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Illinois Wesleyan University Celebrates With History, Noel Kerr 2012 Illinois Wesleyan University

Illinois Wesleyan University Celebrates With History, Noel Kerr

Noël M Kerr PhD, RN, CMSRN

No abstract provided.


Phase I Clinical Trial Of Oral Rosiglitazone In Combination With Intravenous Carboplatin In Cancer-Bearing Dogs, Sara Frazier, D McKemie, T Guerrero, H Lachapelle, K Skorupski, P Kass, C Rodriguez CO 2012 University of California - Davis

Phase I Clinical Trial Of Oral Rosiglitazone In Combination With Intravenous Carboplatin In Cancer-Bearing Dogs, Sara Frazier, D Mckemie, T Guerrero, H Lachapelle, K Skorupski, P Kass, C Rodriguez Co

Sara Allstadt, DVM, Diplomate ACVIM (Oncology)

Rosiglitazone is an FDA-approved peroxisome proliferator-activated receptor gamma (PPARγ) agonist and antidiabetic agent in humans that has been investigated for its ability to reduce tumor cell growth. The purpose of this study was to determine the maximally tolerated dose, peak plasma concentrations and side effect profile of oral rosiglitazone when combined with carboplatin in dogs with cancer. Rosiglitazone was administered at 6 and 8 mg/m(2) to seven dogs. Carboplatin was administered at 240-300 mg/m(2) in combination with rosiglitazone. For toxicity evaluation, the toxicity data for the seven dogs in this study were combined with the toxicity ...


Academic Safety During Nursing Simulation: Perceptions Of Nursing Students And Faculty, Barbara Ganley, Luanne Linnard-Palmer 2012 Department of Nursing, Dominican University of California

Academic Safety During Nursing Simulation: Perceptions Of Nursing Students And Faculty, Barbara Ganley, Luanne Linnard-Palmer

Luanne Linnard-Palmer

Background Nursing simulation is said to be a safe learning environment. However, research and anecdotal information suggest it may be safe for patients but not academically safe for students. Academic safety is defined. Method Nursing students (n = 101) and faculty (n = 24) from schools in the San Francisco area completed online surveys to describe an academically safe learning environment. Results/Conclusions Faculty and students defined academically safe as supportive, and a climate where freedom to learn and grow is enjoyed by all.


Medical And Medication Errors In America: A National Catastrophe, Luanne Linnard-Palmer 2012 Department of Nursing, Dominican University of California

Medical And Medication Errors In America: A National Catastrophe, Luanne Linnard-Palmer

Luanne Linnard-Palmer

No abstract available


Biomechanical Examination Of The ‘Plateau Phenomenon’ In Actigraph Vertical Activity Counts, Dinesh John, Ross Miller, Sarah Kozey-Keadle1, Graham E. Caldwell, Patty Freedson 2012 University of Massachusetts - Amherst

Biomechanical Examination Of The ‘Plateau Phenomenon’ In Actigraph Vertical Activity Counts, Dinesh John, Ross Miller, Sarah Kozey-Keadle1, Graham E. Caldwell, Patty Freedson

Graham E. Caldwell

Purpose—Determine if the leveling off (‘plateau/inverted-U’ phenomenon) of vertical ActiGraph activity counts during running at higher speeds is attributable to the monitor’s signal filtering and acceleration detection characteristics. Methods—Ten endurance-trained male participants [mean (SD) age= 28.2 (4.7) yrs] walked at 3, 5 and 7 km˙hr−1, and ran at 8, 10, 12, 14, 16, 18 and 20 km˙hr−1 on a force treadmill while wearing an ActiGraph GT3X monitor at the waist. Triaxial accelerations of the body’s center of mass (CoM) and frequency content of these accelerations were computed from the ...


Latent Print Examination And Human Factors: Improving The Practice Through A Systems Approach, David H. Kaye, Thomas Busey, Melissa R. Gische, Gerry LaPorte, Scott A. Shappell, et al. 2012 Expert Working Group on Human Factors in Latent Print Analysis

Latent Print Examination And Human Factors: Improving The Practice Through A Systems Approach, David H. Kaye, Thomas Busey, Melissa R. Gische, Gerry Laporte, Scott A. Shappell, Et Al.

Scott Shappell

Fingerprints have provided a valuable method of personal identification in forensic science and criminal investigations for more than 100 years. Fingerprints left at crime scenes generally are latent prints--unintentional reproductions of the arrangement of ridges on the skin made by the transfer of materials (such as amino acids, proteins, polypeptides, and salts) to a surface. Palms and the soles of feet also have friction ridge skin that can leave latent prints. The examination of a latent print consists of a series of steps involving a comparison of the latent print to a known (or exemplar) print. Courts have accepted latent ...


