of pathogens. The innate immune system involves a variety of immune cells, which express different profiles of surveillance or detection receptors. Upon sensing pathogens, these receptors trigger cell signalling to turn on transcription of inflammatory cytokines, chemokines, anti-microbial peptides and type I Interferons. These effectors have direct effects on the control of pathogen load and also activate the adaptive immune system, which is ultimately required to ...


Lybarger, Shaunn Maree (Fa 115), Manuscripts & Folklife Archives 2010 Western Kentucky University

Lybarger, Shaunn Maree (Fa 115), Manuscripts & Folklife Archives

FA Finding Aids

"Menstruation: Childbirth and Child-rearing." Independent study compiled for a Western Kentucky University Folk Studies class. Utilizing existing Folklife Archives collections, Lybarger referenced beliefs, customs, and cures associated with fertility, families, child-rearing, and menstruation.


Governmental Public Health: An Overview Of State And Local Public Health Agencies, Eileen Salinsky 2010 George Washington University

Governmental Public Health: An Overview Of State And Local Public Health Agencies, Eileen Salinsky

National Health Policy Forum

The Patient Protection and Affordable Care Act significantly expands federal support for community prevention and public health. This paper describes the governmental public health infrastructure at both the state and local level in terms of organizational structure, activities, financing, workforce, partnerships, and performance improvement efforts.


Understanding The Health Beliefs Of First Time Mothers Who Request An Elective Cesarean Versus Mothers Who Request A Vaginal Delivery, Deborah T. MacMillan 2010 Georgia State University

Understanding The Health Beliefs Of First Time Mothers Who Request An Elective Cesarean Versus Mothers Who Request A Vaginal Delivery, Deborah T. Macmillan

Nursing Dissertations (PhD)

Little is known about how the decision for elective cesarean section comes about in the clinical environment. A prospective longitudinal study based on the Health Belief Model was conducted about first time mothers’ decision making processes and their health beliefs which led to their satisfaction with their decision about their mode of delivery. A convenience sample of 144 nulliparous women with singleton pregnancies and no medical indications requiring a cesarean delivery were recruited using internet based informational notices and with flyers. Women (n = 127) planning a vaginal delivery (VDMR) represented 88.2% of the sample and women (n = 17) requesting ...


Development And Applications Of The Hint Forcefield In Prediction Of Antibiotic Efflux And Virtual Screening For Antivirals, Aurijit Sarkar 2010 Virginia Commonwealth University

Development And Applications Of The Hint Forcefield In Prediction Of Antibiotic Efflux And Virtual Screening For Antivirals, Aurijit Sarkar

Theses and Dissertations

This work was aimed at developing novel tools that utilize HINT, an empirical forcefield capable of quantitating both hydrophobic and hydrophilic (hydropathic) interactions, for implementation in theoretical biology and drug discovery/design. The role of hydrophobicity in determination of macromolecular structure and formation of complexes in biological molecules is undeniable and has been the subject of research across several decades. Hydrophobicity is introduced, with a review of its history and contemporary theories. This is followed by a description of various methods that quantify this all-pervading phenomenon and their use in protein folding and contemporary drug design projects – including a detailed ...


Acute Lymphoblastic Leukemia Subsequent To Temozolomide Use In A 26-Year-Old Man: A Case Report., Asim Jamal Shaikh, Nehal Masood 2010 Aga Khan University

Acute Lymphoblastic Leukemia Subsequent To Temozolomide Use In A 26-Year-Old Man: A Case Report., Asim Jamal Shaikh, Nehal Masood

Section of Haematology/Oncology

Introduction: We report the development of acute lymphoblastic leukemia in a Patient in whom temozolomide was used for the treatment of a brain tumor. Unlike that of other alkylating agents, the leukemogenic potential of temozolomide is considered to be very low, and very rarely are such cases reported. Case Presentation: A 26-year-old Pakistani man who was treated for glioblastoma with temozolomide in an adjuvant setting was diagnosed to have acute lymphoblastic leukemia one year after stopping temozolomide. Conclusion: Temozolomide is a highly active agent, used in the management of high-grade brain neoplasms. The agent is generally regarded to be safe ...


Inhibition Of Allogeneic Inflammatory Responses By The Ribonucleotide Reductase Inhibitors, Didox And Trimidox, Mohammed S. Inayat, Ismail S. El-Amouri, Mohammad Bani-Ahmad, Howard L. Elford, Vincent S. Gallicchio, Oliver R. Oakley 2010 University of Kentucky

Inhibition Of Allogeneic Inflammatory Responses By The Ribonucleotide Reductase Inhibitors, Didox And Trimidox, Mohammed S. Inayat, Ismail S. El-Amouri, Mohammad Bani-Ahmad, Howard L. Elford, Vincent S. Gallicchio, Oliver R. Oakley

Clinical Sciences Faculty Publications

BACKGROUND: Graft-versus-host disease is the single most important obstacle facing successful allogeneic stem cell transplantation (SCT). Even with current immunosuppressive therapies, morbidity and mortality rates are high. Current therapies including cyclosporine A (CyA) and related compounds target IL-2 signaling. However, although these compounds offer great benefit, they are also associated with multiple toxicities. Therefore, new compounds with a greater efficacy and reduced toxicity are needed to enable us to overcome this hurdle.