2011 Keane High-Avidity, High-Ifnγ-Producing Cd8 T-Cell Responses Following Immune Selection During Hiv-1 Infection.Pdf, M Tschochner 2012 The University of Notre Dame Australia

2011 Keane High-Avidity, High-Ifnγ-Producing Cd8 T-Cell Responses Following Immune Selection During Hiv-1 Infection.Pdf, M Tschochner

Monika Tschochner

No abstract provided.


Social Stress Promotes And Γ-Aminobutyric Acid Inhibits Tumor Growth In Mouse Models Of Non-Small Cell Lung Cancer, H. A. Al-Wadei, H. K. Plummer III, M. F. Ullah, J. R. Brody, Hildegard M. Schuller 2012 University of Tennessee, Knoxville

Social Stress Promotes And Γ-Aminobutyric Acid Inhibits Tumor Growth In Mouse Models Of Non-Small Cell Lung Cancer, H. A. Al-Wadei, H. K. Plummer Iii, M. F. Ullah, J. R. Brody, Hildegard M. Schuller

Hildegard M. Schuller

Psychologic distress is associated with increased lung cancer incidence and mortality. We have shown that non-small cell lung cancer (NSCLC) cells in vitro are stimulated by the cyclic AMP (cAMP)-dependent activation of cAMP-responsive element binding protein (CREB) and extracellular signal-regulated kinase (ERK) downstream of β-adrenergic receptors and that this pathway is inhibited by the neurotransmitter γ-aminobutyric acid (GABA). Because the stress neurotransmitters noradrenalin and adrenalin are β-adrenergic agonists, the current study has tested the hypothesis that social stress stimulates NSCLC growth in vivo and that GABA inhibits this effect. Social stress was induced in mice carrying xenografts from two ...


Pancreatic Cancer Cells And Normal Pancreatic Duct Epithelial Cells Express An Autocrine Catecholamine Loop That Is Activated By Nicotinic Acetylcholine Receptors Α3, Α5, And Α7, M. H. Al-Wadei, H. A. Al-Wadei, Hildegard M. Schuller 2012 University of Tennessee, Knoxville

Pancreatic Cancer Cells And Normal Pancreatic Duct Epithelial Cells Express An Autocrine Catecholamine Loop That Is Activated By Nicotinic Acetylcholine Receptors Α3, Α5, And Α7, M. H. Al-Wadei, H. A. Al-Wadei, Hildegard M. Schuller

Hildegard M. Schuller

Pancreatic cancer is the fourth leading cause of cancer deaths in developed countries. Smoking is an established risk factor for this malignancy but the underlying mechanisms are poorly understood. Previous reports have provided evidence that nicotinic acetylcholine receptors (nAChR) and beta adrenergic receptors (β-AR) stimulate the growth and migration of pancreatic cancer cells. However, a potential cooperation of these two receptor families in the regulation of pancreatic cancer has not been studied to date. Using two pancreatic cancer cell lines and immortalized pancreatic duct epithelia in vitro, our current data show that all three cell lines synthesized and released the ...


Comparison Of Arch Form Between Ethnic Malays And Malaysian Aborigines In Peninsular Malaysia, Siti Adibah Othman, Soh Xinwei Eunice, Sheh Yinn Lim, Jamaludin Marhazlinda, Mohamed Nor Himazian, Mohd Yusof Zamros Yuzaidi, Shoaib Lily Azura, Nik Hussein Nik Noriah 2012 University of Malaya

Comparison Of Arch Form Between Ethnic Malays And Malaysian Aborigines In Peninsular Malaysia, Siti Adibah Othman, Soh Xinwei Eunice, Sheh Yinn Lim, Jamaludin Marhazlinda, Mohamed Nor Himazian, Mohd Yusof Zamros Yuzaidi, Shoaib Lily Azura, Nik Hussein Nik Noriah

Siti Adibah Othman

Objective: To determine and compare the frequency distribution of various arch shapes in ethnic Malays and Malaysian Aborigines in Peninsular Malaysia and to investigate the morphological diff erences of arch form between these two ethnic groups. Methods: We examined 120 ethnic Malay study models (60 maxillary, 60 mandibular) and 129 Malaysian Aboriginal study models (66 maxillary, 63 mandibular). We marked 18 buccal tips and incisor line angles on each model, and digitized them using 2-dimensional coordinate system. Dental arches were classified as square, ovoid, or tapered by printing the scanned images and superimposing Orthoform arch templates on them. Results: Th ...


Active Living In The Trucking Sector: Environmental Barriers And Health Promotion Strategies, Yorghos Apostolopoulos, Mona Shattell, Sevil Sönmez, Robert Strack, Lauren Haldman, Victoria Jones 2012 University of North Carolina at Greensboro

Active Living In The Trucking Sector: Environmental Barriers And Health Promotion Strategies, Yorghos Apostolopoulos, Mona Shattell, Sevil Sönmez, Robert Strack, Lauren Haldman, Victoria Jones

Mona Shattell

Background: As one of the most underserved segments of the U.S. labor force, truck drivers have been associated with a series of morbid conditions intimately linked to their occupational milieux, their mostly unhealthful nutritional intake and sedentary lifestyles, and their resulting excess weight-gain. Methods: This paper reports data from a baseline assessment of 25 trucking work settings located around interstate highways I-40 and I-85 in North Carolina. It examines how the environmental attributes of these work settings influence the physical and recreational activity behaviors of truckers, compares findings with those from other occupational environments, and brings to the fore ...


Long Term Predictive Validity Of Diagnostic Models For Personality Disorder: Integrating Trait And Disorder Concepts, Leslie C. Morey, Christopher J. Hopwood, John C. Markowitz, John G. Gunderson, Carlos M. Grilo, Thomas H. McGlashan, M. Tracie Shea, Shirley Yen, Charles A. Sanislow, Andrew E. Skodol 2012 Texas A & M University - College Station

Long Term Predictive Validity Of Diagnostic Models For Personality Disorder: Integrating Trait And Disorder Concepts, Leslie C. Morey, Christopher J. Hopwood, John C. Markowitz, John G. Gunderson, Carlos M. Grilo, Thomas H. Mcglashan, M. Tracie Shea, Shirley Yen, Charles A. Sanislow, Andrew E. Skodol

Charles A. Sanislow, Ph.D.

Background. Several conceptual models have been considered for the assessment of personality pathology in DSM-5. This study sought to extend our previous findings to compare the long-term predictive validity of three such models: the Five-Factor Model (FFM), the Schedule for Nonadaptive and Adaptive Personality (SNAP), and DSM-IV personality disorders (PDs).

Method. An inception cohort from the Collaborative Longitudinal Personality Disorder Study (CLPS) was followed for 10 years. Baseline data were used to predict long-term outcomes, including functioning, Axis I psychopathology, and medication use.

Results. Each model was significantly valid, predicting a host of important clinical outcomes. Lower-order elements of the ...


Long-Term Outcomes In Borderline Psychopathology: Old Assumptions, Current Findings, And New Directions, Charles A. Sanislow, Katherine L. Marcus, Elizabeth M. Reagan 2012 Wesleyan University

Long-Term Outcomes In Borderline Psychopathology: Old Assumptions, Current Findings, And New Directions, Charles A. Sanislow, Katherine L. Marcus, Elizabeth M. Reagan

Charles A. Sanislow, Ph.D.

Borderline personality disorder (BPD) and historical variants of the diagnosis were long held to represent an intractable syndrome of psychopathology consisting of interpersonal, intrapsychic, and affective disturbances. For years, patients labeled “borderline” were regarded pejoratively due at least in part to the lack of effective treatments. Prospective data from recent naturalistic follow-along studies along with the development of treatments with empirically demonstrated efficacy have changed how BPD is viewed. It is now less common to hide the diagnosis from the patient, and BPD has become a useful label to guide the treatment process and help the patient make sense of ...


Constructivism Applied To Psychiatric–Mental Health Nursing: An Alternative To Supplement Traditional Clinical Education, Michelle D. Hampton 2012 Samuel Merritt University

Constructivism Applied To Psychiatric–Mental Health Nursing: An Alternative To Supplement Traditional Clinical Education, Michelle D. Hampton

Michelle DeCoux Hampton

With the popularity of accelerated pre‐licensure nursing programmes and the growth in nursing student enrolments, traditional clinical education continues to be a challenge to deliver. Nursing faculty members are required to develop and implement educational innovations that achieve effective learning outcomes, while using fewer resources. The purpose of this qualitative study was to explore the effectiveness of a constructivism‐based learning project to achieve specific learning outcomes and to supplement approximately 30 clinical hours in a psychiatric–mental health nursing course. Students participated in a 10‐week, multistage project that examined life histories, treatment resources, and evidence‐based practice ...