METHODS: The allogeneic mixed lymphocyte reaction (MLR) is a unique ex vivo method to study a drug's action on the initial events resulting in T-cell activation and ...


What's New In Spine Surgery, Keith H. Bridwell, Paul A. Anderson, Scott D. Boden, Alexander R. Vaccaro, Jeffrey C. Wang 2010 Washington University School of Medicine in St. Louis

What's New In Spine Surgery, Keith H. Bridwell, Paul A. Anderson, Scott D. Boden, Alexander R. Vaccaro, Jeffrey C. Wang

Open Access Publications

No abstract provided.


W. Beaumont’S “On Physical Man Or The Phenomena Of Life Principally In Relation To Nutrition.” Undated, 2010 Washington University School of Medicine

W. Beaumont’S “On Physical Man Or The Phenomena Of Life Principally In Relation To Nutrition.” Undated

Undated

No abstract provided.


W. Beaumont’S Notes From Works Of Jan Baptist Van Helmont Including “His Dream On The Flux Or Flowing Unto Generation” And “Prophetic Poems On Himself And His Works With An Acrostic On His Name.” Undated, 2010 Washington University School of Medicine

W. Beaumont’S Notes From Works Of Jan Baptist Van Helmont Including “His Dream On The Flux Or Flowing Unto Generation” And “Prophetic Poems On Himself And His Works With An Acrostic On His Name.” Undated

Undated

No abstract provided.


Kids Into Health Careers: A Rural Initiative, Lori S. Lauver PhD, Beth Ann Swan PhD, Margaret Mary West PhD, Ksenia Zukowsky PhD, Mary Powell PhD, Tony Frisby PhD, Sue Neyhard MA, Alexis Marsella BA 2010 Thomas Jefferson University

Kids Into Health Careers: A Rural Initiative, Lori S. Lauver Phd, Beth Ann Swan Phd, Margaret Mary West Phd, Ksenia Zukowsky Phd, Mary Powell Phd, Tony Frisby Phd, Sue Neyhard Ma, Alexis Marsella Ba

College of Nursing Faculty Papers & Presentations

Abstract

Purpose: To describe a project that introduces middle school and high school students living in Pennsylvania’s rural geographic regions to nursing careers through outreach extended to students regardless of gender, ethnicity, or socioeconomic status.

Method: The authors employed many strategies to inform students about careers in nursing. The methods included: working with guidance counselors, participating in community health fairs, taking part in school health career fairs, collaborating with Area Health Education Centers, serving on volunteer local education advisory boards, developing a health careers resource guide, and establishing a rural health advisory board.

Findings: Developing developmentally appropriate programs may ...


Mechanisms Of Oxidant Generation By Catalase, Diane E. Heck, Michael Shakarjian, Hong-Duck Kim, Jeffrey Laskin, Anna M. Vetrano 2010 New York Medical College

Mechanisms Of Oxidant Generation By Catalase, Diane E. Heck, Michael Shakarjian, Hong-Duck Kim, Jeffrey Laskin, Anna M. Vetrano

NYMC Faculty Publications

The enzyme catalase converts solar radiation into reactive oxidant species (ROS). In this study, we report that several bacterial catalases (hydroperoxidases, HP), including Escherichia coli HP-I and HP-II also generate reactive oxidants in response to ultraviolet B light (UVB). HP-I and HP-II are identical except for the presence of NADPH. We found that only one of the catalases, HPI, produces oxidants in response to UVB light, indicating a potential role for the nucleotide in ROS production. This prompts us to speculate that NADPH may act as a cofactor regulating ROS generation by mammalian catalases. Structural analysis of the NADPH domains ...


Triggers Of Self-Conscious Emotions In The Sexually Transmitted Infection Testing Process., Myles Balfe, Ruairi Brugha, Diarmuid O' Donovan, Emer O' Connell, Deirdre Vaughan 2010 Royal College of Surgeons in Ireland

Triggers Of Self-Conscious Emotions In The Sexually Transmitted Infection Testing Process., Myles Balfe, Ruairi Brugha, Diarmuid O' Donovan, Emer O' Connell, Deirdre Vaughan

Epidemiology and Public Health Medicine Articles

BACKGROUND: Self-conscious emotions (shame, guilt and embarrassment) are part of many individuals' experiences of seeking STI testing. These emotions can have negative impacts on individuals' interpretations of the STI testing process, their willingness to seek treatment and their willingness to inform sexual partners in light of positive STI diagnoses. Because of these impacts, researchers have called for more work to be completed on the connections between shame, guilt, embarrassment and STI testing. We examine the specific events in the STI testing process that trigger self-conscious emotions in young adults who seek STI testing; and to understand what it is about ...


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