The Efficacy And Toxicity Of Bupropion In The Elderly, William T. Howard M.D., M.S., Julia K. Warnock M.D., Ph.D. 2012 Johns Hopkins Department of Mental Hygiene

The Efficacy And Toxicity Of Bupropion In The Elderly, William T. Howard M.D., M.S., Julia K. Warnock M.D., Ph.D.

Jefferson Journal of Psychiatry

Bupropion is an antidepressant with excellent tolerability and few side effects or drug interactions. These characteristics suite it well for use both in the elderly and in the medically ill. However, early reports of seizures with bupropion therapy in patients with bulimia limited its use. The pharmacology, efficacy, toxicity, and side effect profile of both the immediate release (IR) and the recently available sustained release (SR) formulations of bupropion are reviewed. Bupropion SR is associated with a reduced seizure incidence (0.1%) compared to that found with the IR formulation (0.4%). Recent reports, however, demonstrate that the half-life of ...


The Malingering Of Psychotic Disorders, Michael R. Harris M.D. 2012 University of Louisville School of Medicine

The Malingering Of Psychotic Disorders, Michael R. Harris M.D.

Jefferson Journal of Psychiatry

The phenomenon of malingered psychosis is examined through a review of the available literature. Possible motivations for malingering are discussed, and clinical indicators of feigned psychotic symptoms are reviewed. The methods discussed focus on the inpatient evaluation of suspected malingerers and include discussions of interview techniques and psychometric testing to supplement clinical impressions. A differential diagnosis is presented, and techniques for confronting a malingering patient are reviewed.


Use Of A Constant Rate Infusion Of Insulin For The Treatment Of Hyperglycemic, Hypernatremic, Hyperosmolar Syndrome In An Alpaca Cria, T Buchheit, Carla Sommardahl, Nicholas Frank, Jerry Roberson 2012 University of Tennessee, Knoxville

Use Of A Constant Rate Infusion Of Insulin For The Treatment Of Hyperglycemic, Hypernatremic, Hyperosmolar Syndrome In An Alpaca Cria, T Buchheit, Carla Sommardahl, Nicholas Frank, Jerry Roberson

Jerry R. Roberson DVM, DACVIM

CASE DESCRIPTION: A 3-day-old 9.5-kg (21-lb) female alpaca cria was examined because of lethargy and anorexia. CLINICAL FINDINGS: Physical examination revealed hyperthermia, muscle fasciculations, and tremors of the head. Seizures were also observed, which indicated CNS dysfunction. Hyperosmolar syndrome (HOS) was diagnosed on the basis of hyperglycemia, hypernatremia, azotemia, high plasma osmolarity, and metabolic acidosis. TREATMENT AND OUTCOME: A constant rate infusion of regular insulin was administered with hypo-osmolar fluids to treat HOS, and blood glucose and sodium concentrations were successfully lowered. Neurologic deficits resolved with treatment, and the cria was discharged 11 days after admission. CLINICAL RELEVANCE: Administration ...


Size Of Food Bowl And Scoop Affects Amount Of Food Owners Feed Their Dogs, Maryanne Murphy, Angela Witzel, Joe Bartges, Claudia Kirk 2012 University of Tennessee - Knoxville

Size Of Food Bowl And Scoop Affects Amount Of Food Owners Feed Their Dogs, Maryanne Murphy, Angela Witzel, Joe Bartges, Claudia Kirk

Angela L Witzel (Lusby) DVM, PhD, DACVN

The incidence of canine obesity appears to be increasing dramatically and understanding factors impacting the amount of food pet owners provide their dogs may improve weight management. Human research has shown the size of food bowls, plates and utensils can significantly impact the amount of food portioned and consumed. This effect can be attributed to both the Delboeuf optical illusion and the Ebbinghaus-Titchener size-contrast illusion. To investigate the existence of a similar effect with dog owners, 54 dogs and their owners were recruited for a four treatment randomized prospective trial. Owners scooped out a normal kibble-based meal using a small ...


What Is Your Diagnosis? Osteosarcoma In A Dog, L Fromberg, Federica Morandi, Angela Lusby 2012 University of Tennessee, Knoxville

What Is Your Diagnosis? Osteosarcoma In A Dog, L Fromberg, Federica Morandi, Angela Lusby

Angela L Witzel (Lusby) DVM, PhD, DACVN

No abstract provided.


The Role Of Key Adipokines In Obesity And Insulin Resistance In Cats, Angela Lusby, Claudia Kirk, Joe Bartges 2012 University of Tennessee - Knoxville

The Role Of Key Adipokines In Obesity And Insulin Resistance In Cats, Angela Lusby, Claudia Kirk, Joe Bartges

Angela L Witzel (Lusby) DVM, PhD, DACVN

No abstract provided.


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